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Article Open Access

A novel peptide relieves endothelial cell dysfunction in preeclampsia by regulating the PI3K/mTOR/HIF1α pathway

  • Authors:
    • Lu Xue
    • Kaipeng Xie
    • Lan Wu
    • Xiang Yu
    • Wei Long
    • Chanjuan Li
    • Ruizhe Jia
    • Hongjuan Ding
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, Jiangsu 210004, P.R. China, Nanjing Maternal and Child Health Institute, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, Jiangsu 210004, P.R. China
    Copyright: © Xue et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 276-288
    |
    Published online on: November 19, 2020
       https://doi.org/10.3892/ijmm.2020.4793
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Abstract

Preeclampsia (PE) is a pregnancy‑specific complication characterized by hypertension and proteinuria, and it is one of the primary global causes of maternal and perinatal mortality. Poor remodeling of placental arteries and endothelial dysfunction serve important roles in the pathogenesis of PE. Peptide derived from complement C4 A chain (PDCC4) was identified in our previous peptidome analysis of serum from patients with PE. The present study aimed to investigate the effect of PDCC4 on endothelial dysfunction in PE. TNF‑α stimulated HUVECs were employed to mimic endothelial dysfunction in PE, and Cell Counting Kit 8 assay, wound healing assay, tube formation assay, RNA‑sequencing (seq) and western blot analysis were performed using HUVECs. Moreover, an in vivo model of PE was established using pregnant rats treated with lipopolysaccharide (LPS), and blood pressure monitoring, histopathological examination, ELISA and immunohistochemistry were performed on rats. It was found that TNF‑α impaired proliferation, migration and tube formation of HUVECs, but pretreatment with PDCC4 moderated these effects. RNA‑seq and western blotting demonstrated that the PI3K/mTOR/HIF1α signaling pathway was activated by PDCC4, and a selective PI3K inhibitor reversed the protective function of PDCC4 on TNF‑α stimulated HUVECs. Additionally, PDCC4 alleviated hypertension, histopathological changes of placenta and kidney and the expression levels of endothelial injury markers and inflammatory cytokines induced by LPS in rats. These results suggested that PDCC4 relieved endothelial dysfunction in PE via PI3K/mTOR/HIF1α signaling pathway and may be a potential therapy for PE.
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1 

Mol BWJ, Roberts CT, Thangaratinam S, Magee LA, de Groot CJM and Hofmeyr GJ: Preeclampsia. Lancet. 387:999–1011. 2016. View Article : Google Scholar

2 

Khan KS, Wojdyla D, Say L, Gulmezoglu AM and Van Look PF: WHO analysis of causes of maternal death: A systematic review. Lancet. 367:1066–1074. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Duley L: The global impact of preeclampsia and eclampsia. Semin Perinatol. 33:130–137. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Rana S, Lemoine E, Granger JP and Karumanchi SA: Preeclampsia: Pathophysiology, challenges, and perspectives. Circ Res. 124:1094–1112. 2019. View Article : Google Scholar : PubMed/NCBI

5 

Wirka RC and Quertermous T: Circulating peptide prevents preeclampsia. Science. 357:643–644. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Ghulmiyyah L and Sibai B: Maternal mortality from preeclampsia/eclampsia. Semin Perinatol. 36:56–59. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Rolnik DL, Wright D, Poon LC, O'Gorman N, Syngelaki A, de Paco Matallana C, Akolekar R, Cicero S, Janga D, Singh M, et al: Aspirin versus placebo in pregnancies at high risk for preterm preeclampsia. N Engl J Med. 377:613–622. 2017. View Article : Google Scholar : PubMed/NCBI

