Open Access

Apoptotic mechanism activated by blue light and cisplatinum in cutaneous squamous cell carcinoma cells

  • Authors:
    • Maria Fiorella Tartaglione
    • María Eléxpuru Zabaleta
    • Raffaella Lazzarini
    • Francesco Piva
    • Elena Marinelli Busilacchi
    • Antonella Poloni
    • Caterina Ledda
    • Venerando Rapisarda
    • Lory Santarelli
    • Massimo Bracci
  • View Affiliations

  • Published online on: February 9, 2021     https://doi.org/10.3892/ijmm.2021.4881
  • Article Number: 48
  • Copyright: © Tartaglione et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

New approaches are being studied for the treatment of skin cancer. It has been reported that light combined with cisplatinum may be effective against skin cancer. In the present study, the effects of specific light radiations and cisplatinum on A431 cutaneous squamous cell carcinoma (cSCC) and HaCaT non‑tumorigenic cell lines were investigated. Both cell lines were exposed to blue and red light sources for 3 days prior to cisplatinum treatment. Viability, apoptosis, cell cycle progression and apoptotic‑related protein expression levels were investigated. The present results highlighted that combined treatment with blue light and cisplatinum was more effective in reducing cell viability compared with single treatments. Specifically, an increase in the apoptotic rate was observed when the cells were treated with blue light and cisplatinum, as compared to treatment with blue light or cisplatinum alone. Combined treatment with blue light and cisplatinum also caused cell cycle arrest at the S phase. Treatment with cisplatinum following light exposure induced the expression of apoptotic proteins in the A431 and HaCaT cell lines, which tended to follow different apoptotic mechanisms. On the whole, these data indicate that blue light combined with cisplatinum may be a promising treatment for cSCC.
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April-2021
Volume 47 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Tartaglione MF, Eléxpuru Zabaleta M, Lazzarini R, Piva F, Busilacchi EM, Poloni A, Ledda C, Rapisarda V, Santarelli L, Bracci M, Bracci M, et al: Apoptotic mechanism activated by blue light and cisplatinum in cutaneous squamous cell carcinoma cells. Int J Mol Med 47: 48, 2021
APA
Tartaglione, M.F., Eléxpuru Zabaleta, M., Lazzarini, R., Piva, F., Busilacchi, E.M., Poloni, A. ... Bracci, M. (2021). Apoptotic mechanism activated by blue light and cisplatinum in cutaneous squamous cell carcinoma cells. International Journal of Molecular Medicine, 47, 48. https://doi.org/10.3892/ijmm.2021.4881
MLA
Tartaglione, M. F., Eléxpuru Zabaleta, M., Lazzarini, R., Piva, F., Busilacchi, E. M., Poloni, A., Ledda, C., Rapisarda, V., Santarelli, L., Bracci, M."Apoptotic mechanism activated by blue light and cisplatinum in cutaneous squamous cell carcinoma cells". International Journal of Molecular Medicine 47.4 (2021): 48.
Chicago
Tartaglione, M. F., Eléxpuru Zabaleta, M., Lazzarini, R., Piva, F., Busilacchi, E. M., Poloni, A., Ledda, C., Rapisarda, V., Santarelli, L., Bracci, M."Apoptotic mechanism activated by blue light and cisplatinum in cutaneous squamous cell carcinoma cells". International Journal of Molecular Medicine 47, no. 4 (2021): 48. https://doi.org/10.3892/ijmm.2021.4881