Differential gene expression pattern in early gastric cancer by an integrative systematic approach

Nam,Seungyoon; Lee,Jieun; Goh,Sung-Ho; Hong,Seung-Hyun; Song,Naaleum; Jang,Sang-Geun; Choi,Il  Ju; Lee,Yeon-Su

doi:10.3892/ijo.2012.1621

November 2012 Volume 41 Issue 5

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November 2012 Volume 41 Issue 5

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Article

Differential gene expression pattern in early gastric cancer by an integrative systematic approach

Authors:
- Seungyoon Nam
- Jieun Lee
- Sung-Ho Goh
- Seung-Hyun Hong
- Naaleum Song
- Sang-Geun Jang
- Il Ju Choi
- Yeon-Su Lee
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Affiliations: Cancer Genomics Branch, Research Institute, National Cancer Center, Goyang, Gyeonggi-do 410-769, Republic of Korea, New Experimental Therapeutics Branch, , Research Institute, National Cancer Center, Goyang, Gyeonggi-do 410-769, Republic of Korea, Colorectal Cancer Branch, Research Institute, National Cancer Center, Goyang, Gyeonggi-do 410-769, Republic of Korea, Gastric Cancer Branch, Research Institute, National Cancer Center, Goyang, Gyeonggi-do 410-769, Republic of Korea
Pages: 1675-1682
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Published online on: September 6, 2012

https://doi.org/10.3892/ijo.2012.1621
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Abstract

To elucidate the molecular basis of early gastric cancer (EGC), the genome-wide expression pattern of cancer and normal tissues from 27 patients were analyzed by a microarray-based method. Using an integrative systematic bioinformatics approach, we classified the differentially expressed genes in EGC. Interestingly, the more highly expressed genes in EGC exhibited the most significant correlation with cell migration and metastasis. This implies that, even at the early stage of gastric cancer, the molecular properties usually observed in late-stage cancer are already present. Furthermore, we have found a novel association between the expression pattern and molecular pathways of EGC and estrogen receptor α (ERα)-negative breast cancer through cross-experimental analysis. These results provide new insights into the biological properties of EGC, as well as yielding useful basic data for the study of molecular mechanisms of EGC carcinogenesis.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Differential gene expression pattern in early gastric cancer by an integrative systematic approach

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