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Article

Inhibition of androgen-responsive LNCaP prostate cancer cell tumor xenograft growth by dietary phenethyl isothiocyanate correlates with decreased angiogenesis and inhibition of cell attachment

  • Authors:
    • Tamaro S. Hudson
    • Susan N. Perkins
    • Stephen D. Hursting
    • Heather A. Young
    • Young S. Kim
    • Tien-Chung Wang
    • Thomas T.Y. Wang
  • View Affiliations / Copyright

    Affiliations: Laboratory of Cellular Regulation and Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA, Genomics and Immunology Laboratory, Beltsville Human Nutrition Research Center, ARS, USDA, 1300 Baltimore Avenue Building 307C, Room 132, Beltsville, MD 20705, USA
  • Pages: 1113-1121
    |
    Published online on: January 17, 2012
       https://doi.org/10.3892/ijo.2012.1335
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Abstract

Phenethyl isothiocyanate (PEITC) is a candidate anticancer compound found in certain cruciferous vegetables. In our tumor cell xenograft model, dietary administration of PEITC (100-150 mg/kg body weight/d) inhibited androgen-responsive LNCaP human prostate cancer cell tumor growth. We found that dietary treatment with PEITC significantly inhibited tumor platelet/endothelial cell adhesion molecule (PECAM-1/CD31) expression, a marker of angiogenesis. By contrast, we did not find the inhibitory effects of PEITC on tumor growth to be associated with alteration of specific markers for apoptosis, cell proliferation or androgen receptor-mediated pathways. Consistent with in vivo results, PEITC exerted little effects on cell proliferation, cell cycle and androgen-dependent pathways. Interestingly, PEITC significantly attenuated LNCaP cell plating efficiency that correlated with inhibition of integrin family proteins integrin β1, α2 and α6 mRNA expression. Thus, PEITC may be a dietary factor that inhibits androgen-responsive prostate tumor growth indirectly by selectively targeting factors involved in the tumor microenvironment.
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Copy and paste a formatted citation
Spandidos Publications style
Hudson TS, Perkins SN, Hursting SD, Young HA, Kim YS, Wang T and Wang TT: Inhibition of androgen-responsive LNCaP prostate cancer cell tumor xenograft growth by dietary phenethyl isothiocyanate correlates with decreased angiogenesis and inhibition of cell attachment. Int J Oncol 40: 1113-1121, 2012.
APA
Hudson, T.S., Perkins, S.N., Hursting, S.D., Young, H.A., Kim, Y.S., Wang, T., & Wang, T.T. (2012). Inhibition of androgen-responsive LNCaP prostate cancer cell tumor xenograft growth by dietary phenethyl isothiocyanate correlates with decreased angiogenesis and inhibition of cell attachment. International Journal of Oncology, 40, 1113-1121. https://doi.org/10.3892/ijo.2012.1335
MLA
Hudson, T. S., Perkins, S. N., Hursting, S. D., Young, H. A., Kim, Y. S., Wang, T., Wang, T. T."Inhibition of androgen-responsive LNCaP prostate cancer cell tumor xenograft growth by dietary phenethyl isothiocyanate correlates with decreased angiogenesis and inhibition of cell attachment". International Journal of Oncology 40.4 (2012): 1113-1121.
Chicago
Hudson, T. S., Perkins, S. N., Hursting, S. D., Young, H. A., Kim, Y. S., Wang, T., Wang, T. T."Inhibition of androgen-responsive LNCaP prostate cancer cell tumor xenograft growth by dietary phenethyl isothiocyanate correlates with decreased angiogenesis and inhibition of cell attachment". International Journal of Oncology 40, no. 4 (2012): 1113-1121. https://doi.org/10.3892/ijo.2012.1335
Copy and paste a formatted citation
x
Spandidos Publications style
Hudson TS, Perkins SN, Hursting SD, Young HA, Kim YS, Wang T and Wang TT: Inhibition of androgen-responsive LNCaP prostate cancer cell tumor xenograft growth by dietary phenethyl isothiocyanate correlates with decreased angiogenesis and inhibition of cell attachment. Int J Oncol 40: 1113-1121, 2012.
APA
Hudson, T.S., Perkins, S.N., Hursting, S.D., Young, H.A., Kim, Y.S., Wang, T., & Wang, T.T. (2012). Inhibition of androgen-responsive LNCaP prostate cancer cell tumor xenograft growth by dietary phenethyl isothiocyanate correlates with decreased angiogenesis and inhibition of cell attachment. International Journal of Oncology, 40, 1113-1121. https://doi.org/10.3892/ijo.2012.1335
MLA
Hudson, T. S., Perkins, S. N., Hursting, S. D., Young, H. A., Kim, Y. S., Wang, T., Wang, T. T."Inhibition of androgen-responsive LNCaP prostate cancer cell tumor xenograft growth by dietary phenethyl isothiocyanate correlates with decreased angiogenesis and inhibition of cell attachment". International Journal of Oncology 40.4 (2012): 1113-1121.
Chicago
Hudson, T. S., Perkins, S. N., Hursting, S. D., Young, H. A., Kim, Y. S., Wang, T., Wang, T. T."Inhibition of androgen-responsive LNCaP prostate cancer cell tumor xenograft growth by dietary phenethyl isothiocyanate correlates with decreased angiogenesis and inhibition of cell attachment". International Journal of Oncology 40, no. 4 (2012): 1113-1121. https://doi.org/10.3892/ijo.2012.1335
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