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Lactobacillus rhamnosus attenuates intestinal inflammation induced by Fusobacterium nucleatum infection by restoring the autophagic flux

  • Authors:
    • Caihan Duan
    • Xuelian Tang
    • Weijun Wang
    • Wei Qian
    • Xiaochao Fu
    • Xiaohua Deng
    • Shunchang Zhou
    • Chaoqun Han
    • Xiaohua Hou
  • View Affiliations / Copyright

    Affiliations: Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China, Hubei Center of Industrial Culture Collection and Research, Wuhan, Hubei 430020, P.R. China, Division of Experimental Animals, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China
    Copyright: © Duan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 125-136
    |
    Published online on: November 3, 2020
       https://doi.org/10.3892/ijmm.2020.4780
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Abstract

Autophagy plays a dual role in the responses to the gut microflora. The present study aimed to examine the effects of Lactobacillus rhamnosus (L. rhamnosus) on Fusobacterium nucleatum (F. nucleatum)‑induced intestinal dysfunction and to elucidate the underlying mechanisms, with particular focus on autophagy. Inflammatory models were established by treatment with L. rhamnosus following F. nucleatum intervention using cells or a mouse model of dextran sulfate sodium (DSS)‑induced acute colitis. Autophagosomes were visualized by confocal microscopy following transfection with a tandem GFP‑mCherry‑LC3 construct and also by transmission electron microscopy. Autophagy‑associated protein levels were examined by western blot analysis and immunohistochemistry. It was observed that F. nucleatum induced the production of pro‑inflammatory cytokines in Caco‑2 cells and aggravated DSS‑induced acute colitis. The autophagic flux was impaired following infection with F. nucleatum. L. rhamnosus treatment attenuated the inflammation induced by F. nucleatum infection and effectively recovered the impaired autophagic flux. In addition, the production of pro‑inflammatory cytokines induced by F. nucleatum was enhanced with autophagy inhibitors or the RNA interference of autophagy‑related gene 16 like 1 (Atg16L1) in Caco‑2 cells. Notably, this inhibition of autophagy weakened the effects of L. rhamnosus. Finally, the PI3K/AKT/mTOR pathway was found to be involved in this process. On the whole, the present study demonstrates that the mediation of autophagy by L. rhamnosus may be involved in the protective effects against F. nucleatum‑related intestinal inflammation. Thus, L. rhamnosus treatment may prove to be a novel therapeutic strategy for F. nucleatum‑realated gut disorders.
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1 

Kaser A, Zeissig S and Blumberg RS: Inflammatory bowel disease. Annu Rev Immunol. 28:573–621. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Olivera P, Danese S, Jay N, Natoli G and Peyrin-Biroulet L: Big data in IBD: A look into the future. Nat Rev Gastroenterol Hepatol. 16:312–321. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Mazmanian SK, Round JL and Kasper DL: A microbial symbiosis factor prevents intestinal inflammatory disease. Nature. 453:620–625. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Garrett WS, Gallini CA, Yatsunenko T, Michaud M, DuBois A, Delaney ML, Punit S, Karlsson M, Bry L, Glickman JN, et al: Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis. Cell Host Microbe. 8:292–300. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Chu H, Khosravi A, Kusumawardhani IP, Kwon AH, Vasconcelos AC, Cunha LD, Mayer AE, Shen Y, Wu WL, Kambal A, et al: Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease. Science. 352:1116–1120. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Strauss J, Kaplan GG, Beck PL, Rioux K, Panaccione R, Devinney R, Lynch T and Allen-Vercoe E: Invasive potential of gut mucosa-derived Fusobacterium nucleatum positively correlates with IBD status of the host. Inflamm Bowel Dis. 17:1971–1978. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Klionsky DJ: Autophagy: From phenomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol. 8:931–937. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Lévy J, Cacheux W, Bara MA, L'Hermitte A, Lepage P, Fraudeau M, Trentesaux C, Lemarchand J, Durand A, Crain AM, et al: Intestinal inhibition of Atg7 prevents tumour initiation through a microbiome-influenced immune response and suppresses tumour growth. Nat Cell Biol. 17:1062–1073. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Narendra D, Tanaka A, Suen DF and Youle RJ: Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol. 183:795–803. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Mialet-Perez J and Vindis C: Autophagy in health and disease: Focus on the cardiovascular system. Essays Biochem. 61:721–732. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Chai P, Ni H, Zhang H and Fan X: The evolving functions of autophagy in Ocular health: A double-edged sword. Int J Biol Sci. 12:1332–1340. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Tsuboi K, Nishitani M, Takakura A, Imai Y, Komatsu M and Kawashima H: Autophagy protects against colitis by the maintenance of normal gut microflora and secretion of mucus. J Biol Chem. 290:20511–20526. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Benjamin JL, Sumpter R Jr, Levine B and Hooper LV: Intestinal epithelial autophagy is essential for host defense against invasive bacteria. Cell Host Microbe. 13:723–734. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Sanders ME, Guarner F, Guerrant R, Holt PR, Quigley EM, Sartor RB, Sherman PM and Mayer EA: An update on the use and investigation of probiotics in health and disease. Gut. 62:787–796. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Gionchetti P, Lammers KM, Rizzello F and Campieri M: Probiotics and barrier function in colitis. Gut. 54:898–900. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Ng SC, Plamondon S, Kamm MA, Hart AL, Al-Hassi HO, Guenther T, Stagg AJ and Knight SC: Immunosuppressive effects via human intestinal dendritic cells of probiotic bacteria and steroids in the treatment of acute ulcerative colitis. Inflamm Bowel Dis. 16:1286–1298. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Claes IJ, Lebeer S, Shen C, Verhoeven TL, Dilissen E, De Hertogh G, Bullens DM, Ceuppens JL, Van Assche G, Vermeire S, et al: Impact of lipoteichoic acid modification on the performance of the probiotic Lactobacillus rhamnosus GG in experimental colitis. Clin Exp Immunol. 162:306–314. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Plaza-Díaz J, Ruiz-Ojeda FJ, Vilchez-Padial LM and Gil A: Evidence of the anti-inflammatory effects of probiotics and synbiotics in intestinal chronic diseases. Nutrients. 9:5552017. View Article : Google Scholar :

