|
1
|
Furnari FB, Fenton T, Bachoo RM, et al:
Malignant astrocytic glioma: genetics, biology, and paths to
treatment. Genes Dev. 21:2683–2710. 2007.
|
|
2
|
Van Meir EG, Hadjipanayis CG, Norden AD,
Shu HK, Wen PY and Olson JJ: Exciting new advances in
neuro-oncology: the avenue to a cure for malignant glioma. CA
Cancer J Clin. 60:166–193. 2010.
|
|
3
|
Gal H, Pandi G, Kanner AA, et al: MIR-451
and imatinib mesylate inhibit tumor growth of glioblastoma stem
cells. Biochem Biophys Res Commun. 376:86–90. 2008.
|
|
4
|
Zhang CZ, Zhang JX, Zhang AL, et al:
MiR-221 and miR-222 target PUMA to induce cell survival in
glioblastoma. Mol Cancer. 9:2292010.
|
|
5
|
Liu T, Tang H, Lang Y, Liu M and Li X:
MicroRNA-27a functions as an oncogene in gastric adenocarcinoma by
targeting prohibitin. Cancer Lett. 273:233–242. 2009.
|
|
6
|
Moriyama T, Ohuchida K, Mizumoto K, et al:
MicroRNA-21 modulates biological functions of pancreatic cancer
cells including their proliferation, invasion, and chemoresistance.
Mol Cancer Ther. 8:1067–1074. 2009.
|
|
7
|
Selbach M, Schwanhausser B, Thierfelder N,
Fang Z, Khanin R and Rajewsky N: Widespread changes in protein
synthesis induced by microRNAs. Nature. 455:58–63. 2008.
|
|
8
|
Tay Y, Zhang J, Thomson AM, Lim B and
Rigoutsos I: MicroRNAs to Nanog, Oct4 and Sox2 coding regions
modulate embryonic stem cell differentiation. Nature.
455:1124–1128. 2008.
|
|
9
|
Chi SW, Zang JB, Mele A and Darnell RB:
Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps. Nature.
460:479–486. 2009.
|
|
10
|
He L and Hannon GJ: MicroRNAs: small RNAs
with a big role in gene regulation. Nat Rev Genet. 5:522–531.
2004.
|
|
11
|
Griffiths-Jones S, Grocock RJ, van Dongen
S, Bateman A and Enright AJ: miRBase: microRNA sequences, targets
and gene nomenclature. Nucleic Acids Res. 34:D140–D144. 2006.
|
|
12
|
Ambros V: The functions of animal
microRNAs. Nature. 431:350–355. 2004.
|
|
13
|
Bartel DP: MicroRNAs: genomics,
biogenesis, mechanism, and function. Cell. 116:281–297. 2004.
|
|
14
|
Hwang HW and Mendell JT: MicroRNAs in cell
proliferation, cell death, and tumorigenesis. Br J Cancer.
94:776–780. 2006.
|
|
15
|
Bandres E, Agirre X, Ramirez N, Zarate R
and Garcia-Foncillas J: MicroRNAs as cancer players: potential
clinical and biological effects. DNA Cell Biol. 26:273–282.
2007.
|
|
16
|
Mahlamaki EH, Barlund M, Tanner M, et al:
Frequent amplification of 8q24, 11q, 17q, and 20q-specific genes in
pancreatic cancer. Genes Chromosomes Cancer. 35:353–358. 2002.
|
|
17
|
Varis A, Wolf M, Monni O, et al: Targets
of gene amplification and overexpression at 17q in gastric cancer.
Cancer Res. 62:2625–2629. 2002.
|
|
18
|
Nan Y, Han L, Zhang A, et al: MiRNA-451
plays a role as tumor suppressor in human glioma cells. Brain Res.
1359:14–21. 2010.
|
|
19
|
von Mering C, Huynen M, Jaeggi D, Schmidt
S, Bork P and Snel B: STRING: a database of predicted functional
associations between proteins. Nucleic Acids Res. 31:258–261.
2003.
|
|
20
|
Kanehisa M and Goto S: KEGG: kyoto
encyclopedia of genes and genomes. Nucleic Acids Res. 28:27–30.
