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Article Open Access

Zinc and SARS‑CoV‑2: A molecular modeling study of Zn interactions with RNA‑dependent RNA‑polymerase and 3C‑like proteinase enzymes

  • Authors:
    • Ali Pormohammad
    • Nadia K. Monych
    • Raymond J. Turner
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    Affiliations: Department of Biological Sciences, University of Calgary, Calgary, Alberta T2N4V8, Canada
    Copyright: © Pormohammad et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 326-334
    |
    Published online on: November 18, 2020
       https://doi.org/10.3892/ijmm.2020.4790
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Abstract

RNA‑dependent RNA‑polymerase (RdRp) and 3C‑like proteinase (3CLpro) are two main enzymes that play a key role in the replication of SARS‑CoV‑2. Zinc (Zn) has strong immunogenic properties and is known to bind to a number of proteins, modulating their activities. Zn also has a history of use in viral infection control. Thus, the present study models potential Zn binding to RdRp and the 3CLpro. Through molecular modeling, the Zn binding sites in the aforementioned two important enzymes of viral replication were found to be conserved between severe acute respiratory syndrome (SARS)‑coronavirus (CoV) and SARS‑CoV‑2. The location of these sites may influence the enzymatic activity of 3CLpro and RdRp in coronavirus disease 2019 (COVID‑19). Since Zn has established immune health benefits, is readily available, non‑expensive and a safe food supplement, with the comparisons presented here between SARS‑CoV and COVID‑19, the present study proposes that Zn could help ameliorate the disease process of COVID‑19 infection.
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Copy and paste a formatted citation
Spandidos Publications style
Pormohammad A, Monych NK and Turner RJ: Zinc and SARS‑CoV‑2: A molecular modeling study of Zn interactions with RNA‑dependent RNA‑polymerase and 3C‑like proteinase enzymes. Int J Mol Med 47: 326-334, 2021.
APA
Pormohammad, A., Monych, N.K., & Turner, R.J. (2021). Zinc and SARS‑CoV‑2: A molecular modeling study of Zn interactions with RNA‑dependent RNA‑polymerase and 3C‑like proteinase enzymes. International Journal of Molecular Medicine, 47, 326-334. https://doi.org/10.3892/ijmm.2020.4790
MLA
Pormohammad, A., Monych, N. K., Turner, R. J."Zinc and SARS‑CoV‑2: A molecular modeling study of Zn interactions with RNA‑dependent RNA‑polymerase and 3C‑like proteinase enzymes". International Journal of Molecular Medicine 47.1 (2021): 326-334.
Chicago
Pormohammad, A., Monych, N. K., Turner, R. J."Zinc and SARS‑CoV‑2: A molecular modeling study of Zn interactions with RNA‑dependent RNA‑polymerase and 3C‑like proteinase enzymes". International Journal of Molecular Medicine 47, no. 1 (2021): 326-334. https://doi.org/10.3892/ijmm.2020.4790
Copy and paste a formatted citation
x
Spandidos Publications style
Pormohammad A, Monych NK and Turner RJ: Zinc and SARS‑CoV‑2: A molecular modeling study of Zn interactions with RNA‑dependent RNA‑polymerase and 3C‑like proteinase enzymes. Int J Mol Med 47: 326-334, 2021.
APA
Pormohammad, A., Monych, N.K., & Turner, R.J. (2021). Zinc and SARS‑CoV‑2: A molecular modeling study of Zn interactions with RNA‑dependent RNA‑polymerase and 3C‑like proteinase enzymes. International Journal of Molecular Medicine, 47, 326-334. https://doi.org/10.3892/ijmm.2020.4790
MLA
Pormohammad, A., Monych, N. K., Turner, R. J."Zinc and SARS‑CoV‑2: A molecular modeling study of Zn interactions with RNA‑dependent RNA‑polymerase and 3C‑like proteinase enzymes". International Journal of Molecular Medicine 47.1 (2021): 326-334.
Chicago
Pormohammad, A., Monych, N. K., Turner, R. J."Zinc and SARS‑CoV‑2: A molecular modeling study of Zn interactions with RNA‑dependent RNA‑polymerase and 3C‑like proteinase enzymes". International Journal of Molecular Medicine 47, no. 1 (2021): 326-334. https://doi.org/10.3892/ijmm.2020.4790
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