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Article

Chronic exposure to asbestos enhances TGF-β1 production in the human adult T cell leukemia virus-immortalized T cell line MT-2

  • Authors:
    • Megumi Maeda
    • Ying Chen
    • Hiroaki Hayashi
    • Naoko Kumagai-Takei
    • Hidenori Matsuzaki
    • Suni Lee
    • Yasumitsu Nishimura
    • Takemi Otsuki
  • View Affiliations / Copyright

    Affiliations: Department of Biofunctional Chemistry, Graduate School of Environmental and Life Science, Okayama University, Okayama 7008530, Japan, Department of Hygiene, Kawasaki Medical School, Kurashiki, Okayama 7010192, Japan
  • Pages: 2522-2532
    |
    Published online on: September 29, 2014
       https://doi.org/10.3892/ijo.2014.2682
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Abstract

Asbestos exposure causes various tumors such as lung cancer and malignant mesothelioma. To elucidate the immunological alteration in asbestos-related tumors, an asbestos-induced apoptosis-resistant subline (MT-2Rst) was established from a human adult T cell leukemia virus-immortalized T cell line (MT-2Org) by long-term exposure to asbestos chrysotile-B (CB). In this study, transforming growth factor-β1 (TGF-β1) knockdown using lentiviral vector-mediated RNA interference showed that MT-2Rst cells secreted increased levels of TGF-β1, and acquired resistance to TGF-β1-mediated growth inhibition. We showed that exposure of MT-2Org cells to CB activated the mitogen-activated protein kinases (MAPKs), ERK1/2, p38 and JNK1. Furthermore, TGF-β1-knockdown cells and treatment with MAPK inhibitors revealed that MT-2Rst cells secreted a high level of TGF-β1 mainly through phosphorylation of p38. However, an Annexin V assay indicated that TGF-β1 resistance in MT-2Rst cells was not directly involved in the acquisition of resistance to apoptosis that is triggered by CB exposure. The overall results demonstrate that long-term exposure of MT-2Org cells to CB induces a regulatory T cell-like phenotype, suggesting that chronic exposure to asbestos leads to a state of immune suppression.
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1 

Pan XL, Day HW, Wang W, Beckett LA and Schenker MB: Residential proximity to naturally occurring asbestos and mesothelioma risk in California. Am J Respir Crit Care Med. 172:1019–1025. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Kurumatani N and Kumagai S: Mapping the risk of mesothelioma due to neighborhood asbestos exposure. Am J Respir Crit Care Med. 178:624–629. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Heintz NH, Janssen-Heininger YM and Mossman BT: Asbestos, lung cancers, and mesotheliomas: from molecular approaches to targeting tumor survival pathways. Am J Respir Cell Mol Biol. 42:133–139. 2010. View Article : Google Scholar : PubMed/NCBI

4 

LaDou J, Castleman B, Frank A, et al: The case for a global ban on asbestos. Environ Health Perspect. 118:897–901. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Ueki A, Yamaguchi M, Ueki H, et al: Polyclonal human T-cell activation by silicate in vitro. Immunology. 82:332–335. 1994.PubMed/NCBI

6 

Aikoh T, Tomokuni A, Matsukii T, et al: Activation-induced cell death in human peripheral blood lymphocytes after stimulation with silicate in vitro. Int J Oncol. 12:1355–1359. 1998.

7 

Nishimura Y, Miura Y, Maeda M, et al: Impairment in cytotoxicity and expression of NK cell- activating receptors on human NK cells following exposure to asbestos fibers. Int J Immunopathol Pharmacol. 22:579–590. 2009.

8 

Nishimura Y, Maeda M, Kumagai N, Hayashi H, Miura Y and Otsuki T: Decrease in phosphorylation of ERK following decreased expression of NK cell-activating receptors in human NK cell line exposed to asbestos. Int J Immunopathol Pharmacol. 22:879–888. 2009.PubMed/NCBI

9 

Kumagai-Takei N, Nishimura Y, Maeda M, et al: Effect of asbestos exposure on differentiation of cytotoxic T lymphocytes in mixed lymphocyte reaction of human peripheral blood mononuclear cells. Am J Respir Cell Mol Biol. 49:28–36. 2013. View Article : Google Scholar

10 

Nishimura Y, Maeda M, Kumagai-Takei N, et al: Altered functions of alveolar macrophages and NK cells involved in asbestos-related diseases. Environ Health Prev Med. 18:198–204. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Miyoshi I, Kubonishi I, Yoshimoto S, et al: Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells. Nature. 294:770–771. 1981. View Article : Google Scholar : PubMed/NCBI

12 

Maeda M, Miura Y, Nishimura Y, et al: Immunological changes in mesothelioma patients and their experimental detection. Clin Med Circ Respirat Pulm Med. 2:11–17. 2008.PubMed/NCBI

13 

Hyodoh F, Takata-Tomokuni A, Miura Y, et al: Inhibitory effects of anti-oxidants on apoptosis of a human polyclonal T-cell line, MT-2, induced by an asbestos, chrysotile-A. Scand J Immunol. 61:442–448. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Miura Y, Nishimura Y, Katsuyama H, et al: Involvement of IL-10 and Bcl-2 in resistance against an asbestos-induced apoptosis of T cells. Apoptosis. 11:1825–1835. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Nishimura Y, Miura Y, Maeda M, et al: Expression of the T cell receptor Vbeta repertoire in a human T cell resistant to asbestos-induced apoptosis and peripheral blood T cells from patients with silica and asbestos-related diseases. Int J Immunopathol Pharmacol. 19:795–805. 2006.

