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Pathology and physiology of acid‑sensitive ion channels in the digestive system (Review)

  • Authors:
    • Li Zhang
    • Liming Zheng
    • Xingyue Yang
    • Shun Yao
    • Hui Wang
    • Jiaxing An
    • Hai Jin
    • Guorong Wen
    • Biguang Tuo
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 94
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    Published online on: May 23, 2022
       https://doi.org/10.3892/ijmm.2022.5150
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Abstract

As a major proton‑gated cation channel, acid‑sensitive ion channels (ASICs) can perceive large extracellular pH changes. ASICs play an important role in the occurrence and development of diseases of various organs and tissues including in the heart, brain, and gastrointestinal tract, as well as in tumor proliferation, invasion, and metastasis in acidosis and regulation of an acidic microenvironment. The permeability of ASICs to sodium and calcium ions is the basis of their physiological and pathological roles in the body. This review summarizes the physiological and pathological mechanisms of ASICs in digestive system diseases, which plays an important role in the early diagnosis, treatment, and prognosis of digestive system diseases related to ASIC expression.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang L, Zheng L, Yang X, Yao S, Wang H, An J, Jin H, Wen G and Tuo B: Pathology and physiology of acid‑sensitive ion channels in the digestive system (Review). Int J Mol Med 50: 94, 2022.
APA
Zhang, L., Zheng, L., Yang, X., Yao, S., Wang, H., An, J. ... Tuo, B. (2022). Pathology and physiology of acid‑sensitive ion channels in the digestive system (Review). International Journal of Molecular Medicine, 50, 94. https://doi.org/10.3892/ijmm.2022.5150
MLA
Zhang, L., Zheng, L., Yang, X., Yao, S., Wang, H., An, J., Jin, H., Wen, G., Tuo, B."Pathology and physiology of acid‑sensitive ion channels in the digestive system (Review)". International Journal of Molecular Medicine 50.1 (2022): 94.
Chicago
Zhang, L., Zheng, L., Yang, X., Yao, S., Wang, H., An, J., Jin, H., Wen, G., Tuo, B."Pathology and physiology of acid‑sensitive ion channels in the digestive system (Review)". International Journal of Molecular Medicine 50, no. 1 (2022): 94. https://doi.org/10.3892/ijmm.2022.5150
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang L, Zheng L, Yang X, Yao S, Wang H, An J, Jin H, Wen G and Tuo B: Pathology and physiology of acid‑sensitive ion channels in the digestive system (Review). Int J Mol Med 50: 94, 2022.
APA
Zhang, L., Zheng, L., Yang, X., Yao, S., Wang, H., An, J. ... Tuo, B. (2022). Pathology and physiology of acid‑sensitive ion channels in the digestive system (Review). International Journal of Molecular Medicine, 50, 94. https://doi.org/10.3892/ijmm.2022.5150
MLA
Zhang, L., Zheng, L., Yang, X., Yao, S., Wang, H., An, J., Jin, H., Wen, G., Tuo, B."Pathology and physiology of acid‑sensitive ion channels in the digestive system (Review)". International Journal of Molecular Medicine 50.1 (2022): 94.
Chicago
Zhang, L., Zheng, L., Yang, X., Yao, S., Wang, H., An, J., Jin, H., Wen, G., Tuo, B."Pathology and physiology of acid‑sensitive ion channels in the digestive system (Review)". International Journal of Molecular Medicine 50, no. 1 (2022): 94. https://doi.org/10.3892/ijmm.2022.5150
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