Open Access

Liriopesides B induces apoptosis and cell cycle arrest in human non‑small cell lung cancer cells

  • Authors:
    • Hongxu Sheng
    • Wang Lv
    • Linhai Zhu
    • Luming Wang
    • Zhitian Wang
    • Jia Han
    • Jian Hu
  • View Affiliations

  • Published online on: June 16, 2020     https://doi.org/10.3892/ijmm.2020.4645
  • Pages: 1039-1050
  • Copyright: © Sheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Although significant progress has been made in the treatment of lung cancer, it remains the leading cause of cancer‑associated mortality. Liriopesides B (LPB) is a natural product isolated from the tuber of Liriope platyphylla, whose effective substances have exhibited antitumor activity in several types of cancer. However, the functions of LPB in non‑small cell lung cancer (NSCLC) require further investigation. Therefore, the present study aimed to investigate whether LPB influences the pathogenic effects of NSCLC. In the present study, it was demonstrated that LPB reduced proliferation, and induced apoptosis and cell cycle arrest in non‑small cell lung cancer cells. CCK‑8 and colony formation assays demonstrated that LPB decreased cell viability and proliferation of H460 and H1975 cells in a dose‑dependent manner. Flow cytometry revealed that LPB significantly induced apoptosis of NSCLC cells, along with changes in the expression of apoptosis‑associated proteins, including an increase in Bax, caspase‑3, and caspase‑8 expression, and a decrease in Bcl‑2 and Bcl‑xl expression. LPB inhibited the progression of the cell cycle from the G1 to the S phase. Furthermore, autophagy was increased in cells treated with LPB. Finally, the expression of programmed death‑ligand 1 was significantly decreased by LPB. In conclusion, the results of the present study highlight a potential novel strategy for the clinical treatment of NSCLC.

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September-2020
Volume 46 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Sheng H, Lv W, Zhu L, Wang L, Wang Z, Han J and Hu J: Liriopesides B induces apoptosis and cell cycle arrest in human non‑small cell lung cancer cells. Int J Mol Med 46: 1039-1050, 2020
APA
Sheng, H., Lv, W., Zhu, L., Wang, L., Wang, Z., Han, J., & Hu, J. (2020). Liriopesides B induces apoptosis and cell cycle arrest in human non‑small cell lung cancer cells. International Journal of Molecular Medicine, 46, 1039-1050. https://doi.org/10.3892/ijmm.2020.4645
MLA
Sheng, H., Lv, W., Zhu, L., Wang, L., Wang, Z., Han, J., Hu, J."Liriopesides B induces apoptosis and cell cycle arrest in human non‑small cell lung cancer cells". International Journal of Molecular Medicine 46.3 (2020): 1039-1050.
Chicago
Sheng, H., Lv, W., Zhu, L., Wang, L., Wang, Z., Han, J., Hu, J."Liriopesides B induces apoptosis and cell cycle arrest in human non‑small cell lung cancer cells". International Journal of Molecular Medicine 46, no. 3 (2020): 1039-1050. https://doi.org/10.3892/ijmm.2020.4645