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Article

Curcumin-loaded nanoparticles induce apoptotic cell death through regulation of the function of MDR1 and reactive oxygen species in cisplatin-resistant CAR human oral cancer cells

  • Authors:
    • Pei-Ying Chang
    • Shu-Fen Peng
    • Chao-Ying Lee
    • Chi-Cheng Lu
    • Shih-Chang Tsai
    • Tzong-Ming Shieh
    • Tian-Shung Wu
    • Ming-Gene Tu
    • Michael Yuanchien Chen
    • Jai-Sing Yang
  • View Affiliations / Copyright

    Affiliations: Department of Dentistry, China Medical University, Taichung 404, Taiwan, R.O.C., Department of Biological Science and Technology, China Medical University, Taichung 404, Taiwan, R.O.C., School of Pharmacy, China Medical University, Taichung 404, Taiwan, R.O.C., Department of Pharmacology, China Medical University, Taichung 404, Taiwan, R.O.C., Department of Dental Hygiene, China Medical University, Taichung 404, Taiwan, R.O.C., Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan, R.O.C., Dental Department and Division of Oral Maxillofacial Surgery, China Medical University Hospital, Taichung 40447, Taiwan, R.O.C.
  • Pages: 1141-1150
    |
    Published online on: August 5, 2013
       https://doi.org/10.3892/ijo.2013.2050
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Abstract

Curcumin is a polyphenolic compound which possesses anticancer potential. It has been shown to induce cell death in a variety of cancer cells, however, its effect on CAL27‑cisplatin-resistant human oral cancer cells (CAR cells) has not been elucidated to date. The low water solubility of curcumin which leads to poor bioavailability, however, has been highlighted as a major limiting factor. In this study, we utilized water-soluble PLGA curcumin nanoparticles (Cur-NPs), and investigated the effects of Cur-NPs on CAR cells. The results showed Cur-NPs induced apoptosis in CAR cells but exhibited low cytotoxicity to normal human gingival fibroblasts (HGFs) and normal human oral keratinocytes (OKs). Cur-NPs triggered DNA concentration, fragmentation and subsequent apoptosis. Compared to untreated CAR cells, a more detectable amount of Calcein-AM accumulation was found inside the treated CAR cells. Cur-NPs suppressed the protein and mRNA expression levels of MDR1. Both the activity and the expression levels of caspase-3 and caspase-9 were elevated in the treated CAR cells. The Cur-NP-triggered apoptosis was blocked by specific inhibitors of pan-caspase (z-VAD-fmk), caspase-3 (z-DEVD-fmk), caspase-9 (z-LEHD-fmk) and antioxidant agent (N-acetylcysteine; NAC). Cur-NPs increased reactive oxygen species (ROS) production, upregulated the protein expression levels of cleaved caspase-3/caspase-9, cytochrome c, Apaf-1, AIF, Bax and downregulated the protein levels of Bcl-2. Our results suggest that Cur-NPs triggered the intrinsic apoptotic pathway through regulating the function of multiple drug resistance protein 1 (MDR1) and the production of reactive oxygen species (ROS) in CAR cells. Cur-NPs could be potentially efficacious in the treatment of cisplatin-resistant human oral cancer.
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1. 

Nagadia R, Pandit P, Coman WB, Cooper-White J and Punyadeera C: miRNAs in head and neck cancer revisited. Cell Oncol (Dordr). 36:1–7. 2013. View Article : Google Scholar : PubMed/NCBI

2. 

Duvvuri U and Myers JN: Cancer of the head and neck is the sixth most common cancer worldwide. Curr Probl Surg. 46:114–117. 2009.PubMed/NCBI

3. 

Chen YJ, Chang JT, Liao CT, et al: Head and neck cancer in the betel quid chewing area: recent advances in molecular carcinogenesis. Cancer Sci. 99:1507–1514. 2008. View Article : Google Scholar : PubMed/NCBI

4. 

Chang PM, Chen PM, Chu PY, et al: Effectiveness of pharmacokinetic modulating chemotherapy combined with cisplatin as induction chemotherapy in resectable locally advanced head and neck cancer: phase II study. Cancer Chemother Pharmacol. 63:9–17. 2008. View Article : Google Scholar : PubMed/NCBI

5. 

