Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
December-2020 Volume 46 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2020 Volume 46 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Honokiol protects against epidural fibrosis by inhibiting fibroblast proliferation and extracellular matrix overproduction in rats post‑laminectomy

  • Authors:
    • Daoliang Xu
    • Weimin Zeng
    • Xuyao Han
    • Tianchen Qian
    • Jingyu Sun
    • Fangzhou Qi
    • Chen Liu
    • Quan Wang
    • Haiming Jin
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China, The Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2057-2068
    |
    Published online on: October 22, 2020
       https://doi.org/10.3892/ijmm.2020.4765
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Epidural fibrosis (EF)‑induced failed back surgery syndrome (FBSS) in patients post‑laminectomy remains a medical challenge. Although the scarring mechanisms remain unclear, the majority of aetiological studies have reported fibroblast dysfunction. Honokiol, the major bioactive constituent of the magnolia tree, exerts a variety of pharmacological effects, including anti‑proliferative and anti‑fibrotic effects, on various cell types. The present study investigated whether honokiol attenuates EF progression. In vitro, it was found that honokiol inhibited excessive fibroblast proliferation induced by transforming growth factor‑β1 (TGF‑β1) and the synthesis of extracellular matrix (ECM) components, including fibronectin and type I collagen, in a dose‑dependent manner. These effects were attributed to the ability of honokiol to suppress the activity of connective tissue growth factor (CTGF), which is indispensable for the progression of fibrosis. Mechanistically, honokiol attenuated the TGF‑β1‑induced activation of the Smad2/3 and mitogen‑activated protein kinase (MAPK) signalling pathways in fibroblasts. In vivo, honokiol reduced the proliferation of fibroblasts and the synthesis of ECM components, thus ameliorating EF in a rat model post‑laminectomy. Taken together, these preclinical findings suggest that honokiol deserves further consideration as a candidate therapeutic agent for EF.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Liu P, Chen H, Yan L and Sun Y: Laminin alpha5 modu-lates fibroblast proliferation in epidural fibrosis through the PI3K/AKT/mTOR signaling pathway. Mol Med Rep. 21:1491–1500. 2020.PubMed/NCBI

2 

Burton CV: Causes of failure of surgery on the lumbar spine: Ten-Year follow-up. Mt Sinai J Med. 58:183–187. 1991.PubMed/NCBI

3 

Burton CV, Kirkaldy-Willis WH, Yong-Hing K and Heithoff KB: Causes of failure of surgery on the lumbar spine. Clin Orthop Relat Res. 157:191–199. 1981.

4 

Chen F, Zuo Z, Wang K, Zhang C, Gong H, Ye F, Ji A and Tao H: Study on salvianolic acid B in the reduction of epidural fibrosis in laminectomy rats. BMC Musculoskelet Disord. 15:3372014. View Article : Google Scholar : PubMed/NCBI

5 

Zhang K, Zhao J, Su W, Lu R and Lv P: Immunomodulatory effectiveness of licofelone in preventing epidural fibrosis in post-laminectomy rat. Eur J Orthop Surg Traumatol. 25:S63–S68. 2015. View Article : Google Scholar

6 

Kasimcan MO, Bakar B, Aktaş S, Alhan A and Yilmaz M: Effectiveness of the biophysical barriers on the peridural fibrosis of a postlaminectomy rat model: An experimental research. Injury. 42:778–781. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Wu CY, Huang YH, Lee JS, Tai TW, Wu PT and Jou IM: Efficacy of topical cross-linked hyaluronic acid hydrogel in preventing post laminectomy/laminotomy fibrosis in a rat model. J Orthop Res. 34:299–306. 2016. View Article : Google Scholar

8 

Lubina ZI, Baranovic S, Karlak I, Novacic K, Potocki-Karacic T and Lovrić D: The grading model for the assessment of the total amount of epidural fibrosis in postoperative lumbar spine. Eur Spine J. 22:892–897. 2013. View Article : Google Scholar :

9 

Ross JS, Robertson JT, Frederickson RC, Petrie JL, Obuchowski N, Modic MT and deTribolet N: Association between peridural scar and recurrent radicular pain after lumbar discectomy: Magnetic resonance evaluation. ADCON-L european study group. Neurosurgery. 38:855–861. 1996. View Article : Google Scholar : PubMed/NCBI

10 

Wang H, Sun W, Fu D, Shen Y, Chen YY and Wang LL: Update on biomaterials for prevention of epidural adhesion after lumbar laminectomy. J Orthop Translat. 13:41–49. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Brzezicki G, Jankowski R, Blok T, Klimczak A, Szymas J, Huber J, Szukala A, Siemionow M and Nowak S: Postlaminectomy osteo-pontin expression and associated neurophysiological findings in rat peridural scar model. Spine (Phila Pa 1976). 36:378–385. 2011. View Article : Google Scholar

