Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
December-2020 Volume 46 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2020 Volume 46 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
Article Open Access

Hyperoxia exposure arrests alveolarization in neonatal rats via PTEN‑induced putative kinase 1‑Parkin and Nip3‑like protein X‑mediated mitophagy disorders

  • Authors:
    • Xuefei Yu
    • Yanli Sun
    • Qing Cai
    • Xinyi Zhao
    • Ziyun Liu
    • Xindong Xue
    • Jianhua Fu
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China
    Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2126-2136
    |
    Published online on: October 22, 2020
       https://doi.org/10.3892/ijmm.2020.4766
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Bronchopulmonary dysplasia (BPD), also known as chronic lung disease, is one of the most common respiratory diseases in premature new‑born humans. Mitochondria are not only the main source of reactive oxygen species but are also critical for the maintenance of homeostasis and a wide range of biological activities, such as producing energy, buffering cytosolic calcium and regulating signal transduction. However, as a critical quality control method for mitochondria, little is known about the role of mitophagy in BPD. The present study assessed mitochondrial function in hyperoxia‑exposed alveolar type II (AT‑II) cells of rats during lung development. New‑born Sprague‑Dawley rats were divided into hyperoxia (85% oxygen) and control (21% oxygen) groups. Histopathological and morphological properties of the lung tissues were assessed at postnatal days 1, 3, 7 and 14. Ultrastructural mitochondrial alteration was observed using transmission electron microscopy and the expression of the mitophagy proteins putative kinase (PINK)1, Parkin and Nip3‑like protein X (NIX) in the lung tissues was evaluated using western blotting. Immunofluorescence staining was used to determine the co‑localisation of PINK1 and Parkin. Real‑time analyses of extracellular acidification rate and oxygen consumption rate were performed using primary AT‑II cells to evaluate metabolic changes. Mitochondria in hyperoxia‑exposed rat AT‑II cells began to show abnormal morphological and physiological features. These changes were accompanied by decreased mitochondrial membrane potential and increased expression levels of PINK1‑Parkin and NIX. Increased binding between a mitochondria marker (cytochrome C oxidase subunit IV isoform I) and an autophagy marker (microtubule‑associated protein‑1 light chain‑3B) was observed in primary AT‑II cells and was accompanied by decreased mitochondrial metabolic capacity in model rats. Thus, mitophagy mediated by PINK1, Parkin and NIX in AT‑II cells occurred in hyperoxia‑exposed new‑born rats. These findings suggested that the accumulation of dysfunctional mitochondria may be a key factor in the pathogenesis of BPD and result in attenuated alveolar development.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Abman SH, Bancalari E and Jobe A: The evolution of bronchopulmonary dysplasia after 50 years. Am J Respir Crit Care Med. 195:421–424. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Surate Solaligue DE, Rodriguez-Castillo JA, Ahlbrecht K and Morty RE: Recent advances in our understanding of the mechanisms of late lung development and bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 313:L1101–L1153. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Stoll BJ, Hansen NI, Bell EF, Shankaran S, Laptook AR, Walsh MC, Hale EC, Newman NS, Schibler K, Carlo WA, et al: Neonatal outcomes of extremely preterm infants from the NICHD neonatal research network. Pediatrics. 126:443–456. 2010. View Article : Google Scholar : PubMed/NCBI

4 

García-Muñoz Rodrigo F, Losada Martínez A, Elorza Fernández MD, Moreno Hernando J, Figueras Aloy J and Vento Torres M: The burden of respiratory disease in very-low-birth-weight infants: Changes in perinatal care and outcomes in a decade in Spain. Neonatology. 112:30–39. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Dumpa V and Bhandari V: Surfactant, steroids and non-invasive ventilation in the prevention of BPD. Semin Perinatol. 42:444–452. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Kalikkot Thekkeveedu R, Guaman MC and Shivanna B: Bronchopulmonary dysplasia: A review of pathogenesis and pathophysiology. Respir Med. 132:170–177. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Jobe AH and Abman SH: Bronchopulmonary dysplasia: A continuum of lung disease from the fetus to the adult. Am J Respir Crit Care Med. 200:659–660. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Chen Y, Chang L, Li W, Rong Z, Liu W, Shan R and Pan R: Thioredoxin protects fetal type II epithelial cells from hyperoxia-induced injury. Pediatr Pulmonol. 45:1192–1200. 2010. View Article : Google Scholar : PubMed/NCBI

9 

McGrath-Morrow SA and Stahl J: Apoptosis in neonatal murine lung exposed to hyperoxia. Am J Respir Cell Mol Biol. 25:150–155. 2001. View Article : Google Scholar : PubMed/NCBI

