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Review Open Access

Connexins and angiogenesis: Functional aspects, pathogenesis, and emerging therapies (Review)

  • Authors:
    • Zizi Zhou
    • Wenxiang Chai
    • Yi Liu
    • Meng Zhou
    • Xiaoming Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Cardio‑Thoracic Surgery, Shenzhen University General Hospital, Shenzhen, Guangdong 518055, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 110
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    Published online on: June 24, 2022
       https://doi.org/10.3892/ijmm.2022.5166
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Abstract

Connexins (Cxs) play key roles in cellular communication. By facilitating metabolite exchange or interfering with distinct signaling pathways, Cxs affect cell homeostasis, proliferation, and differentiation. Variations in the activity and expression of Cxs have been linked to numerous clinical conditions including carcinomas, cardiac disorders, and wound healing. Recent discoveries on the association between Cxs and angiogenesis have sparked interest in Cx‑mediated angiogenesis due to its essential functions in tissue formation, wound repair, tumor growth, and metastasis. It is now widely recognized that understanding the association between Cxs and angiogenesis may aid in the development of new targeted therapies for angiogenic diseases. The aim of the present review was to provide a comprehensive overview of Cxs and Cx‑mediated angiogenesis, with a focus on therapeutic implications.
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1 

Carmeliet P: Mechanisms of angiogenesis and arteriogenesis. Nat Med. 6:389–395. 2000. View Article : Google Scholar : PubMed/NCBI

2 

Koepple C, Zhou Z, Huber L, Schulte M, Schmidt K, Gloe T, Kneser U, Schmidt VJ and de Wit C: Expression of Connexin43 Stimulates Endothelial Angiogenesis Independently of Gap junctional communication in vitro. Int J Mol Sci. 22:74002021. View Article : Google Scholar : PubMed/NCBI

3 

Haefliger JA, Meda P and Alonso F: Endothelial connexins in developmental and pathological angiogenesis. Cold Spring Harb Perspect Med. 12:a0411582022. View Article : Google Scholar : PubMed/NCBI

4 

Qiu Y, Zheng J, Chen S and Sun Y: Connexin mutations and hereditary diseases. Int J Mol Sci. 23:42552022. View Article : Google Scholar : PubMed/NCBI

5 

Peracchia C and Leverone Peracchia LM: Calmodulin-Connexin partnership in Gap junction channel regulation-calmodulin-cork gating model. Int J Mol Sci. 22:130552021. View Article : Google Scholar : PubMed/NCBI

6 

Okamoto T, Park EJ, Kawamoto E, Usuda H, Wada K, Taguchi A and Shimaoka M: Endothelial connexin-integrin crosstalk in vascular inflammation. Biochim Biophys Acta Mol Basis Dis. 1867:1661682021. View Article : Google Scholar : PubMed/NCBI

7 

Laird DW and Lampe PD: Cellular mechanisms of connexin-based inherited diseases. Trends Cell Biol. 32:58–69. 2022. View Article : Google Scholar

8 

King DR, Sedovy MW, Leng X, Xue J, Lamouille S, Koval M, Isakson BE and Johnstone SR: Mechanisms of connexin regulating peptides. Int J Mol Sci. 22:101862021. View Article : Google Scholar : PubMed/NCBI

9 

Htet M, Nally JE, Martin PE and Dempsie Y: New insights into pulmonary hypertension: A role for connexin-mediated signal- ling. Int J Mol Sci. 23:3792021. View Article : Google Scholar

10 

Roy S, Jiang JX, Li AF and Kim D: Connexin channel and its role in diabetic retinopathy. Prog Retin Eye Res. 61:35–59. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Nielsen MS, Axelsen LN, Sorgen PL, Verma V, Delmar M and Holstein-Rathlou NH: Gap junctions. Compr Physiol. 2:1981–2035. 2012. View Article : Google Scholar

12 

Zhou JZ and Jiang JX: Gap junction and hemichannel-independent actions of connexins on cell and tissue functions-an update. FEBS Lett. 588:1186–1192. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Tarzemany R, Jiang G, Jiang JX, Larjava H and Häkkinen L: Connexin 43 hemichannels regulate the expression of wound healing-associated genes in human gingival fibroblasts. Sci Rep. 7:141572017. View Article : Google Scholar : PubMed/NCBI

