Open Access

CircRNAs open a new era in the study of cardiovascular disease (Review)

  • Authors:
    • Zhikang Yu
    • Qingyan Huang
    • Qunji Zhang
    • Heming Wu
    • Zhixiong Zhong
  • View Affiliations

  • Published online on: November 18, 2020     https://doi.org/10.3892/ijmm.2020.4792
  • Pages: 49-64
  • Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Circular RNAs (circRNAs) are non‑coding RNAs that are found in the cytoplasm or stored in the exosomes, where they are not affected by RNA exonucleases. CircRNAs are widely expressed in mammalian tissues and cells. A number of studies have suggested that circRNAs are associated with the physiology and pathology of cardiovascular diseases (CVDs). Therefore, circRNAs have been considered as effector molecules and biomarkers in the cardiovascular system. The present review article summarizes the biological origin and roles of circRNAs as well as the available databases and research methods for their identification. Furthermore, it describes their regulatory mechanisms in cardiovascular physiology and pathology, including the regulation of atherosclerosis, immunity, cell proliferation, apoptosis and autophagy. In addition, the current review discusses the unresolved problems in circRNA research and the application of circRNAs in the treatment of CVDs. Finally, the CVD‑associated circRNAs are also reviewed.
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January-2021
Volume 47 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Yu Z, Huang Q, Zhang Q, Wu H and Zhong Z: CircRNAs open a new era in the study of cardiovascular disease (Review). Int J Mol Med 47: 49-64, 2021
APA
Yu, Z., Huang, Q., Zhang, Q., Wu, H., & Zhong, Z. (2021). CircRNAs open a new era in the study of cardiovascular disease (Review). International Journal of Molecular Medicine, 47, 49-64. https://doi.org/10.3892/ijmm.2020.4792
MLA
Yu, Z., Huang, Q., Zhang, Q., Wu, H., Zhong, Z."CircRNAs open a new era in the study of cardiovascular disease (Review)". International Journal of Molecular Medicine 47.1 (2021): 49-64.
Chicago
Yu, Z., Huang, Q., Zhang, Q., Wu, H., Zhong, Z."CircRNAs open a new era in the study of cardiovascular disease (Review)". International Journal of Molecular Medicine 47, no. 1 (2021): 49-64. https://doi.org/10.3892/ijmm.2020.4792