12 

Yakovlev AE, Timchenko AA and Parmentier AM: Spinal cord stimulation and sacral nerve stimulation for postlaminectomy syndrome with significant low back pain. Neuromodulation. 17:763–765. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Xu H, Liu C, Sun Z, Guo X, Zhang Y, Liu M and Li P: CCN5 attenuates profibrotic phenotypes of fibroblasts through the smad6-CCN2 pathway: Potential role in epidural fi brosis. Int J Mol Med. 36:123–129. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Yan L, Li X, Wang J, Sun Y, Wang D, Gu J, He J, Hu H, Chen G, Wang Q and Feng X: Immunomodulatory effectiveness of tacrolimus in preventing epidural scar adhesion after laminectomy in rat model. Eur J Pharmacol. 699:194–199. 2013. View Article : Google Scholar

15 

Zhang C, Kong X, Liu C, Liang Z, Zhao H, Tong W, Ning G, Shen W, Yao L and Feng S: ERK2 small interfering RNAs prevent epidural fibrosis via the efficient inhibition of collagen expression and inflammation in laminectomy rats. Biochem Biophys Res Commun. 444:395–400. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Sun HH, Wang JC, Feng XM, Zhu SL and Cai J: Allicin inhibits proliferation and promotes apoptosis of human epidural scar fibroblasts. World Neurosurg. 136:e460–e468. 2020. View Article : Google Scholar : PubMed/NCBI

17 

Penn JW, Grobbelaar AO and Rolfe KJ: The role of the TGF-β family in wound healing, burns and scarring: A review. Int J Burns Trauma. 2:18–28. 2012.

18 

Zhang C, Kong X, Zhou H, Liu C, Zhao X, Zhou X, Su Y, Sharma HS and Feng S: An experimental novel study: Angelica sinensis prevents epidural fibrosis in laminectomy rats via down-regulation of hydroxyproline, IL-6, and TGF-β1. Evid Based Complement Alternat Med. 2013:2918142013. View Article : Google Scholar

19 

Lakos G, Takagawa S, Chen SJ, Ferreira AM, Han G, Masuda K, Wang XJ, DiPietro LA and Varga J: Targeted disruption of TGF-beta/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma. Am J Pathol. 165:203–217. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Wu CS, Wu PH, Fang AH and Lan CC: FK506 inhibits the enhancing effects of transforming growth factor (TGF)-β1 on collagen expression and TGF-β/Smad signalling in keloid fibroblasts: Implication for new therapeutic approach. Br J Dermatol. 167:532–541. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Massagué J and Wotton D: Transcriptional control by the TGF-beta/smad signaling system. EMBO J. 19:1745–1754. 2000. View Article : Google Scholar : PubMed/NCBI

22 

Nakao A, Imamura T, Souchelnytskyi S, Kawabata M, Ishisaki A, Oeda E, Tamaki K, Hanai J, Heldin CH, Miyazono K and Dijke Pt: TGF-beta receptor-mediated signalling through smad2, smad3 and smad4. EMBO J. 16:5353–5362. 1997. View Article : Google Scholar : PubMed/NCBI

23 

Javelaud D and Mauviel A: Mammalian transforming growth factor-betas: Smad signaling and physio-pathological roles. Int J Biochem Cell Biol. 36:1161–1165. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Derynck R and Zhang YE: Smad-Dependent and smad-independent pathways in TGF-beta family signalling. Nature. 425:577–584. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Fried LE and Arbiser JL: Honokiol, a multifunctional antiangiogenic and antitumor agent. Antioxid Redox Signal. 11:1139–1148. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Lee YJ, Lee YM, Lee CK, Jung JK, Han SB and Hong JT: Therapeutic applications of compounds in the magnolia family. Pharmacol Ther. 130:157–176. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Woodbury A, Yu SP, Wei L and García P: Neuro-Modulating effects of honokiol: A review. Front Neurol. 4:1302013. View Article : Google Scholar : PubMed/NCBI

28 

Pan J, Lee Y, Wang Y and You M: Honokiol targets mitochondria to halt cancer progression and metastasis. Mol Nutr Food Res. 60:1383–1395. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Shen JL, Man KM, Huang PH, Chen WC, Chen DC, Cheng YW, Liu PL, Chou MC and Chen YH: Honokiol and magnolol as multifunctional antioxidative molecules for dermatologic disorders. Molecules. 15:6452–6465. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Zhao D, Wang Y, Du C, Shan S, Zhang Y, Du Z and Han D: Honokiol alleviates hypertrophic scar by targeting transforming growth factor-β/smad2/3 signaling pathway. Front Pharmacol. 8:2062017. View Article : Google Scholar

