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KIF4A promotes the development of bladder cancer by transcriptionally activating the expression of CDCA3

Retraction in: /10.3892/ijmm.2023.5265
  • Authors:
    • Pengyi Zheng
    • Kaijie Wu
    • Zhongwei Gao
    • Huibing Li
    • Wensheng Li
    • Xiaohui Wang
    • Zhenguo Shi
    • Fei Xiao
    • Kaixuan Wang
    • Zhijun Li
    • Qingjiang Han
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The First Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China, Department of Urology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China
    Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 99
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    Published online on: April 9, 2021
       https://doi.org/10.3892/ijmm.2021.4932
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Abstract

Bladder cancer (BC) is among the most common urinary system tumors with a high morbidity and mortality worldwide. Despite advancements being made in the diagnosis and treatment of bladder cancer, targeted therapy remains the most promising treatment, and novel therapeutic targets are urgently required in to improve the outcomes of patients with BC. Kinesin family member 4A (KIF4A) is a plus‑end directed motor protein involved in the regulation of multiple cellular processes, such as mitosis and axon growth. Notably, KIF4A plays important roles in tumor growth and progression, and its expression is associated with the prognosis of several types of cancer. However, the potential role and molecular mechanisms of KIF4A in bladder cancer development remain unclear. The present study demonstrated that KIF4A was highly expressed in human BC tissues, and its expression was associated with patient clinicopathological characteristics, such as tumor stage (P=0.012) and with the prognosis of patients with BC. It was further found that KIF4A promoted the cell proliferation of bladder cancer both in vitro and in vivo. On the whole, the data presented herein provide evidence that KIF4A promotes the development of BC through the transcriptional activation of the expression of CDCA3. The present study indicates the involvement of KIF4A in the progression of BC and suggests that KIF4A may be a promising therapeutic target for the treatment of BC.
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View References

1 

Williams SB, Shan Y, Jazzar U, Mehta HB, Baillargeon JG, Huo J, Huo J, Senagore AJ, Orihuela E, Tyler DS, et al: Comparing survival outcomes and costs associated with radical cystectomy and trimodal therapy for older adults with Muscle-Invasive bladder cancer. JAMA Surg. 153:881–889. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Giulietti M, Occhipinti G, Righetti A, Bracci M, Conti A, Ruzzo A, Cerigioni E, Cacciamani T, Principato G and Piva F: Emerging biomarkers in bladder cancer identified by network analysis of transcriptomic data. Front Oncol. 8:4502018. View Article : Google Scholar : PubMed/NCBI

3 

Terzic M, Ladjevic IL, Ladjevic N, Terzic S, Dotlic J, Cekerevac M, Arsenovic N, Laganà AS and Vereczkey A: Anaplastic T-cell lymphoma of the urinary bladder with unspecific clinical and radiological characteristics - a unique case report. Eur J Gynaecol Oncol. 40:136–139. 2019.

4 

Tan WS, Rodney S, Lamb B, Feneley M and Kelly J: Management of non-muscle invasive bladder cancer: A comprehensive analysis of guidelines from the United States, Europe and Asia. Cancer Treat Rev. 47:22–31. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Wang Y, Chang Q and Li Y: Racial differences in Urinary bladder cancer in the United States. Sci Rep. 8:125212018. View Article : Google Scholar : PubMed/NCBI

6 

Crabb SJ and Douglas J: The latest treatment options for bladder cancer. Br Med Bull. 128:85–95. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Sakaguchi M, Maebayashi T, Aizawa T, Ishibashi N and Saito T: Clinical results for bladder cancer treated by radiotherapy without concurrent standard chemotherapy. Anticancer Res. 36:5519–5525. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Li R, Metcalfe MJ, Ferguson JE III, Mokkapati S, Nogueras Gonzalez GM, Dinney CP, Navai N, McConkey DJ, Sahai SK and Kamat AM: Effects of thiazolidinedione in patients with active bladder cancer. BJU Int. 121:244–251. 2018. View Article : Google Scholar :

9 

DeGeorge KC, Holt HR and Hodges SC: Bladder cancer: Diagnosis and treatment. Am Fam Physician. 96:507–514. 2017.PubMed/NCBI

10 

Abbosh PH, McConkey DJ and Plimack ER: Targeting signaling transduction pathways in bladder cancer. Curr Oncol Rep. 17:582015. View Article : Google Scholar : PubMed/NCBI

