Open Access

The roles of transforming growth factor-β, Wnt, Notch and hypoxia on liver progenitor cells in primary liver tumours (Review)

  • Authors:
    • Eliene Bogaerts
    • Femke Heindryckx
    • Yves-Paul Vandewynckel
    • Leo A. Van Grunsven
    • Hans Van Vlierberghe
  • View Affiliations

  • Published online on: February 3, 2014     https://doi.org/10.3892/ijo.2014.2286
  • Pages: 1015-1022
  • Copyright: © Bogaerts et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

Primary liver tumours have a high incidence and mortality. The most important forms are hepatocellular carcinoma and intrahepatic cholangiocarcinoma, both can occur together in the mixed phenotype hepatocellular-cholangiocarcinoma. Liver progenitor cells (LPCs) are bipotential stem cells activated in case of severe liver damage and are capable of forming both cholangiocytes and hepatocytes. Possibly, alterations in Wnt, transforming growth factor-β, Notch and hypoxia pathways in these LPCs can cause them to give rise to cancer stem cells, capable of driving tumourigenesis. In this review, we summarize and discuss current knowledge on the role of these pathways in LPC activation and differentiation during hepatocarcinogenesis.
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2014-April
Volume 44 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Bogaerts E, Heindryckx F, Vandewynckel Y, Van Grunsven LA and Van Vlierberghe H: The roles of transforming growth factor-β, Wnt, Notch and hypoxia on liver progenitor cells in primary liver tumours (Review). Int J Oncol 44: 1015-1022, 2014.
APA
Bogaerts, E., Heindryckx, F., Vandewynckel, Y., Van Grunsven, L.A., & Van Vlierberghe, H. (2014). The roles of transforming growth factor-β, Wnt, Notch and hypoxia on liver progenitor cells in primary liver tumours (Review). International Journal of Oncology, 44, 1015-1022. https://doi.org/10.3892/ijo.2014.2286
MLA
Bogaerts, E., Heindryckx, F., Vandewynckel, Y., Van Grunsven, L. A., Van Vlierberghe, H."The roles of transforming growth factor-β, Wnt, Notch and hypoxia on liver progenitor cells in primary liver tumours (Review)". International Journal of Oncology 44.4 (2014): 1015-1022.
Chicago
Bogaerts, E., Heindryckx, F., Vandewynckel, Y., Van Grunsven, L. A., Van Vlierberghe, H."The roles of transforming growth factor-β, Wnt, Notch and hypoxia on liver progenitor cells in primary liver tumours (Review)". International Journal of Oncology 44, no. 4 (2014): 1015-1022. https://doi.org/10.3892/ijo.2014.2286