The pterocarpanquinone LQB-118 induces apoptosis in acute myeloid leukemia cells of distinct molecular subtypes and targets FoxO3a and FoxM1 transcription factors

Corrigendum in: /10.3892/ijo.2019.4874

  • Authors:
    • Gabriela Nestal de Moraes
    • Carolina Pereira Castro
    • Eduardo Jesus Salustiano
    • Matheus Lourenço Dumas
    • Fernanda Costas
    • Eric Wing-Fai Lam
    • Paulo Roberto Ribeiro Costa
    • Raquel Ciuvalschi Maia
  • View Affiliations

  • Published online on: August 21, 2014     https://doi.org/10.3892/ijo.2014.2615
  • Pages: 1949-1958
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Abstract

Acute myeloid leukemia (AML) patients' outcome is usually poor, mainly because of drug resistance phenotype. The identification of new drugs able to overcome mechanisms of chemoresistance is essential. The pterocarpanquinone LQB-118 compound has been shown to have a potent cytotoxic activity in myeloid leukemia cell lines and patient cells. Our aim was to investigate if LQB-118 is able to target FoxO3a and FoxM1 signaling pathways while sensitizing AML cell lines. LQB-118 induced apoptosis in both AML cell lines HL60 (M3 FAB subtype) and U937 (M4/M5 FAB subtype). Cell death occurred independently of alterations in cell cycle distribution. In vivo administration revealed that LQB-118 was not cytotoxic to normal bone marrow-derived cells isolated from mice. LQB-118 induced FoxO3a nuclear translocation and upregulation of its direct transcriptional target Bim, in HL60 cells. However, LQB-118 induced FoxO3a nuclear exclusion, followed by Bim downregulation, in U937 cells. Concomitantly, LQB-118 exposure reduced FoxM1 and Survivin expression in U937 cells, but this effect was more subtle in HL60 cells. Taken together, our data suggest that LQB-118 has a selective and potent antitumor activity against AML cells with distinct molecular subtypes, and it involves differential modulation of the signaling pathways associated with FoxO3a and FoxM1 transcription factors.
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November-2014
Volume 45 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Nestal de Moraes G, Castro CP, Salustiano EJ, Dumas ML, Costas F, Lam EW, Costa PR and Maia RC: The pterocarpanquinone LQB-118 induces apoptosis in acute myeloid leukemia cells of distinct molecular subtypes and targets FoxO3a and FoxM1 transcription factors Corrigendum in /10.3892/ijo.2019.4874. Int J Oncol 45: 1949-1958, 2014
APA
Nestal de Moraes, G., Castro, C.P., Salustiano, E.J., Dumas, M.L., Costas, F., Lam, E.W. ... Maia, R.C. (2014). The pterocarpanquinone LQB-118 induces apoptosis in acute myeloid leukemia cells of distinct molecular subtypes and targets FoxO3a and FoxM1 transcription factors Corrigendum in /10.3892/ijo.2019.4874. International Journal of Oncology, 45, 1949-1958. https://doi.org/10.3892/ijo.2014.2615
MLA
Nestal de Moraes, G., Castro, C. P., Salustiano, E. J., Dumas, M. L., Costas, F., Lam, E. W., Costa, P. R., Maia, R. C."The pterocarpanquinone LQB-118 induces apoptosis in acute myeloid leukemia cells of distinct molecular subtypes and targets FoxO3a and FoxM1 transcription factors Corrigendum in /10.3892/ijo.2019.4874". International Journal of Oncology 45.5 (2014): 1949-1958.
Chicago
Nestal de Moraes, G., Castro, C. P., Salustiano, E. J., Dumas, M. L., Costas, F., Lam, E. W., Costa, P. R., Maia, R. C."The pterocarpanquinone LQB-118 induces apoptosis in acute myeloid leukemia cells of distinct molecular subtypes and targets FoxO3a and FoxM1 transcription factors Corrigendum in /10.3892/ijo.2019.4874". International Journal of Oncology 45, no. 5 (2014): 1949-1958. https://doi.org/10.3892/ijo.2014.2615