11 

Liang YJ and Yang WX: Kinesins in MAPK cascade: How kinesin motors are involved in the MAPK pathway? Gene. 684:1–9. 2019. View Article : Google Scholar

12 

Rath O and Kozielski F: Kinesins and cancer. Nat Rev Cancer. 12:527–539. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Chudy A, Gajewska B, Gutowicz M and Baranczyk-Kuzma A: Intracellular transport proteins: Classification, structure and function of kinesins. Postepy Hig Med Dosw (Online). 65:588–596. 2011. View Article : Google Scholar

14 

Heintz TG, Heller JP, Zhao R, Caceres A, Eva R and Fawcett JW: Kinesin KIF4A transports integrin β1 in developing axons of cortical neurons. Mol Cell Neurosci. 63:60–71. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Wu G and Chen PL: Structural requirements of chromokinesin Kif4A for its proper function in mitosis. Biochem Biophys Res Commun. 372:454–458. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Mazumdar M, Sundareshan S and Misteli T: Human chromokinesin KIF4A functions in chromosome condensation and segregation. J Cell Biol. 166:613–620. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Tipton AR, Wren JD, Daum JR, Siefert JC and Gorbsky GJ: GTSE1 regulates spindle microtubule dynamics to control Aurora B kinase and Kif4A chromokinesin on chromosome arms. J Cell Biol. 216:3117–3132. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Tang F, Pan MH, Lu Y, Wan X, Zhang Y and Sun SC: Involvement of Kif4a in Spindle formation and chromosome segregation in Mouse Oocytes. Aging Dis. 9:623–633. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Wu G, Zhou L, Khidr L, Guo XE, Kim W, Lee YM, Krasieva T and Chen PL: A novel role of the chromokinesin Kif4A in DNA damage response. Cell Cycle. 7:2013–2020. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Matsumoto Y, Saito M, Saito K, Kanke Y, Watanabe Y, Onozawa H, Hayase S, Sakamoto W, Ishigame T, Momma T, et al: Enhanced expression of KIF4A in colorectal cancer is associated with lymph node metastasis. Oncol Lett. 15:2188–2194. 2018.PubMed/NCBI

21 

Taniwaki M, Takano A, Ishikawa N, Yasui W, Inai K, Nishimura H, Tsuchiya E, Kohno N, Nakamura Y and Daigo Y: Activation of KIF4A as a prognostic biomarker and therapeutic target for lung cancer. Clin Cancer Res. 13:6624–6631. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Hou G, Dong C, Dong Z, Liu G, Xu H, Chen L, Liu L, Wang H and Zhou W: Upregulate KIF4A enhances proliferation, invasion of hepatocellular carcinoma and indicates poor prognosis across human cancer types. Sci Rep. 7:41482017. View Article : Google Scholar : PubMed/NCBI

23 

Phan NN, Wang CY, Li KL, Chen CF, Chiao CC, Yu HG, Huang PL and Lin YC: Distinct expression of CDCA3, CDCA5, and CDCA8 leads to shorter relapse free survival in breast cancer patient. Oncotarget. 9:6977–6992. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Zhang Y, Yin W, Cao W, Chen P, Bian L and Ni Q: CDCA3 is a potential prognostic marker that promotes cell proliferation in gastric cancer. Oncol Rep. 41:2471–2481. 2019.PubMed/NCBI

25 

Dou D, Ren X, Han M, Xu X, Ge X, Gu Y, Wang X and Zhao S: CircUBE2D2 (hsa_circ_0005728) promotes cell proliferation, metastasis and chemoresistance in triple-negative breast cancer by regulating miR-512-3p/CDCA3 axis. Cancer Cell Int. 20:4542020. View Article : Google Scholar : PubMed/NCBI

26 

Chen Q, Zhou L, Ye X, Tao M and Wu J: MiR-145-5p suppresses proliferation, metastasis and EMT of colorectal cancer by targeting CDCA3. Pathol Res Pract. 216:1528722020. View Article : Google Scholar : PubMed/NCBI

27 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

28 

Yamaoka T, Kusumoto S, Ando K, Ohba M and Ohmori T: Receptor tyrosine kinase-targeted cancer therapy. Int J Mol Sci. 19:34912018. View Article : Google Scholar :

29 

He YT, Li DJ, Liang D, Zheng RS, Zhang SW, Zeng HM, Chen WQ and He J: Incidence and mortality of BC in China. Zhonghua Zhong Liu Za Zhi. 40:647–652. 2018.In Chinese. PubMed/NCBI

