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Article Open Access

Propofol‑induced HOXA11‑AS promotes proliferation, migration and invasion, but inhibits apoptosis in hepatocellular carcinoma cells by targeting miR‑4458

Corrigendum in: /10.3892/ijmm.2024.5351
  • Authors:
    • Furong Song
    • Jun Liu
    • Yawei Feng
    • Yi Jin
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, The Third Affiliated Hospital of Sun Yat‑Sen University, Guangzhou, Guangdong 510630, P.R. China, Department of Pathology, The Third Affiliated Hospital of Sun Yat‑Sen University, Guangzhou, Guangdong 510630, P.R. China
    Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1135-1145
    |
    Published online on: July 3, 2020
       https://doi.org/10.3892/ijmm.2020.4667
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Abstract

Propofol is a commonly used drug for the induction and maintenance of anesthesia. Previous studies have reported that propofol is involved in the progression of numerous human cancer types, including hepatocellular carcinoma (HCC). However, the underlying molecular mechanisms in HCC are yet to be elucidated. The present study aimed to investigate the potential mechanism of propofol in HCC development. MTT assay, flow cytometry analysis and Transwell assays were conducted to examine cell proliferation, apoptosis, migration and invasion, respectively. Western blotting was also performed to determine the protein expression levels of Bcl‑2 and cleaved‑caspase 3. An in vivo experiment was performed to assess the effect of propofol on tumor growth. Moreover, reverse transcription‑quantitative PCR was conducted to measure the mRNA expression levels of HOMEOBOX A11 (HOXA11) antisense RNA (HOXA11‑AS) and microRNA (miR)‑4458. Dual‑luciferase reporter and RNA pull‑down assays were performed to evaluate the target relationship between HOXA11‑AS and miR‑4458. It was demonstrated that propofol inhibited HCC cell proliferation, migration and invasion, and promoted cell apoptosis in vitro. Furthermore, propofol could suppress tumor growth in vivo. Propofol suppressed the expression of HOXA11‑AS in HCC cells, while HOXA11‑AS overexpression reversed the inhibitory effect of propofol treatment on cell progression in HCC. In addition, miR‑4458 was identified as a target of HOXA11‑AS, and miR‑4458 inhibition reversed the effect of HOXA11‑AS knockdown on HCC cell progression. The results also indicated that propofol promoted the expression of miR‑4458, while HOXA11‑AS restored this effect in HCC. Thus, it was suggested that propofol suppressed cell progression by modulating the HOXA11‑AS/miR‑4458 axis in HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Song F, Liu J, Feng Y and Jin Y: Propofol‑induced HOXA11‑AS promotes proliferation, migration and invasion, but inhibits apoptosis in hepatocellular carcinoma cells by targeting miR‑4458 Corrigendum in /10.3892/ijmm.2024.5351. Int J Mol Med 46: 1135-1145, 2020.
APA
Song, F., Liu, J., Feng, Y., & Jin, Y. (2020). Propofol‑induced HOXA11‑AS promotes proliferation, migration and invasion, but inhibits apoptosis in hepatocellular carcinoma cells by targeting miR‑4458 Corrigendum in /10.3892/ijmm.2024.5351. International Journal of Molecular Medicine, 46, 1135-1145. https://doi.org/10.3892/ijmm.2020.4667
MLA
Song, F., Liu, J., Feng, Y., Jin, Y."Propofol‑induced HOXA11‑AS promotes proliferation, migration and invasion, but inhibits apoptosis in hepatocellular carcinoma cells by targeting miR‑4458 Corrigendum in /10.3892/ijmm.2024.5351". International Journal of Molecular Medicine 46.3 (2020): 1135-1145.
Chicago
Song, F., Liu, J., Feng, Y., Jin, Y."Propofol‑induced HOXA11‑AS promotes proliferation, migration and invasion, but inhibits apoptosis in hepatocellular carcinoma cells by targeting miR‑4458 Corrigendum in /10.3892/ijmm.2024.5351". International Journal of Molecular Medicine 46, no. 3 (2020): 1135-1145. https://doi.org/10.3892/ijmm.2020.4667
Copy and paste a formatted citation
x
Spandidos Publications style
Song F, Liu J, Feng Y and Jin Y: Propofol‑induced HOXA11‑AS promotes proliferation, migration and invasion, but inhibits apoptosis in hepatocellular carcinoma cells by targeting miR‑4458 Corrigendum in /10.3892/ijmm.2024.5351. Int J Mol Med 46: 1135-1145, 2020.
APA
Song, F., Liu, J., Feng, Y., & Jin, Y. (2020). Propofol‑induced HOXA11‑AS promotes proliferation, migration and invasion, but inhibits apoptosis in hepatocellular carcinoma cells by targeting miR‑4458 Corrigendum in /10.3892/ijmm.2024.5351. International Journal of Molecular Medicine, 46, 1135-1145. https://doi.org/10.3892/ijmm.2020.4667
MLA
Song, F., Liu, J., Feng, Y., Jin, Y."Propofol‑induced HOXA11‑AS promotes proliferation, migration and invasion, but inhibits apoptosis in hepatocellular carcinoma cells by targeting miR‑4458 Corrigendum in /10.3892/ijmm.2024.5351". International Journal of Molecular Medicine 46.3 (2020): 1135-1145.
Chicago
Song, F., Liu, J., Feng, Y., Jin, Y."Propofol‑induced HOXA11‑AS promotes proliferation, migration and invasion, but inhibits apoptosis in hepatocellular carcinoma cells by targeting miR‑4458 Corrigendum in /10.3892/ijmm.2024.5351". International Journal of Molecular Medicine 46, no. 3 (2020): 1135-1145. https://doi.org/10.3892/ijmm.2020.4667
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