|
1
|
Zhao Y, Zhang H, Cheng J, Zou Y, Zhang D
and Duan X: Association between dyslipidaemia and cognitive
impairment: A meta-analysis of cohort and case-control studies. J
Integr Neurosci. 23:402024. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Iwagami M, Qizilbash N, Gregson J, Douglas
I, Johnson M, Pearce N, Evans S and Pocock S: Blood cholesterol and
risk of dementia in more than 1•8 million people over two decades:
A retrospective cohort study. Lancet Healthy Longev. 2:e498–e506.
2021. View Article : Google Scholar
|
|
3
|
Rochoy M, Rivas V, Chazard E, Decarpentry
E, Saudemont G, Hazard PA, Puisieux F, Gautier S and Bordet R:
Factors associated with Alzheimer's disease: An overview of
reviews. J Prev Alzheimers Dis. 6:121–134. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Pappolla MA, Refolo L, Sambamurti K,
Zambon D and Duff K: Hypercholesterolemia and Alzheimer's disease:
Unraveling the connection and assessing the efficacy of
lipid-lowering therapies. J Alzheimers Dis. 101(S1): S371–S393.
2024. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Libby P: The changing landscape of
atherosclerosis. Nature. 592:524–533. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Sánchez-Alegría K and Arias C: Functional
consequences of brain exposure to saturated fatty acids: From
energy metabolism and insulin resistance to neuronal damage.
Endocrinol Diabetes Metab. 6:e3862023. View Article : Google Scholar :
|
|
7
|
Moseholm KF, Jensen MK, Buzkova P, Aroner
SA, Fitzpatrick AL, Longstreth WT Jr, Lopez O, Siscovick DS, Kizer
JR, Ix JH, et al: Circulating non-esterified fatty acids, risk of
dementia and cognitive decline: The cardiovascular health study and
multi-ethnic study of atherosclerosis. Neurobiol Aging. 148:71–79.
2025. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Kalyan-Masih P, Vega-Torres JD, Miles C,
Haddad E, Rainsbury S, Baghchechi M, Obenaus A and Figueroa JD:
Western high-fat diet consumption during adolescence increases
susceptibility to traumatic stress while selectively disrupting
hippocampal and ventricular volumes. eNeuro.
3:ENEURO.0125-16.20162016. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Gao XR, Chen Z, Fang K, Xu JX and Ge JF:
Protective effect of quercetin against the metabolic dysfunction of
glucose and lipids and its associated learning and memory
impairments in NAFLD rats. Lipids Health Dis. 20:1642021.
View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Chen XX, Xu YY, Wu R, Chen Z, Fang K, Han
YX, Yu Y, Huang LL, Peng L and Ge JF: Resveratrol reduces
glucolipid metabolic dysfunction and learning and memory impairment
in a NAFLD rat model: involvement in regulating the imbalance of
nesfatin-1 abundance and copine 6 expression. Front Endocrinol
(Lausanne). 10:4342019. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Gao X, Sun H, Wei Y, Niu J, Hao S, Sun H,
Tang G, Qi C and Ge J: Protective effect of melatonin against
metabolic disorders and neuropsychiatric injuries in type 2
diabetes mellitus mice. Phytomedicine. 131:1558052024. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Gao X, Sun H, Hao S, Sun H and Ge J:
Melatonin protects HT-22 cells against palmitic acid-induced
glucolipid metabolic dysfunction and cell injuries: Involved in the
regulation of synaptic plasticity and circadian rhythms. Biochem
Pharmacol. 217:1158462023. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Zhang K, Wu D and Huang C: Crosstalk
between non-coding RNA and apoptotic signaling in diabetic
nephropathy. Biochem Pharmacol. 230:1166212024. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Zhou W, Wang Z, Tao Y, Chen C, Zhang Q,
Liu Z, Li L, Xia P and Ye Z: LncRNA-MEG3 attenuates
hyperglycemia-induced damage by enhancing mitochondrial
translocation of HSP90A in the primary hippocampal neurons. Exp
Cell Res. 419:1133202022. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Che F, Han Y, Fu J, Wang N, Jia Y, Wang K
and Ge J: LncRNA MALAT1 induced by hyperglycemia promotes
microvascular endothelial cell apoptosis through activation of the
miR-7641/TPR axis to exacerbate neurologic damage caused by
cerebral small vessel disease. Ann Transl Med. 9:17622021.
View Article : Google Scholar
|
|
16
|
Young TL, Matsuda T and Cepko CL: The
noncoding RNA taurine upregulated gene 1 is required for
differentiation of the murine retina. Curr Biol. 15:501–512. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Chen Y, Li Z, Chen X and Zhang S: Long
non-coding RNAs: From disease code to drug role. Acta Pharm Sin B.
