Cell division cycle-associated protein 1 overexpression is essential for the malignant potential of colorectal cancers

  • Authors:
    • Yu Kobayashi
    • Atsushi Takano
    • Yohei Miyagi
    • Eiju Tsuchiya
    • Hiromichi Sonoda
    • Tomoharu Shimizu
    • Hidetoshi Okabe
    • Toru Tani
    • Yoshihide Fujiyama
    • Yataro Daigo
  • View Affiliations

  • Published online on: November 15, 2013     https://doi.org/10.3892/ijo.2013.2177
  • Pages: 69-77
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Abstract

To identify new cancer biomarkers and therapeutic targets for colorectal cancers (CRCs), we performed immunohistochemical analysis using tissue microarrays covering archival tumor tissue samples from 434 CRC patients and antibodies to cell division cycle-associated protein 1 (CDCA1) that was originally identified as an oncoantigen by our gene expression profile database, and compared its expression with several clinicopathological factors. Strong CDCA1 positivity was associated with poorer prognosis for patients with CRC (P=0.019) and multivariate analysis confirmed its independent prognostic value. In addition, transfection of siRNAs against CDCA1 suppressed its expression and induced apoptosis of CRC cells. These results suggest that CDCA1 could be a prognostic biomarker and a potential therapeutic target for CRCs.
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2014-January
Volume 44 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Kobayashi Y, Takano A, Miyagi Y, Tsuchiya E, Sonoda H, Shimizu T, Okabe H, Tani T, Fujiyama Y, Daigo Y, Daigo Y, et al: Cell division cycle-associated protein 1 overexpression is essential for the malignant potential of colorectal cancers. Int J Oncol 44: 69-77, 2014
APA
Kobayashi, Y., Takano, A., Miyagi, Y., Tsuchiya, E., Sonoda, H., Shimizu, T. ... Daigo, Y. (2014). Cell division cycle-associated protein 1 overexpression is essential for the malignant potential of colorectal cancers. International Journal of Oncology, 44, 69-77. https://doi.org/10.3892/ijo.2013.2177
MLA
Kobayashi, Y., Takano, A., Miyagi, Y., Tsuchiya, E., Sonoda, H., Shimizu, T., Okabe, H., Tani, T., Fujiyama, Y., Daigo, Y."Cell division cycle-associated protein 1 overexpression is essential for the malignant potential of colorectal cancers". International Journal of Oncology 44.1 (2014): 69-77.
Chicago
Kobayashi, Y., Takano, A., Miyagi, Y., Tsuchiya, E., Sonoda, H., Shimizu, T., Okabe, H., Tani, T., Fujiyama, Y., Daigo, Y."Cell division cycle-associated protein 1 overexpression is essential for the malignant potential of colorectal cancers". International Journal of Oncology 44, no. 1 (2014): 69-77. https://doi.org/10.3892/ijo.2013.2177