30 

Yang Y, Zhao Z, Xie C and Zhao Y: Dual-targeting liposome modified by glutamic hexapeptide and folic acid for bone metastatic breast cancer. Chem Phys Lipids. 228:1048822020. View Article : Google Scholar : PubMed/NCBI

31 

Zhao Z, Zhao Y, Xie C, Chen C, Lin D, Wang S, Lin D, Cui X, Guo Z and Zhou J: Dual-active targeting liposomes drug delivery system for bone metastatic breast cancer: Synthesis and biological evaluation. Chem Phys Lipids. 223:1047852019. View Article : Google Scholar : PubMed/NCBI

32 

Soria F, Krabbe LM, Todenhofer T, Dobruch J, Mitra AP, Inman BA, Gust KM, Lotan Y and Shariat SF: Molecular markers in bladder cancer. World J Urol. 37:31–40. 2019. View Article : Google Scholar :

33 

Dong Z, Zhu C, Zhan Q and Jiang W: Cdk phosphorylation licenses Kif4A chromosome localization required for early mitotic progression. J Mol Cell Biol. 10:358–370. 2018. View Article : Google Scholar : PubMed/NCBI

34 

Nunes Bastos R, Gandhi SR, Baron RD, Gruneberg U, Nigg EA and Barr FA: Aurora B suppresses microtubule dynamics and limits central spindle size by locally activating KIF4A. J Cell Biol. 202:605–621. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Wan Q, Shen Y, Zhao H, Wang B, Zhao L, Zhang Y, Bu X, Wan M and Shen C: Impaired DNA double-strand breaks repair by kinesin family member 4A inhibition renders human H1299 non-small-cell lung cancer cells sensitive to cisplatin. J Cell Physiol. 234:10360–10371. 2019. View Article : Google Scholar

36 

Huang Y, Wang H, Lian Y, Wu X, Zhou L, Wang J, Deng M and Huang Y: Upregulation of kinesin family member 4A enhanced cell proliferation via activation of Akt signaling and predicted a poor prognosis in hepatocellular carcinoma. Cell Death Dis. 9:1412018. View Article : Google Scholar : PubMed/NCBI

37 

Minakawa Y, Kasamatsu A, Koike H, Higo M, Nakashima D, Kouzu Y, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H and Uzawa K: Kinesin family member 4A: A potential predictor for progression of human oral cancer. PLoS One. 8:e859512013. View Article : Google Scholar

38 

Wang H, Lu C, Li Q, Xie J, Chen T, Tan Y, Wu C and Jiang J: The role of Kif4A in doxorubicin-induced apoptosis in breast cancer cells. Mol Cells. 37:812–818. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Gao J, Sai N, Wang C, Sheng X, Shao Q, Zhou C, Shi Y, Sun S, Qu X and Zhu C: Overexpression of chromokinesin KIF4 inhibits proliferation of human gastric carcinoma cells both in vitro and in vivo. Tumour Biol. 32:53–61. 2011. View Article : Google Scholar

40 

Lee YM and Kim W: Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35. Biochem J. 374:497–503. 2003. View Article : Google Scholar : PubMed/NCBI

41 

Gao H, Chen X, Cai Q, Shang Z and Niu Y: Increased KIF4A expression is a potential prognostic factor in prostate cancer. Oncol Lett. 15:7941–7947. 2018.PubMed/NCBI

42 

Li S, Liu X, Liu T, Meng X, Yin X, Fang C, Huang D, Cao Y, Weng H, Zeng X and Wang X: Identification of biomarkers correlated with the TNM staging and overall survival of patients with bladder cancer. Front Physiol. 8:9472017. View Article : Google Scholar : PubMed/NCBI

43 

Li B, Liu B, Zhang X, Liu H and He L: KIF18B promotes the proliferation of pancreatic ductal adenocarcinoma via activating the expression of CDCA8. J Cell Physiol. 235:4227–4238. 2020. View Article : Google Scholar

44 

Chen J, Zhu S, Jiang N, Shang Z, Quan C and Niu Y: HoxB3 promotes prostate cancer cell progression by transactivating CDCA3. Cancer Lett. 330:217–224. 2013. View Article : Google Scholar

45 

Uchida F, Uzawa K, Kasamatsu A, Takatori H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H and Bukawa H: Overexpression of cell cycle regulator CDCA3 promotes oral cancer progression by enhancing cell proliferation with prevention of G1 phase arrest. BMC Cancer. 12:3212012. View Article : Google Scholar : PubMed/NCBI

