Overexpression of the truncated form of Livin reveals a complex interaction with caspase-3

  • Authors:
    • Gui-Hong Liu
    • Chun Wang
    • Zhen-Yu Ding
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  • Published online on: April 4, 2013     https://doi.org/10.3892/ijo.2013.1883
  • Pages: 2037-2045
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Abstract

Disruption in apoptosis are involved in cancer development and progression. Livin-β, has been identified as a critical modulator for cell death in several tumor cell lines. It was demonstrated that a truncated fragment of Livin-β (tLivin) without its N-terminal 52 amino acids is produced in cells through protein cleavage. However, the biological consequence of the cleavage remains largely ignored. In the present study, we report that tLivin exerted a pro-apoptotic effect on cells. The subcellular localization of tLivin was mainly restricted to the cytoplasm. To explore the underlying mechanism, we observed an elevated caspase-3 activity which may account for the apoptosis. Furthermore, we observed that tLivin was further cleaved into a smaller fragment in cells. This second cleavage was possibly related to activated caspase-3. The resulted C-terminal fragment (livC) was an anti-apoptotic factor. Our study may help to deepen our understanding of the role of Livin in the regulation of cell death.
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June 2013
Volume 42 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Liu G, Wang C and Ding Z: Overexpression of the truncated form of Livin reveals a complex interaction with caspase-3. Int J Oncol 42: 2037-2045, 2013
APA
Liu, G., Wang, C., & Ding, Z. (2013). Overexpression of the truncated form of Livin reveals a complex interaction with caspase-3. International Journal of Oncology, 42, 2037-2045. https://doi.org/10.3892/ijo.2013.1883
MLA
Liu, G., Wang, C., Ding, Z."Overexpression of the truncated form of Livin reveals a complex interaction with caspase-3". International Journal of Oncology 42.6 (2013): 2037-2045.
Chicago
Liu, G., Wang, C., Ding, Z."Overexpression of the truncated form of Livin reveals a complex interaction with caspase-3". International Journal of Oncology 42, no. 6 (2013): 2037-2045. https://doi.org/10.3892/ijo.2013.1883