Chen MK, Su SC, Lin CW, Tsai CM, Yang SF and Weng CJ: Cathepsin B SNPs elevate the pathological development of oral cancer and raise the susceptibility to carcinogen-mediated oral cancer. Hum Genet. 131:1861–1868. 2012. View Article : Google Scholar : PubMed/NCBI

6. 

Lou JL, Guo L, Zhao JQ and Wang SY: Squamous cell carcinoma of cervical lymph nodes from an unknown primary site: a retrospective analysis of treatment strategies and prognosis. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 48:32–36. 2013.(In Chinese).

7. 

Bose P, Brockton NT and Dort JC: Head and neck cancer: from anatomy to biology. Int J Cancer. Feb 18–2013.(Epub ahead of print).

8. 

Kubicek GJ, Kimler BF, Wang F, Reddy EK, Girod DA and Williamson SK: Chemotherapy in head and neck cancer: clinical predictors of tolerance and outcomes. Am J Clin Oncol. 34:380–384. 2011. View Article : Google Scholar : PubMed/NCBI

9. 

Rades D, Ulbricht T, Hakim SG and Schild SE: Cisplatin superior to carboplatin in adjuvant radiochemotherapy for locally advanced cancers of the oropharynx and oral cavity. Strahlenther Onkol. 188:42–48. 2012. View Article : Google Scholar : PubMed/NCBI

10. 

Mandic R, Rodgarkia-Dara CJ, Krohn V, Wiegand S, Grenman R and Werner JA: Cisplatin resistance of the HNSCC cell line UT-SCC-26A can be overcome by stimulation of the EGF-receptor. Anticancer Res. 29:1181–1187. 2009.PubMed/NCBI

11. 

Sunwoo JB: A cisplatin-resistant subpopulation of mesenchymal-like cells in head and neck squamous cell carcinoma. Cell Cycle. 10:2834–2835. 2011. View Article : Google Scholar : PubMed/NCBI

12. 

Vyas A, Dandawate P, Padhye S, Ahmad A and Sarkar F: Perspectives on new synthetic curcumin analogs and their potential anticancer properties. Curr Pharm Des. 19:2047–2069. 2013.PubMed/NCBI

13. 

Baliga MS, Joseph N, Venkataranganna MV, Saxena A, Ponemone V and Fayad R: Curcumin, an active component of turmeric in the prevention and treatment of ulcerative colitis: preclinical and clinical observations. Food Funct. 3:1109–1117. 2012. View Article : Google Scholar : PubMed/NCBI

14. 

Hanai H and Sugimoto K: Curcumin has bright prospects for the treatment of inflammatory bowel disease. Curr Pharm Des. 15:2087–2094. 2009. View Article : Google Scholar : PubMed/NCBI

15. 

Li Y and Wang P: Neuroprotective effects of curcumin. Zhongguo Zhong Yao Za Zhi. 34:3173–3175. 2009.(In Chinese).

16. 

Shishodia S: Molecular mechanisms of curcumin action: gene expression. Biofactors. 39:37–55. 2013. View Article : Google Scholar : PubMed/NCBI

17. 

Noorafshan A and Ashkani-Esfahani S: A review of therapeutic effects of curcumin. Curr Pharm Des. 19:2032–2046. 2013.PubMed/NCBI

18. 

Zhang X, Chen LX, Ouyang L, Cheng Y and Liu B: Plant natural compounds: targeting pathways of autophagy as anti-cancer therapeutic agents. Cell Prolif. 45:466–476. 2012. View Article : Google Scholar : PubMed/NCBI

19. 

Ye MX, Li Y, Yin H and Zhang J: Curcumin: updated molecular mechanisms and intervention targets in human lung cancer. Int J Mol Sci. 13:3959–3978. 2012. View Article : Google Scholar : PubMed/NCBI

20. 

Saha S, Adhikary A, Bhattacharyya P, Das T and Sa G: Death by design: where curcumin sensitizes drug-resistant tumours. Anticancer Res. 32:2567–2584. 2012.PubMed/NCBI

21. 

Gupta SC, Kismali G and Aggarwal BB: Curcumin, a component of turmeric: from farm to pharmacy. Biofactors. 39:2–13. 2013. View Article : Google Scholar : PubMed/NCBI

22. 