31 

Chiang CK, Sheu ML, Lin YW, Wu CT, Yang CC, Chen MW, Hung KY, Wu KD and Liu SH: Honokiol ameliorates renal fibrosis by inhibiting extracellular matrix and pro-inflammatory factors in vivo and in vitro. Br J Pharmacol. 163:586–597. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Elfeky MG, Mantawy EM, Gad AM, Fawzy HM and El-Demerdash E: Mechanistic aspects of antifibrotic effects of honokiol in con A-induced liver fibrosis in rats: Emphasis on TGF-β/SMAD/MAPK signaling pathways. Life Sci. 240:1170962020. View Article : Google Scholar

33 

Sun Y, Wang LX, Wang L, Sun SX, Cao XJ, Wang P and Feng L: A comparison of the effectiveness of mitomycin C and 5-fluoro-uracil in the prevention of peridural adhesion after laminectomy. J Neurosurg Spine. 7:423–428. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

35 

American Veterinary Medical Association (AVMA): AVMA Guidelines for the Euthanasia of Animals: 2020 Edition. AVMA; Schaumburg, IL: 2020, https://www.avma.org/sites/default/files/2020-01/2020-Euthanasia-Final-1-17-20.pdfurisimplehttps://www.avma.org/sites/default/files/2020-01/2020-Euthanasia-Final-1-17-20.pdf.

36 

Rydell N: Decreased granulation tissue reaction after installment of hyaluronic acid. Acta Orthop Scand. 41:307–311. 1970. View Article : Google Scholar : PubMed/NCBI

37 

Fukui N, Tashiro T, Hiraoka H, Oda H and Nakamura K: Adhesion formation can be reduced by the suppression of transforming growth factor-beta1 activity. J Orth Res. 18:212–219. 2000. View Article : Google Scholar

38 

Möröy T and Geisen C: Cyclin E. Int J Biochem Cell Biol. 36:1424–1439. 2004. View Article : Google Scholar : PubMed/NCBI

39 

Maggioni D, Nicolini G, Rigolio R, Biffi L, Pignataro L, Gaini R and Garavello W: Myricetin and naringenin inhibit human squamous cell carcinoma proliferation and migration in vitro. Nutr Cancer. 66:1257–1267. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Schnittger A and De Veylder L: The dual face of cyclin B1. Trends Plant Sci. 23:475–478. 2018. View Article : Google Scholar : PubMed/NCBI

41 

Engel ME, McDonnell MA, Law BK and Moses HL: Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription. J Biol Chem. 274:37413–37420. 1999. View Article : Google Scholar : PubMed/NCBI

42 

Dai J, Li X, Yan L, Chen H, He J, Wang S, Wang J and Sun Y: The effect of suramin on inhibiting fibroblast proliferation and preventing epidural fibrosis after laminectomy in rats. J Orthop Surg Res. 11:1082016. View Article : Google Scholar : PubMed/NCBI

43 

Jiao R, Chen H, Wan Q, Zhang X, Dai J, Li X, Yan L and Sun Y: Apigenin inhibits fibroblast proliferation and reduces epidural fibrosis by regulating wnt3a/β-catenin signaling pathway. J Orthop Surg Res. 14:2582019. View Article : Google Scholar

44 

Cruccu G, Aziz TZ, Garcia-Larrea L, Hansson P, Jensen TS, Lefaucheur JP, Simpson BA and Taylor RS: EFNS guidelines on neurostimulation therapy for neuropathic pain. Eur J Neurol. 14:952–970. 2007. View Article : Google Scholar : PubMed/NCBI

45 

Armour A, Scott PG and Tredget EE: Cellular and molecular pathology of HTS: Basis for treatment. Wound Repair Regen. 15:S6–S17. 2007. View Article : Google Scholar

46 

Chrysanthopoulou A, Mitroulis I, Apostolidou E, Arelaki S, Mikroulis D, Konstantinidis T, Sivridis E, Koffa M, Giatromanolaki A, Boumpas DT, et al: Neutrophil extracellular traps promote differentiation and function of fibroblasts. J Pathol. 233:294–307. 2014. View Article : Google Scholar : PubMed/NCBI

47 

Cicha I and Goppelt-Struebe M: Connective tissue growth factor: Context-Dependent functions and mechanisms of regulation. Biofactors. 35:200–208. 2009. View Article : Google Scholar : PubMed/NCBI