10 

O'Reilly MA, Staversky RJ, Finkelstein JN and Keng PC: Activation of the G2 cell cycle checkpoint enhances survival of epithelial cells exposed to hyperoxia. Am J Physiol Lung cell Mol Physiol. 284:L368–L375. 2003. View Article : Google Scholar

11 

Bayne AN and Trempe JF: Mechanisms of PINK1, ubiquitin and Parkin interactions in mitochondrial quality control and beyond. Cell Mol Life Sci. 76:4589–4611. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Wang Y, Liu N and Lu B: Mechanisms and roles of mitophagy in neurodegenerative diseases. cNS Neurosci Ther. 25:859–875. 2019.PubMed/NCBI

13 

Sureshbabu A and Bhandari V: Targeting mitochondrial dysfunction in lung diseases: Emphasis on mitophagy. Front Physiol. 4:3842013. View Article : Google Scholar

14 

Meissner C, Lorenz H, Weihofen A, Selkoe DJ and Lemberg MK: The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking. J Neurochem. 117:856–867. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Nardin A, Schrepfer E and Ziviani E: Counteracting PINK/Parkin deficiency in the activation of mitophagy: A potential therapeutic intervention for Parkinson's disease. Curr Neuropharmacol. 14:250–259. 2016. View Article : Google Scholar :

16 

Liu H, Dai C, Fan Y, Guo B, Ren K, Sun T and Wang W: From autophagy to mitophagy: The roles of P62 in neurodegenerative diseases. J Bioenerg Biomembr. 49:413–422. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Wei H, Liu L and Chen Q: Selective removal of mitochondria via mitophagy: Distinct pathways for different mitochondrial stresses. Biochim Biophys Acta. 1853:2784–2790. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Deczkowska A and Schwartz M: NIX-ing mitochondria: From development to pathology. EMBO J. 36:1650–1652. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Um JH and Yun J: Emerging role of mitophagy in human diseases and physiology. BMB Rep. 50:299–307. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Yee M, Vitiello PF, Roper JM, Staversky RJ, Wright TW, McGrath-Morrow SA, Maniscalco WM, Finkelstein JN and O'Reilly MA: Type II epithelial cells are critical target for hyperoxia-mediated impairment of postnatal lung development. Am J Physiol Lung Cell Mol Physiol. 291:L1101–L1111. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Cliff TS and Dalton S: Metabolic switching and cell fate decisions: Implications for pluripotency, reprogramming and development. Curr Opin Genet dev. 46:44–49. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Aravamudan B, Thompson MA, Pabelick CM and Prakash YS: Mitochondria in lung diseases. Expert Rev Respir Med. 7:631–646. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Hou A, Fu J, Yang H, Zhu Y, Pan Y, Xu S and Xue X: Hyperoxia stimulates the transdifferentiation of type II alveolar epithelial cells in newborn rats. Am J Physiol Lung Cell Mol Physiol. 308:L861–L872. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Hara H, Araya J, Ito S, Kobayashi K, Takasaka N, Yoshii Y, Wakui H, Kojima J, Shimizu K, Numata T, et al: Mitochondrial fragmentation in cigarette smoke-induced bronchial epithelial cell senescence. Am J Physiol Lung Cell Mol Physiol. 305:L737–L746. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Resseguie EA, Brookes PS and O'Reilly MA: SMG-1 kinase attenuates mitochondrial ROS production but not cell respiration deficits during hyperoxia. Exp Lung Res. 43:229–239. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Song SB, Jang SY, Kang HT, Wei B, Jeoun UW, Yoon GS and Hwang ES: Modulation of mitochondrial membrane potential and ROS generation by nicotinamide in a manner independent of SIRT1 and mitophagy. Mol cells. 40:503–514. 2017.PubMed/NCBI

27 

Peixoto P, Grandvallet C, Feugeas JP, Guittaut M and Hervouet E: Epigenetic control of autophagy in cancer cells: A key process for cancer-related phenotypes. Cells. 8:16562019. View Article : Google Scholar

28 

Zachari M and Ktistakis NT: Mammalian mitophagosome formation: A focus on the early signals and steps. Front Cell Dev Biol. 8:1712020. View Article : Google Scholar : PubMed/NCBI

29 

Walsh BK, Brooks TM and Grenier BM: Oxygen therapy in the neonatal care environment. Respir Care. 54:1193–1202. 2009.PubMed/NCBI