8 

LeFevre ML; U.S. Preventive Services Task Force: Low-dose aspirin use for the prevention of morbidity and mortality from preeclampsia: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 161:819–826. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Duley L, Meher S and Abalos E: Management of preeclampsia. BMJ. 332:463–468. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Hossain N, Schatz F and Paidas MJ: Heparin and maternal fetal interface: Why should it work to prevent pregnancy complications? Thromb Res. 124:653–655. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Lowe SA, Brown MA, Dekker GA, Gatt S, McLintock CK, McMahon LP, Mangos G, Moore MP, Muller P, Paech M, et al: Guidelines for the management of hypertensive disorders of pregnancy 2008. Aust N Z J Obstet Gynaecol. 49:242–246. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Pijnenborg R, Vercruysse L and Hanssens M: The uterine spiral arteries in human pregnancy: Facts and controversies. Placenta. 27:939–958. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Jeyabalan A: Epidemiology of preeclampsia: Impact of obesity. Nutr Rev. 71(Suppl 1): S18–S25. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Powe CE, Levine RJ and Karumanchi SA: Preeclampsia, a disease of the maternal endothelium: The role of antiangiogenic factors and implications for later cardiovascular disease. Circulation. 123:2856–2869. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Young BC, Levine RJ and Karumanchi SA: Pathogenesis of preeclampsia. Annu Rev Pathol. 5:173–192. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Roberts JM, Taylor RN, Musci TJ, Rodgers GM, Hubel CA and McLaughlin MK: Preeclampsia: An endothelial cell disorder. Am J Obstet Gynecol. 161:1200–1204. 1989. View Article : Google Scholar : PubMed/NCBI

17 

Brownfoot FC, Hastie R, Hannan NJ, Cannon P, Tuohey L, Parry LJ, Senadheera S, Illanes SE, Kaitu'u-Lino TJ and Tong S: Metformin as a prevention and treatment for preeclampsia: Effects on soluble fms-like tyrosine kinase 1 and soluble endoglin secretion and endothelial dysfunction. Am J Obstet Gynecol. 214:356.e1–356.e15. 2016. View Article : Google Scholar

18 

Papo N and Shai Y: Host defense peptides as new weapons in cancer treatment. Cell Mol Life Sci. 62:784–790. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Ellerby HM, Arap W, Ellerby LM, Kain R, Andrusiak R, Rio GD, Krajewski S, Lombardo CR, Rao R, Ruoslahti E, et al: Anti-cancer activity of targeted pro-apoptotic peptides. Nat Med. 5:1032–1038. 1999. View Article : Google Scholar : PubMed/NCBI

20 

Kim SJ, Xiao J, Wan J, Cohen P and Yen K: Mitochondrially derived peptides as novel regulators of metabolism. J Physiol. 595:6613–6621. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Petkov V, Mosgoeller W, Ziesche R, Raderer M, Stiebellehner L, Vonbank K, Funk GC, Hamilton G, Novotny C, Burian B and Block LH: Vasoactive intestinal peptide as a new drug for treatment of primary pulmonary hypertension. J Clin Invest. 111:1339–1346. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Ho L, van Dijk M, Chye STJ, Messerschmidt DM, Chng SC, Ong S, Yi LK, Boussata S, Goh GH, Afink GB, et al: ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice. Science. 357:707–713. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Jacobsen LV, Flint A, Olsen AK and Ingwersen SH: Liraglutide in type 2 diabetes mellitus: Clinical pharmacokinetics and pharmacodynamics. Clin Pharmacokinet. 55:657–672. 2016. View Article : Google Scholar :

24 

Sleeman A and Clements JN: Abaloparatide: A new pharmacological option for osteoporosis. Am J Health Syst Pharm. 76:130–135. 2019. View Article : Google Scholar : PubMed/NCBI

25 

Dai X, Song X, Rui C, Meng L, Xue X, Ding H, Shen R, Li J, Li J, Lu Y and Long W: Peptidome analysis of human serum from normal and preeclamptic pregnancies. J Cell Biochem. 118:4341–4348. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Chen TG, Zhong ZY, Sun GF, Zhou YX and Zhao Y: Effects of tumour necrosis factor-alpha on activity and nitric oxide synthase of endothelial progenitor cells from peripheral blood. Cell Prolif. 44:352–359. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Gerhardt S, König V, Doll M, Hailemariam-Jahn T, Hrgovic I, Zöller N, Kaufmann R, Kippenberger S and Meissner M: Dimethylfumarate protects against TNF-α-induced secretion of inflammatory cytokines in human endothelial cells. J Inflamm (Lond). 12:492015. View Article : Google Scholar