48 

Fan WH, Pech M and Karnovsky MJ: Connective tissue growth factor (CTGF) stimulates vascular smooth muscle cell growth and migration in vitro. Eur J Cell Biol. 79:915–923. 2000. View Article : Google Scholar

49 

Yamanaka O, Saika S, Ikeda K, Miyazaki KI, Kitano A and Ohnishi Y: Connective tissue growth factor modulates extracellular matrix production in human subconjunctival fibroblasts and their proliferation and migration in vitro. Jpn J Ophthalmol. 52:8–15. 2008. View Article : Google Scholar : PubMed/NCBI

50 

Burns WC, Twigg SM, Forbes JM, Pete J, Tikellis C, Thallas-Bonke V, Thomas MC, Cooper ME and Kantharidis P: Connective tissue growth factor plays an important role in advanced glycation end product-induced tubular epithelial-to-mesenchymal transition: Implications for diabetic renal disease. J Am Soc Nephrol. 17:2484–2494. 2006. View Article : Google Scholar : PubMed/NCBI

51 

Jin H, Wang Z, Gu Z, Wu J, Bai X, Shao Z, Miao J, Wang Q, Wang Q and Wang X: Schisandrin B attenuates epidural fibrosis in postlaminectomy rats by inhibiting proliferation and extracellular matrix production of fibroblasts. Phytother Res. 33:107–116. 2019. View Article : Google Scholar

52 

Kroening S, Solomovitch S, Sachs M, Wullich B and Goppelt-Struebe M: Regulation of connective tissue growth factor (CTGF) by hepatocyte growth factor in human tubular epithelial cells. Nephrol Dial Transplant. 24:755–762. 2009. View Article : Google Scholar

53 

Ruiz-Ortega M, Rodríguez-Vita J, Sanchez-Lopez E, Carvajal G and Egido J: TGF-Beta signaling in vascular fibrosis. Cardiovasc Res. 74:196–206. 2007. View Article : Google Scholar : PubMed/NCBI

54 

Heldin CH, Miyazono K and ten Dijke P: TGF-Beta signal-ling from cell membrane to nucleus through SMAD proteins. Nature. 390:465–471. 1997. View Article : Google Scholar : PubMed/NCBI

55 

Shi Y and Massagué J: Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell. 113:685–700. 2003. View Article : Google Scholar : PubMed/NCBI

56 

Schiller M, Javelaud D and Mauviel A: TGF-Beta-induced SMAD signaling and gene regulation: Consequences for extra-cellular matrix remodeling and wound healing. J Dermatol Sci. 35:83–92. 2004. View Article : Google Scholar : PubMed/NCBI

57 

Ryer EJ, Hom RP, Sakakibara K, Nakayama KI, Nakayama K, Faries PL, Liu B and Kent KC: PKCdelta is necessary for smad3 expression and transforming growth factor beta-induced fibronectin synthesis in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 26:780–786. 2006. View Article : Google Scholar : PubMed/NCBI

58 

Arnott JA, Zhang X, Sanjay A, Owen TA, Smock SL, Rehman S, DeLong WG, Safadi FF and Popoff SN: Molecular requirements for induction of CTGF expression by TGF-beta1 in primary osteoblasts. Bone. 42:871–885. 2008. View Article : Google Scholar : PubMed/NCBI

59 

Lin SL, Chen RH, Chen YM, Chiang WC, Lai CF, Wu KD and Tsai TJ: Pentoxifylline attenuates tubulointerstitial fibrosis by blocking smad3/4-activated transcription and profibrogenic effects of connective tissue growth factor. J Am Soc Nephrol. 16:2702–2713. 2005. View Article : Google Scholar : PubMed/NCBI

60 

Phan TT, Lim IJ, Chan SY, Tan EK, Lee ST and Longaker MT: Suppression of transforming growth factor beta/smad signaling in keloid-derived fibroblasts by quercetin: Implications for the treatment of excessive scars. J Trauma. 57:1032–1037. 2004. View Article : Google Scholar : PubMed/NCBI

61 

Fu M, Zhang J, Zhu X, Myles DE, Willson TM, Liu X and Chen YE: Peroxisome proliferator-activated receptor gamma inhibits transforming growth factor beta-induced connective tissue growth factor expression in human aortic smooth muscle cells by interfering with smad3. J Biol Chem. 276:45888–45894. 2001. View Article : Google Scholar : PubMed/NCBI

