|
1.
|
Bray SJ: Notch signalling: a simple
pathway becomes complex. Nat Rev Mol Cell Biol. 7:678–689. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
2.
|
Radtke F and Raj K: The role of Notch in
tumorigenesis: oncogene or tumour suppressor? Nat Rev Cancer.
3:756–767. 2003. View
Article : Google Scholar : PubMed/NCBI
|
|
3.
|
Benedito R, Roca C, Sorensen I, et al: The
notch ligands Dll4 and Jagged1 have opposing effects on
angiogenesis. Cell. 137:1124–1135. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
4.
|
Fre S, Huyghe M, Mourikis P, Robine S,
Louvard D and Artavanis-Tsakonas S: Notch signals control the fate
of immature progenitor cells in the intestine. Nature. 435:964–968.
2005. View Article : Google Scholar : PubMed/NCBI
|
|
5.
|
Schroder N and Gossler A: Expression of
Notch pathway components in fetal and adult mouse small intestine.
Gene Expr Patterns. 2:247–250. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
6.
|
Jensen J, Pedersen EE, Galante P, et al:
Control of endodermal endocrine development by Hes-1. Nat Genet.
24:36–44. 2000. View
Article : Google Scholar : PubMed/NCBI
|
|
7.
|
Riccio O, van Gijn ME, Bezdek AC, et al:
Loss of intestinal crypt progenitor cells owing to inactivation of
both Notch1 and Notch2 is accompanied by derepression of CDK
inhibitors p27Kip1 and p57Kip2. EMBO Rep. 9:377–383. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
8.
|
Qiao L and Wong BC: Role of Notch
signaling in colorectal cancer. Carcinogenesis. 30:1979–1986. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
9.
|
Zhang Y, Li B, Ji ZZ and Zheng PS: Notch1
regulates the growth of human colon cancers. Cancer. 116:5207–5218.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
10.
|
Zolkiewska A: ADAM proteases: ligand
processing and modulation of the Notch pathway. Cell Mol Life Sci.
65:2056–2068. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
11.
|
Fortini ME: Gamma-secretase-mediated
proteolysis in cell-surface-receptor signalling. Nat Rev Mol Cell
Biol. 3:673–684. 2002. View
Article : Google Scholar : PubMed/NCBI
|
|
12.
|
Katoh M and Katoh M: Integrative genomic
analyses on HES/HEY family: Notch-independent HES1, HES3
transcription in undifferentiated ES cells, and Notch-dependent
HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult
tissues, or cancer. Int J Oncol. 31:461–466. 2007.PubMed/NCBI
|
|
13.
|
Chu IM, Hengst L and Slingerland JM: The
Cdk inhibitor p27 in human cancer: prognostic potential and
relevance to anti-cancer therapy. Nat Rev Cancer. 8:253–267. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
14.
|
Lu Z and Hunter T: Ubiquitylation and
proteasomal degradation of the p21(Cip1), p27(Kip1) and p57(Kip2)
CDK inhibitors. Cell Cycle. 9:2342–2352. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
15.
|
Kamura T, Hara T, Matsumoto M, et al:
Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1)
at G1 phase. Nat Cell Biol. 6:1229–1235. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
16.
|
Ishida N, Hara T, Kamura T, Yoshida M,
Nakayama K and Nakayama KI: Phosphorylation of p27Kip1 on serine 10
is required for its binding to CRM1 and nuclear export. J Biol
Chem. 277:14355–14358. 2002. View Article : Google Scholar
|
|
17.
|
Castro F, Dirks WG, Fahnrich S,
Hotz-Wagenblatt A, Pawlita M and Schmitt M: High-throughput
SNP-based authentication of human cell lines. Int J Cancer.
132:308–314. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
18.
|
Schmitt M and Pawlita M: High-throughput
detection and multiplex identification of cell contaminations.
Nucleic Acids Res. 37:e1192009. View Article : Google Scholar : PubMed/NCBI
|
|
19.
|
Sikandar SS, Pate KT, Anderson S, et al:
NOTCH signaling is required for formation and self-renewal of
tumor-initiating cells and for repression of secretory cell
differentiation in colon cancer. Cancer Res. 70:1469–1478. 2010.
View Article : Google Scholar
|
|
20.
|
Sarmento LM, Huang H, Limon A, et al:
Notch1 modulates timing of G1-S progression by inducing SKP2
transcription and p27 Kip1 degradation. J Exp Med. 202:157–168.
