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Adipose tissue and age‑dependent insulin resistance: New insights into WAT browning (Review)

  • Authors:
    • Chuanlong Wu
    • Pei Yu
    • Ruixin Sun
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China, State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 71
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    Published online on: March 2, 2021
       https://doi.org/10.3892/ijmm.2021.4904
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Abstract

Insulin resistance (IR) is defined as impaired insulin function, reduced glucose uptake and increased glucose production, which can result in type II diabetes, metabolic syndrome and even bone metabolic disorders. A possible reason for the increasing incidence of IR is population aging. Adipose tissue (AT) is an important endocrine organ that serves a crucial role in whole‑body energy homeostasis. AT can be divided into white AT (WAT), beige AT and brown AT (BAT). Several mechanisms have been previously associated with age‑dependent IR in WAT. However, BAT, a metabolically active tissue, controls the levels of plasma glucose and triglyceride metabolism. Therefore, the present review aimed to summarize the mechanisms of age‑dependent IR induced by AT and to determine the role of WAT browning in achieving positive therapeutic outcomes in age‑dependent IR.
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Copy and paste a formatted citation
Spandidos Publications style
Wu C, Yu P and Sun R: Adipose tissue and age‑dependent insulin resistance: New insights into WAT browning (Review). Int J Mol Med 47: 71, 2021.
APA
Wu, C., Yu, P., & Sun, R. (2021). Adipose tissue and age‑dependent insulin resistance: New insights into WAT browning (Review). International Journal of Molecular Medicine, 47, 71. https://doi.org/10.3892/ijmm.2021.4904
MLA
Wu, C., Yu, P., Sun, R."Adipose tissue and age‑dependent insulin resistance: New insights into WAT browning (Review)". International Journal of Molecular Medicine 47.5 (2021): 71.
Chicago
Wu, C., Yu, P., Sun, R."Adipose tissue and age‑dependent insulin resistance: New insights into WAT browning (Review)". International Journal of Molecular Medicine 47, no. 5 (2021): 71. https://doi.org/10.3892/ijmm.2021.4904
Copy and paste a formatted citation
x
Spandidos Publications style
Wu C, Yu P and Sun R: Adipose tissue and age‑dependent insulin resistance: New insights into WAT browning (Review). Int J Mol Med 47: 71, 2021.
APA
Wu, C., Yu, P., & Sun, R. (2021). Adipose tissue and age‑dependent insulin resistance: New insights into WAT browning (Review). International Journal of Molecular Medicine, 47, 71. https://doi.org/10.3892/ijmm.2021.4904
MLA
Wu, C., Yu, P., Sun, R."Adipose tissue and age‑dependent insulin resistance: New insights into WAT browning (Review)". International Journal of Molecular Medicine 47.5 (2021): 71.
Chicago
Wu, C., Yu, P., Sun, R."Adipose tissue and age‑dependent insulin resistance: New insights into WAT browning (Review)". International Journal of Molecular Medicine 47, no. 5 (2021): 71. https://doi.org/10.3892/ijmm.2021.4904
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