62 

Kwon S, Munroe X, Crawley SC, Lee HY, Spong S, Bradham D, Gum JR Jr, Sleisenger MH and Kim YS: Expression of connective tissue growth factor in pancreatic cancer cell lines. Int J Oncol. 31:693–703. 2007.PubMed/NCBI

63 

Park JH, Yoon J, Lee KY and Park B: Effects of geniposide on hepatocytes undergoing epithelial-mesenchymal transition in hepatic fibrosis by targeting TGFβ/smad and ERK-MAPK signaling pathways. Biochimie. 113:26–34. 2015. View Article : Google Scholar : PubMed/NCBI

64 

Tang N, Zhang YP, Ying W and Yao XX: Interleukin-1β upregu-lates matrix metalloproteinase-13 gene expression via c-jun N-terminal kinase and p38 MAPK pathways in rat hepatic stellate cells. Mol Med Rep. 8:1861–1865. 2013. View Article : Google Scholar : PubMed/NCBI

65 

Tsukada S, Westwick JK, Ikejima K, Sato N and Rippe RA: SMAD and p38 MAPK signaling pathways independently regulate alpha1(I) collagen gene expression in unstimulated and transforming growth factor-beta-stimulated hepatic stellate cells. J Biol Chem. 280:10055–10064. 2005. View Article : Google Scholar : PubMed/NCBI

66 

Tang X, Yao K, Zhang L, Yang Y and Yao H: Honokiol inhibits H(2)O(2)-induced apoptosis in human lens epithelial cells via inhibition of the mitogen-activated protein kinase and akt path-ways. Eur J Pharmacol. 650:72–78. 2011. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xu D, Zeng W, Han X, Qian T, Sun J, Qi F, Liu C, Wang Q and Jin H: Honokiol protects against epidural fibrosis by inhibiting fibroblast proliferation and extracellular matrix overproduction in rats post‑laminectomy. Int J Mol Med 46: 2057-2068, 2020.
APA
Xu, D., Zeng, W., Han, X., Qian, T., Sun, J., Qi, F. ... Jin, H. (2020). Honokiol protects against epidural fibrosis by inhibiting fibroblast proliferation and extracellular matrix overproduction in rats post‑laminectomy. International Journal of Molecular Medicine, 46, 2057-2068. https://doi.org/10.3892/ijmm.2020.4765
MLA
Xu, D., Zeng, W., Han, X., Qian, T., Sun, J., Qi, F., Liu, C., Wang, Q., Jin, H."Honokiol protects against epidural fibrosis by inhibiting fibroblast proliferation and extracellular matrix overproduction in rats post‑laminectomy". International Journal of Molecular Medicine 46.6 (2020): 2057-2068.
Chicago
Xu, D., Zeng, W., Han, X., Qian, T., Sun, J., Qi, F., Liu, C., Wang, Q., Jin, H."Honokiol protects against epidural fibrosis by inhibiting fibroblast proliferation and extracellular matrix overproduction in rats post‑laminectomy". International Journal of Molecular Medicine 46, no. 6 (2020): 2057-2068. https://doi.org/10.3892/ijmm.2020.4765
Copy and paste a formatted citation
x
Spandidos Publications style
Xu D, Zeng W, Han X, Qian T, Sun J, Qi F, Liu C, Wang Q and Jin H: Honokiol protects against epidural fibrosis by inhibiting fibroblast proliferation and extracellular matrix overproduction in rats post‑laminectomy. Int J Mol Med 46: 2057-2068, 2020.
APA
Xu, D., Zeng, W., Han, X., Qian, T., Sun, J., Qi, F. ... Jin, H. (2020). Honokiol protects against epidural fibrosis by inhibiting fibroblast proliferation and extracellular matrix overproduction in rats post‑laminectomy. International Journal of Molecular Medicine, 46, 2057-2068. https://doi.org/10.3892/ijmm.2020.4765
MLA
Xu, D., Zeng, W., Han, X., Qian, T., Sun, J., Qi, F., Liu, C., Wang, Q., Jin, H."Honokiol protects against epidural fibrosis by inhibiting fibroblast proliferation and extracellular matrix overproduction in rats post‑laminectomy". International Journal of Molecular Medicine 46.6 (2020): 2057-2068.
Chicago
Xu, D., Zeng, W., Han, X., Qian, T., Sun, J., Qi, F., Liu, C., Wang, Q., Jin, H."Honokiol protects against epidural fibrosis by inhibiting fibroblast proliferation and extracellular matrix overproduction in rats post‑laminectomy". International Journal of Molecular Medicine 46, no. 6 (2020): 2057-2068. https://doi.org/10.3892/ijmm.2020.4765
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team