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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 2013 Volume 43 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

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International Journal of Epigenetics

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Article

From AR to c-Met: Androgen deprivation leads to a signaling pathway switch in prostate cancer cells

  • Authors:
    • Tiancheng Liu
    • Desiree E. Mendes
    • Clifford E. Berkman
  • View Affiliations / Copyright

    Affiliations: Department of Chemistry, Washington State University, Pullman, WA 99164, USA
  • Pages: 1125-1130
    |
    Published online on: July 18, 2013
       https://doi.org/10.3892/ijo.2013.2020
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Abstract

Elucidating the role of androgen deprivation in the transition from androgen-dependence to independence may enable the development of more specific therapeutic strategies against prostate cancer. Our previous in vitro model was employed to further assess the effects of continuous androgen‑deprivation on prostate cancer cells (LNCaP) with respect to both androgen receptor (AR) and c-Met expression. The results indicated that long-term androgen deprivation resulted in a signaling pathway switch from AR to c-Met in androgen-sensitive cells, which was confirmed by immunofluorescence imaging and western blot analysis. This signaling pathway switch may be predictive of a more aggressive disease state following androgen deprivation therapy.
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1. 

Gustavsson H, Welen K and Damber JE: Transition of an androgen-dependent human prostate cancer cell line into an androgen-independent subline is associated with increased angiogenesis. Prostate. 62:364–373. 2005. View Article : Google Scholar : PubMed/NCBI

2. 

Niu Y, Altuwaijri S, Lai KP, et al: Androgen receptor is a tumor suppressor and proliferator in prostate cancer. Proc Natl Acad Sci USA. 105:12182–12187. 2008. View Article : Google Scholar : PubMed/NCBI

3. 

Lee SO, Dutt SS, Nadiminty N, Pinder E, Liao H and Gao AC: Development of an androgen-deprivation induced and androgen suppressed human prostate cancer cell line. Prostate. 67:1293–1300. 2007. View Article : Google Scholar : PubMed/NCBI

4. 

Saraon P, Jarvi K and Diamandis EP: Molecular alterations during progression of prostate cancer to androgen independence. Clin Chem. 57:1366–1375. 2011. View Article : Google Scholar : PubMed/NCBI

5. 

Devlin HL and Mudryj M: Progression of prostate cancer: multiple pathways to androgen independence. Cancer Lett. 274:177–186. 2009. View Article : Google Scholar : PubMed/NCBI

6. 

Watson PA, Chen YF, Balbas MD, et al: Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor. Proc Natl Acad Sci USA. 107:16759–16765. 2010. View Article : Google Scholar

7. 

Hendriksen PJ, Dits NF, Kokame K, et al: Evolution of the androgen receptor pathway during progression of prostate cancer. Cancer Res. 66:5012–5020. 2006. View Article : Google Scholar : PubMed/NCBI

8. 

Lorenzo GD, Bianco R, Tortora G and Ciardiello F: Involvement of growth factor receptors of the epidermal growth factor receptor family in prostate cancer development and progression to androgen independence. Clin Prostate Cancer. 2:50–57. 2003. View Article : Google Scholar : PubMed/NCBI

9. 

Maeda A, Nakashiro K, Hara S, et al: Inactivation of AR activates HGF/c-Met system in human prostatic carcinoma cells. Biochem Biophys Res Commun. 347:1158–1165. 2006. View Article : Google Scholar : PubMed/NCBI

10. 

Nishida S, Hirohashi Y, Torigoe T, et al: Prostate cancer stem-like cells/cancer-initiating cells have an autocrine system of hepatocyte growth factor. Cancer Sci. 104:431–436. 2013. View Article : Google Scholar : PubMed/NCBI

11. 

Matsumoto K and Nakamura T: Emerging multipotent aspects of hepatocyte growth factor. J Biochem. 119:591–600. 1996. View Article : Google Scholar : PubMed/NCBI

12. 

Verras M, Lee J, Xue H, Li TH, Wang Y and Sun Z: The androgen receptor negatively regulates the expression of c-Met: implications for a novel mechanism of prostate cancer progression. Cancer Res. 67:967–975. 2007. View Article : Google Scholar : PubMed/NCBI

13. 

Christensen JG, Burrows J and Salgia R: c-Met as a target for human cancer and characterization of inhibitors for therapeutic intervention. Cancer Lett. 225:1–26. 2005. View Article : Google Scholar : PubMed/NCBI

14. 

Gherardi E, Birchmeier W, Birchmeier C and Vande Woude G: Targeting MET in cancer: rationale and progress. Nat Rev Cancer. 12:89–103. 2012. View Article : Google Scholar : PubMed/NCBI

15. 

Peruzzi B and Bottaro DP: Targeting the c-Met signaling pathway in cancer. Clin Cancer Res. 12:3657–3660. 2006. View Article : Google Scholar : PubMed/NCBI

16. 

