Open Access

Adipose tissue and age‑dependent insulin resistance: New insights into WAT browning (Review)

  • Authors:
    • Chuanlong Wu
    • Pei Yu
    • Ruixin Sun
  • View Affiliations

  • Published online on: March 2, 2021     https://doi.org/10.3892/ijmm.2021.4904
  • Article Number: 71
  • Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Insulin resistance (IR) is defined as impaired insulin function, reduced glucose uptake and increased glucose production, which can result in type II diabetes, metabolic syndrome and even bone metabolic disorders. A possible reason for the increasing incidence of IR is population aging. Adipose tissue (AT) is an important endocrine organ that serves a crucial role in whole‑body energy homeostasis. AT can be divided into white AT (WAT), beige AT and brown AT (BAT). Several mechanisms have been previously associated with age‑dependent IR in WAT. However, BAT, a metabolically active tissue, controls the levels of plasma glucose and triglyceride metabolism. Therefore, the present review aimed to summarize the mechanisms of age‑dependent IR induced by AT and to determine the role of WAT browning in achieving positive therapeutic outcomes in age‑dependent IR.
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May-2021
Volume 47 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Wu C, Yu P and Sun R: Adipose tissue and age‑dependent insulin resistance: New insights into WAT browning (Review). Int J Mol Med 47: 71, 2021
APA
Wu, C., Yu, P., & Sun, R. (2021). Adipose tissue and age‑dependent insulin resistance: New insights into WAT browning (Review). International Journal of Molecular Medicine, 47, 71. https://doi.org/10.3892/ijmm.2021.4904
MLA
Wu, C., Yu, P., Sun, R."Adipose tissue and age‑dependent insulin resistance: New insights into WAT browning (Review)". International Journal of Molecular Medicine 47.5 (2021): 71.
Chicago
Wu, C., Yu, P., Sun, R."Adipose tissue and age‑dependent insulin resistance: New insights into WAT browning (Review)". International Journal of Molecular Medicine 47, no. 5 (2021): 71. https://doi.org/10.3892/ijmm.2021.4904