Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies

  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
December-2025 Volume 56 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2025 Volume 56 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
  • Supplementary Files
    • Supplementary_Data1.pdf
    • Supplementary_Data2.pdf
Article Open Access

YWHAH‑driven autophagy via MAPK/ERK signaling enhances CRC cell migration and invasion

  • Authors:
    • Qiang Li
    • Yuan Wang
    • Zhao Yuan
    • Peng Zhai
    • Jian Wang
    • Chen Zhang
    • Ziqi Shao
    • Chungen Xing

  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, P.R. China, Department of General Surgery of the Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221000, P.R. China, Department of General Surgery, Huai'an Fifth People's Hospital, Huai'an, Jiangsu 223300, P.R. China, Department of General Surgery, The Affiliated Huaian First People's Hospital of Nanjing Medical University, Huai'an, Jiangsu 223300, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 228
    |
    Published online on: October 20, 2025
       https://doi.org/10.3892/ijmm.2025.5669
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study investigated the role of YWHAH in colorectal cancer (CRC) progression, focusing on its regulation of autophagy via the MAPK/ERK signaling pathway and subsequent effects on cell migration and invasion. Clinical sample analysis revealed that YWHAH was highly expressed in CRC tissues, associating with poor differentiation, advanced TNM stage, lymph node metastasis, vascular invasion and unfavorable prognosis. In vitro experiments showed that YWHAH overexpression promoted proliferation, and epithelial‑mesenchymal transition of CRC cells, while inhibiting apoptosis. Conversely, YWHAH knockdown exerted opposite effects. Autophagy assays demonstrated that YWHAH knockdown enhanced autophagy by upregulating autophagy related 7 and LC3II/I and downregulating P62, whereas overexpression suppressed autophagy. Mechanistically, YWHAH negatively regulated the MAPK/ERK pathway [reducing phosphorylated (p)‑ERK1/2 and p‑ELK‑1 levels] to inhibit autophagy. The ERK inhibitor PD98059 reversed autophagy activation by YWHAH knockdown, while the ERK agonist U‑46619 reversed autophagy suppression by YWHAH overexpression. Additionally, the autophagy inhibitor 3‑methyladenine abrogated the inhibitory effects of YWHAH knockdown on migration and invasion, and the autophagy inducer rapamycin reversed the promoting effects of YWHAH overexpression. In vivo, nude mouse xenograft models confirmed that YWHAH inhibited autophagy via the MAPK/ERK pathway to accelerate tumor growth. These findings underscore the role of YWHAH as a critical regulator of CRC progression and suggest it as a potential therapeutic target. Interventions targeting YWHAH or its downstream factors may provide innovative approaches for treating CRC, particularly by modulating autophagy to inhibit tumor growth and metastasis.
View Figures

Figure 1

Expression and prognostic value of YWHAH. (A) The expression distribution of YWHAH in CRC and normal tissues using R package. (B) Relative expression of YWHAH in CRC tissue and PCT using reverse transcription-quantitative PCR. (C) Analysis of survival rates in patients with CRC with high and low expression of YWHAH. (D) Relative expression of YWHAH in colorectal tumor and PCT using immunohistochemistry. *P<0.05 and ****P<0.0001. YWHAH, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein Eta; CRC, colorectal cancer; PCT, paracancerous tissue.

Figure 2

Impact of differential YWHAH expression levels on colorectal cancer cell proliferation in vitro and in vivo. (A and B) Cell Counting Kit-8 was used to detect cell viability. (C and D) Impact of different YWHAH expression levels on tumor formation in nude mice. (E and F) The tumor volume was determined. *P<0.05, **P<0.01 and ***P<0.001. Data are presented as the mean ± standard deviation (n=3 independent experiments). YWHAH, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein Eta; OE, overexpression; si-, small interfering; NC, negative control.