14 

Jacobsen NL, Pontifex TK, Li H, Solan JL, Lampe PD, Sorgen PL and Burt JM: Regulation of Cx37 channel and growth-suppressive properties by phosphorylation. J Cell Sci. 130:3308–3321. 2017.PubMed/NCBI

15 

Cocozzelli AG and White TW: Connexin 43 mutations lead to increased hemichannel functionality in skin disease. Int J Mol Sci. 20:61862019. View Article : Google Scholar

16 

Mannell H, Kameritsch P, Beck H, Pfeifer A, Pohl U and Pogoda K: Cx43 promotes endothelial cell migration and angiogenesis via the tyrosine phosphatase SHP-2. Int J Mol Sci. 23:2942021. View Article : Google Scholar

17 

Falleni A, Moscato S, Sabbatini ARM, Bernardeschi M, Bianchi F, Cecchettini A and Mattii L: Subcellular localization of connexin 26 in cardiomyocytes and in cardiomyocyte-derived extracellular vesicles. Molecules. 26:67262021. View Article : Google Scholar : PubMed/NCBI

18 

Wang DG, Zhang FX, Chen ML, Zhu HJ, Yang B and Cao KJ: Cx43 in mesenchymal stem cells promotes angiogenesis of the infarcted heart independent of gap junctions. Mol Med Rep. 9:1095–1102. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Moorby C and Patel M: Dual functions for connexins: Cx43 regulates growth independently of gap junction formation. Exp Cell Res. 271:238–248. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Sathiyanadan K, Alonso F, Domingos-Pereira S, Santoro T, Hamard L, Cesson V, Meda P, Nardelli-Haefliger D and Haefliger JA: Targeting Endothelial Connexin37 reduces angiogenesis and decreases tumor growth. Int J Mol Sci. 23:29302022. View Article : Google Scholar : PubMed/NCBI

21 

Thuringer D, Jego G, Berthenet K, Hammann A, Solary E and Garrido C: Gap junction-mediated transfer of miR-145-5p from microvascular endothelial cells to colon cancer cells inhibits angiogenesis. Oncotarget. 7:28160–28168. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Choudhary M, Naczki C, Chen W, Barlow KD, Case LD and Metheny-Barlow LJ: Tumor-induced loss of mural Connexin 43 gap junction activity promotes endothelial proliferation. BMC Cancer. 15:4272015. View Article : Google Scholar : PubMed/NCBI

23 

Aasen T, Leithe E, Graham SV, Kameritsch P, Mayán MD, Mesnil M, Pogoda K and Tabernero A: Connexins in cancer: Bridging the gap to the clinic. Oncogene. 38:4429–4451. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Distler O, Neidhart M, Gay RE and Gay S: The molecular control of angiogenesis. Int Rev Immunol. 21:33–49. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Polverini PJ: The pathophysiology of angiogenesis. Crit Rev Oral Biol Med. 6:230–247. 1995. View Article : Google Scholar : PubMed/NCBI

26 

Goel S, Duda DG, Xu L, Munn LL, Boucher Y, Fukumura D and Jain RK: Normalization of the vasculature for treatment of cancer and other diseases. Physiol Rev. 91:1071–1121. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Zefferino R, Piccoli C, Gioia SD, Capitanio N and Conese M: Gap junction intercellular communication in the carcinogenesis Hallmarks: Is this a phenomenon or epiphenomenon? Cells. 8:8962019. View Article : Google Scholar :

28 

Wang HH, Su CH, Wu YJ, Li JY, Tseng YM, Lin YC, Hsieh CL, Tsai CH and Yeh HI: Reduction of connexin43 in human endothelial progenitor cells impairs the angiogenic potential. Angiogenesis. 16:553–560. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Kandasamy K, Escue R, Manna J, Adebiyi A and Parthasarathi K: Changes in endothelial connexin 43 expression inversely correlate with microvessel permeability and VE-cadherin expression in endotoxin-challenged lungs. Am J Physiol Lung Cell Mol Physiol. 309:L584–L592. 2015. View Article : Google Scholar : PubMed/NCBI

30 

O'Donnell JJ III, Birukova AA, Beyer EC and Birukov KG: Gap junction protein connexin43 exacerbates lung vascular permeability. PLoS One. 9:e1009312014. View Article : Google Scholar : PubMed/NCBI