30 

Jobe AH and Kallapur SG: Long term consequences of oxygen therapy in the neonatal period. Semin Fetal Neonatal Med. 15:230–235. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Wang J and Dong W: Oxidative stress and bronchopulmonary dysplasia. Gene. 678:177–183. 2018. View Article : Google Scholar : PubMed/NCBI

32 

Bancalari E, Claure N and Sosenko IR: Bronchopulmonary dysplasia: Changes in pathogenesis, epidemiology and definition. Semin Neonatol. 8:63–71. 2003. View Article : Google Scholar : PubMed/NCBI

33 

Scherz-Shouval R and Elazar Z: Regulation of autophagy by ROS: Physiology and pathology. Trends Biochem Sci. 36:30–38. 2011. View Article : Google Scholar

34 

El-Merhie N, Baumgart-Vogt E, Pilatz A, Pfreimer S, Pfeiffer B, Pak O, Kosanovic D, Seimetz M, Schermuly RT, Weissmann N and Karnati S: differential alterations of the mitochondrial morphology and respiratory chain complexes during postnatal development of the mouse lung. Oxid Med Cell Longev. 2017:91691462017. View Article : Google Scholar

35 

Anzell AR, Maizy R, Przyklenk K and Sanderson TH: Mitochondrial quality control and disease: Insights into ischemia-reperfusion injury. Mol Neurobiol. 55:2547–2564. 2018. View Article : Google Scholar

36 

Eiyama A and Okamoto K: PINK1/Parkin-mediated mitophagy in mammalian cells. Curr Opin Cell Biol. 33:95–101. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Ahmad T, Sundar IK, Lerner CA, Gerloff J, Tormos AM, Yao H and Rahman I: Impaired mitophagy leads to cigarette smoke stress-induced cellular senescence: Implications for chronic obstructive pulmonary disease. FASEB J. 29:2912–2929. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Patel AS, Song JW, Chu SG, Mizumura K, Osorio JC, Shi Y, El-chemaly S, Lee CG, Rosas IO, Elias JA, et al: Epithelial cell mitochondrial dysfunction and PINK1 are induced by transforming growth factor-beta1 in pulmonary fibrosis. PLoS One. 10:e01212462015. View Article : Google Scholar : PubMed/NCBI

39 

Araya J, Tsubouchi K, Sato N, Ito S, Minagawa S, Hara H, Hosaka Y, Ichikawa A, Saito N, Kadota T, et al: PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis. Autophagy. 15:510–526. 2019. View Article : Google Scholar :

40 

Zhang D, Wu L, Du Y, Zhu Y, Pan B, Xue X and Fu J: Autophagy inducers restore impaired autophagy, reduce apoptosis, and attenuate blunted alveolarization in hyperoxia-exposed newborn rats. Pediatr Pulmonol. 53:1053–1066. 2018. View Article : Google Scholar : PubMed/NCBI

41 

Durcan TM and Fon EA: The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications. Genes dev. 29:989–999. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Esteban-Martinez L, Sierra-Filardi E, McGreal RS, Salazar-Roa M, Mariño G, Seco E, Durand S, Enot D, Graña O, Malumbres M, et al: Programmed mitophagy is essential for the glycolytic switch during cell differentiation. EMBO J. 36:1688–1706. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Esteban-Martinez L and Boya P: BNIP3L/NIX-dependent mitophagy regulates cell differentiation via metabolic reprogramming. Autophagy. 14:915–917. 2018. View Article : Google Scholar :

44 

Gao F, Chen D, Si J, Hu Q, Qin Z, Fang M and Wang G: The mitochondrial protein BNIP3L is the substrate of PARK2 and mediates mitophagy in PINK1/PARK2 pathway. Hum Mol Genet. 24:2528–2538. 2015. View Article : Google Scholar : PubMed/NCBI

45 

Zhao H, Dennery PA and Yao H: Metabolic reprogramming in the pathogenesis of chronic lung diseases, including BPD, COPD, and pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 314:L544–L554. 2018. View Article : Google Scholar : PubMed/NCBI

46 

Lottes RG, Newton DA, Spyropoulos DD and Baatz JE: Lactate as substrate for mitochondrial respiration in alveolar epithelial type II cells. Am J Physiol Lung cell Mol Physiol. 308:L953–L961. 2015. View Article : Google Scholar : PubMed/NCBI

47 

Ratner V, Starkov A, Matsiukevich D, Polin RA and Ten VS: Mitochondrial dysfunction contributes to alveolar developmental arrest in hyperoxia-exposed mice. Am J Respir Cell Mol Biol. 40:511–518. 2009. View Article : Google Scholar : PubMed/NCBI