2005. View Article : Google Scholar : PubMed/NCBI
|
|
21.
|
Sharma VM, Calvo JA, Draheim KM, et al:
Notch1 contributes to mouse T-cell leukemia by directly inducing
the expression of c-myc. Mol Cell Biol. 26:8022–8031. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
22.
|
Weng AP, Millholland JM, Yashiro-Ohtani Y,
et al: c-Myc is an important direct target of Notch1 in T-cell
acute lymphoblastic leukemia/lymphoma. Genes Dev. 20:2096–2109.
2006. View Article : Google Scholar : PubMed/NCBI
|
|
23.
|
Palomero T, Sulis ML, Cortina M, et al:
Mutational loss of PTEN induces resistance to NOTCH1 inhibition in
T-cell leukemia. Nat Med. 13:1203–1210. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
24.
|
Klinakis A, Szabolcs M, Politi K, Kiaris
H, Artavanis-Tsakonas S and Efstratiadis A: Myc is a Notch1
transcriptional target and a requisite for Notch1-induced mammary
tumorigenesis in mice. Proc Natl Acad Sci USA. 103:9262–9267. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
25.
|
Ling H, Sylvestre JR and Jolicoeur P:
Notch1-induced mammary tumor development is cyclin D1-dependent and
correlates with expansion of pre-malignant multipotent duct-limited
progenitors. Oncogene. 29:4543–4554. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
26.
|
Cohen B, Shimizu M, Izrailit J, et al:
Cyclin D1 is a direct target of JAG1-mediated Notch signaling in
breast cancer. Breast Cancer Res Treat. 123:113–124. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
27.
|
Stahl M, Ge C, Shi S, Pestell RG and
Stanley P: Notch1-induced transformation of RKE-1 cells requires
up-regulation of cyclin D1. Cancer Res. 66:7562–7570. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
28.
|
Sicinska E, Aifantis I, Le Cam L, et al:
Requirement for cyclin D3 in lymphocyte development and T cell
leukemias. Cancer Cell. 4:451–461. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
29.
|
Ronchini C and Capobianco AJ: Induction of
cyclin D1 transcription and CDK2 activity by Notch(ic): implication
for cell cycle disruption in transformation by Notch(ic). Mol Cell
Biol. 21:5925–5934. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
30.
|
Gotte M, Greve B, Kelsch R, et al: The
adult stem cell marker Musashi-1 modulates endometrial carcinoma
cell cycle progression and apoptosis via Notch-1 and p21WAF1/CIP1.
Int J Cancer. 129:2042–2049. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
31.
|
Dohda T, Maljukova A, Liu L, et al: Notch
signaling induces SKP2 expression and promotes reduction of p27Kip1
in T-cell acute lymphoblastic leukemia cell lines. Exp Cell Res.
313:3141–3152. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
32.
|
Hara T, Kamura T, Kotoshiba S, et al: Role
of the UBL-UBA protein KPC2 in degradation of p27 at G1 phase of
the cell cycle. Mol Cell Biol. 25:9292–9303. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
33.
|
Lu Y, Adegoke OA, Nepveu A, et al: USP19
deubiquitinating enzyme supports cell proliferation by stabilizing
KPC1, a ubiquitin ligase for p27Kip1. Mol Cell Biol. 29:547–558.
2009. View Article : Google Scholar : PubMed/NCBI
|
|
34.
|
Zhao J, Zhang S, Wu X, et al: KPC1
expression and essential role after acute spinal cord injury in
adult rat. Neurochem Res. 36:549–558. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
35.
|
Lu C, Huang X, Zhang X, et al: miR-221 and
miR-155 regulate human dendritic cell development, apoptosis, and
IL-12 production through targeting of p27kip1, KPC1, and SOCS-1.
Blood. 117:4293–4303. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
36.
|
Susaki E, Nakayama K and Nakayama KI:
Cyclin D2 translocates p27 out of the nucleus and promotes its
degradation at the G0-G1 transition. Mol Cell Biol. 27:4626–4640.
2007. View Article : Google Scholar : PubMed/NCBI
|
|
37.
|
Giovannini C, Gramantieri L, Minguzzi M,
et al: CDKN1C/P57 is regulated by the Notch target gene Hes1 and
induces senescence in human hepatocellular carcinoma. Am J Pathol.
