|
1
|
Sugawara Y and Hibi T: Recent trends and
new developments in liver transplantation. Biosci Trends.
18:206–211. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Saidi RF and Hejazii Kenari SK: Challenges
of organ shortage for transplantation: Solutions and opportunities.
Int J Organ Transplant Med. 5:87–96. 2014.PubMed/NCBI
|
|
3
|
Hahn JW, Woo S, Park J, Lee H, Kim HJ, Ko
JS, Moon JS, Rahmati M, Smith L, Kang J, et al: Global, regional,
and national trends in liver Disease-related mortality across 112
countries from 1990 to 2021, with projections to 2050:
Comprehensive analysis of the WHO mortality database. J Korean Med
Sci. 39:e2922024. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Monbaliu D, Pirenne J and Talbot D: Liver
transplantation using donation after cardiac death donors. J
Hepatol. 56:474–485. 2012. View Article : Google Scholar
|
|
5
|
Yue P, Lv X, You J, Zou Y, Luo J, Lu Z,
Cao H, Liu Z, Fan X and Ye Q: Hypothermic oxygenated perfusion
attenuates DCD liver ischemia-reperfusion injury by activating the
JAK2/STAT3/HAX1 pathway to regulate endoplasmic reticulum stress.
Cell Mol Biol Lett. 28:552023. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Czigany Z, Craigie EC, Lurje G, Song S,
Yonezawa K, Yamamoto Y, Minor T and Tolba RH: Adenosine A2a
receptor stimulation attenuates Ischemia-reperfusion injury and
improves survival in A porcine model of DCD liver transplantation.
Int J Mol Sci. 21:67472020. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Sousa Da Silva RX, Weber A, Dutkowski P
and Clavien PA: Machine perfusion in liver transplantation.
Hepatology. 76:1531–1549. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Feng GY, Feng X, Tao J, Ao YP, Wu XH, Qi
SG, He ZB and Shi ZR: Benefits of hypothermic oxygenated perfusion
versus static cold storage in liver transplant: A comprehensive
systematic review and Meta-analysis. J Clin Exp Hepatol.
14:1013372024. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Parmar KM, Larman HB, Dai G, Zhang Y, Wang
ET, Moorthy SN, Kratz JR, Lin Z, Jain MK, Gimbrone MA Jr and
García-Cardeña G: Integration of flow-dependent endothelial
phenotypes by Kruppel-like factor 2. J Clin Invest. 116:49–58.
2006. View Article : Google Scholar :
|
|
10
|
Gracia-Sancho J, Villarreal G Jr, Zhang Y,
Yu JX, Liu Y, Tullius SG and García-Cardeña G: Flow cessation
triggers endothelial dysfunction during organ cold storage
conditions: Strategies for pharmacologic intervention.
Transplantation. 90:142–149. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Russo L, Gracia-Sancho J, García-Calderó
H, Marrone G, García-Pagán JC, García-Cardeña G and Bosch J:
Addition of simvastatin to cold storage solution prevents
endothelial dysfunction in explanted rat livers. Hepatology.
55:921–930. 2012. View Article : Google Scholar
|
|
12
|
Hu X, Wang W, Zeng C, He W, Zhong Z, Liu
Z, Wang Y and Ye Q: Appropriate timing for hypothermic machine
perfusion to preserve livers donated after circulatory death. Mol
Med Rep. 22:2003–2011. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Burlage LC, Karimian N, Westerkamp AC,
Visser N, Matton APM, van Rijn R, Adelmeijer J, Wiersema-Buist J,
Gouw ASH, Lisman T and Porte RJ: Oxygenated hypothermic machine
perfusion after static cold storage improves endothelial function
of extended criteria donor livers. HPB (Oxford). 19:538–546. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Liu Z, Zhang X, Xiao Q, Ye S, Lai CH, Luo
J, Huang X, Wang W, Zeng C, Zhong Z, et al: Pretreatment donors
after circulatory death with simvastatin alleviates liver ischemia
reperfusion injury through a KLF2-dependent mechanism in rat. Oxid
Med Cell Longev. 2017:38619142017. View Article : Google Scholar
|
|
15
|
Doran AC, Yurdagul A Jr and Tabas I:
Efferocytosis in health and disease. Nat Rev Immunol. 20:254–267.