19 

Neish AS: Microbes in gastrointestinal health and disease. Gastroenterology. 136:65–80. 2009. View Article : Google Scholar

20 

Hussain QA, McKay IJ, Gonzales-Marin C and Allaker RP: Regulation of adrenomedullin and nitric oxide production by periodontal bacteria. J Periodontal Res. 50:650–657. 2015. View Article : Google Scholar

21 

Sadeghi-Aliabadi H, Mohammadi F, Fazeli H and Mirlohi M: Effects of Lactobacillus plantarum A7 with probiotic potential on colon cancer and normal cells proliferation in comparison with a commercial strain. Iran J Basic Med Sci. 17:815–819. 2014.

22 

Liu L, Liang L, Liang H, Wang M, Lu B, Xue M, Deng J and Chen Y: Fusobacterium nucleatum aggravates the progression of colitis by regulating M1 macrophage polarization via AKT2 pathway. Front Immunol. 10:13242019. View Article : Google Scholar :

23 

Liu H, Hong X, Sun T, Huang X, Wang J and Xiong H: Fusobacterium nucleatum exacerbates colitis by damaging epithelial barrier and inducing aberrant inflammation. J Dig Dis. May 22–2020.Epub ahead of print. View Article : Google Scholar

24 

Cooper HS, Murthy SN, Shah RS and Sedergran DJ: Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Invest. 69:238–249. 1993.PubMed/NCBI

25 

Dutton JW III, Artwohl JE, Huang X and Fortman JD: Assessment of pain associated with the injection of sodium pentobarbital in laboratory mice (Mus musculus). J Am Assoc Lab Anim Sci. 58:373–379. 2019. View Article : Google Scholar : PubMed/NCBI

26 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

27 

Zhang Q, Gao M, Zhang Y, Song Y, Cheng H and Zhou R: The germline-enriched Ppp1r36 promotes autophagy. Sci Rep. 6:246092016. View Article : Google Scholar : PubMed/NCBI

28 

Cardiff RD, Miller CH and Munn RJ: Manual hematoxylin and eosin staining of mouse tissue sections. Cold Spring Harbor protocols. 2014:655–658. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Horino J, Fujimoto M, Terabe F, Serada S, Takahashi T, Soma Y, Tanaka K, Chinen T, Yoshimura A, Nomura S, et al: Suppressor of cytokine signaling-1 ameliorates dextran sulfate sodium-induced colitis in mice. Int Immunol. 20:753–762. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Misra RM, Bajaj MS and Kale VP: Vasculogenic mimicry of HT1080 tumour cells in vivo: Critical role of HIF-1α-neuropilin-1 axis. PLoS One. 7:e501532012. View Article : Google Scholar