Gao W, Chan JY, Wei WI and Wong TS: Anti-cancer effects of curcumin on head and neck cancers. Anticancer Agents Med Chem. 12:1110–1116. 2012. View Article : Google Scholar : PubMed/NCBI

23. 

Yallapu MM, Jaggi M and Chauhan SC: Curcumin nanoformulations: a future nanomedicine for cancer. Drug Discov Today. 17:71–80. 2012. View Article : Google Scholar : PubMed/NCBI

24. 

Varinska L, Mirossay L, Mojzisova G and Mojzis J: Antiangogenic effect of selected phytochemicals. Pharmazie. 65:57–63. 2010.PubMed/NCBI

25. 

Basnet P and Skalko-Basnet N: Curcumin: an anti-inflammatory molecule from a curry spice on the path to cancer treatment. Molecules. 16:4567–4598. 2011. View Article : Google Scholar : PubMed/NCBI

26. 

Haddad M, Sauvain M and Deharo E: Curcuma as a parasiticidal agent: a review. Planta Med. 77:672–678. 2011. View Article : Google Scholar : PubMed/NCBI

27. 

Ji JL, Huang XF and Zhu HL: Curcumin and its formulations: potential anti-cancer agents. Anticancer Agents Med Chem. 12:210–218. 2012. View Article : Google Scholar : PubMed/NCBI

28. 

Shehzad A, Wahid F and Lee YS: Curcumin in cancer chemoprevention: molecular targets, pharmacokinetics, bioavailability, and clinical trials. Arch Pharm (Weinheim). 343:489–499. 2010. View Article : Google Scholar : PubMed/NCBI

29. 

Epstein J, Sanderson IR and Macdonald TT: Curcumin as a therapeutic agent: the evidence from in vitro, animal and human studies. Br J Nutr. 103:1545–1557. 2010. View Article : Google Scholar : PubMed/NCBI

30. 

Yallapu MM, Ebeling MC, Khan S, et al: Novel curcumin loaded magnetic nanoparticles for pancreatic cancer treatment. Mol Cancer Ther. May 23–2013.(Epub ahead of print).

31. 

Pawar YB, Purohit H, Valicherla GR, et al: Novel lipid based oral formulation of curcumin: development and optimization by design of experiments approach. Int J Pharm. 436:617–623. 2012. View Article : Google Scholar : PubMed/NCBI

32. 

Gupta NK and Dixit VK: Bioavailability enhancement of curcumin by complexation with phosphatidyl choline. J Pharm Sci. 100:1987–1995. 2011. View Article : Google Scholar : PubMed/NCBI

33. 

Verderio P, Bonetti P, Colombo M, Pandolfi L and Prosperi D: Intracellular drug release from curcumin-loaded PLGA nanoparticles induces G2/M block in breast cancer cells. Biomacromolecules. 14:672–682. 2013. View Article : Google Scholar : PubMed/NCBI

34. 

Tsai YM, Chang-Liao WL, Chien CF, Lin LC and Tsai TH: Effects of polymer molecular weight on relative oral bioavailability of curcumin. Int J Nanomed. 7:2957–2966. 2012. View Article : Google Scholar : PubMed/NCBI

35. 

Doggui S, Sahni JK, Arseneault M, Dao L and Ramassamy C: Neuronal uptake and neuroprotective effect of curcumin-loaded PLGA nanoparticles on the human SK-N-SH cell line. J Alzheimers Dis. 30:377–392. 2012.PubMed/NCBI

36. 

Das M and Sahoo SK: Folate decorated dual drug loaded nanoparticle: role of curcumin in enhancing therapeutic potential of nutlin-3a by reversing multidrug resistance. PLoS One. 7:e329202012. View Article : Google Scholar : PubMed/NCBI

37. 

Xie X, Tao Q, Zou Y, et al: PLGA nanoparticles improve the oral bioavailability of curcumin in rats: characterizations and mechanisms. J Agric Food Chem. 59:9280–9289. 2011. View Article : Google Scholar : PubMed/NCBI

38. 

Bansal SS, Goel M, Aqil F, Vadhanam MV and Gupta RC: Advanced drug delivery systems of curcumin for cancer chemoprevention. Cancer Prev Res (Phila). 4:1158–1171. 2011. View Article : Google Scholar : PubMed/NCBI

39. 