31 

Salmina AB, Morgun AV, Kuvacheva NV, Lopatina OL, Komleva YK, Malinovskaya NA and Pozhilenkova EA: Establishment of neurogenic microenvironment in the neurovascular unit: The connexin 43 story. Rev Neurosci. 25:97–111. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Schmidt VJ, Hilgert JG, Covi JM, Weis C, Wietbrock JO, de Wit C, Horch RE and Kneser U: High flow conditions increase connexin43 expression in a rat arteriovenous and angioinductive loop model. PLoS One. 8:e787822013. View Article : Google Scholar : PubMed/NCBI

33 

Gerbaud P and Pidoux G: Review: An overview of molecular events occurring in human trophoblast fusion. Placenta. 36(Suppl 1): S35–S42. 2015. View Article : Google Scholar : PubMed/NCBI

34 

He X and Chen Q: Reduced expressions of connexin 43 and VEGF in the first-trimester tissues from women with recurrent pregnancy loss. Reprod Biol Endocrinol. 14:462016. View Article : Google Scholar : PubMed/NCBI

35 

Zhang XF and Cui X: Connexin 43: Key roles in the skin. Biomed Rep. 6:605–611. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Alonso F, Domingos-Pereira S, Le Gal L, Derré L, Meda P, Jichlinski P, Nardelli-Haefliger D and Haefliger JA: Targeting endothelial connexin40 inhibits tumor growth by reducing angiogenesis and improving vessel perfusion. Oncotarget. 7:14015–14028. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Haefliger JA, Allagnat F, Hamard L, Le Gal L, Meda P, Nardelli-Haefliger D, Génot E and Alonso F: Targeting Cx40 (Connexin40) expression or function reduces angiogenesis in the developing mouse retina. Arterioscler Thromb Vasc Biol. 37:2136–2146. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Fang JS, Angelov SN, Simon AM and Burt JM: Cx37 deletion enhances vascular growth and facilitates ischemic limb recovery. Am J Physiol Heart Circ Physiol. 301:H1872–H1881. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Li H, Spagnol G, Pontifex TK, Burt JM and Sorgen PL: Chemical shift assignments of the connexin37 carboxyl terminal domain. Biomol NMR Assign. 11:137–141. 2017. View Article : Google Scholar : PubMed/NCBI

40 

Pogoda K, Füller M, Pohl U and Kameritsch P: NO, via its target Cx37, modulates calcium signal propagation selectively at myoendothelial gap junctions. Cell Commun Signal. 12:332014. View Article : Google Scholar : PubMed/NCBI

41 

Fang JS, Angelov SN, Simon AM and Burt JM: Cx40 is required for, and cx37 limits, postischemic hindlimb perfusion, survival and recovery. J Vasc Res. 49:2–12. 2012. View Article : Google Scholar

42 

Le Gal L, Pellegrin M, Santoro T, Mazzolai L, Kurtz A, Meda P, Wagner C and Haefliger JA: Connexin37-Dependent mechanisms selectively contribute to modulate Angiotensin II-Mediated Hypertension. J Am Heart Assoc. 8:e0108232019. View Article : Google Scholar

43 

Taylor SZ, Jacobsen NL, Pontifex TK, Langlais P and Burt JM: Serine 319 phosphorylation is necessary and sufficient to induce a Cx37 conformation that leads to arrested cell cycling. J Cell Sci. 133:jcs2407212020. View Article : Google Scholar : PubMed/NCBI

44 

O'Carroll SJ, Becker DL, Davidson JO, Gunn AJ, Nicholson LF and Green CR: The use of connexin-based therapeutic approaches to target inflammatory diseases. Methods Mol Biol. 1037:519–546. 2013. View Article : Google Scholar : PubMed/NCBI

45 

Yu W, Jin H, Sun W, Nan D, Deng J, Jia J, Yu Z and Huang Y: Connexin43 promotes angiogenesis through activating the HIF-1α/VEGF signaling pathway under chronic cerebral hypo- perfusion. J Cereb Blood Flow Metab. 41:2656–2675. 2021. View Article : Google Scholar : PubMed/NCBI

46 

Lorraine C, Wright CS and Martin PE: Connexin43 plays diverse roles in co-ordinating cell migration and wound closure events. Biochem Soc Trans. 43:482–488. 2015. View Article : Google Scholar : PubMed/NCBI

47 

Hoffmann A, Gloe T, Pohl U and Zahler S: Nitric oxide enhances de novo formation of endothelial gap junctions. Cardiovasc Res. 60:421–430. 2003. View Article : Google Scholar : PubMed/NCBI