48 

Das KC: Hyperoxia decreases glycolytic capacity, glycolytic reserve and oxidative phosphorylation in MLE-12 cells and inhibits complex I and II function, but not complex IV in isolated mouse lung mitochondria. PLoS One. 8:e733582013. View Article : Google Scholar : PubMed/NCBI

49 

Simon LM, Raffin TA, Douglas WH, Theodore J and Robin ED: Effects of high oxygen exposure on bioenergetics in isolated type II pneumocytes. J Appl Physiol Respir Environ Exerc Physiol. 47:98–103. 1979.PubMed/NCBI

50 

Naik PP, Birbrair A and Bhutia SK: Mitophagy-driven metabolic switch reprograms stem cell fate. cell Mol Life Sci. 76:27–43. 2019. View Article : Google Scholar

51 

McCoy MK, Kaganovich A, Rudenko IN, Ding J and Cookson MR: Hexokinase activity is required for recruitment of parkin to depolarized mitochondria. Hum Mol Genet. 23:145–156. 2014. View Article : Google Scholar

52 

Liu K, Li F, Han H, Chen Y, Mao Z, Luo J, Zhao Y, Zheng B, Gu W and Zhao W: Parkin regulates the activity of pyruvate kinase M2. J Biol chem. 291:10307–10317. 2016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yu X, Sun Y, Cai Q, Zhao X, Liu Z, Xue X and Fu J: Hyperoxia exposure arrests alveolarization in neonatal rats via PTEN‑induced putative kinase 1‑Parkin and Nip3‑like protein X‑mediated mitophagy disorders. Int J Mol Med 46: 2126-2136, 2020.
APA
Yu, X., Sun, Y., Cai, Q., Zhao, X., Liu, Z., Xue, X., & Fu, J. (2020). Hyperoxia exposure arrests alveolarization in neonatal rats via PTEN‑induced putative kinase 1‑Parkin and Nip3‑like protein X‑mediated mitophagy disorders. International Journal of Molecular Medicine, 46, 2126-2136. https://doi.org/10.3892/ijmm.2020.4766
MLA
Yu, X., Sun, Y., Cai, Q., Zhao, X., Liu, Z., Xue, X., Fu, J."Hyperoxia exposure arrests alveolarization in neonatal rats via PTEN‑induced putative kinase 1‑Parkin and Nip3‑like protein X‑mediated mitophagy disorders". International Journal of Molecular Medicine 46.6 (2020): 2126-2136.
Chicago
Yu, X., Sun, Y., Cai, Q., Zhao, X., Liu, Z., Xue, X., Fu, J."Hyperoxia exposure arrests alveolarization in neonatal rats via PTEN‑induced putative kinase 1‑Parkin and Nip3‑like protein X‑mediated mitophagy disorders". International Journal of Molecular Medicine 46, no. 6 (2020): 2126-2136. https://doi.org/10.3892/ijmm.2020.4766
Copy and paste a formatted citation
x
Spandidos Publications style
Yu X, Sun Y, Cai Q, Zhao X, Liu Z, Xue X and Fu J: Hyperoxia exposure arrests alveolarization in neonatal rats via PTEN‑induced putative kinase 1‑Parkin and Nip3‑like protein X‑mediated mitophagy disorders. Int J Mol Med 46: 2126-2136, 2020.
APA
Yu, X., Sun, Y., Cai, Q., Zhao, X., Liu, Z., Xue, X., & Fu, J. (2020). Hyperoxia exposure arrests alveolarization in neonatal rats via PTEN‑induced putative kinase 1‑Parkin and Nip3‑like protein X‑mediated mitophagy disorders. International Journal of Molecular Medicine, 46, 2126-2136. https://doi.org/10.3892/ijmm.2020.4766
MLA
Yu, X., Sun, Y., Cai, Q., Zhao, X., Liu, Z., Xue, X., Fu, J."Hyperoxia exposure arrests alveolarization in neonatal rats via PTEN‑induced putative kinase 1‑Parkin and Nip3‑like protein X‑mediated mitophagy disorders". International Journal of Molecular Medicine 46.6 (2020): 2126-2136.
Chicago
Yu, X., Sun, Y., Cai, Q., Zhao, X., Liu, Z., Xue, X., Fu, J."Hyperoxia exposure arrests alveolarization in neonatal rats via PTEN‑induced putative kinase 1‑Parkin and Nip3‑like protein X‑mediated mitophagy disorders". International Journal of Molecular Medicine 46, no. 6 (2020): 2126-2136. https://doi.org/10.3892/ijmm.2020.4766
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team