Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
May-2021 Volume 47 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2021 Volume 47 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Lipoxin A4 protects against paraquat‑induced acute lung injury by inhibiting the TLR4/MyD88‑mediated activation of the NF‑κB and PI3K/AKT pathways

  • Authors:
    • Yuhua Li
    • Na Wang
    • Zhongliang Ma
    • Yunwen Wang
    • Yuan Yuan
    • Zhitao Zhong
    • Yi Hong
    • Min Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 86
    |
    Published online on: March 19, 2021
       https://doi.org/10.3892/ijmm.2021.4919
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Paraquat (PQ) causes serious oxidative stress and inflammatory responses, particularly to the lungs. Since lipoxin A4 (LXA4) functions as an anti‑inflammatory mediator, the present study aimed to explore its effects on PQ‑induced acute lung injury (ALI) and to elucidate the possible underlying mechanisms. PQ was administered to male SD rats and RAW264.7 cells to establish a model of poisoning, and LXA4 was used as an intervention drug. LXA4 treatment attenuated PQ‑induced lung injury, and this was accompanied by decreased tumor necrosis factor (TNF)‑α and interleukin (IL)‑1β secretion levels, and reduced oxidative stress damage. Additionally, LXA4 treatment inhibited the activation of the inflammation‑related signaling molecules, Toll‑like receptor 4 (TLR4), myeloid differentiation primary response 88 (MyD88), nuclear factor (NF)‑κB p65, p‑phosphoinositide 3‑kinase (PI3K) and p‑AKT. Furthermore, the in vitro experiments further confirmed that the beneficial effects of LXA4 on PQ‑induced damage were TLR4‑dependent. Hence, the present study demonstrated that LXA4 attenuated PQ‑induced toxicity in lung tissue and RAW264.7 macrophages, and that this protective effect may be closely related to the mitigation of inflammatory responses, oxidative stress damage and the TLR4/MyD88‑mediated activation of the PI3K/AKT/NF‑κB pathway.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

View References

1 

Baltazar T, Dinis-Oliveira RJ, Duarte JA, de Lourdes Bastos M and Carvalho F: Paraquat research: Do recent advances in limiting its toxicity make its use safer? Br J Pharmacol. 168:44–45. 2013. View Article : Google Scholar :

2 

Moon JM, Chun BJ and Cho YS: The characteristics of emergency department presentations related to acute herbicide or insecticide poisoning in South Korea between 2011-2014. J Toxicol Environ Health A. 79:466–476. 2016. View Article : Google Scholar

3 

Sun B and Chen YG: Advances in the mechanism of paraquat-induced pulmonary injury. Eur Rev Med Pharmacol Sci. 20:1597–1602. 2016.PubMed/NCBI

4 

Li G, Yuzhen L, Yi C, Xiaoxiang C, Wei Z, Changqing Z and Shuang Y: DNaseI protects against paraquat-induced acute lung injury and pulmonary fibrosis mediated by mitochondrial DNA. Biomed Res Int. 2015:3869522015.PubMed/NCBI

5 

Liu ZN, Zhao M, Zheng Q, Zhao HY, Hou WJ and Bai SL: Inhibitory effects of rosiglitazone on paraquat-induced acute lung injury in rats. Acta Pharmacol Sin. 34:1317–1324. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Liu Z, Sun M, Wang Y, Zhang L, Zhao H and Zhao M: Silymarin attenuated paraquat-induced cytotoxicity in macrophage by regulating Trx/TXNIP complex, inhibiting NLRP3 inflammasome activation and apoptosis. Toxicol In Vitro. 46:265–272. 2018. View Article : Google Scholar

7 

Toygar M, Aydin I, Agilli M, Aydin FN, Oztosun M, Gul H, Macit E, Karslioglu Y, Topal T, Uysal B and Honca M: The relation between oxidative stress, inflammation, and neopterin in the paraquat-induced lung toxicity. Hum Exp Toxicol. 34:198–1204. 2015. View Article : Google Scholar

8 

Chen T, Wang R, Jiang W, Wang H, Xu A, Lu G, Ren Y, Xu Y, Song Y, Yong S, et al: Protective effect of astragaloside IV against paraquat-induced lung injury in mice by suppressing rho signaling. Inflammation. 39:483–492. 2016. View Article : Google Scholar

9 

Levy BD and Serhan CN: Resolution of acute inflammation in the lung. Annu Rev Physiol. 76:467–492. 2014. View Article : Google Scholar

