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International Journal of Oncology
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Article

PI3K/Akt and Stat3 signaling regulated by PTEN control of the cancer stem cell population, proliferation and senescence in a glioblastoma cell line

  • Authors:
    • Seok-Ho Moon
    • Dae-Kwan Kim
    • Young Cha
    • Iksoo Jeon
    • Jihwan Song
    • Kyung-Soon Park
  • View Affiliations / Copyright

    Affiliations: Department of Biomedical Science, College of Life Science, CHA University, Seoul, Republic of Korea
  • Pages: 921-928
    |
    Published online on: January 10, 2013
       https://doi.org/10.3892/ijo.2013.1765
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Abstract

Malignant gliomas are the most common primary brain tumor in adults. A number of genes have been implicated in glioblastoma including mutation and deletion of PTEN. PTEN is a regulator of PI3K-mediated Akt signaling pathways and has been recognized as a therapeutic target in glioblastoma. To achieve potent therapeutic inhibition of the PI3K-Akt pathway in glioblastoma, it is essential to understand the interplay between the regulators of its activation. Here, ectopic expression of PTEN in the U-87MG human glioblastoma-astrocytoma cell line is shown to result in the depletion of glioblastoma stem cells (GSCs) and to cause growth retardation and senescence. These effects are likely to be associated with PTEN-mediated cooperative perturbation of Akt and Stat3 signals. Using an in vivo rat model of glioblastoma, we showed that PTEN-overexpressing U-87MG cells failed to induce tumor formation, while untreated U-87MG cells did so. Furthermore, cells expressing the phosphorylated form of Stat3 were completely absent from the brain of rats implanted with PTEN-overexpressing U-87MG cells. Based on these results, PTEN appears to function as a crucial inhibitor of GSCs and as an inducer of senescence, suggesting that functional enhancement of the PTEN pathway will be useful to provide a therapeutic strategy for targeting glioblastoma.
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Copy and paste a formatted citation
Spandidos Publications style
Moon S, Kim D, Cha Y, Jeon I, Song J and Park K: PI3K/Akt and Stat3 signaling regulated by PTEN control of the cancer stem cell population, proliferation and senescence in a glioblastoma cell line. Int J Oncol 42: 921-928, 2013.
APA
Moon, S., Kim, D., Cha, Y., Jeon, I., Song, J., & Park, K. (2013). PI3K/Akt and Stat3 signaling regulated by PTEN control of the cancer stem cell population, proliferation and senescence in a glioblastoma cell line. International Journal of Oncology, 42, 921-928. https://doi.org/10.3892/ijo.2013.1765
MLA
Moon, S., Kim, D., Cha, Y., Jeon, I., Song, J., Park, K."PI3K/Akt and Stat3 signaling regulated by PTEN control of the cancer stem cell population, proliferation and senescence in a glioblastoma cell line". International Journal of Oncology 42.3 (2013): 921-928.
Chicago
Moon, S., Kim, D., Cha, Y., Jeon, I., Song, J., Park, K."PI3K/Akt and Stat3 signaling regulated by PTEN control of the cancer stem cell population, proliferation and senescence in a glioblastoma cell line". International Journal of Oncology 42, no. 3 (2013): 921-928. https://doi.org/10.3892/ijo.2013.1765
Copy and paste a formatted citation
x
Spandidos Publications style
Moon S, Kim D, Cha Y, Jeon I, Song J and Park K: PI3K/Akt and Stat3 signaling regulated by PTEN control of the cancer stem cell population, proliferation and senescence in a glioblastoma cell line. Int J Oncol 42: 921-928, 2013.
APA
Moon, S., Kim, D., Cha, Y., Jeon, I., Song, J., & Park, K. (2013). PI3K/Akt and Stat3 signaling regulated by PTEN control of the cancer stem cell population, proliferation and senescence in a glioblastoma cell line. International Journal of Oncology, 42, 921-928. https://doi.org/10.3892/ijo.2013.1765
MLA
Moon, S., Kim, D., Cha, Y., Jeon, I., Song, J., Park, K."PI3K/Akt and Stat3 signaling regulated by PTEN control of the cancer stem cell population, proliferation and senescence in a glioblastoma cell line". International Journal of Oncology 42.3 (2013): 921-928.
Chicago
Moon, S., Kim, D., Cha, Y., Jeon, I., Song, J., Park, K."PI3K/Akt and Stat3 signaling regulated by PTEN control of the cancer stem cell population, proliferation and senescence in a glioblastoma cell line". International Journal of Oncology 42, no. 3 (2013): 921-928. https://doi.org/10.3892/ijo.2013.1765
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