11:340–354. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Yang B, Liang RS, Wu XY and Lin YJ: LncRNA
TUG1 inhibits neuronal apoptosis in status epilepticus rats via
targeting the miR-421/mTOR axis. Cell Signal. 76:1097872020.
View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Zhai K, Liu B and Gao L: Long-noncoding
RNA TUG1 promotes parkinson's disease via modulating
MiR-152-3p/PTEN pathway. Hum Gene Ther. 31:1274–1287. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Li X, Wang SW, Li XL, Yu FY and Cong HM:
Knockdown of long non-coding RNA TUG1 depresses apoptosis of
hippocampal neurons in Alzheimer's disease by elevating
microRNA-15a and repressing ROCK1 expression. Inflamm Res.
69:897–910. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Wang K, Lin Y, Shen H, Yu S and Xu J:
LncRNA TUG1 exacerbates myocardial fibrosis in diabetic
cardiomyopathy by modulating the microRNA-145a-5p/Cfl2 axis. J
Cardiovasc Pharmacol. 81:192–202. 2023. View Article : Google Scholar
|
|
22
|
Li C, Zheng X, Liu P and Li M: Clinical
value of lncRNA TUG1 in temporal lobe epilepsy and its role in the
proliferation of hippocampus neuron via sponging miR-199a-3p.
Bioengineered. 12:10666–10673. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
He C, Li Z, Yu W, Luo R, Zhou J, He J,
Chen Q, Song Z and Cheng S: LncRNA TUG1 mediates microglial
inflammatory activation by regulating glucose metabolic
reprogramming. Sci Rep. 14:121432024. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Wang W, Miao Z, Qi X, Wang B, Liu Q, Shi X
and Xu S: LncRNA Tug1 relieves the steatosis of SelenoF-knockout
hepatocytes via sponging miR-1934-3p. Cell Biol Toxicol.
39:3175–3195. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
López-Noriega L and Rutter GA: Long
non-coding RNAs as key modulators of pancreatic β-cell mass and
function. Front Endocrinol (Lausanne). 11:6102132021. View Article : Google Scholar
|
|
26
|
Gao X, Wei Y, Sun H, Hao S, Ma M, Sun H,
Zang D, Qi C and Ge J: Role of bmal1 in type 2 diabetes
mellitus-related glycolipid metabolic disorder and neuropsychiatric
injury: Involved in the regulation of synaptic plasticity and
circadian rhythms. Mol Neurobiol. 60:4595–4617. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Zhao Y and Ai Y: Overexpression of lncRNA
Gm15621 alleviates apoptosis and inflammation response resulting
from sevoflurane treatment through inhibiting miR-133a/Sox4. J Cell
Physiol. 235:957–965. 2020. View Article : Google Scholar
|
|
28
|
Feng X, Zhan F, Luo D, Hu J, Wei G, Hua F
and Xu G: LncRNA 4344 promotes NLRP3-related neuroinflammation and
cognitive impairment by targeting miR-138-5p. Brain Behav Immun.
98:283–298. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar
|
|
30
|
Liu S, Fan M, Xu JX, Yang LJ, Qi CC, Xia
QR and Ge JF: Exosomes derived from bone-marrow mesenchymal stem
cells alleviate cognitive decline in AD-like mice by improving
BDNF-related neuropathology. J Neuroinflammation. 19:352022.
View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Diez H, Garrido JJ and Wandosell F:
Specific roles of Akt iso forms in apoptosis and axon growth
regulation in neurons. PLoS One. 7:e327152012. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Jin B, Chen Y, Yang D and Wang M: Linarin
from Lycii cortex alleviates high-fat diet-induced cognitive
impairment by improving hippocampal insulin signaling and synaptic
plasticity. J Nutr Biochem. 158:1104662026. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Qiu Q, Yang Z, Zhao J, Zhang R, Zheng S,
Wang C, Xu H, Deng H, Zhao K and Liu M: Integrative analysis of
cuproptosis-related lncRNAs for prognostic risk assessment and
tumor immune microenvironment evaluation in laryngeal squamous cell
carcinoma. Int J Biol Macromol. 306:1418462025. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
De Santis R, Liepelt A, Mossanen JC, Dueck
A, Simons N, Mohs A, Trautwein C, Meister G, Marx G,
Ostareck-Lederer A and Ostareck DH: miR-155 targets caspase-3 mRNA
in activated macrophages. RNA Biol. 13:43–58. 2016. View Article : Google Scholar :
|
|
35
|
Stern A, Teng P and Frishman WH: Lipid
lowering agents and late life cognitive dysfunction. Cardiol Rev.
May 16–2025.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Horgusluoglu E, Neff R, Song WM, Wang M,
Wang Q, Arnold M, Krumsiek J, Galindo-Prieto B, Ming C, Nho K, et
al: Integrative metabolomics-genomics approach reveals key
metabolic pathways and regulators of Alzheimer's disease.