10 

Shimizu S, Ogawa T, Seno S, Kouzaki H and Shimizu T: Pro-Resolution mediator lipoxin A4 and its receptor in upper airway inflammation. Ann Otol Rhinol Laryngol. 122:683–689. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Romano M, Cianci E, Simiele F and Recchiuti A: Lipoxins and aspirin-triggered lipoxins in resolution of inflammation. Eur J Pharmacol. 5:49–63. 2015. View Article : Google Scholar

12 

Zhang L, Wu P, Jin Sw, Yuan P, Wan Jy, Zhou Xy, Xiong W, Fang F and Ye Dy: Lipoxin A4 negatively regulates lipopolysaccharide-induced differentiation of RAW264.7 murine macrophages into dendritic-like cells. Chin Med J (Engl). 5:981–987. 2007. View Article : Google Scholar

13 

Martini AC, Forner S, Bento AF and Rae GA: Neuroprotective effects of lipoxin A4 in central nervous system pathologies. Biomed Res Int. 2014:3162042014. View Article : Google Scholar : PubMed/NCBI

14 

Wu L, Li HH, Wu Q, Miao S, Liu ZJ, Wu P and Ye DY: Lipoxin A4 activates Nrf2 pathway and ameliorates cell damage in cultured cortical astrocytes exposed to oxygen-glucose deprivation/reperfusion insults. J Mol Neurosci Aug. 56:848–857. 2015. View Article : Google Scholar

15 

Zong L, Li J, Chen X, Chen K, Li W, Li X, Zhang L, Duan W, Lei J, Xu Q, et al: Lipoxin A4 attenuates cell invasion by inhibiting ROS/ERK/MMP pathway in pancreatic cancer. Oxid Med Cell Longev. 2016:68157272016. View Article : Google Scholar

16 

Zhou XY, Wu P, Zhang L, Xiong W, Li YS, Feng YM and Ye DY: Effects of lipoxin A(4) on lipopolysaccharide induced proliferation and reactive oxygen species production in RAW264.7 macrophages through modulation of G-CSF secretion. Inflamm Res. 56:324–333. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Zong H, Li X, Lin H, Hou C and Ma F: Lipoxin A4 pretreatment mitigates skeletal muscle ischemia-reperfusion injury in rats. Am J Transl Res. 9:1139–1150. 2017.PubMed/NCBI

18 

Zhao Q, Shao L, Hu X, Wu G, Du J, Xia J and Qiu H: Lipoxin a4 preconditioning and postconditioning protect myocardial ischemia/reperfusion injury in rats. Mediators Inflamm. 2013:2313512013. View Article : Google Scholar : PubMed/NCBI

19 

Chen XQ, Wu SH, Zhou Y and Tang YR: Lipoxin A4-induced heme oxygenase-1 protects cardiomyocytes against hypoxia/reoxygenation injury via p38 MAPK activation and Nrf2/ARE complex. PLoS One. 24:e671202013. View Article : Google Scholar

20 

Liu ZN, Zhao H, Liu W, Li T, Wang Y and Zhao M: NLRP3 inflammasome activation is essential for paraquat-induced acute lung injury. Inflammation. 38:433–444. 2015. View Article : Google Scholar

21 

Wang Q, Lian QQ, Li R, Ying BY, He Q, Chen F, Zheng X, Yang Y, Wu DR, Zheng SX, et al: Lipoxin A(4) activates alveolar epithelial sodium channel, na, K-ATPase, and increases alveolar fluid clearance. Am J Resp Cell Mol Biol. 48:610–618. 2013. View Article : Google Scholar

22 

Qi W, Li H, Cai XH, Gu JQ, Meng J, Xie HQ, Zhang JL, Chen J, Jin XG, Tang Q, et al: Lipoxin A(4) activates alveolar epithelial sodium channel gamma via the microRNA-21/PTEN/AKT pathway in lipopolysaccharide-induced inflammatory lung injury. Lab Invest. 95:1258–1268. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Mikawa K, Nishina K, Takao Y and Obara H: ONO-1714, a nitric oxide synthase inhibitor, attenuates endotoxin-induced acute lung injury in rabbits. Anesth Analg. 97:1751–1755. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Shen H, Wu N, Wang Y, Guo F, Chen L, Zhang Z, Jia D and Zhao M: MyD88 gene knockout attenuates paraquat-induced acute lung injury. Toxicol Lett. 5:41–46. 2017. View Article : Google Scholar

25 

Kayama H, Ramirez-Carrozzi VR, Yamamoto M, Mizutani T, Kuwata H, Iba H, Matsumoto M, Honda K, Smale ST and Takeda K: Class-Specific regulation of pro-inflammatory genes by MyD88 pathways and IκBζ. J Biol Chem. 290:48152015. View Article : Google Scholar

