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International Journal of Oncology
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2014-March Volume 44 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article

Upregulation of the Kank1 gene-induced brain glioma apoptosis and blockade of the cell cycle in G0/G1 phase

  • Authors:
    • Xiaohang Guo
    • Wenhai Fan
    • Xinchao Bian
    • Dihui Ma
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, The First Hospital of Jilin University, Changchun 130021, P.R. China, Department of Neurosurgery, The Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, P.R. China, Department of Neurosurgery, Zibo Central Hospital, Zibo 255000, P.R. China
  • Pages: 797-804
    |
    Published online on: January 8, 2014
       https://doi.org/10.3892/ijo.2014.2247
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Abstract

The Kank1 gene is one of the important members of the Kank gene family. As an important adaptor protein, Kank1 plays a significant role in the genesis and development of many malignant tumors. It was recently discovered that the Kank1 gene is a new cancer suppressor, and its expression is significantly downregulated or it is not expressed in kidney cancer, bladder cancer, prostate cancer, lung cancer and breast cancer. However, no report on the role of Kank1 in the genesis of brain glioma is available to date. In this study, we found significantly lower expression of the Kank1 gene in human brain glioma cells compared to the other cells evaluated. We used RNA interference techniques to silence Kank1 gene expression and found acceleration of tumor cell proliferation. However, when the Kank1 gene was upregulated, cell apoptosis occurred and the cell cycle was blocked in the G0/G1 phase. Also, we found that upregulating the Kank1 gene may result in the change of mitochondrial membrane potential, and the regulation of Bax and Bcl-2 may promote the mitochondria to release cytochrome C so as to activate Caspase-9 and -3. Thus, the human brain glioma apoptosis induced by upregulation of the Kank1 gene is closely relevant to the mitochondrial pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Guo X, Fan W, Bian X and Ma D: Upregulation of the Kank1 gene-induced brain glioma apoptosis and blockade of the cell cycle in G0/G1 phase. Int J Oncol 44: 797-804, 2014.
APA
Guo, X., Fan, W., Bian, X., & Ma, D. (2014). Upregulation of the Kank1 gene-induced brain glioma apoptosis and blockade of the cell cycle in G0/G1 phase. International Journal of Oncology, 44, 797-804. https://doi.org/10.3892/ijo.2014.2247
MLA
Guo, X., Fan, W., Bian, X., Ma, D."Upregulation of the Kank1 gene-induced brain glioma apoptosis and blockade of the cell cycle in G0/G1 phase". International Journal of Oncology 44.3 (2014): 797-804.
Chicago
Guo, X., Fan, W., Bian, X., Ma, D."Upregulation of the Kank1 gene-induced brain glioma apoptosis and blockade of the cell cycle in G0/G1 phase". International Journal of Oncology 44, no. 3 (2014): 797-804. https://doi.org/10.3892/ijo.2014.2247
Copy and paste a formatted citation
x
Spandidos Publications style
Guo X, Fan W, Bian X and Ma D: Upregulation of the Kank1 gene-induced brain glioma apoptosis and blockade of the cell cycle in G0/G1 phase. Int J Oncol 44: 797-804, 2014.
APA
Guo, X., Fan, W., Bian, X., & Ma, D. (2014). Upregulation of the Kank1 gene-induced brain glioma apoptosis and blockade of the cell cycle in G0/G1 phase. International Journal of Oncology, 44, 797-804. https://doi.org/10.3892/ijo.2014.2247
MLA
Guo, X., Fan, W., Bian, X., Ma, D."Upregulation of the Kank1 gene-induced brain glioma apoptosis and blockade of the cell cycle in G0/G1 phase". International Journal of Oncology 44.3 (2014): 797-804.
Chicago
Guo, X., Fan, W., Bian, X., Ma, D."Upregulation of the Kank1 gene-induced brain glioma apoptosis and blockade of the cell cycle in G0/G1 phase". International Journal of Oncology 44, no. 3 (2014): 797-804. https://doi.org/10.3892/ijo.2014.2247
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