46 

Zhang W, Lu Y and Li X, Zhang J, Zheng L, Zhang W, Lin C, Lin W and Li X: CDCA3 promotes cell proliferation by activating the NF-κB/cyclin D1 signaling pathway in colorectal cancer. Biochem Biophys Res Commun. 500:196–203. 2018. View Article : Google Scholar : PubMed/NCBI

47 

Takeuchi H, Taoka R, Mmeje CO, Jinesh GG, Safe S and Kamat AM: Urol Oncol. CDODA-Me decreases specificity protein transcription factors and induces apoptosis in bladder cancer cells through induction of reactive oxygen species. Urol Oncol. 34:337.e11–8. 2016. View Article : Google Scholar

48 

Takeuchi H, Tanaka M, Tanaka A, Tsunemi A and Yamamoto H: Predominance of M2-polarized macrophages in bladder cancer affects angiogenesis, tumor grade and invasiveness. Oncol Lett. 11:3403–3408. 2016. View Article : Google Scholar : PubMed/NCBI

49 

Takeuchi H, Mmeje CO, Jinesh GG, Taoka R and Kamat AM: Sequential gemcitabine and tamoxifen treatment enhances apoptosis and blocks transformation in bladder cancer cells. Oncol Rep. 34:2738–2744. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zheng P, Wu K, Gao Z, Li H, Li W, Wang X, Shi Z, Xiao F, Wang K, Li Z, Li Z, et al: KIF4A promotes the development of bladder cancer by transcriptionally activating the expression of CDCA3 Retraction in /10.3892/ijmm.2023.5265. Int J Mol Med 47: 99, 2021.
APA
Zheng, P., Wu, K., Gao, Z., Li, H., Li, W., Wang, X. ... Han, Q. (2021). KIF4A promotes the development of bladder cancer by transcriptionally activating the expression of CDCA3 Retraction in /10.3892/ijmm.2023.5265. International Journal of Molecular Medicine, 47, 99. https://doi.org/10.3892/ijmm.2021.4932
MLA
Zheng, P., Wu, K., Gao, Z., Li, H., Li, W., Wang, X., Shi, Z., Xiao, F., Wang, K., Li, Z., Han, Q."KIF4A promotes the development of bladder cancer by transcriptionally activating the expression of CDCA3 Retraction in /10.3892/ijmm.2023.5265". International Journal of Molecular Medicine 47.6 (2021): 99.
Chicago
Zheng, P., Wu, K., Gao, Z., Li, H., Li, W., Wang, X., Shi, Z., Xiao, F., Wang, K., Li, Z., Han, Q."KIF4A promotes the development of bladder cancer by transcriptionally activating the expression of CDCA3 Retraction in /10.3892/ijmm.2023.5265". International Journal of Molecular Medicine 47, no. 6 (2021): 99. https://doi.org/10.3892/ijmm.2021.4932
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng P, Wu K, Gao Z, Li H, Li W, Wang X, Shi Z, Xiao F, Wang K, Li Z, Li Z, et al: KIF4A promotes the development of bladder cancer by transcriptionally activating the expression of CDCA3 Retraction in /10.3892/ijmm.2023.5265. Int J Mol Med 47: 99, 2021.
APA
Zheng, P., Wu, K., Gao, Z., Li, H., Li, W., Wang, X. ... Han, Q. (2021). KIF4A promotes the development of bladder cancer by transcriptionally activating the expression of CDCA3 Retraction in /10.3892/ijmm.2023.5265. International Journal of Molecular Medicine, 47, 99. https://doi.org/10.3892/ijmm.2021.4932
MLA
Zheng, P., Wu, K., Gao, Z., Li, H., Li, W., Wang, X., Shi, Z., Xiao, F., Wang, K., Li, Z., Han, Q."KIF4A promotes the development of bladder cancer by transcriptionally activating the expression of CDCA3 Retraction in /10.3892/ijmm.2023.5265". International Journal of Molecular Medicine 47.6 (2021): 99.
Chicago
Zheng, P., Wu, K., Gao, Z., Li, H., Li, W., Wang, X., Shi, Z., Xiao, F., Wang, K., Li, Z., Han, Q."KIF4A promotes the development of bladder cancer by transcriptionally activating the expression of CDCA3 Retraction in /10.3892/ijmm.2023.5265". International Journal of Molecular Medicine 47, no. 6 (2021): 99. https://doi.org/10.3892/ijmm.2021.4932
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