Figure 3

Western blot assay is used to detect the effect of YWHAH on EMT in colorectal cancer cells. (A and B) Western blot assay was used to detect the impact of YWHAH overexpression and inhibition on EMT. (C and D) Semi-quantitative analysis of EMT-related protein expression levels. Data are presented as the mean ± standard deviation (n=3 independent experiments). *P<0.05, **P<0.01 and ***P<0.0001. YWHAH, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein Eta; EMT, epithelial-to-mesenchymal transition; OE, overexpression; si-, small interfering; NC, negative control.

Figure 4

Effect of YWHAH on apoptosis of different CRC cells. (A) Apoptosis of LOVO cells was measured by flow cytometry quantitative assay of apoptosis. (B) Apoptosis of HCT116 cells was measured by flow cytometry quantitative assay of apoptosis. (C and D) Western blot analysis of Caspase3, BAX and Bcl2 protein expression in CRC cells. (E and F) Quantification of Caspase3 protein expression. (G and H) Ratio of Bcl2 and BAX protein. Data are presented as the mean ± standard deviation (n=3 independent experiments). *P<0.05, **P<0.01, ***P<0.001 and ****P<0.0001. YWHAH, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein Eta; CRC, colorectal cancer; OE, overexpression; si-, small interfering; NC, negative control.

Figure 5

Impact of different YWHAH expression levels on autophagy in colorectal cancer cells. (A and B) Monitoring of the double-tagged LC3 by RFP-GFP-hLC3 tandem fluorescent protein in LOVO and HCT116 cells. (C and D) Quantification of GFP−/RFP+/LC3 dots in LOVO and HCT116 cells. (E and F) Western blot analysis of ATG7, P62 and LC3II/LC3I protein expression. Data are presented as the mean ± standard deviation (n=3 independent experiments). *P<0.05, **P<0.01 and ***P<0.001. YWHAH, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein Eta; ATG7, autophagy related 7; OE, overexpression; si-, small interfering; NC, negative control.

Figure 6

Inhibition of autophagy reverses the suppressive effects of si-YWHAH on migration and invasion in CRC cells. (A and B) Western blot assay detected the expression of autophagy-related proteins in CRC cells after the addition of the autophagy inhibitor 3-MA. (C and D) Quantitative analysis of changes in migration of CRC cells following 3-MA treatment and YWHAH knockdown. (E and F) Quantitative analysis of changes in invasion of CRC cells following 3-MA treatment and YWHAH knockdown. Data are presented as the mean ± standard deviation (n=3 independent experiments). *P<0.05, **P<0.01 and ***P<0.001. YWHAH, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein Eta; si-, small interfering; 3-MA, 3-methyladenine; CRC, colorectal cancer; NC, negative control.

Figure 7

Activation of autophagy reverses the promoting effect of OE-YWHAH on the migration and invasion of CRC cells. (A and B) Western blot assay detected the expression of autophagy-related proteins in CRC cells after the addition of the autophagy activator RAPA. (C and D) Quantitative analysis of changes in migration of CRC cells following RAPA treatment and YWHAH overexpression. (E and F) Quantitative analysis of changes in invasion of CRC cells following RAPA treatment and YWHAH overexpression. Data are presented as the mean ± standard deviation (n=3 independent experiments). *P<0.05, **P<0.01 and ***P<0.001. OE-, overexpression; YWHAH, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein Eta; CRC, colorectal cancer; RAPA, rapamycin; si-, small interfering; NC, negative control.

Figure 8

Western blot assay detects the expression of autophagy-related proteins and MAPK/ERK signaling pathway-related proteins in colorectal cancer cells after the addition of the MAPK/ERK pathway inhibitor PD-98059. (A and B) Western blot assays was sued to detect the expression of autophagy-related proteins and MAPK/ERK signaling pathway-related proteins. (C-F) Semi-quantitative analysis of autophagy-related protein and MAPK/ERK signaling pathway-related protein expression. Data are presented as the mean ± standard deviation (n=3 independent experiments). *P<0.05, **P<0.01 and ***P<0.001. si-, small interfering; NC, negative control; t-, total; p-, phosphorylated; YWHAH, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein Eta; ns, not significant (P>0.05).