28 

Fratantonio D, Speciale A, Molonia MS, Bashllari R, Palumbo M, Saija A, Cimino F, Monastra G and Virgili F: Alpha-lipoic acid, but not di-hydrolipoic acid, activates Nrf2 response in primary human umbilical-vein endothelial cells and protects against TNF-α induced endothelium dysfunction. Arch Biochem Biophys. 655:18–25. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Zeng RJ, Zheng CW, Gu JE, Zhang HX, Xie L, Xu LY and Li EM: RAC1 inhibition reverses cisplatin resistance in esophageal squamous cell carcinoma and induces downregulation of glycolytic enzymes. Mol Oncol. 13:2010–2030. 2019. View Article : Google Scholar : PubMed/NCBI

30 

Cai S, Zhu Q, Guo C, Yuan R, Zhang X, Nie Y, Chen L, Fang Y, Chen K, Zhang J, et al: MLL1 promotes myogenesis by epigenetically regulating Myf5. Cell Prolif. 53:e127442020. View Article : Google Scholar :

31 

Sun Q, Li Q and Xie F: LncRNA-MALAT1 regulates proliferation and apoptosis of ovarian cancer cells by targeting miR-503-5p. Onco Targets Ther. 12:6297–6307. 2019. View Article : Google Scholar : PubMed/NCBI

32 

Lv Y, Lu X, Li C, Fan Y, Ji X, Long W, Meng L, Wu L, Wang L, Lv M and Ding H: miR-145-5p promotes trophoblast cell growth and invasion by targeting FLT1. Life Sci. 239:1170082019. View Article : Google Scholar : PubMed/NCBI

33 

Lip SV, Boekschoten MV, Hooiveld GJ, van Pampus MG, Scherjon SA, Plösch T and Faas MM: Early-onset preeclampsia, plasma microRNAs, and endothelial cell function. Am J Obstet Gynecol. 222:497.e1–497.e12. 2020. View Article : Google Scholar

34 

Liu L, Bi N, Wu L, Ding X, Men Y, Zhou W, Li L, Zhang W, Shi S, Song Y and Wang L: MicroRNA-29c functions as a tumor suppressor by targeting VEGFA in lung adenocarcinoma. Mol Cancer. 16:502017. View Article : Google Scholar : PubMed/NCBI

35 

Wang C, Tao W, Wang Y, Bikow J, Lu B, Keating A, Verma S, Parker TG, Han R and Wen XY: Rosuvastatin, identified from a zebrafish chemical genetic screen for antiangiogenic compounds, suppresses the growth of prostate cancer. Eur Urol. 58:418–426. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Chen J, Zhang W, Xu Q, Zhang J, Chen W, Xu Z, Li C, Wang Z, Zhang Y, Zhen Y, et al: Ang-(17) protects HUVECs from high glucose-induced injury and inflammation via inhibition of the JAK2/STAT3 pathway. Int J Mol Med. 41:2865–2878. 2018.PubMed/NCBI

37 

Jin J, Qiu S, Wang P, Liang X, Huang F, Wu H, Zhang B, Zhang W, Tian X, Xu R, et al: Cardamonin inhibits breast cancer growth by repressing HIF-1α-dependent metabolic reprogramming. J Exp Clin Cancer Res. 38:3772019. View Article : Google Scholar

38 

Mi L, Zhang Y, Xu Y, Zheng X, Zhang X, Wang Z, Xue M and Jin X: HMGB1/RAGE pro-inflammatory axis promotes vascular endothelial cell apoptosis in limb ischemia/reperfusion injury. Biomed Pharmacother. 116:1090052019. View Article : Google Scholar : PubMed/NCBI

39 

Xiang Y, Yao X, Wang X, Zhao H, Zou H, Wang L and Zhang QX: Houshiheisan promotes angiogenesis via HIF-1α/VEGF and SDF-1/CXCR4 pathways: In vivo and in vitro. Biosci Rep. 39:BSR201910062019. View Article : Google Scholar

40 

Liu Y, Yang J, Bao J, Li X, Ye A, Zhang G and Liu H: Activation of the cholinergic anti-inflammatory pathway by nicotine ameliorates lipopolysaccharide-induced preeclampsia-like symptoms in pregnant rats. Placenta. 49:23–32. 2017. View Article : Google Scholar