16 

Maeda M, Chen Y, Kumagai-Takei N, et al: Alteration of cytoskeletal molecules in a human T cell line caused by continuous exposure to chrysotile asbestos. Immunobiology. 218:1184–1191. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Maeda M, Yamamoto S, Chen Y, et al: Resistance to asbestos-induced apoptosis with continuous exposure to crocidolite on a human T cell. Sci Total Environ. 429:174–182. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Maeda M, Nishimura Y, Hayashi H, et al: Reduction of CXC chemokine receptor 3 in an in vitro model of continuous exposure to asbestos in a human T-cell line, MT-2. Am J Respir Cell Mol Biol. 45:470–479. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Maeda M, Nishimura Y, Hayashi H, et al: Decreased CXCR3 expression in CD4+ T cells exposed to asbestos or derived from asbestos-exposed patients. Am J Respir Cell Mol Biol. 795–803. 2011.

20 

Chen S, Ishii N, Ine S, et al: Regulatory T cell-like activity of Foxp3+ adult T cell leukemia cells. Int Immunol. 18:269–277. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Sakaguchi S, Miyara M, Costantino CM and Hafler DA: FOXP3+ regulatory T cells in the human immune system. Nat Rev Immunol. 10:490–500. 2010.

22 

Flavell RA, Sanjabi S, Wrzesinski SH and Licona-Limon P: The polarization of immune cells in the tumour environment by TGFbeta. Nat Rev Immunol. 554–567. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Kohyama N, Shinohara Y and Suzuki Y: Mineral phases and some reexamined characteristics of the International Union Against Cancer standard asbestos samples. Am J Ind Med. 30:515–528. 1996. View Article : Google Scholar : PubMed/NCBI

24 

Brummelkamp TR, Bernards R and Agami R: A system for stable expression of short interfering RNAs in mammalian cells. Science. 296:550–553. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Bridge AJ, Pebernard S, Ducraux A, Nicoulaz AL and Iggo R: Induction of an interferon response by RNAi vectors in mammalian cells. Nat Genet. 34:263–264. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Naldini L, Blomer U, Gallay P, et al: In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science. 272:263–267. 1996. View Article : Google Scholar : PubMed/NCBI

27 

Zufferey R, Nagy D, Mandel RJ, Naldini L and Trono D: Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo. Nat Biotechnol. 15:871–875. 1997. View Article : Google Scholar : PubMed/NCBI

28 

Arnulf B, Villemain A, Nicot C, et al: Human T-cell lymphotropic virus oncoprotein Tax represses TGF-beta 1 signaling in human T cells via c-Jun activation: a potential mechanism of HTLV-I leukemogenesis. Blood. 100:4129–4138. 2002. View Article : Google Scholar : PubMed/NCBI

29 

Li MO, Wan YY, Sanjabi S, Robertson AK and Flavell RA: Transforming growth factor-beta regulation of immune responses. Annu Rev Immunol. 24:99–146. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Zhang W and Liu HT: MAPK signal pathways in the regulation of cell proliferation in mammalian cells. Cell Res. 12:9–18. 2002. View Article : Google Scholar

31 

Letterio JJ: TGF-beta signaling in T cells: roles in lymphoid and epithelial neoplasia. Oncogene. 24:5701–5712. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Li L, Iwamoto Y, Berezovskaya A and Boussiotis VA: A pathway regulated by cell cycle inhibitor p27Kip1 and checkpoint inhibitor Smad3 is involved in the induction of T cell tolerance. Nat Immunol. 7:1157–1165. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Delisle JS, Giroux M, Boucher G, et al: The TGF-beta-Smad3 pathway inhibits CD28-dependenT cell growth and proliferation of CD4 T cells. Genes Immun. 14:115–126. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Yoshimura A, Wakabayashi Y and Mori T: Cellular and molecular basis for the regulation of inflammation by TGF-beta. J Biochem. 147:781–792. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Zhu H, Kavsak P, Abdollah S, Wrana JL and Thomsen GH: A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature. 400:687–693. 1999. View Article : Google Scholar : PubMed/NCBI

36 

Wrzesinski SH, Wan YY and Flavell RA: Transforming growth factor-beta and the immune response: implications for anticancer therapy. Clin Cancer Res. 13:5262–5270. 2007. View Article : Google Scholar : PubMed/NCBI