48 

Li H, He J, Yu H, Green CR and Chang J: Bioglass promotes wound healing by affecting gap junction connexin 43 mediated endothelial cell behavior. Biomaterials. 84:64–75. 2016. View Article : Google Scholar : PubMed/NCBI

49 

Zhang K, Chai B, Ji H, Chen L, Ma Y, Zhu L, Xu J, Wu Y, Lan Y, Li H, et al: Bioglass promotes wound healing by inhibiting endothelial cell pyroptosis through regulation of the connexin 43/reactive oxygen species (ROS) signaling pathway. Lab Invest. 102:90–101. 2022. View Article : Google Scholar

50 

Faniku C, O'Shaughnessy E, Lorraine C, Johnstone SR, Graham A, Greenhough S and Martin PEM: The connexin mimetic peptide Gap27 and Cx43-Knockdown reveal differential roles for Connexin43 in wound closure events in skin model systems. Int J Mol Sci. 19:6042018. View Article : Google Scholar :

51 

Martin PE, Easton JA, Hodgins MB and Wright CS: Connexins: Sensors of epidermal integrity that are therapeutic targets. FEBS Lett. 588:1304–1314. 2014. View Article : Google Scholar : PubMed/NCBI

52 

Tarzemany R, Jiang G, Larjava H and Häkkinen L: Expression and function of connexin 43 in human gingival wound healing and fibroblasts. PLoS One. 10:e01155242015. View Article : Google Scholar : PubMed/NCBI

53 

Montgomery J, Ghatnekar GS, Grek CL, Moyer KE and Gourdie RG: Connexin 43-Based therapeutics for dermal wound healing. Int J Mol Sci. 19:17782018. View Article : Google Scholar :

54 

Arshad M, Conzelmann C, Riaz MA, Noll T and Gündüz D: Inhibition of Cx43 attenuates ERK1/2 activation, enhances the expression of Cav-1 and suppresses cell proliferation. Int J Mol Med. 42:2811–2818. 2018.PubMed/NCBI

55 

Wu PC, Hsu WL, Chen CL, Lam CF, Huang YB, Huang CC, Lin MH and Lin MW: Morphine induces fibroblast activation through Up-regulation of Connexin 43 expression: Implication of fibrosis in wound healing. Int J Med Sci. 15:875–882. 2018. View Article : Google Scholar : PubMed/NCBI

56 

Asencio-Barría C, Defamie N, Sáez JC, Mesnil M and Godoy AS: Direct intercellular communications and cancer: A snapshot of the biological roles of connexins in prostate cancer. Cancers (Basel). 11:13702019. View Article : Google Scholar

57 

Gleisner MA, Navarrete M, Hofmann F, Salazar-Onfray F and Tittarelli A: Mind the Gaps in tumor immunity: Impact of connexin-mediated intercellular connections. Front Immunol. 8:10672017. View Article : Google Scholar : PubMed/NCBI

58 

Graham SV, Jiang JX and Mesnil M: Connexins and pannexins: Important players in tumorigenesis, metastasis and potential therapeutics. Int J Mol Sci. 19:16452018. View Article : Google Scholar :

59 

Acuña RA, Varas-Godoy M, Herrera-Sepulveda D and Retamal MA: Connexin46 expression enhances cancer stem cell and Epithelial-to-Mesenchymal transition characteristics of human breast cancer MCF-7 cells. Int J Mol Sci. 22:126042021. View Article : Google Scholar : PubMed/NCBI

60 

Karpinich NO and Caron KM: Gap junction coupling is required for tumor cell migration through lymphatic endothelium. Arterioscler Thromb Vasc Biol. 35:1147–1155. 2015. View Article : Google Scholar : PubMed/NCBI

61 

Fang JS, Coon BG, Gillis N, Chen Z, Qiu J, Chittenden TW, Burt JM, Schwartz MA and Hirschi KK: Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification. Nat Commun. 8:21492017. View Article : Google Scholar : PubMed/NCBI

62 

Wang WK, Chen MC, Leong HF, Kuo YL, Kuo CY and Lee CH: Connexin 43 suppresses tumor angiogenesis by down-regulation of vascular endothelial growth factor via hypoxic-induced factor-1α. Int J Mol Sci. 16:439–451. 2014. View Article : Google Scholar : PubMed/NCBI

