Open Access

Cartilage intermediate layer protein affects the progression of intervertebral disc degeneration by regulating the extracellular microenvironment (Review)

  • Authors:
    • Libangxi Liu
    • Jinyue He
    • Chang Liu
    • Minghui Yang
    • Jiawei Fu
    • Jiarong Yi
    • Xuezheng Ai
    • Miao Liu
    • Yong Zhuang
    • Yaqing Zhang
    • Bo Huang
    • Changqing Li
    • Yue Zhou
    • Chencheng Feng
  • View Affiliations

  • Published online on: December 24, 2020     https://doi.org/10.3892/ijmm.2020.4832
  • Pages: 475-484
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Intervertebral disc degeneration (IDD), which is caused by multiple factors, affects the health of individuals and contributes to low back pain. The pathology of IDD is complicated, and changes in the extracellular microenvironment play an important role in promoting the process of degeneration. Cartilage intermediate layer protein (CILP) is a matrix protein that resides in the middle of human articular cartilage and is involved in numerous diseases that affect cartilage. However, there is no detailed review of the relationship between CILP and degenerative disc disease. Growing evidence has revealed the presence of CILP in the extracellular microenvironment of intervertebral discs (IVDs) and has suggested that there is a gradual increase in CILP in degenerative discs. Specifically, CILP plays an important role in regulating the metabolism of the extracellular matrix (ECM), an important component of the extracellular microenvironment. CILP can combine with transforming growth factor‑β or insulin‑like growth factor‑1 to regulate the ECM synthesis of IVDs and influence the balance of ECM metabolism, which leads to changes in the extracellular microenvironment to promote the process of IDD. It may be possible to show the correlation of CILP with IDD and to target CILP to interfere with IDD. For this purpose, in the present study, the current knowledge on CILP was summarized and a detailed description of CILP in discs was provided.
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February-2021
Volume 47 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Liu L, He J, Liu C, Yang M, Fu J, Yi J, Ai X, Liu M, Zhuang Y, Zhang Y, Zhang Y, et al: Cartilage intermediate layer protein affects the progression of intervertebral disc degeneration by regulating the extracellular microenvironment (Review). Int J Mol Med 47: 475-484, 2021
APA
Liu, L., He, J., Liu, C., Yang, M., Fu, J., Yi, J. ... Feng, C. (2021). Cartilage intermediate layer protein affects the progression of intervertebral disc degeneration by regulating the extracellular microenvironment (Review). International Journal of Molecular Medicine, 47, 475-484. https://doi.org/10.3892/ijmm.2020.4832
MLA
Liu, L., He, J., Liu, C., Yang, M., Fu, J., Yi, J., Ai, X., Liu, M., Zhuang, Y., Zhang, Y., Huang, B., Li, C., Zhou, Y., Feng, C."Cartilage intermediate layer protein affects the progression of intervertebral disc degeneration by regulating the extracellular microenvironment (Review)". International Journal of Molecular Medicine 47.2 (2021): 475-484.
Chicago
Liu, L., He, J., Liu, C., Yang, M., Fu, J., Yi, J., Ai, X., Liu, M., Zhuang, Y., Zhang, Y., Huang, B., Li, C., Zhou, Y., Feng, C."Cartilage intermediate layer protein affects the progression of intervertebral disc degeneration by regulating the extracellular microenvironment (Review)". International Journal of Molecular Medicine 47, no. 2 (2021): 475-484. https://doi.org/10.3892/ijmm.2020.4832