41 

National Research Council Committee for the Update of the Guide for the Care and use of Laboratory Animals: The National Academies Collection: Reports funded by National Institutes of Health. Guide for the Care and Use of Laboratory Animals. 8th edition. National Academies Press; Washington, DC: 2011

42 

Shu W, Li H, Gong H, Zhang M, Niu X, Ma Y, Zhang X, Cai W, Yang G, Wei M, et al: Evaluation of blood vessel injury, oxidative stress and circulating inflammatory factors in an L-NAME-induced preeclampsia-like rat model. Exp Ther Med. 16:585–594. 2018.PubMed/NCBI

43 

Yalamati P, Bhongir AV, Karra M and Beedu SR: comparative analysis of urinary total proteins by bicinchoninic acid and pyrogallol red molybdate methods. J Clin Diagn Res. 9:Bc01–04. 2015.PubMed/NCBI

44 

Lai WS and Ding YL: GNG7 silencing promotes the proliferation and differentiation of placental cytotrophoblasts in preeclampsia rats through activation of the mTOR signaling pathway. Int J Mol Med. 43:1939–1950. 2019.PubMed/NCBI

45 

Feldman AT and Wolfe D: Tissue processing and hematoxylin and eosin staining. Methods Mol Biol. 1180:31–43. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Matsumoto K, Arao T, Tanaka K, Kaneda H, Kudo K, Fujita Y, Tamura D, Aomatsu K, Tamura T, Yamada Y, et al: mTOR signal and hypoxia-inducible factor-1 alpha regulate CD133 expression in cancer cells. Cancer Res. 69:7160–7164. 2009. View Article : Google Scholar : PubMed/NCBI

47 

Yuan Y, Shan N, Tan B, Deng Q, Liu Y, Wang H, Luo X, He C, Luo X, Zhang H, et al: SRC-3 plays a critical role in human umbilical vein endothelial cells by regulating the PI3K/Akt/mTOR pathway in preeclampsia. Reprod Sci. 25:748–758. 2018. View Article : Google Scholar

48 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

49 

Jonsson Y, Rubèr M, Matthiesen L, Berg G, Nieminen K, Sharma S, Ernerudh J and Ekerfelt C: Cytokine mapping of sera from women with preeclampsia and normal pregnancies. J Reprod Immunol. 70:83–91. 2006. View Article : Google Scholar : PubMed/NCBI

50 

Chen J, Yue C, Xu J, Zhan Y, Zhao H, Li Y and Ye Y: Downregulation of receptor tyrosine kinase-like orphan receptor 1 in preeclampsia placenta inhibits human trophoblast cell proliferation, migration, and invasion by PI3K/AKT/mTOR pathway accommodation. Placenta. 82:17–24. 2019. View Article : Google Scholar : PubMed/NCBI

51 

Harati-Sadegh M, Kohan L, Teimoori B, Mehrabani M and Salimi S: The association of the placental Hypoxia-inducible factor1-α polymorphisms and HIF1-α mRNA expression with preeclampsia. Placenta. 67:31–37. 2018. View Article : Google Scholar : PubMed/NCBI

52 

Grotegut CA: Prevention of preeclampsia. J Clin Invest. 126:4396–4398. 2016. View Article : Google Scholar : PubMed/NCBI

53 

Cohen JM, Kramer MS, Platt RW, Basso O, Evans RW and Kahn SR: The association between maternal antioxidant levels in midpregnancy and preeclampsia. Am J Obstet Gynecol. 213. pp. 695.e1–613. 2015, View Article : Google Scholar

54 

Bahado-Singh RO, Syngelaki A, Akolekar R, Mandal R, Bjondahl TC, Han B, Dong E, Bauer S, Alpay-Savasan Z, Graham S, et al: Validation of metabolomic models for prediction of early-onset preeclampsia. Am J Obstet Gynecol. 213:530.e1–530.e10. 2015. View Article : Google Scholar