Alzheimers Dement. 18:1260–1278. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Saipuljumri EN, Zeng J and Lo CH: Palmitic
acid-induced autolysosomal dysfunction and lipotoxicity in
neuroinflammation and neurodegeneration. Neural Regen Res.
21:2806–2811. 2026. View Article : Google Scholar :
|
|
38
|
Wei YD, Chen XX, Yang LJ, Gao XR, Xia QR,
Qi CC and Ge JF: Resveratrol ameliorates learning and memory
impairments induced by bilateral hippocampal injection of
streptozotocin in mice. Neurochem Int. 159:1053852022. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Shi X, Liu S, Zou Y, Wu H, Ma J, Lin J and
Zhang X: LncRNA taurine Up-regulated 1 knockout provides
neuroprotection in ischemic stroke rats by inhibiting
nuclear-cytoplasmic shuttling of HuR. Biomedicines. 12:25202024.
View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Yao M, Wang X, Lin H, Shu H, Xu Z, Tang L,
Guo W and Xu P: LncRNA Tug1 regulates post-stroke microglial
pyroptosis via PINK1/Parkin-mediated mitophagy. Inflammation.
48:2677–2691. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Sultana R, Banks WA and Butterfield DA:
Decreased levels of PSD95 and two associated proteins and increased
levels of BCl2 and caspase 3 in hippocampus from subjects with
amnestic mild cognitive impairment: Insights into their potential
roles for loss of synapses and memory, accumulation of Abeta, and
neurodegeneration in a prodromal stage of Alzheimer's disease. J
Neurosci Res. 88:469–477. 2010. View Article : Google Scholar
|
|
42
|
Li Z, Jo J, Jia JM, Lo SC, Whitcomb DJ,
Jiao S, Cho K and Sheng M: Caspase-3 activation via mitochondria is
required for long-term depression and AMPA receptor
internalization. Cell. 141:859–871. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
D'Amelio M, Cavallucci V, Middei S,
Marchetti C, Pacioni S, Ferri A, Diamantini A, De Zio D, Carrara P,
Battistini L, et al: Caspase-3 triggers early synaptic dysfunction
in a mouse model of Alzheimer's disease. Nat Neurosci. 14:69–76.
2011. View Article : Google Scholar
|
|
44
|
Contreras A, Del Rio D, Martinez A, Gil C,
Morales L, Ruiz-Gayo M and Del Olmo N: Inhibition of hippocampal
long-term potentiation by high-fat diets: Is it related to an
effect of palmitic acid involving glycogen synthase kinase-3?
Neuroreport. 28:354–359. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Cardone MH, Roy N, Stennicke HR, Salvesen
GS, Franke TF, Stanbridge E, Frisch S and Reed JC: Regulation of
cell death protease caspase-9 by phosphorylation. Science.
282:1318–1321. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Widmann C, Gibson S and Johnson GL:
Caspase-dependent cleavage of signaling proteins during apoptosis.
A turn-off mechanism for anti-apoptotic signals. J Biol Chem.
273:7141–7147. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Jope RS and Johnson GVW: The glamour and
gloom of glycogen synthase kinase-3. Trends Biochem Sci. 29:95–102.
2004. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Chen K and Yu G: Tetrahydroalstonine
possesses protective potentials on palmitic acid stimulated SK-N-MC
cells by suppression of Aβ1-42 and tau through regulation of
PI3K/Akt signaling pathway. Eur J Pharmacol. 962:1762512024.
View Article : Google Scholar
|
|
49
|
Zhao Y, Wang H, Tang G, Wang L, Tian X and
Li R: Risk factors for mild cognitive impairment in type 2
diabetes: A systematic review and meta-analysis. Front Endocrinol
(Lausanne). 16:16172482025. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Tabesh M, Sacre JW, Mehta K, Chen L,
Sajjadi SF, Magliano DJ and Shaw JE: Associations of
glycaemia-related risk factors with dementia and cognitive decline
in individuals with type 2 diabetes: A systematic review and
meta-analysis. Diabet Med. 42:e701232025. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Zhang X, Chen D, Zhu C, Zhou X, Liu H and
Zhu G: Expression significance and relationship of serum miR-542-3p
and lncRNA TUG1 in STBI patients and their predictive value for
prognosis. Int J Gen Med. 18:3441–3450. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Gu X, Song Y, Liu X, Cheng Z, Min J and
Zhang Y: METTL14-mediated m6A modification of TUG1 represses
ferroptosis in Alzheimer's disease via inhibiting GDF15
ubiquitination. Front Biosci (Landmark Ed). 29:2982024. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Chen J, Su C, Ma Z, Ou X, Zhan M and Hu J:
Aerobic exercise suppresses cognitive injury in patients with
Alzheimer's disease by regulating long non-coding RNA TUG1.
Neurosci Lett. 826:1377322024. View Article : Google Scholar : PubMed/NCBI
|