2020. View Article : Google Scholar
|
|
16
|
Ni M, Zhang J, Sosa R, Zhang H, Wang H,
Jin D, Crowley K, Naini B, Reed FE, Busuttil RW, et al: T-Cell
immunoglobulin and mucin Domain-containing Protein-4 is critical
for kupffer cell homeostatic function in the activation and
resolution of liver ischemia reperfusion injury. Hepatology.
74:2118–2132. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Miao L, Yu C, Guan G, Luan X, Jin X, Pan
M, Yang Y, Yan J, Chen P and Di G: Extracellular vesicles
containing GAS6 protect the liver from ischemia-reperfusion injury
by enhancing macrophage efferocytosis via MerTK-ERK-COX2 signaling.
Cell Death Discov. 10:4012024. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Mihaila AC, Ciortan L, Tucureanu MM,
Simionescu M and Butoi E: Anti-Inflammatory neutrophils reprogram
macrophages toward a Pro-healing phenotype with increased
efferocytosis capacity. Cells. 13:2082024. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Pisetsky DS: The role of HMGB1 in
efferocytosis: When the dead go unburied. Focus on 'HMGB1 inhibits
macrophage activity in efferocytosis through binding to the
alphavbeta3-integrin'. Am J Physiol Cell Physiol. 299:C1253–C1255.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Zhang J, Muri J, Fitzgerald G, Gorski T,
Gianni-Barrera R, Masschelein E, D'Hulst G, Gilardoni P, Turiel G,
Fan Z, et al: Endothelial lactate controls muscle regeneration from
ischemia by inducing M2-like macrophage polarization. Cell Metab.
31:1136–1153.e7. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Zhou B, Magana L, Hong Z, Huang LS,
Chakraborty S, Tsukasaki Y, Huang C, Wang L, Di A, Ganesh B, et al:
The angiocrine Rspondin3 instructs interstitial macrophage
transition via metabolic-epigenetic reprogramming and resolves
inflammatory injury. Nat Immunol. 21:1430–1443. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Li C, Fang F, Wang E, Yang H, Yang X, Wang
Q, Si L, Zhang Z and Liu X: Engineering extracellular vesicles
derived from endothelial cells sheared by laminar flow for
anti-atherosclerotic therapy through reprogramming macrophage.
Biomaterials. 314:1228322025. View Article : Google Scholar
|
|
23
|
He S, Wu C, Xiao J, Li D, Sun Z and Li M:
Endothelial extracellular vesicles modulate the macrophage
phenotype: Potential implications in atherosclerosis. Scand J
Immunol. 87:e126482018. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Ni CW, Qiu H, Rezvan A, Kwon K, Nam D, Son
DJ, Visvader JE and Jo H: Discovery of novel mechanosensitive genes
in vivo using mouse carotid artery endothelium exposed to disturbed
flow. Blood. 116:e66–e73. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Nam D, Ni CW, Rezvan A, Suo J, Budzyn K,
Llanos A, Harrison D, Giddens D and Jo H: Partial carotid ligation
is a model of acutely induced disturbed flow, leading to rapid
endothelial dysfunction and atherosclerosis. Am J Physiol Heart
Circ Physiol. 297:H1535–H1543. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Lv JJ, Wang H, Zhang C, Zhang TJ, Wei HL,
Liu ZK, Ma YH, Yang Z, He Q, Wang LJ, et al: CD147 sparks
atherosclerosis by driving M1 phenotype and impairing
efferocytosis. Circ Res. 134:165–185. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Adkar SS and Leeper NJ: Efferocytosis in
atherosclerosis. Nat Rev Cardiol. 21:762–779. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Kojima Y, Weissman IL and Leeper NJ: The
role of efferocytosis in atherosclerosis. Circulation. 135:476–489.