26 

Hazeki K, Nigorikawa K and Hazeki O: Role of phosphoinositide 3-kinase in innate immunity. Biol Pharm Bull. 30:1617–1623. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Androulidaki A, Iliopoulos D, Arranz A, Doxaki C, Schworer S, Zacharioudaki V, Margioris AN, Tsichlis PN and Tsatsanis C: The kinase akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs. Immunity. 21:220–231. 2009. View Article : Google Scholar

28 

Ruse M and Knaus UG: New players in TLR-mediated innate immunity: PI3K and small rho GTPases. Immunol Res. 34:33–48. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Rose MS, Smith LL and Wyatt I: Evidence for energy-dependent accumulation of paraquat into rat lung. Nature. 22:314–315. 1974. View Article : Google Scholar

30 

Wang X, Jiao W, Lin M, Lu C, Liu C, Wang Y, Ma D, Wang X, Yin P, Feng J, et al: Resolution of inflammation in neuromyelitis optica spectrum disorders. Mult Scler Relat Disord. 27:34–41. 2019. View Article : Google Scholar

31 

Börgeson E, Johnson AM, Lee YS, Till A, Syed GH, Ali-Shah ST, Guiry PJ, Dalli J, Colas RA, Serhan CN, et al: Lipoxin A4 attenuates obesity-induced adipose inflammation and associated liver and kidney disease. Cell Metab. 7:125–137. 2015. View Article : Google Scholar

32 

Liu L, Zhang P, Zhang Z, Hu Q, He J, Liu H, Zhao J, Liang Y, He Z, Li X, et al: LXA4 ameliorates cerebrovascular endothelial dysfunction by reducing acute inflammation after subarachnoid hemorrhage in rats. Neuroscience. 1:105–114. 2019. View Article : Google Scholar

33 

Lu H, Zhen J, Wu T, Peng A, Ye T, Wang T, Yu X, Vaziri ND, Mohan C and Zhou XJ: Superoxide dismutase mimetic drug tempol aggravates anti-GBM antibody-induced glomerulonephritis in mice. Am J Physiol Renal Physiol. 299:F445–F452. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Li Y, Liu Y, Peng X, Liu W, Zhao F, Feng D, Han J, Huang Y, Luo S, Li L, et al: NMDA receptor antagonist attenuates bleomycin-induced acute lung injury. PLoS One. 5:e01258732015. View Article : Google Scholar

35 

Kovach MA and Standiford TJ: Toll like receptors in diseases of the lung. Int Immunopharmacol. 11:1399–1406. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Oakes JL, O'Connor BP, Warg LA, Burton R, Hock A, Loader J, Laflamme D, Jing J, Hui L, Schwartz DA and Yang IV: Ozone enhances pulmonary innate immune response to a toll-like receptor-2 agonist. Am J Respir Cell Mol Biol. 48:27–34. 2013. View Article : Google Scholar :

37 

Qin C, Zhang B, Zhang L, Zhang Z, Wang L, Tang L, Li S, Yang Y, Yang F, Zhang P and Yang B: MyD88-Dependent toll-like receptor 4 signal pathway in intervertebral disc degeneration. Exp Ther Med. 12:611–618. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Liu W, Shan LP, Dong XS and Liu Z: Toll-Like receptor 4 implicated in acute lung injury induced by paraquat poisoning in mice. Int J Clin Exp Med. 5:3392–3397. 2014.

39 

Dong XS, Xu XY, Sun YQ, Wei-Liu, Jiang ZH and Liu Z: Toll-Like receptor 4 is involved in myocardial damage following paraquat poisoning in mice. Toxicology. 312:115–122. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Hu R, Xu H, Jiang H, Zhang Y and Sun Y: The role of TLR4 in the pathogenesis of indirect acute lung injury. Front Biosci (Landmark Ed). 2013 Jun 1;18:1244–55. View Article : Google Scholar

41 

Li TT, Ogino S and Qian ZR: Toll-Like receptor signaling in colorectal cancer: Carcinogenesis to cancer therapy. World J Gastroenterol. 1:17699–17708. 2014. View Article : Google Scholar

42 

Lawrence T: The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect Biol. 1:a0016512009. View Article : Google Scholar

43 

Liu P, Zhou YS, Qin YL, Li L, Liu Y, Xu B, Huang K, Ji CC, Lin F, Wang YG, et al: Mechanism of action for oligomeric proanthocyaniclins in pava qnat-induced acute lung injury. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 20:818–822. 2017.In Chinese.

