Open Access

Extracellular matrix grafts: From preparation to application (Review)

  • Authors:
    • Yongsheng Jiang
    • Rui Li
    • Chunchan Han
    • Lijiang Huang
  • View Affiliations

  • Published online on: December 15, 2020     https://doi.org/10.3892/ijmm.2020.4818
  • Pages: 463-474
  • Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Recently, the increasing emergency of traffic accidents and the unsatisfactory outcome of surgical intervention are driving research to seek a novel technology to repair traumatic soft tissue injury. From this perspective, decellularized matrix grafts (ECM‑G) including natural ECM materials, and their prepared hydrogels and bioscaffolds, have emerged as possible alternatives for tissue engineering and regenerative medicine. Over the past decades, several physical and chemical decellularization methods have been used extensively to deal with different tissues/organs in an attempt to carefully remove cellular antigens while maintaining the non‑immunogenic ECM components. It is anticipated that when the decellularized biomaterials are seeded with cells in vitro or incorporated into irregularly shaped defects in vivo, they can provide the appropriate biomechanical and biochemical conditions for directing cell behavior and tissue remodeling. The aim of this review is to first summarize the characteristics of ECM‑G and describe their major decellularization methods from different sources, followed by analysis of how the bioactive factors and undesired residual cellular compositions influence the biologic function and host tissue response following implantation. Lastly, we also provide an overview of the in vivo application of ECM‑G in facilitating tissue repair and remodeling.
View Figures
View References

Related Articles

Journal Cover

February-2021
Volume 47 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Jiang Y, Li R, Han C and Huang L: Extracellular matrix grafts: From preparation to application (Review). Int J Mol Med 47: 463-474, 2021
APA
Jiang, Y., Li, R., Han, C., & Huang, L. (2021). Extracellular matrix grafts: From preparation to application (Review). International Journal of Molecular Medicine, 47, 463-474. https://doi.org/10.3892/ijmm.2020.4818
MLA
Jiang, Y., Li, R., Han, C., Huang, L."Extracellular matrix grafts: From preparation to application (Review)". International Journal of Molecular Medicine 47.2 (2021): 463-474.
Chicago
Jiang, Y., Li, R., Han, C., Huang, L."Extracellular matrix grafts: From preparation to application (Review)". International Journal of Molecular Medicine 47, no. 2 (2021): 463-474. https://doi.org/10.3892/ijmm.2020.4818