2017. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Parmar KM, Nambudiri V, Dai G, Larman HB,
Gimbrone MA Jr and García-Cardeña G: Statins exert endothelial
atheroprotective effects via the KLF2 transcription factor. J Biol
Chem. 280:26714–26719. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Yao X, Liu Y, Mao M, Yang L, Zhan Q and
Xiao J: Calorie restriction mimetic, resveratrol, attenuates
hepatic ischemia and reperfusion injury through enhancing
efferocytosis of macrophages via AMPK/STAT3/S1PR1 pathway. J Nutr
Biochem. 126:1095872024. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Chen F, Xu W, Tang M, Tian Y, Shu Y, He X,
Zhou L, Liu Q, Zhu Q, Lu X, et al: hnRNPA2B1 deacetylation by SIRT6
restrains local transcription and safeguards genome stability. Cell
Death Differ. 32:382–396. 2025. View Article : Google Scholar
|
|
32
|
Yurdagul A Jr, Subramanian M, Wang X,
Crown SB, Ilkayeva OR, Darville L, Kolluru GK, Rymond CC, Gerlach
BD, Zheng Z, et al: Macrophage metabolism of apoptotic Cell-derived
arginine promotes continual efferocytosis and resolution of injury.
Cell Metab. 31:518–533.e10. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
He W, Ye S, Zeng C, Xue S, Hu X, Zhang X,
Gao S, Xiong Y, He X, Vivalda S, et al: Hypothermic oxygenated
perfusion (HOPE) attenuates ischemia/reperfusion injury in the
liver through inhibition of the TXNIP/NLRP3 inflammasome pathway in
a rat model of donation after cardiac death. FASEB J. Jun
5–2018.Epub ahead of print. View Article : Google Scholar
|
|
34
|
Zeng X, Li M, Fan X, Xue S, Liang W, Fang
Z, Zeng C, Fan L, Xiong Y, Wang Y and Ye Q: Hypothermic oxygenated
machine perfusion alleviates donation after circulatory death liver
injury through regulating P-selectin-dependent and -independent
pathways in mice. Transplantation. 103:918–928. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Suzuki S, Toledo-Pereyra LH, Rodriguez FJ
and Cejalvo D: Neutrophil infiltration as an important factor in
liver ischemia and reperfusion injury. Modulating effects of FK506
and cyclosporine. Transplantation. 55:1265–1272. 1993. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Hu Q, Chen H, Lan J, Chen Y, Liu Z, Xiong
Y, Zhou W, Zhong Z and Ye Q: KLF10 induced by hypothermic machine
perfusion alleviates renal inflammation through BIRC2/Noncanonical
NF-κB pathway. Transplantation. 109:e273–e286. 2025. View Article : Google Scholar
|
|
37
|
Petrusca DN, Gu Y, Adamowicz JJ, Rush NI,
Hubbard WC, Smith PA, Berdyshev EV, Birukov KG, Lee CH, Tuder RM,
et al: Sphingolipid-mediated inhibition of apoptotic cell clearance
by alveolar macrophages. J Biol Chem. 285:40322–40332. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar
|
|
39
|
Yurdagul A Jr, Kong N, Gerlach BD, Wang X,
Ampomah P, Kuriakose G, Tao W, Shi J and Tabas I: ODC (Ornithine
Decarboxylase)-Dependent putrescine synthesis maintains MerTK (MER
Tyrosine-Protein Kinase) expression to drive resolution.
Arterioscler Thromb Vasc Biol. 41:e144–e159. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Wang Y, Zhang W, Xu Y, Wu D, Gao Z, Zhou
J, Qian H, He B and Wang G: Extracellular HMGB1 impairs
macrophage-mediated efferocytosis by suppressing the
Rab43-controlled cell surface transport of CD91. Front Immunol.
13:7676302022. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Vasudevan SO, Behl B and Rathinam VA:
Pyroptosis-induced inflammation and tissue damage. Semin Immunol.
69:1017812023. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Jiang K, Tu Z, Chen K, Xu Y, Chen F, Xu S,
Shi T, Qian J, Shen L, Hwa J, et al: Gasdermin D inhibition confers
antineutrophil-mediated cardioprotection in acute myocardial
infarction. J Clin Invest. 132:e1512682022. View Article : Google Scholar :
|
|
43
|
Li S, Sun Y, Song M, Song Y, Fang Y, Zhang
Q, Li X, Song N, Ding J, Lu M and Hu G:
NLRP3/caspase-1/GSDMD-mediated pyroptosis exerts a crucial role in
astrocyte pathological injury in mouse model of depression. JCI
Insight. 6:e1468522021. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Liang F, Zhang F, Zhang L and Wei W: The
advances in pyroptosis initiated by inflammasome in inflammatory
and immune diseases. Inflamm Res. 69:159–166. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Liu Y, Pan R, Ouyang Y, Gu W, Xiao T, Yang
H, Tang L, Wang H, Xiang B and Chen P: Pyroptosis in health and
disease: Mechanisms, regulation and clinical perspective. Signal
Transduct Target Ther. 9:2452024. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Zhang X, Wang Z, Li X, Chen J, Yu Z, Li X,
Sun C, Hu L, Wu M and Liu L: Polydatin protects against
atherosclerosis by activating autophagy and inhibiting pyroptosis
mediated by the NLRP3 inflammasome. J Ethnopharmacol.