44 

Hu X, Shen H, Wang Y and Zhao M: Liver X receptor agonist TO901317 attenuates paraquat-induced acute lung injury through inhibition of NF-κB and JNK/p38 MAPK signal pathways. Biomed Res Int. 2017:46526952017. View Article : Google Scholar

45 

Liu Mw, Su Mx, Zhang W, Wang Yq, Chen M, Wang L and Qian Cy: Protective effect of Xuebijing injection on paraquat-induced pulmonary injury via down-regulating the expression of p38 MAPK in rats. BMC Complement Altern Med. 16:4982014. View Article : Google Scholar

46 

Troutman TD, Hu W, Fulenchek S, Yamazaki T, Kurosaki T, Bazan JF and Pasare C: Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt. Proc Natl Acad Sci USA. 3:273–278. 2012. View Article : Google Scholar

47 

Chu AJ: Antagonism by bioactive polyphenols against inflammation: A systematic view. Inflamm Allergy Drug Targets. 13:34–64. 2014. View Article : Google Scholar

48 

Lo JY, Kamarudin MN, Hamdi OA, Awang K and Kadir HA: Curcumenol isolated from curcuma zedoaria suppresses akt-mediated NF-κB activation and p38 MAPK signaling pathway in LPS-stimulated BV-2 microglial cells. Food Funct. 6:3550–3559. 2015. View Article : Google Scholar : PubMed/NCBI

49 

Madrid LV, Mayo MW, Reuther JY and Baldwin AS Jr: Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38. J Biol Chem. 1:18934–18940. 2001. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li Y, Wang N, Ma Z, Wang Y, Yuan Y, Zhong Z, Hong Y and Zhao M: Lipoxin A4 protects against paraquat‑induced acute lung injury by inhibiting the TLR4/MyD88‑mediated activation of the NF‑κB and PI3K/AKT pathways. Int J Mol Med 47: 86, 2021.
APA
Li, Y., Wang, N., Ma, Z., Wang, Y., Yuan, Y., Zhong, Z. ... Zhao, M. (2021). Lipoxin A4 protects against paraquat‑induced acute lung injury by inhibiting the TLR4/MyD88‑mediated activation of the NF‑κB and PI3K/AKT pathways. International Journal of Molecular Medicine, 47, 86. https://doi.org/10.3892/ijmm.2021.4919
MLA
Li, Y., Wang, N., Ma, Z., Wang, Y., Yuan, Y., Zhong, Z., Hong, Y., Zhao, M."Lipoxin A4 protects against paraquat‑induced acute lung injury by inhibiting the TLR4/MyD88‑mediated activation of the NF‑κB and PI3K/AKT pathways". International Journal of Molecular Medicine 47.5 (2021): 86.
Chicago
Li, Y., Wang, N., Ma, Z., Wang, Y., Yuan, Y., Zhong, Z., Hong, Y., Zhao, M."Lipoxin A4 protects against paraquat‑induced acute lung injury by inhibiting the TLR4/MyD88‑mediated activation of the NF‑κB and PI3K/AKT pathways". International Journal of Molecular Medicine 47, no. 5 (2021): 86. https://doi.org/10.3892/ijmm.2021.4919
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Wang N, Ma Z, Wang Y, Yuan Y, Zhong Z, Hong Y and Zhao M: Lipoxin A4 protects against paraquat‑induced acute lung injury by inhibiting the TLR4/MyD88‑mediated activation of the NF‑κB and PI3K/AKT pathways. Int J Mol Med 47: 86, 2021.
APA
Li, Y., Wang, N., Ma, Z., Wang, Y., Yuan, Y., Zhong, Z. ... Zhao, M. (2021). Lipoxin A4 protects against paraquat‑induced acute lung injury by inhibiting the TLR4/MyD88‑mediated activation of the NF‑κB and PI3K/AKT pathways. International Journal of Molecular Medicine, 47, 86. https://doi.org/10.3892/ijmm.2021.4919
MLA
Li, Y., Wang, N., Ma, Z., Wang, Y., Yuan, Y., Zhong, Z., Hong, Y., Zhao, M."Lipoxin A4 protects against paraquat‑induced acute lung injury by inhibiting the TLR4/MyD88‑mediated activation of the NF‑κB and PI3K/AKT pathways". International Journal of Molecular Medicine 47.5 (2021): 86.
Chicago
Li, Y., Wang, N., Ma, Z., Wang, Y., Yuan, Y., Zhong, Z., Hong, Y., Zhao, M."Lipoxin A4 protects against paraquat‑induced acute lung injury by inhibiting the TLR4/MyD88‑mediated activation of the NF‑κB and PI3K/AKT pathways". International Journal of Molecular Medicine 47, no. 5 (2021): 86. https://doi.org/10.3892/ijmm.2021.4919
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team