Figure 9

Western blot assay determines the expression of autophagy-related proteins and MAPK/ERK signaling pathway-related proteins in colorectal cancer cells after the addition of the MAPK/ERK pathway activator U-46619. (A and B) Western blot assays detected the expression of autophagy-related proteins and MAPK/ERK signaling pathway-related proteins. (C-F) Semi-quantitative analysis of the expression levels of autophagy-related proteins and MAPK/ERK signaling pathway-related proteins. Data are presented as the mean ± standard deviation (n=3 independent experiments). *P<0.05, **P<0.01 and ***P<0.001. OE, overexpression; NC, negative control; t-, total; p-, phosphorylated; YWHAH, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein Eta; ns, not significant (P>0.05).

Figure 10

YWHAH inhibits autophagy through MAPK/ERK signaling pathway in vivo. (A and B) Western blotting was used to evaluate the protein expression of ATG7, P62, LC3II/I, t-ERK1/2, p-ERK1/2 and p-ELK-1 when the nude mice were injected with CRC cells. (C-F) Semi-quantitative analysis of autophagy related proteins and MAPK/ERK signaling related proteins when the nude mice were injected with CRC cells. *P<0.05, **P<0.01 and ***P<0.001. Data are presented as the mean ± standard deviation (n=3 independent experiments). YWHAH, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein Eta; t-, total; p-, phosphorylated; CRC, colorectal cancer; ATG7, autophagy related 7; OE, overexpression; si-, small interfering; NC, negative control; ns, not significant (P>0.05).
View References

1 

Keum N and Giovannucci E: Global burden of colorectal cancer: Emerging trends, risk factors and prevention strategies. Nat Rev Gastroenterol Hepatol. 16:713–732. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018.PubMed/NCBI

3 

Baidoun F, Elshiwy K, Elkeraie Y, Merjaneh Z, Khoudari G, Sarmini MT, Gad M, Al-Husseini M and Saad A: Colorectal cancer epidemiology: Recent trends and impact on outcomes. Curr Drug Targets. 22:998–1009. 2021. View Article : Google Scholar

4 

Gonzalez NS, Ros Montana FJ, Illescas DG, Argota IB, Ballabrera FS and Elez Fernandez ME: New insights into adjuvant therapy for localized colon cancer. Hematol Oncol Clin North Am. 36:507–520. 2022. View Article : Google Scholar : PubMed/NCBI

5 

Long J, He Q, Yin Y, Lei X, Li Z and Zhu W: The effect of miRNA and autophagy on colorectal cancer. Cell Prolif. 53:e129002020. View Article : Google Scholar : PubMed/NCBI

6 

Orlandi G, Roncucci L, Carnevale G and Sena P: Different roles of apoptosis and autophagy in the development of human colorectal cancer. Int J Mol Sci. 24:102012023. View Article : Google Scholar : PubMed/NCBI

7 

Wang D, He J, Dong J, Wu S, Liu S, Zhu H and Xu T: UM-6 induces autophagy and apoptosis via the Hippo-YAP signaling pathway in cervical cancer. Cancer Lett. 519:2–19. 2021. View Article : Google Scholar : PubMed/NCBI

8 

Jiao YN, Wu LN, Xue D, Liu XJ, Tian ZH, Jiang ST, Han SY and Li PP: Marsdenia tenacissima extract induces apoptosis and suppresses autophagy through ERK activation in lung cancer cells. Cancer Cell Int. 18:1492018. View Article : Google Scholar : PubMed/NCBI

9 

Pohl C and Dikic I: Cellular quality control by the ubiquitin-proteasome system and autophagy. Science. 366:818–822. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Li X, He S and Ma B: Autophagy and autophagy-related proteins in cancer. Mol Cancer. 19:122020. View Article : Google Scholar : PubMed/NCBI