309:1163042023. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Gimbrone MA Jr, Topper JN, Nagel T,
Anderson KR and Garcia-Cardeña G: Endothelial dysfunction,
hemodynamic forces, and atherogenesis. Ann N Y Acad Sci.
902:230–240. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Ando J and Yamamoto K: Hemodynamic forces,
endothelial mechanotransduction, and vascular diseases. Magn Reson
Med Sci. 21:258–266. 2022. View Article : Google Scholar :
|
|
49
|
Caldwell-Kenkel JC, Currin RT, Tanaka Y,
Thurman RG and Lemasters JJ: Reperfusion injury to endothelial
cells following cold ischemic storage of rat livers. Hepatology.
10:292–299. 1989. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Peralta C, Jiménez-Castro MB and
Gracia-Sancho J: Hepatic ischemia and reperfusion injury: Effects
on the liver sinusoidal milieu. J Hepatol. 59:1094–1106. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Upadhya GA, Topp SA, Hotchkiss RS, Anagli
J and Strasberg SM: Effect of cold preservation on intracellular
calcium concentration and calpain activity in rat sinusoidal
endothelial cells. Hepatology. 37:313–323. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Knijff LWD, van Kooten C and Ploeg RJ: The
effect of hypothermic machine perfusion to ameliorate
Ischemia-Reperfusion injury in donor organs. Front Immunol.
13:8483522022. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Schlegel A, de Rougemont O, Graf R,
Clavien PA and Dutkowski P: Protective mechanisms of end-ischemic
cold machine perfusion in DCD liver grafts. J Hepatol. 58:278–286.
2013. View Article : Google Scholar
|
|
54
|
Chatauret N, Coudroy R, Delpech PO,
Vandebrouck C, Hosni S, Scepi M and Hauet T: Mechanistic analysis
of nonoxygenated hypothermic machine perfusion's protection on warm
ischemic kidney uncovers greater eNOS phosphorylation and
vasodilation. Am J Transplant. 14:2500–2514. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Hergenreider E, Heydt S, Tréguer K,
Boettger T, Horrevoets AJ, Zeiher AM, Scheffer MP, Frangakis AS,
Yin X, Mayr M, et al: Atheroprotective communication between
endothelial cells and smooth muscle cells through miRNAs. Nat Cell
Biol. 14:249–256. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Jha P and Das H: KLF2 in regulation of
NF-κB-Mediated immune cell function and inflammation. Int J Mol
Sci. 18:23832017. View Article : Google Scholar
|
|
57
|
Dekker RJ, Boon RA, Rondaij MG, Kragt A,
Volger OL, Elderkamp YW, Meijers JC, Voorberg J, Pannekoek H and
Horrevoets AJ: KLF2 provokes a gene expression pattern that
establishes functional quiescent differentiation of the
endothelium. Blood. 107:4354–4363. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Nayak L, Lin Z and Jain MK: 'Go with the
flow': How Krüppel-like factor 2 regulates the vasoprotective
effects of shear stress. Antioxid Redox Signal. 15:1449–1461. 2011.
View Article : Google Scholar
|
|
59
|
Gallinat A, Efferz P, Paul A and Minor T:
One or 4 h of 'in-house' reconditioning by machine perfusion after
cold storage improve reperfusion parameters in porcine kidneys.
Transpl Int. 27:1214–1219. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Xiao L, Magupalli VG and Wu H: Cryo-EM
structures of the active NLRP3 inflammasome disc. Nature.
613:595–600. 2023. View Article : Google Scholar
|
|
61
|
Lamkanfi M and Dixit VM: Inflammasomes and
their roles in health and disease. Annu Rev Cell Dev Biol.
