Open Access

KIF4A promotes the development of bladder cancer by transcriptionally activating the expression of CDCA3

  • Authors:
    • Pengyi Zheng
    • Kaijie Wu
    • Zhongwei Gao
    • Huibing Li
    • Wensheng Li
    • Xiaohui Wang
    • Zhenguo Shi
    • Fei Xiao
    • Kaixuan Wang
    • Zhijun Li
    • Qingjiang Han
  • View Affiliations

  • Published online on: April 9, 2021     https://doi.org/10.3892/ijmm.2021.4932
  • Article Number: 99
  • Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Bladder cancer (BC) is among the most common urinary system tumors with a high morbidity and mortality worldwide. Despite advancements being made in the diagnosis and treatment of bladder cancer, targeted therapy remains the most promising treatment, and novel therapeutic targets are urgently required in to improve the outcomes of patients with BC. Kinesin family member 4A (KIF4A) is a plus‑end directed motor protein involved in the regulation of multiple cellular processes, such as mitosis and axon growth. Notably, KIF4A plays important roles in tumor growth and progression, and its expression is associated with the prognosis of several types of cancer. However, the potential role and molecular mechanisms of KIF4A in bladder cancer development remain unclear. The present study demonstrated that KIF4A was highly expressed in human BC tissues, and its expression was associated with patient clinicopathological characteristics, such as tumor stage (P=0.012) and with the prognosis of patients with BC. It was further found that KIF4A promoted the cell proliferation of bladder cancer both in vitro and in vivo. On the whole, the data presented herein provide evidence that KIF4A promotes the development of BC through the transcriptional activation of the expression of CDCA3. The present study indicates the involvement of KIF4A in the progression of BC and suggests that KIF4A may be a promising therapeutic target for the treatment of BC.
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June-2021
Volume 47 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Zheng P, Wu K, Gao Z, Li H, Li W, Wang X, Shi Z, Xiao F, Wang K, Li Z, Li Z, et al: KIF4A promotes the development of bladder cancer by transcriptionally activating the expression of CDCA3. Int J Mol Med 47: 99, 2021
APA
Zheng, P., Wu, K., Gao, Z., Li, H., Li, W., Wang, X. ... Han, Q. (2021). KIF4A promotes the development of bladder cancer by transcriptionally activating the expression of CDCA3. International Journal of Molecular Medicine, 47, 99. https://doi.org/10.3892/ijmm.2021.4932
MLA
Zheng, P., Wu, K., Gao, Z., Li, H., Li, W., Wang, X., Shi, Z., Xiao, F., Wang, K., Li, Z., Han, Q."KIF4A promotes the development of bladder cancer by transcriptionally activating the expression of CDCA3". International Journal of Molecular Medicine 47.6 (2021): 99.
Chicago
Zheng, P., Wu, K., Gao, Z., Li, H., Li, W., Wang, X., Shi, Z., Xiao, F., Wang, K., Li, Z., Han, Q."KIF4A promotes the development of bladder cancer by transcriptionally activating the expression of CDCA3". International Journal of Molecular Medicine 47, no. 6 (2021): 99. https://doi.org/10.3892/ijmm.2021.4932