11 

Green DR: The coming decade of cell death research: Five riddles. Cell. 177:1094–1107. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Li Q, Yuan Z, Wang Y, Zhai P, Wang J, Zhang C, Shao Z and Xing C: Unveiling YWHAH: A potential therapeutic target for overcoming CD8(+) T cell exhaustion in colorectal cancer. Int Immunopharmacol. 135:1123172024. View Article : Google Scholar : PubMed/NCBI

13 

Kacirova M, Novacek J, Man P, Obsilova V and Obsil T: Structural basis for the 14-3-3 protein-dependent inhibition of phosducin function. Biophys J. 112:1339–1349. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Obsil T and Obsilova V: Structural basis of 14-3-3 protein functions. Semin Cell Dev Biol. 22:663–672. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Darling DL, Yingling J and Wynshaw-Boris A: Role of 14-3-3 proteins in eukaryotic signaling and development. Curr Top Dev Biol. 68:281–315. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Nguyen NM, Meyer D, Meyer L, Chand S, Jagadesan S, Miravite M, Guda C, Yelamanchili SV and Pendyala G: Identification of YWHAH as a novel brain-derived extracellular vesicle marker post long-term midazolam exposure during early development. Cells. 12:9662023. View Article : Google Scholar : PubMed/NCBI

17 

Huang Y, Yang M and Huang W: 14-3-3 σ: A potential biomolecule for cancer therapy. Clin Chim Acta. 511:50–58. 2020. View Article : Google Scholar : PubMed/NCBI

18 

Munier CC, Ottmann C and Perry MWD: 14-3-3 modulation of the inflammatory response. Pharmacol Res. 163:1052362021. View Article : Google Scholar

19 

Malki A, ElRuz RA, Gupta I, Allouch A, Vranic S and Al Moustafa AE: Molecular Mechanisms of colon cancer progression and metastasis: Recent insights and advancements. Int J Mol Sci. 22:1302020. View Article : Google Scholar : PubMed/NCBI

20 

Nicolini A and Ferrari P: Involvement of tumor immune microenvironment metabolic reprogramming in colorectal cancer progression, immune escape, and response to immunotherapy. Front Immunol. 15:13537872024. View Article : Google Scholar : PubMed/NCBI

21 

Shin AE, Giancotti FG and Rustgi AK: Metastatic colorectal cancer: Mechanisms and emerging therapeutics. Trends Pharmacol Sci. 44:222–236. 2023. View Article : Google Scholar : PubMed/NCBI

22 

Lu J, Kornmann M and Traub B: Role of epithelial to mesenchymal transition in colorectal cancer. Int J Mol Sci. 24:148152023. View Article : Google Scholar : PubMed/NCBI

23 

Zhang Y, Yang Y, Qi X, Cui P, Kang Y, Liu H, Wei Z and Wang H: SLC14A1 and TGF-β signaling: A feedback loop driving EMT and colorectal cancer metachronous liver metastasis. J Exp Clin Cancer Res. 43:2082024. View Article : Google Scholar

24 

Li W, Zhou C, Yu L, Hou Z, Liu H, Kong L, Xu Y, He J, Lan J, Ou Q, et al: Tumor-derived lactate promotes resistance to bevacizumab treatment by facilitating autophagy enhancer protein RUBCNL expression through histone H3 lysine 18 lactylation (H3K18la) in colorectal cancer. Autophagy. 20:114–130. 2024. View Article : Google Scholar :

25 

Xie Q, Liu Y and Li X: The interaction mechanism between autophagy and apoptosis in colon cancer. Transl Oncol. 13:1008712020. View Article : Google Scholar : PubMed/NCBI

26 

Foerster EG, Mukherjee T, Cabral-Fernandes L, Rocha JDB, Girardin SE and Philpott DJ: How autophagy controls the intestinal epithelial barrier. Autophagy. 18:86–103. 2022. View Article : Google Scholar :