Jain AK, Das M, Swarnakar NK and Jain S: Engineered PLGA nanoparticles: an emerging delivery tool in cancer therapeutics. Crit Rev Ther Drug Carrier Syst. 28:1–45. 2011. View Article : Google Scholar : PubMed/NCBI

40. 

Berginc K, Trontelj J, Basnet NS and Kristl A: Physiological barriers to the oral delivery of curcumin. Pharmazie. 67:518–524. 2012.PubMed/NCBI

41. 

Shukla S, Zaher H, Hartz A, Bauer B, Ware JA and Ambudkar SV: Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice. Pharm Res. 26:480–487. 2009. View Article : Google Scholar : PubMed/NCBI

42. 

Yue GG, Cheng SW, Yu H, et al: The role of turmerones on curcumin transportation and P-glycoprotein activities in intestinal Caco-2 cells. J Med Food. 15:242–252. 2012. View Article : Google Scholar : PubMed/NCBI

43. 

Zhou S, Lim LY and Chowbay B: Herbal modulation of P-glycoprotein. Drug Metab Rev. 36:57–104. 2004. View Article : Google Scholar

44. 

Gosepath EM, Eckstein N, Hamacher A, et al: Acquired cisplatin resistance in the head-neck cancer cell line Cal27 is associated with decreased DKK1 expression and can partially be reversed by overexpression of DKK1. Int J Cancer. 123:2013–2019. 2008. View Article : Google Scholar : PubMed/NCBI

45. 

Shih YH, Chang KW, Hsia SM, et al: In vitro antimicrobial and anticancer potential of hinokitiol against oral pathogens and oral cancer cell lines. Microbiol Res. 168:254–262. 2013. View Article : Google Scholar : PubMed/NCBI

46. 

Mathew A, Fukuda T, Nagaoka Y, et al: Curcumin loaded-PLGA nanoparticles conjugated with Tet-1 peptide for potential use in Alzheimer’s disease. PLoS One. 7:e326162012.PubMed/NCBI

47. 

Luz PP, Magalhaes LG, Pereira AC, Cunha WR, Rodrigues V and Andrade ESML: Curcumin-loaded into PLGA nanoparticles: preparation and in vitro schistosomicidal activity. Parasitol Res. 110:593–598. 2012. View Article : Google Scholar : PubMed/NCBI

48. 

Anand P, Nair HB, Sung B, et al: Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo. Biochem Pharmacol. 79:330–338. 2010. View Article : Google Scholar : PubMed/NCBI

49. 

Koppolu B, Rahimi M, Nattama S, Wadajkar A and Nguyen KT: Development of multiple-layer polymeric particles for targeted and controlled drug delivery. Nanomedicine. 6:355–361. 2010. View Article : Google Scholar : PubMed/NCBI

50. 

Chang CM, Chang PY, Tu MG, et al: Epigallocatechin gallate sensitizes CAL-27 human oral squamous cell carcinoma cells to the anti-metastatic effects of gefitinib (Iressa) via synergistic suppression of epidermal growth factor receptor and matrix metalloproteinase-2. Oncol Rep. 28:1799–1807. 2012.

51. 

Tsai SC, Lu CC, Lee CY, et al: AKT serine/threonine protein kinase modulates bufalin-triggered intrinsic pathway of apoptosis in CAL 27 human oral cancer cells. Int J Oncol. 41:1683–1692. 2012.PubMed/NCBI

52. 

Yallapu MM, Othman SF, Curtis ET, et al: Curcumin-loaded magnetic nanoparticles for breast cancer therapeutics and imaging applications. Int J Nanomed. 7:1761–1779. 2012.PubMed/NCBI

53. 

Tsai SC, Yang JS, Peng SF, et al: Bufalin increases sensitivity to AKT/mTOR-induced autophagic cell death in SK-HEP-1 human hepatocellular carcinoma cells. Int J Oncol. 41:1431–1442. 2012.PubMed/NCBI

54. 

Mozaffarieh M, Konieczka K, Hauenstein D, Schoetzau A and Flammer J: Half a pack of cigarettes a day more than doubles DNA breaks in circulating leukocytes. Tob Induc Dis. 8:142010. View Article : Google Scholar : PubMed/NCBI

55. 

Kuo TC, Yang JS, Lin MW, et al: Emodin has cytotoxic and protective effects in rat C6 glioma cells: roles of Mdr1a and nuclear factor kappaB in cell survival. J Pharmacol Exp Ther. 330:736–744. 2009. View Article : Google Scholar : PubMed/NCBI

56. 

