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Article

Significance of podoplanin expression in cancer-associated fibroblasts: A comprehensive review

  • Authors:
    • Bartosz Pula
    • Wojciech Witkiewicz
    • Piotr Dziegiel
    • Marzena Podhorska-Okolow
  • View Affiliations / Copyright

    Affiliations: Regional Specialist Hospital, Research and Development Center, 51-124 Wroclaw, Poland, Department of Histology and Embryology, Medical University of Wroclaw, 50-368 Wroclaw, Poland
  • Pages: 1849-1857
    |
    Published online on: April 8, 2013
       https://doi.org/10.3892/ijo.2013.1887
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Abstract

Cancer-associated fibroblasts (CAFs) are well-known to be part of the tumor microenvironment. This heterogeneous population of cells of the tumor microenvironment via secretion of various growth factors and cytokines was shown to contribute to increased cancer cell proliferation rate, migration, invasiveness and other key processes such as angiogenesis and lymphangiogenesis. Recent studies identified podoplanin as a marker of CAFs in various malignancies and its expression in these cells was shown to influence cancer progression. In some studies it yielded a prognostic impact on patient survival which was strongly dependent on the entity of the tumor. This review summarizes recent findings concerning the biology of podoplanin in cancer progression with particular emphasis on its expression in CAFs.
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Copy and paste a formatted citation
Spandidos Publications style
Pula B, Witkiewicz W, Dziegiel P and Podhorska-Okolow M: Significance of podoplanin expression in cancer-associated fibroblasts: A comprehensive review. Int J Oncol 42: 1849-1857, 2013.
APA
Pula, B., Witkiewicz, W., Dziegiel, P., & Podhorska-Okolow, M. (2013). Significance of podoplanin expression in cancer-associated fibroblasts: A comprehensive review. International Journal of Oncology, 42, 1849-1857. https://doi.org/10.3892/ijo.2013.1887
MLA
Pula, B., Witkiewicz, W., Dziegiel, P., Podhorska-Okolow, M."Significance of podoplanin expression in cancer-associated fibroblasts: A comprehensive review". International Journal of Oncology 42.6 (2013): 1849-1857.
Chicago
Pula, B., Witkiewicz, W., Dziegiel, P., Podhorska-Okolow, M."Significance of podoplanin expression in cancer-associated fibroblasts: A comprehensive review". International Journal of Oncology 42, no. 6 (2013): 1849-1857. https://doi.org/10.3892/ijo.2013.1887
Copy and paste a formatted citation
x
Spandidos Publications style
Pula B, Witkiewicz W, Dziegiel P and Podhorska-Okolow M: Significance of podoplanin expression in cancer-associated fibroblasts: A comprehensive review. Int J Oncol 42: 1849-1857, 2013.
APA
Pula, B., Witkiewicz, W., Dziegiel, P., & Podhorska-Okolow, M. (2013). Significance of podoplanin expression in cancer-associated fibroblasts: A comprehensive review. International Journal of Oncology, 42, 1849-1857. https://doi.org/10.3892/ijo.2013.1887
MLA
Pula, B., Witkiewicz, W., Dziegiel, P., Podhorska-Okolow, M."Significance of podoplanin expression in cancer-associated fibroblasts: A comprehensive review". International Journal of Oncology 42.6 (2013): 1849-1857.
Chicago
Pula, B., Witkiewicz, W., Dziegiel, P., Podhorska-Okolow, M."Significance of podoplanin expression in cancer-associated fibroblasts: A comprehensive review". International Journal of Oncology 42, no. 6 (2013): 1849-1857. https://doi.org/10.3892/ijo.2013.1887
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