55 

Ray JG, Booth GL, Alter DA and Vermeulen MJ: Prognosis after maternal placental events and revascularization: PAMPER study. Am J Obstet Gynecol. 214:106.e1–106.e14. 2016. View Article : Google Scholar

56 

Szabo G, Molvarec A, Nagy B and Rigo J Jr: Increased B-type natriuretic peptide levels in early-onset versus late-onset preeclampsia. Clin Chem Lab Med. 52:281–288. 2014. View Article : Google Scholar

57 

Borges VTM, Zanati SG, Peraçoli MTS, Poiati JR, Romão-Veiga M, Peraçoli JC and Thilaganathan B: Maternal left ventricular hypertrophy and diastolic dysfunction and brain natriuretic peptide concentration in early- and late-onset pre-eclampsia. Ultrasound Obstet Gynecol. 51:519–523. 2018. View Article : Google Scholar

58 

Chatterjee P, Chiasson VL, Seerangan G, De Guzman E, Milad M, Bounds KR, Gasheva O, Tobin RP, Hatahet M, Kopriva S, et al: Depletion of MHC class II invariant chain peptide or γ-δ T-cells ameliorates experimental preeclampsia. Clin Sci (Lond). 131:2047–2058. 2017. View Article : Google Scholar

59 

Kim J, Lee KS, Kim JH, Lee DK, Park M, Choi S, Park W, Kim S, Choi YK, Hwang JY, et al: Aspirin prevents TNF-α-induced endothelial cell dysfunction by regulating the NF-κB-dependent miR-155/eNOS pathway: Role of a miR-155/eNOS axis in preeclampsia. Free Radic Biol Med. 104:185–198. 2017. View Article : Google Scholar : PubMed/NCBI

60 

Shaw J, Tang Z, Schneider H, Salje K, Hansson SR and Guller S: Inflammatory processes are specifically enhanced in endothelial cells by placental-derived TNF-α: Implications in preeclampsia (PE). Placenta. 43:1–8. 2016. View Article : Google Scholar : PubMed/NCBI

61 

Barone Gibbs B, Dobrosielski DA, Bonekamp S, Stewart KJ and Clark JM: A randomized trial of exercise for blood pressure reduction in type 2 diabetes: Effect on flow-mediated dilation and circulating biomarkers of endothelial function. Atherosclerosis. 224:446–453. 2012. View Article : Google Scholar : PubMed/NCBI

62 

Onda K, Tong S, Nakahara A, Kondo M, Monchusho H, Hirano T, Kaitu'u-Lino T, Beard S, Binder N, Tuohey L, et al: Sofalcone upregulates the nuclear factor (erythroid-derived 2)-like 2/heme oxygenase-1 pathway, reduces soluble fms-like tyrosine kinase-1, and quenches endothelial dysfunction: Potential therapeutic for preeclampsia. Hypertension. 65:855–862. 2015. View Article : Google Scholar : PubMed/NCBI

63 

Vanhaesebroeck B, Stephens L and Hawkins P: PI3K signalling: The path to discovery and understanding. Nat Rev Mol Cell Biol. 13:195–203. 2012. View Article : Google Scholar : PubMed/NCBI

64 

Bartholomeusz C and Gonzalez-Angulo AM: Targeting the PI3K signaling pathway in cancer therapy. Expert Opin Ther Targets. 16:121–130. 2012. View Article : Google Scholar : PubMed/NCBI

65 

Kawahara T, Asthana S and Kneteman NM: m-TOR inhibitors: What role in liver transplantation? J Hepatol. 55:1441–1451. 2011. View Article : Google Scholar : PubMed/NCBI

66 

Zhang X, Li Q, Jiang W, Xiong X, Li H, Zhao J and Qi H: LAMA5 promotes human umbilical vein endothelial cells migration, proliferation, and angiogenesis and is decreased in preeclampsia. J Matern Fetal Neonatal Med. 33:1114–1124. 2020. View Article : Google Scholar

67 

Oladipupo S, Hu S, Kovalski J, Yao J, Santeford A, Sohn RE, Shohet R, Maslov K, Wang LV and Arbeit JM: VEGF is essential for hypoxia-inducible factor-mediated neovascularization but dispensable for endothelial sprouting. Proc Natl Acad Sci USA. 108:13264–13269. 2011. View Article : Google Scholar : PubMed/NCBI