Huang WW, Tsai SC, Peng SF, et al: Kaempferol induces autophagy through AMPK and AKT signaling molecules and causes G2/M arrest via downregulation of CDK1/cyclin B in SK-HEP-1 human hepatic cancer cells. Int J Oncol. 42:2069–2077. 2013.PubMed/NCBI

57. 

Lan YH, Chiang JH, Huang WW, et al: Activations of both extrinsic and intrinsic pathways in HCT 116 human colorectal cancer cells contribute to apoptosis through p53-mediated ATM/Fas signaling by Emilia sonchifolia extract, a folklore medicinal plant. Evid Based Complement Alternat Med. 2012:1781782012.PubMed/NCBI

58. 

Lin C, Tsai SC, Tseng MT, et al: AKT serine/threonine protein kinase modulates baicalin-triggered autophagy in human bladder cancer T24 cells. Int J Oncol. 42:993–1000. 2013.

59. 

Taurin S, Nehoff H, Diong J, Larsen L, Rosengren RJ and Greish K: Curcumin-derivative nanomicelles for the treatment of triple negative breast cancer. J Drug Target. May 16–2013.(Epub ahead of print).

60. 

Yen FL, Wu TH, Tzeng CW, Lin LT and Lin CC: Curcumin nanoparticles improve the physicochemical properties of curcumin and effectively enhance its antioxidant and antihepatoma activities. J Agric Food Chem. 58:7376–7382. 2010. View Article : Google Scholar : PubMed/NCBI

61. 

Anand P, Kunnumakkara AB, Newman RA and Aggarwal BB: Bioavailability of curcumin: problems and promises. Mol Pharm. 4:807–818. 2007. View Article : Google Scholar : PubMed/NCBI

62. 

Yallapu MM, Dobberpuhl MR, Maher DM, Jaggi M and Chauhan SC: Design of curcumin loaded cellulose nanoparticles for prostate cancer. Curr Drug Metab. 13:120–128. 2012. View Article : Google Scholar : PubMed/NCBI

63. 

Yin HT, Zhang DG, Wu XL, Huang XE and Chen G: In vivo evaluation of curcumin-loaded nanoparticles in a A549 xenograft mice model. Asian Pac J Cancer Prev. 14:409–412. 2013. View Article : Google Scholar : PubMed/NCBI

64. 

Misra R and Sahoo SK: Coformulation of doxorubicin and curcumin in poly(D,L-lactide-co-glycolide) nanoparticles suppresses the development of multidrug resistance in K562 cells. Mol Pharm. 8:852–866. 2011. View Article : Google Scholar : PubMed/NCBI

65. 

Pramanik D, Campbell NR, Das S, et al: A composite polymer nanoparticle overcomes multidrug resistance and ameliorates doxorubicin-associated cardiomyopathy. Oncotarget. 3:640–650. 2012.

66. 

Ganta S, Devalapally H and Amiji M: Curcumin enhances oral bioavailability and anti-tumor therapeutic efficacy of paclitaxel upon administration in nanoemulsion formulation. J Pharm Sci. 99:4630–4641. 2010. View Article : Google Scholar : PubMed/NCBI

67. 

Ganta S and Amiji M: Coadministration of Paclitaxel and curcumin in nanoemulsion formulations to overcome multidrug resistance in tumor cells. Mol Pharm. 6:928–939. 2009. View Article : Google Scholar : PubMed/NCBI

68. 

Punfa W, Yodkeeree S, Pitchakarn P, Ampasavate C and Limtrakul P: Enhancement of cellular uptake and cytotoxicity of curcumin-loaded PLGA nanoparticles by conjugation with anti-P-glycoprotein in drug resistance cancer cells. Acta Pharmacol Sin. 33:823–831. 2012. View Article : Google Scholar : PubMed/NCBI

69. 

Cort A, Ozdemir E, Timur M and Ozben T: Effects of curcumin on bleomycininduced oxidative stress in malignant testicular germ cell tumors. Mol Med Rep. 6:860–866. 2012.PubMed/NCBI

70. 