63 

Schulz R, Görge PM, Görbe A, Ferdinandy P, Lampe PD and Leybaert L: Connexin 43 is an emerging therapeutic target in ischemia/reperfusion injury, cardioprotection and neuroprotection. Pharmacol Ther. 153:90–106. 2015. View Article : Google Scholar : PubMed/NCBI

64 

Michela P, Velia V, Aldo P and Ada P: Role of connexin 43 in cardiovascular diseases. Eur J Pharmacol. 768:71–76. 2015. View Article : Google Scholar : PubMed/NCBI

65 

Hegner P, Lebek S, Tafelmeier M, Camboni D, Schopka S, Schmid C, Maier LS, Arzt M and Wagner S: Sleep-disordered breathing is independently associated with reduced atrial connexin 43 expression. Heart Rhythm. 18:2187–2194. 2021. View Article : Google Scholar : PubMed/NCBI

66 

Ugwu N, Atzmony L, Ellis KT, Panse G, Jain D, Ko CJ, Nassiri N and Choate KA: Cutaneous and hepatic vascular lesions due to a recurrent somatic GJA4 mutation reveal a pathway for vascular malformation. HGG Adv. 2:1000282021.

67 

Huang GY, Xie LJ, Linask KL, Zhang C, Zhao XQ, Yang Y, Zhou GM, Wu YJ, Marquez-Rosado L, McElhinney DB, et al: Evaluating the role of connexin43 in congenital heart disease: Screening for mutations in patients with outflow tract anomalies and the analysis of knock-in mouse models. J Cardiovasc Dis Res. 2:206–212. 2011. View Article : Google Scholar : PubMed/NCBI

68 

Salameh A, Haunschild J, Bräuchle P, Peim O, Seidel T, Reitmann M, Kostelka M, Bakhtiary F, Dhein S and Dähnert I: On the role of the gap junction protein Cx43 (GJA1) in human cardiac malformations with Fallot-pathology. a study on paediatric cardiac specimen. PLoS One. 9:e953442014. View Article : Google Scholar : PubMed/NCBI

69 

Milberg P, Klocke R, Frommeyer G, Quang TH, Dieks K, Stypmann J, Osada N, Kuhlmann M, Fehr M, Milting H, et al: G-CSF therapy reduces myocardial repolarization reserve in the presence of increased arteriogenesis, angiogenesis and connexin 43 expression in an experimental model of pacing-induced heart failure. Basic Res Cardiol. 106:995–1008. 2011. View Article : Google Scholar : PubMed/NCBI

70 

Li L, Liu H, Xu C, Deng M, Song M, Yu X, Xu S and Zhao X: VEGF promotes endothelial progenitor cell differentiation and vascular repair through connexin 43. Stem Cell Res Ther. 8:2372017. View Article : Google Scholar : PubMed/NCBI

71 

Yu H, Kalogeris T and Korthuis RJ: Reactive species-induced microvascular dysfunction in ischemia/reperfusion. Free Radic Biol Med. 135:182–197. 2019. View Article : Google Scholar : PubMed/NCBI

72 

Bellafiore M, Sivverini G, Palumbo D, Macaluso F, Bianco A, Palma A and Farina F: Increased cx43 and angiogenesis in exercised mouse hearts. Int J Sports Med. 28:749–755. 2007. View Article : Google Scholar : PubMed/NCBI

73 

Grippo AJ, Moffitt JA, Henry MK, Firkins R, Senkler J, McNeal N, Wardwell J, Scotti MA, Dotson A and Schultz R: Altered Connexin 43 and Connexin 45 protein expression in the heart as a function of social and environmental stress in the prairie vole. Stress. 18:107–114. 2015. View Article : Google Scholar :

74 

Vilà-González M, Kelaini S, Magee C, Caines R, Campbell D, Eleftheriadou M, Cochrane A, Drehmer D, Tsifaki M, O'Neill K, et al: Enhanced function of induced pluripotent stem cell-derived endothelial cells through ESM1 signaling. Stem Cells. 37:226–239. 2019. View Article : Google Scholar

75 

Su F, Zhao L, Zhang S, Wang J, Chen N, Gong Q, Tang J, Wang H, Yao J, Wang Q, et al: Cardioprotection by PI3K-mediated signaling is required for anti-arrhythmia and myocardial repair in response to ischemic preconditioning in infarcted pig hearts. Lab Invest. 95:860–871. 2015. View Article : Google Scholar : PubMed/NCBI