28:137–161. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Zhang Y, Yang W, Li W and Zhao Y: NLRP3
Inflammasome: Checkpoint connecting innate and adaptive immunity in
autoimmune diseases. Front Immunol. 12:7329332021. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Mangan MSJ, Olhava EJ, Roush WR, Seidel
HM, Glick GD and Latz E: Targeting the NLRP3 inflammasome in
inflammatory diseases. Nat Rev Drug Discov. 17:588–606. 2018.
View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Franchi L, Eigenbrod T, Muñoz-Planillo R
and Nuñez G: The inflammasome: A caspase-1-activation platform that
regulates immune responses and disease pathogenesis. Nat Immunol.
10:241–247. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Chen Y, Ye X, Escames G, Lei W, Zhang X,
Li M, Li M, Jing T, Yao Y, Qiu Z, et al: The NLRP3 inflammasome:
Contributions to inflammation-related diseases. Cell Mol Biol Lett.
28:512023. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Dai J, Chen Q, Huang W, Shi K, Zhang Y, Li
T, Mou T, Huang Z and Wu Z: Liver kinase B1 attenuates liver
ischemia/reperfusion injury via inhibiting the NLRP3 inflammasome.
Acta Biochim Biophys Sin (Shanghai). 53:601–611. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
67
|
Pu JL, Huang ZT, Luo YH, Mou T, Li TT, Li
ZT, Wei XF and Wu ZJ: Fisetin mitigates hepatic
ischemia-reperfusion injury by regulating GSK3β/AMPK/NLRP3
inflammasome pathway. Hepatobiliary Pancreat Dis Int. 20:352–360.
2021. View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Bai B, Yang Y, Wang Q, Li M, Tian C, Liu
Y, Aung LHH, Li PF, Yu T and Chu XM: NLRP3 inflammasome in
endothelial dysfunction. Cell Death Dis. 11:7762020. View Article : Google Scholar : PubMed/NCBI
|
|
69
|
Xu T, Chen T, Fang H, Shen X, Shen X, Tang
Z and Zhao J: Human umbilical cord mesenchymal stem cells repair
endothelial injury and dysfunction by regulating NLRP3 to inhibit
endothelial cell pyroptosis in Kawasaki disease. Inflammation.
47:483–502. 2024. View Article : Google Scholar
|
|
70
|
Chen Z, Martin M, Li Z and Shyy JY:
Endothelial dysfunction: The role of sterol regulatory
element-binding protein-induced NOD-like receptor family pyrin
domain-containing protein 3 inflammasome in atherosclerosis. Curr
Opin Lipidol. 25:339–349. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
71
|
Keyel PA: How is inflammation initiated?
Individual influences of IL-1, IL-18 and HMGB1. Cytokine.
69:136–145. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
72
|
Poon IKH and Ravichandran KS: Targeting
efferocytosis in inflammaging. Annu Rev Pharmacol Toxicol.
64:339–357. 2024. View Article : Google Scholar
|
|
73
|
Boada-Romero E, Martinez J, Heckmann BL
and Green DR: The clearance of dead cells by efferocytosis. Nat Rev
Mol Cell Biol. 21:398–414. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
74
|
Kourtzelis I, Hajishengallis G and
Chavakis T: Phagocytosis of apoptotic cells in resolution of
inflammation. Front Immunol. 11:5532020. View Article : Google Scholar : PubMed/NCBI
|
|
75
|
Shi H, Wang X, Li F, Gerlach BD, Yurdagul
A Jr, Moore MP, Zeldin S, Zhang H, Cai B, Zheng Z, et al:
CD47-SIRPα axis blockade in NASH promotes necroptotic hepatocyte
clearance by liver macrophages and decreases hepatic fibrosis. Sci
Transl Med. 14:eabp83092022. View Article : Google Scholar
|
|
76
|
Hu H, Cheng X, Li F, Guan Z, Xu J, Wu D,
Gao Y, Zhan X, Wang P, Zhou H, et al: Defective efferocytosis by
aged macrophages promotes STING signaling mediated inflammatory
liver injury. Cell Death Discov. 9:2362023. View Article : Google Scholar : PubMed/NCBI
|
|
77
|
Pegg AE: Functions of polyamines in
mammals. J Biol Chem. 291:14904–14912. 2016. View Article : Google Scholar : PubMed/NCBI
|