Misra J, Chanda D, Kim DK, et al: Curcumin differentially regulates endoplasmic reticulum stress through transcriptional corepressor SMILE (small heterodimer partner-interacting leucine zipper protein)-mediated inhibition of CREBH (cAMP responsive element-binding protein H). J Biol Chem. 286:41972–41984. 2011. View Article : Google Scholar

71. 

Wahl H, Tan L, Griffith K, Choi M and Liu JR: Curcumin enhances Apo2L/TRAIL-induced apoptosis in chemoresistant ovarian cancer cells. Gynecol Oncol. 105:104–112. 2007. View Article : Google Scholar : PubMed/NCBI

72. 

Dilnawaz F, Singh A and Sahoo SK: Transferrin-conjugated curcumin-loaded superparamagnetic iron oxide nanoparticles induce augmented cellular uptake and apoptosis in K562 cells. Acta Biomater. 8:704–719. 2012. View Article : Google Scholar

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Spandidos Publications style
Chang P, Peng S, Lee C, Lu C, Tsai S, Shieh T, Wu T, Tu M, Chen MY, Yang J, Yang J, et al: Curcumin-loaded nanoparticles induce apoptotic cell death through regulation of the function of MDR1 and reactive oxygen species in cisplatin-resistant CAR human oral cancer cells. Int J Oncol 43: 1141-1150, 2013.
APA
Chang, P., Peng, S., Lee, C., Lu, C., Tsai, S., Shieh, T. ... Yang, J. (2013). Curcumin-loaded nanoparticles induce apoptotic cell death through regulation of the function of MDR1 and reactive oxygen species in cisplatin-resistant CAR human oral cancer cells. International Journal of Oncology, 43, 1141-1150. https://doi.org/10.3892/ijo.2013.2050
MLA
Chang, P., Peng, S., Lee, C., Lu, C., Tsai, S., Shieh, T., Wu, T., Tu, M., Chen, M. Y., Yang, J."Curcumin-loaded nanoparticles induce apoptotic cell death through regulation of the function of MDR1 and reactive oxygen species in cisplatin-resistant CAR human oral cancer cells". International Journal of Oncology 43.4 (2013): 1141-1150.
Chicago
Chang, P., Peng, S., Lee, C., Lu, C., Tsai, S., Shieh, T., Wu, T., Tu, M., Chen, M. Y., Yang, J."Curcumin-loaded nanoparticles induce apoptotic cell death through regulation of the function of MDR1 and reactive oxygen species in cisplatin-resistant CAR human oral cancer cells". International Journal of Oncology 43, no. 4 (2013): 1141-1150. https://doi.org/10.3892/ijo.2013.2050
Copy and paste a formatted citation
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Spandidos Publications style
Chang P, Peng S, Lee C, Lu C, Tsai S, Shieh T, Wu T, Tu M, Chen MY, Yang J, Yang J, et al: Curcumin-loaded nanoparticles induce apoptotic cell death through regulation of the function of MDR1 and reactive oxygen species in cisplatin-resistant CAR human oral cancer cells. Int J Oncol 43: 1141-1150, 2013.
APA
Chang, P., Peng, S., Lee, C., Lu, C., Tsai, S., Shieh, T. ... Yang, J. (2013). Curcumin-loaded nanoparticles induce apoptotic cell death through regulation of the function of MDR1 and reactive oxygen species in cisplatin-resistant CAR human oral cancer cells. International Journal of Oncology, 43, 1141-1150. https://doi.org/10.3892/ijo.2013.2050
MLA
Chang, P., Peng, S., Lee, C., Lu, C., Tsai, S., Shieh, T., Wu, T., Tu, M., Chen, M. Y., Yang, J."Curcumin-loaded nanoparticles induce apoptotic cell death through regulation of the function of MDR1 and reactive oxygen species in cisplatin-resistant CAR human oral cancer cells". International Journal of Oncology 43.4 (2013): 1141-1150.
Chicago
Chang, P., Peng, S., Lee, C., Lu, C., Tsai, S., Shieh, T., Wu, T., Tu, M., Chen, M. Y., Yang, J."Curcumin-loaded nanoparticles induce apoptotic cell death through regulation of the function of MDR1 and reactive oxygen species in cisplatin-resistant CAR human oral cancer cells". International Journal of Oncology 43, no. 4 (2013): 1141-1150. https://doi.org/10.3892/ijo.2013.2050
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