68 

Fukushima K, Murata M, Hachisuga M, Tsukimori K, Seki H, Takeda S, Asanoma K and Wake N: Hypoxia inducible factor 1 alpha regulates matrigel-induced endovascular differentiation under normoxia in a human extravillous trophoblast cell line. Placenta. 29:324–331. 2008. View Article : Google Scholar : PubMed/NCBI

69 

Kovo M, Schreiber L, Elyashiv O, Ben-Haroush A, Abraham G and Bar J: Pregnancy outcome and placental findings in pregnancies complicated by fetal growth restriction with and without preeclampsia. Reprod Sci. 22:316–321. 2015. View Article : Google Scholar

70 

Cotechini T, Komisarenko M, Sperou A, Macdonald-Goodfellow S, Adams MA and Graham CH: Inflammation in rat pregnancy inhibits spiral artery remodeling leading to fetal growth restriction and features of preeclampsia. J Exp Med. 211:165–179. 2014. View Article : Google Scholar : PubMed/NCBI

71 

Szarka A, Rigó J Jr, Lázár L, Beko G and Molvarec A: Circulating cytokines, chemokines and adhesion molecules in normal pregnancy and preeclampsia determined by multiplex suspension array. BMC immunol. 11:592010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xue L, Xie K, Wu L, Yu X, Long W, Li C, Jia R and Ding H: A novel peptide relieves endothelial cell dysfunction in preeclampsia by regulating the PI3K/mTOR/HIF1α pathway. Int J Mol Med 47: 276-288, 2021.
APA
Xue, L., Xie, K., Wu, L., Yu, X., Long, W., Li, C. ... Ding, H. (2021). A novel peptide relieves endothelial cell dysfunction in preeclampsia by regulating the PI3K/mTOR/HIF1α pathway. International Journal of Molecular Medicine, 47, 276-288. https://doi.org/10.3892/ijmm.2020.4793
MLA
Xue, L., Xie, K., Wu, L., Yu, X., Long, W., Li, C., Jia, R., Ding, H."A novel peptide relieves endothelial cell dysfunction in preeclampsia by regulating the PI3K/mTOR/HIF1α pathway". International Journal of Molecular Medicine 47.1 (2021): 276-288.
Chicago
Xue, L., Xie, K., Wu, L., Yu, X., Long, W., Li, C., Jia, R., Ding, H."A novel peptide relieves endothelial cell dysfunction in preeclampsia by regulating the PI3K/mTOR/HIF1α pathway". International Journal of Molecular Medicine 47, no. 1 (2021): 276-288. https://doi.org/10.3892/ijmm.2020.4793
Copy and paste a formatted citation
x
Spandidos Publications style
Xue L, Xie K, Wu L, Yu X, Long W, Li C, Jia R and Ding H: A novel peptide relieves endothelial cell dysfunction in preeclampsia by regulating the PI3K/mTOR/HIF1α pathway. Int J Mol Med 47: 276-288, 2021.
APA
Xue, L., Xie, K., Wu, L., Yu, X., Long, W., Li, C. ... Ding, H. (2021). A novel peptide relieves endothelial cell dysfunction in preeclampsia by regulating the PI3K/mTOR/HIF1α pathway. International Journal of Molecular Medicine, 47, 276-288. https://doi.org/10.3892/ijmm.2020.4793
MLA
Xue, L., Xie, K., Wu, L., Yu, X., Long, W., Li, C., Jia, R., Ding, H."A novel peptide relieves endothelial cell dysfunction in preeclampsia by regulating the PI3K/mTOR/HIF1α pathway". International Journal of Molecular Medicine 47.1 (2021): 276-288.
Chicago
Xue, L., Xie, K., Wu, L., Yu, X., Long, W., Li, C., Jia, R., Ding, H."A novel peptide relieves endothelial cell dysfunction in preeclampsia by regulating the PI3K/mTOR/HIF1α pathway". International Journal of Molecular Medicine 47, no. 1 (2021): 276-288. https://doi.org/10.3892/ijmm.2020.4793
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