31 

Baxt LA and Xavier RJ: Role of Autophagy in the Maintenance of Intestinal Homeostasis. Gastroenterology. 149:553–562. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Heras-Sandoval D, Pérez-Rojas JM, Hernández-Damián J and Pedraza-Chaverri J: The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration. Cell Signal. 26:2694–2701. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Kostic AD, Chun E, Robertson L, Glickman JN, Gallini CA, Michaud M, Clancy TE, Chung DC, Lochhead P, Hold GL, et al: Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. Cell Host Microbe. 14:207–215. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Shen ZH, Zhu CX, Quan YS, Yang ZY, Wu S, Luo WW, Tan B and Wang XY: Relationship between intestinal microbiota and ulcerative colitis: Mechanisms and clinical application of probiotics and fecal microbiota transplantation. World J Gastroenterol. 24:5–14. 2018. View Article : Google Scholar : PubMed/NCBI

35 

Boonma P, Spinler JK, Venable SF, Versalovic J and Tumwasorn S: Lactobacillus rhamnosus L34 and Lactobacillus casei L39 suppress Clostridium difficile-induced IL-8 production by colonic epithelial cells. BMC Microbiol. 14:1772014. View Article : Google Scholar : PubMed/NCBI

36 

Johnson-Henry KC, Donato KA, Shen-Tu G, Gordanpour M and Sherman PM: Lactobacillus rhamnosus strain GG prevents enterohemorrhagic Escherichia coli O157:H7-induced changes in epithelial barrier function. Infect Immun. 76:1340–1348. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Macias-Ceja DC, Cosin-Roger J, Ortiz-Masiá D, Salvador P, Hernández C, Esplugues JV, Calatayud S and Barrachina MD: Stimulation of autophagy prevents intestinal mucosal inflammation and ameliorates murine colitis. Br J Pharmacol. 174:2501–2511. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Nguyen HT, Dalmasso G, Müller S, Carrière J, Seibold F and Darfeuille-Michaud A: Crohn's disease-associated adherent invasive Escherichia coli modulate levels of microRNAs in intes-tinal epithelial cells to reduce autophagy. Gastroenterology. 146:508–519. 2014. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Duan C, Tang X, Wang W, Qian W, Fu X, Deng X, Zhou S, Han C and Hou X: Lactobacillus rhamnosus attenuates intestinal inflammation induced by Fusobacterium nucleatum infection by restoring the autophagic flux. Int J Mol Med 47: 125-136, 2021.
APA
Duan, C., Tang, X., Wang, W., Qian, W., Fu, X., Deng, X. ... Hou, X. (2021). Lactobacillus rhamnosus attenuates intestinal inflammation induced by Fusobacterium nucleatum infection by restoring the autophagic flux. International Journal of Molecular Medicine, 47, 125-136. https://doi.org/10.3892/ijmm.2020.4780
MLA
Duan, C., Tang, X., Wang, W., Qian, W., Fu, X., Deng, X., Zhou, S., Han, C., Hou, X."Lactobacillus rhamnosus attenuates intestinal inflammation induced by Fusobacterium nucleatum infection by restoring the autophagic flux". International Journal of Molecular Medicine 47.1 (2021): 125-136.
Chicago
Duan, C., Tang, X., Wang, W., Qian, W., Fu, X., Deng, X., Zhou, S., Han, C., Hou, X."Lactobacillus rhamnosus attenuates intestinal inflammation induced by Fusobacterium nucleatum infection by restoring the autophagic flux". International Journal of Molecular Medicine 47, no. 1 (2021): 125-136. https://doi.org/10.3892/ijmm.2020.4780
Copy and paste a formatted citation
x
Spandidos Publications style
Duan C, Tang X, Wang W, Qian W, Fu X, Deng X, Zhou S, Han C and Hou X: Lactobacillus rhamnosus attenuates intestinal inflammation induced by Fusobacterium nucleatum infection by restoring the autophagic flux. Int J Mol Med 47: 125-136, 2021.
APA
Duan, C., Tang, X., Wang, W., Qian, W., Fu, X., Deng, X. ... Hou, X. (2021). Lactobacillus rhamnosus attenuates intestinal inflammation induced by Fusobacterium nucleatum infection by restoring the autophagic flux. International Journal of Molecular Medicine, 47, 125-136. https://doi.org/10.3892/ijmm.2020.4780
MLA
Duan, C., Tang, X., Wang, W., Qian, W., Fu, X., Deng, X., Zhou, S., Han, C., Hou, X."Lactobacillus rhamnosus attenuates intestinal inflammation induced by Fusobacterium nucleatum infection by restoring the autophagic flux". International Journal of Molecular Medicine 47.1 (2021): 125-136.
Chicago
Duan, C., Tang, X., Wang, W., Qian, W., Fu, X., Deng, X., Zhou, S., Han, C., Hou, X."Lactobacillus rhamnosus attenuates intestinal inflammation induced by Fusobacterium nucleatum infection by restoring the autophagic flux". International Journal of Molecular Medicine 47, no. 1 (2021): 125-136. https://doi.org/10.3892/ijmm.2020.4780
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