76 

Taheri SA, Yeh J, Batt RE, Fang Y, Ashraf H, Heffner R, Nemes B and Naughton J: Uterine myometrium as a cell patch as an alternative graft for transplantation to infarcted cardiac myocardium: A preliminary study. Int J Artif Organs. 31:62–67. 2008. View Article : Google Scholar : PubMed/NCBI

77 

Wei X, Chang ACH, Chang H, Xu S, Xue Y, Zhang Y, Lei M, Chang ACY and Zhang Q: Hypoglycemia-exacerbated mitochondrial connexin 43 accumulation aggravates cardiac dysfunction in diabetic cardiomyopathy. Front Cardiovasc Med. 9:8001852022. View Article : Google Scholar : PubMed/NCBI

78 

Marsh SR, Williams ZJ, Pridham KJ and Gourdie RG: Peptidic connexin43 therapeutics in cardiac reparative medicine. J Cardiovasc Dev. 8:522021.

79 

Shao Q, Esseltine JL, Huang T, Novielli-Kuntz N, Ching JE, Sampson J and Laird DW: Connexin43 is dispensable for early stage human mesenchymal stem cell adipogenic differentiation but is protective against cell senescence. Biomolecules. 9:4742019. View Article : Google Scholar :

80 

Liu C, Fan Y, Zhou L, Zhu HY, Song YC, Hu L, Wang Y and Li QP: Pretreatment of mesenchymal stem cells with angiotensin II enhances paracrine effects, angiogenesis, gap junction formation and therapeutic efficacy for myocardial infarction. Int J Cardiol. 188:22–32. 2015. View Article : Google Scholar : PubMed/NCBI

81 

Zhou Y, Zhang YX, Yang KL, Liu YL, Wu FH, Gao YR and Liu W: Connexin 43 mediated the angiogenesis of buyang huanwu decoction via vascular endothelial growth factor and angiopoietin-1 after ischemic stroke. Chin J Physiol. 65:72–79. 2022. View Article : Google Scholar : PubMed/NCBI

82 

Das H, George JC, Joseph M, Das M, Abdulhameed N, Blitz A, Khan M, Sakthivel R, Mao HQ, Hoit BD, et al: Stem cell therapy with overexpressed VEGF and PDGF genes improves cardiac function in a rat infarct model. PLoS One. 4:e73252009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhou Z, Chai W, Liu Y, Zhou M and Zhang X: Connexins and angiogenesis: Functional aspects, pathogenesis, and emerging therapies (Review). Int J Mol Med 50: 110, 2022.
APA
Zhou, Z., Chai, W., Liu, Y., Zhou, M., & Zhang, X. (2022). Connexins and angiogenesis: Functional aspects, pathogenesis, and emerging therapies (Review). International Journal of Molecular Medicine, 50, 110. https://doi.org/10.3892/ijmm.2022.5166
MLA
Zhou, Z., Chai, W., Liu, Y., Zhou, M., Zhang, X."Connexins and angiogenesis: Functional aspects, pathogenesis, and emerging therapies (Review)". International Journal of Molecular Medicine 50.2 (2022): 110.
Chicago
Zhou, Z., Chai, W., Liu, Y., Zhou, M., Zhang, X."Connexins and angiogenesis: Functional aspects, pathogenesis, and emerging therapies (Review)". International Journal of Molecular Medicine 50, no. 2 (2022): 110. https://doi.org/10.3892/ijmm.2022.5166
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou Z, Chai W, Liu Y, Zhou M and Zhang X: Connexins and angiogenesis: Functional aspects, pathogenesis, and emerging therapies (Review). Int J Mol Med 50: 110, 2022.
APA
Zhou, Z., Chai, W., Liu, Y., Zhou, M., & Zhang, X. (2022). Connexins and angiogenesis: Functional aspects, pathogenesis, and emerging therapies (Review). International Journal of Molecular Medicine, 50, 110. https://doi.org/10.3892/ijmm.2022.5166
MLA
Zhou, Z., Chai, W., Liu, Y., Zhou, M., Zhang, X."Connexins and angiogenesis: Functional aspects, pathogenesis, and emerging therapies (Review)". International Journal of Molecular Medicine 50.2 (2022): 110.
Chicago
Zhou, Z., Chai, W., Liu, Y., Zhou, M., Zhang, X."Connexins and angiogenesis: Functional aspects, pathogenesis, and emerging therapies (Review)". International Journal of Molecular Medicine 50, no. 2 (2022): 110. https://doi.org/10.3892/ijmm.2022.5166
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