2000.
|
|
21
|
Griffiths-Jones S, Saini HK, van Dongen S
and Enright AJ: miRBase: tools for microRNA genomics. Nucleic Acids
Res. 36:D154–D158. 2008.
|
|
22
|
Kruger J and Rehmsmeier M: RNAhybrid:
microRNA target prediction easy, fast and flexible. Nucleic Acids
Res. 34:W451–W454. 2006.
|
|
23
|
Kang CS, Zhang ZY, Jia ZF, et al:
Suppression of EGFR expression by antisense or small interference
RNA inhibits U251 glioma cell growth in vitro and in vivo. Cancer
Gene Ther. 13:530–538. 2006.
|
|
24
|
Zhang J, Han L, Zhang A, et al: AKT2
expression is associated with glioma malignant progression and
required for cell survival and invasion. Oncol Rep. 24:65–72.
2010.
|
|
25
|
Wan HY, Guo LM, Liu T, Liu M, Li X and
Tang H: Regulation of the transcription factor NF-kappaB1 by
microRNA-9 in human gastric adenocarcinoma. Mol Cancer.
9:162010.
|
|
26
|
Brazil DP, Park J and Hemmings BA: PKB
binding proteins. Getting in on the Akt. Cell. 111:293–303.
2002.
|
|
27
|
Dufour G, Demers MJ, Gagne D, et al: Human
intestinal epithelial cell survival and anoikis. Differentiation
state-distinct regulation and roles of protein kinase B/Akt
isoforms. J Biol Chem. 279:44113–44122. 2004.
|
|
28
|
Alessi DR, Sakamoto K and Bayascas JR:
LKB1-dependent signaling pathways. Annu Rev Biochem. 75:137–163.
2006.
|
|
29
|
Boudeau J, Baas AF, Deak M, et al:
MO25alpha/beta interact with STRADalpha/beta enhancing their
ability to bind, activate and localize LKB1 in the cytoplasm. EMBO
J. 22:5102–5114. 2003.
|
|
30
|
Milburn CC, Boudeau J, Deak M, Alessi DR
and van Aalten DM: Crystal structure of MO25 alpha in complex with
the C terminus of the pseudo kinase STE20-related adaptor. Nat
Struct Mol Biol. 11:193–200. 2004.
|
|
31
|
Brajenovic M, Joberty G, Kuster B,
Bouwmeester T and Drewes G: Comprehensive proteomic analysis of
human Par protein complexes reveals an interconnected protein
network. J Biol Chem. 279:12804–12811. 2004.
|
|
32
|
Baas AF, Boudeau J, Sapkota GP, et al:
Activation of the tumour suppressor kinase LKB1 by the STE20-like
pseudokinase STRAD. EMBO J. 22:3062–3072. 2003.
|
|
33
|
Hemminki A, Markie D, Tomlinson I, et al:
A serine/threonine kinase gene defective in Peutz-Jeghers syndrome.
Nature. 391:184–187. 1998.
|
|
34
|
Jenne DE, Reimann H, Nezu J, et al:
Peutz-Jeghers syndrome is caused by mutations in a novel serine
threonine kinase. Nat Genet. 18:38–43. 1998.
|
|
35
|
Hardie DG, Scott JW, Pan DA and Hudson ER:
Management of cellular energy by the AMP-activated protein kinase
system. FEBS Lett. 546:113–120. 2003.
|
|
36
|
Hawley SA, Boudeau J, Reid JL, et al:
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and
MO25 alpha/beta are upstream kinases in the AMP-activated protein
kinase cascade. J Biol. 2:282003.
|
|
37
|
Woods A, Johnstone SR, Dickerson K, et al:
LKB1 is the upstream kinase in the AMP-activated protein kinase
cascade. Curr Biol. 13:2004–2008. 2003.
|
|
38
|
Vanhaesebroeck B, Leevers SJ, Ahmadi K, et
al: Synthesis and function of 3-phosphorylated inositol lipids.
Annu Rev Biochem. 70:535–602. 2001.
|
|
39
|
Cheng CK, Fan QW and Weiss WA: PI3K
signaling in glioma-animal models and therapeutic challenges. Brain
Pathol. 19:112–120. 2009.
|
|
40
|
Tao R, Gong J, Luo X, et al: AMPK exerts
dual regulatory effects on the PI3K pathway. J Mol Signal.
5:12010.
|
