HIF‑1α: Its notable role in the maintenance of oxygen, bone and iron homeostasis (Review)

  • Authors:
    • Xinyi Huang
    • Yili Zhang
    • Baoyu Qi
    • Kai Sun
    • Ning Liu
    • Bin Tang
    • Shengjie Fang
    • Liguo Zhu
    • Xu Wei
  • View Affiliations

  • Published online on: October 27, 2022     https://doi.org/10.3892/ijmm.2022.5197
  • Article Number: 141
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Hypoxia is a characteristic feature of numerous diseases, including metabolic bone disease, solid tumors, cardiovascular diseases, neurodegeneration and inflammation. It is also a risk factor for a poor prognosis in various diseases. Hypoxia‑inducible factor‑1α (HIF‑1α) is activated by hypoxia to regulate a series of pathophysiological pathways, which is of utmost significance for maintaining body homeostasis. The present review highlights the role of the HIF‑1α in oxygen, bone and iron homeostasis, and alludes on the biological complexity and dual functions of HIF‑1α regulation. In addition, the pathophysiological significance of HIF‑1α in bone formation, bone absorption, angiogenesis, erythropoiesis, oxidative stress, energy metabolism, iron death, etc., is discussed An accurate understanding of all these processes may aid in the identification of possible therapeutic targets that may then be used in the treatment of related diseases. However, further studies are required to unravel the extensive complexity of HIF‑1α regulation and to develop more precise treatment strategies.
View References

Related Articles

Journal Cover

December-2022
Volume 50 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Huang X, Zhang Y, Qi B, Sun K, Liu N, Tang B, Fang S, Zhu L and Wei X: HIF‑1α: Its notable role in the maintenance of oxygen, bone and iron homeostasis (Review). Int J Mol Med 50: 141, 2022
APA
Huang, X., Zhang, Y., Qi, B., Sun, K., Liu, N., Tang, B. ... Wei, X. (2022). HIF‑1α: Its notable role in the maintenance of oxygen, bone and iron homeostasis (Review). International Journal of Molecular Medicine, 50, 141. https://doi.org/10.3892/ijmm.2022.5197
MLA
Huang, X., Zhang, Y., Qi, B., Sun, K., Liu, N., Tang, B., Fang, S., Zhu, L., Wei, X."HIF‑1α: Its notable role in the maintenance of oxygen, bone and iron homeostasis (Review)". International Journal of Molecular Medicine 50.6 (2022): 141.
Chicago
Huang, X., Zhang, Y., Qi, B., Sun, K., Liu, N., Tang, B., Fang, S., Zhu, L., Wei, X."HIF‑1α: Its notable role in the maintenance of oxygen, bone and iron homeostasis (Review)". International Journal of Molecular Medicine 50, no. 6 (2022): 141. https://doi.org/10.3892/ijmm.2022.5197