Liu T, Wu LY, Fulton MD, Johnson JM and Berkman CE: Prolonged androgen deprivation leads to downregulation of androgen receptor and prostate-specific membrane antigen in prostate cancer cells. Int J Oncol. 41:2087–2092. 2012.PubMed/NCBI

17. 

Liu T, Wu LY, Hopkins MR, Choi JK and Berkman CE: A targeted low molecular weight near-infrared fluorescent probe for prostate cancer. Bioorg Med Chem Lett. 20:7124–7126. 2010. View Article : Google Scholar : PubMed/NCBI

18. 

Matroule JY, Carthy CM, Granville DJ, Jolois O, Hunt DW and Piette J: Mechanism of colon cancer cell apoptosis mediated by pyropheophorbide-a methylester photosensitization. Oncogene. 20:4070–4084. 2001. View Article : Google Scholar : PubMed/NCBI

19. 

Liu T, Wu LY and Berkman CE: Prostate-specific membrane antigen-targeted photodynamic therapy induces rapid cytoskeletal disruption. Cancer Lett. 296:106–112. 2010. View Article : Google Scholar : PubMed/NCBI

20. 

Liu T, Toriyabe Y and Berkman CE: Purification of prostate-specific membrane antigen using conformational epitope-specific antibody-affinity chromatography. Protein Expr Purif. 49:251–255. 2006. View Article : Google Scholar

21. 

Wolf DA, Herzinger T, Hermeking H, Blaschke D and Horz W: Transcriptional and posttranscriptional regulation of human androgen receptor expression by androgen. Mol Endocrinol. 7:924–936. 1993.PubMed/NCBI

22. 

Hu P, Chu GC, Zhu G, et al: Multiplexed quantum dot labeling of activated c-Met signaling in castration-resistant human prostate cancer. PLoS One. 6:e286702011. View Article : Google Scholar : PubMed/NCBI

23. 

Suzuki H, Ueda T, Ichikawa T and Ito H: Androgen receptor involvement in the progression of prostate cancer. Endocr Relat Cancer. 10:209–216. 2003. View Article : Google Scholar : PubMed/NCBI

24. 

Smith DC, Smith MR, Sweeney C, et al: Cabozantinib in patients with advanced prostate cancer: results of a phase II randomized discontinuation trial. J Clin Oncol. 31:412–419. 2013. View Article : Google Scholar

25. 

Humphrey PA, Zhu X, Zarnegar R, et al: Hepatocyte growth factor and its receptor (c-MET) in prostatic carcinoma. Am J Pathol. 147:386–396. 1995.PubMed/NCBI

26. 

Colombel M, Eaton CL, Hamdy F, et al: Increased expression of putative cancer stem cell markers in primary prostate cancer is associated with progression of bone metastases. Prostate. 72:713–720. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu T, Mendes DE and Berkman CE: From AR to c-Met: Androgen deprivation leads to a signaling pathway switch in prostate cancer cells. Int J Oncol 43: 1125-1130, 2013.
APA
Liu, T., Mendes, D.E., & Berkman, C.E. (2013). From AR to c-Met: Androgen deprivation leads to a signaling pathway switch in prostate cancer cells. International Journal of Oncology, 43, 1125-1130. https://doi.org/10.3892/ijo.2013.2020
MLA
Liu, T., Mendes, D. E., Berkman, C. E."From AR to c-Met: Androgen deprivation leads to a signaling pathway switch in prostate cancer cells". International Journal of Oncology 43.4 (2013): 1125-1130.
Chicago
Liu, T., Mendes, D. E., Berkman, C. E."From AR to c-Met: Androgen deprivation leads to a signaling pathway switch in prostate cancer cells". International Journal of Oncology 43, no. 4 (2013): 1125-1130. https://doi.org/10.3892/ijo.2013.2020
Copy and paste a formatted citation
x
Spandidos Publications style
Liu T, Mendes DE and Berkman CE: From AR to c-Met: Androgen deprivation leads to a signaling pathway switch in prostate cancer cells. Int J Oncol 43: 1125-1130, 2013.
APA
Liu, T., Mendes, D.E., & Berkman, C.E. (2013). From AR to c-Met: Androgen deprivation leads to a signaling pathway switch in prostate cancer cells. International Journal of Oncology, 43, 1125-1130. https://doi.org/10.3892/ijo.2013.2020
MLA
Liu, T., Mendes, D. E., Berkman, C. E."From AR to c-Met: Androgen deprivation leads to a signaling pathway switch in prostate cancer cells". International Journal of Oncology 43.4 (2013): 1125-1130.
Chicago
Liu, T., Mendes, D. E., Berkman, C. E."From AR to c-Met: Androgen deprivation leads to a signaling pathway switch in prostate cancer cells". International Journal of Oncology 43, no. 4 (2013): 1125-1130. https://doi.org/10.3892/ijo.2013.2020
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