181:413–422. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
38.
|
See WL, Heinberg AR, Holland EC and Resh
MD: p27 deficiency is associated with migration defects in
PDGF-expressing gliomas in vivo. Cell Cycle. 9:1562–1567. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
39.
|
Wander SA, Zhao D and Slingerland JM: p27:
a barometer of signaling deregulation and potential predictor of
response to targeted therapies. Clin Cancer Res. 17:12–18. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
40.
|
Noguchi T, Kikuchi R, Ono K, Takeno S,
Moriyama H and Uchida Y: Prognostic significance of p27/kip1 and
apoptosis in patients with colorectal carcinoma. Oncol Rep.
10:827–831. 2003.PubMed/NCBI
|
|
41.
|
Manne U, Jhala NC, Jones J, et al:
Prognostic significance of p27(kip-1) expression in colorectal
adenocarcinomas is associated with tumor stage. Clin Cancer Res.
10:1743–1752. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
42.
|
Wu JT, Kakar S, Nelson RL, et al:
Prognostic significance of DCC and p27Kip1 in colorectal cancer.
Appl Immunohistochem Mol Morphol. 13:45–54. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
43.
|
Rosati G, Chiacchio R, Reggiardo G, De
Sanctis D and Manzione L: Thymidylate synthase expression, p53,
bcl-2, Ki-67 and p27 in colorectal cancer: relationships with tumor
recurrence and survival. Tumour Biol. 25:258–263. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
44.
|
Watson NF, Durrant LG, Scholefield JH, et
al: Cytoplasmic expression of p27(kip1) is associated with a
favourable prognosis in colorectal cancer patients. World J
Gastroenterol. 12:6299–6304. 2006.PubMed/NCBI
|
|
45.
|
Gysin S, Lee SH, Dean NM and McMahon M:
Pharmacologic inhibition of RAF→MEK→ERK signaling elicits
pancreatic cancer cell cycle arrest through induced expression of
p27Kip1. Cancer Res. 65:4870–4880. 2005.
|
|
46.
|
Hong F, Larrea MD, Doughty C, Kwiatkowski
DJ, Squillace R and Slingerland JM: mTOR-raptor binds and activates
SGK1 to regulate p27 phosphorylation. Mol Cell. 30:701–711. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
47.
|
Fassl A, Tagscherer KE, Richter J, et al:
Notch1 signaling promotes survival of glioblastoma cells via
EGFR-mediated induction of anti-apoptotic Mcl-1. Oncogene.
31:4698–4708. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
48.
|
Liu WH, Hsiao HW, Tsou WI and Lai MZ:
Notch inhibits apoptosis by direct interference with XIAP
ubiquitination and degradation. EMBO J. 26:1660–1669. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
49.
|
Beverly LJ, Felsher DW and Capobianco AJ:
Suppression of p53 by Notch in lymphomagenesis: implications for
initiation and regression. Cancer Res. 65:7159–7168. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
50.
|
Meng RD, Shelton CC, Li YM, et al:
gamma-Secretase inhibitors abrogate oxaliplatin-induced activation
of the Notch-1 signaling pathway in colon cancer cells resulting in
enhanced chemosensitivity. Cancer Res. 69:573–582. 2009. View Article : Google Scholar
|
|
51.
|
Akiyoshi T, Nakamura M, Yanai K, et al:
Gamma-secretase inhibitors enhance taxane-induced mitotic arrest
and apoptosis in colon cancer cells. Gastroenterology. 134:131–144.
2008. View Article : Google Scholar : PubMed/NCBI
|
|
52.
|
Pannuti A, Foreman K, Rizzo P, et al:
Targeting Notch to target cancer stem cells. Clin Cancer Res.
16:3141–3152. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
53.
|
Real PJ, Tosello V, Palomero T, et al:
Gamma-secretase inhibitors reverse glucocorticoid resistance in T
cell acute lymphoblastic leukemia. Nat Med. 15:50–58. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
54.
|
Van Es JH, van Gijn ME, Riccio O, et al:
Notch/gamma-secretase inhibition turns proliferative cells in
intestinal crypts and adenomas into goblet cells. Nature.
435:959–963. 2005.PubMed/NCBI
|
|
55.
|
Wu Y, Cain-Hom C, Choy L, et al:
Therapeutic antibody targeting of individual Notch receptors.
Nature. 464:1052–1057. 2010. View Article : Google Scholar : PubMed/NCBI
|