27 

Adebayo AS, Agbaje K, Adesina SK and Olajubutu O: Colorectal cancer: Disease process, current treatment options, and future perspectives. Pharmaceutics. 15:26202023. View Article : Google Scholar : PubMed/NCBI

28 

Ma L, Zhang R, Li D, Qiao T and Guo X: Fluoride regulates chondrocyte proliferation and autophagy via PI3K/AKT/mTOR signaling pathway. Chem Biol Interact. 349:1096592021. View Article : Google Scholar : PubMed/NCBI

29 

Yang K, Luan L, Li X, Sun X and Yin J: ERK inhibition in glioblastoma is associated with autophagy activation and tumorigenesis suppression. J Neurooncol. 156:123–137. 2022. View Article : Google Scholar

30 

Guo YJ, Pan WW, Liu SB, Shen ZF, Xu Y and Hu LL: ERK/MAPK signalling pathway and tumorigenesis. Exp Ther Med. 19:1997–2007. 2020.PubMed/NCBI

31 

Lee S, Rauch J and Kolch W: Targeting MAPK signaling in cancer: Mechanisms of drug resistance and sensitivity. Int J Mol Sci. 21:11022020. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li Q, Wang Y, Yuan Z, Zhai P, Wang J, Zhang C, Shao Z and Xing C: YWHAH‑driven autophagy via MAPK/ERK signaling enhances CRC cell migration and invasion. Int J Mol Med 56: 228, 2025.
APA
Li, Q., Wang, Y., Yuan, Z., Zhai, P., Wang, J., Zhang, C. ... Xing, C. (2025). YWHAH‑driven autophagy via MAPK/ERK signaling enhances CRC cell migration and invasion. International Journal of Molecular Medicine, 56, 228. https://doi.org/10.3892/ijmm.2025.5669
MLA
Li, Q., Wang, Y., Yuan, Z., Zhai, P., Wang, J., Zhang, C., Shao, Z., Xing, C."YWHAH‑driven autophagy via MAPK/ERK signaling enhances CRC cell migration and invasion". International Journal of Molecular Medicine 56.6 (2025): 228.
Chicago
Li, Q., Wang, Y., Yuan, Z., Zhai, P., Wang, J., Zhang, C., Shao, Z., Xing, C."YWHAH‑driven autophagy via MAPK/ERK signaling enhances CRC cell migration and invasion". International Journal of Molecular Medicine 56, no. 6 (2025): 228. https://doi.org/10.3892/ijmm.2025.5669
Copy and paste a formatted citation
x
Spandidos Publications style
Li Q, Wang Y, Yuan Z, Zhai P, Wang J, Zhang C, Shao Z and Xing C: YWHAH‑driven autophagy via MAPK/ERK signaling enhances CRC cell migration and invasion. Int J Mol Med 56: 228, 2025.
APA
Li, Q., Wang, Y., Yuan, Z., Zhai, P., Wang, J., Zhang, C. ... Xing, C. (2025). YWHAH‑driven autophagy via MAPK/ERK signaling enhances CRC cell migration and invasion. International Journal of Molecular Medicine, 56, 228. https://doi.org/10.3892/ijmm.2025.5669
MLA
Li, Q., Wang, Y., Yuan, Z., Zhai, P., Wang, J., Zhang, C., Shao, Z., Xing, C."YWHAH‑driven autophagy via MAPK/ERK signaling enhances CRC cell migration and invasion". International Journal of Molecular Medicine 56.6 (2025): 228.
Chicago
Li, Q., Wang, Y., Yuan, Z., Zhai, P., Wang, J., Zhang, C., Shao, Z., Xing, C."YWHAH‑driven autophagy via MAPK/ERK signaling enhances CRC cell migration and invasion". International Journal of Molecular Medicine 56, no. 6 (2025): 228. https://doi.org/10.3892/ijmm.2025.5669
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team