37 

Suzuki E, Kim S, Cheung HK, et al: A novel small-molecule inhibitor of transforming growth factor beta type I receptor kinase (SM16) inhibits murine mesothelioma tumor growth in vivo and prevents tumor recurrence after surgical resection. Cancer Res. 67:2351–2359. 2007. View Article : Google Scholar

38 

Zou W: Regulatory T cells, tumour immunity and immunotherapy. Nat Rev Immunol. 6:295–307. 2006. View Article : Google Scholar : PubMed/NCBI

39 

Fujii M, Toyoda T, Nakanishi H, et al: TGF-beta synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth. J Exp Med. 209:479–494. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Murakami S, Nishimura Y, Maeda M, et al: Cytokine alteration and speculated immunological pathophysiology in silicosis and asbestos-related diseases. Environ Health Prev Med. 14:216–222. 2009. View Article : Google Scholar : PubMed/NCBI

41 

Derynck R and Zhang YE: Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature. 425:577–584. 2003. View Article : Google Scholar : PubMed/NCBI

42 

Brown KA, Pietenpol JA and Moses HL: A tale of two proteins: differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling. J Cell Biochem. 101:9–33. 2007. View Article : Google Scholar : PubMed/NCBI

43 

Siegel PM and Massague J: Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer. Nat Rev Cancer. 3:807–821. 2003. View Article : Google Scholar : PubMed/NCBI

44 

Levy L and Hill CS: Alterations in components of the TGF-beta superfamily signaling pathways in human cancer. Cytokine Growth Factor Rev. 17:41–58. 2006. View Article : Google Scholar : PubMed/NCBI

45 

Xiao YQ, Freire-de-Lima CG, Schiemann WP, Bratton DL, Vandivier RW and Henson PM: Transcriptional and translational regulation of TGF-beta production in response to apoptotic cells. J Immunol. 181:3575–3585. 2008. View Article : Google Scholar : PubMed/NCBI

46 

Huber S, Schrader J, Fritz G, et al: P38 MAP kinase signaling is required for the conversion of CD4+CD25− T cells into iTreg. PLoS One. 3:e33022008. View Article : Google Scholar : PubMed/NCBI

47 

Calabro L, Morra A, Fonsatti E, et al: Tremelimumab for patients with chemotherapy-resistant advanced malignant mesothelioma: an open-label, single-arm, phase 2 trial. Lancet Oncol. 14:1104–1111. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Maeda M, Chen Y, Hayashi H, Kumagai-Takei N, Matsuzaki H, Lee S, Nishimura Y and Otsuki T: Chronic exposure to asbestos enhances TGF-β1 production in the human adult T cell leukemia virus-immortalized T cell line MT-2. Int J Oncol 45: 2522-2532, 2014.
APA
Maeda, M., Chen, Y., Hayashi, H., Kumagai-Takei, N., Matsuzaki, H., Lee, S. ... Otsuki, T. (2014). Chronic exposure to asbestos enhances TGF-β1 production in the human adult T cell leukemia virus-immortalized T cell line MT-2. International Journal of Oncology, 45, 2522-2532. https://doi.org/10.3892/ijo.2014.2682
MLA
Maeda, M., Chen, Y., Hayashi, H., Kumagai-Takei, N., Matsuzaki, H., Lee, S., Nishimura, Y., Otsuki, T."Chronic exposure to asbestos enhances TGF-β1 production in the human adult T cell leukemia virus-immortalized T cell line MT-2". International Journal of Oncology 45.6 (2014): 2522-2532.
Chicago
Maeda, M., Chen, Y., Hayashi, H., Kumagai-Takei, N., Matsuzaki, H., Lee, S., Nishimura, Y., Otsuki, T."Chronic exposure to asbestos enhances TGF-β1 production in the human adult T cell leukemia virus-immortalized T cell line MT-2". International Journal of Oncology 45, no. 6 (2014): 2522-2532. https://doi.org/10.3892/ijo.2014.2682
Copy and paste a formatted citation
x
Spandidos Publications style
Maeda M, Chen Y, Hayashi H, Kumagai-Takei N, Matsuzaki H, Lee S, Nishimura Y and Otsuki T: Chronic exposure to asbestos enhances TGF-β1 production in the human adult T cell leukemia virus-immortalized T cell line MT-2. Int J Oncol 45: 2522-2532, 2014.
APA
Maeda, M., Chen, Y., Hayashi, H., Kumagai-Takei, N., Matsuzaki, H., Lee, S. ... Otsuki, T. (2014). Chronic exposure to asbestos enhances TGF-β1 production in the human adult T cell leukemia virus-immortalized T cell line MT-2. International Journal of Oncology, 45, 2522-2532. https://doi.org/10.3892/ijo.2014.2682
MLA
Maeda, M., Chen, Y., Hayashi, H., Kumagai-Takei, N., Matsuzaki, H., Lee, S., Nishimura, Y., Otsuki, T."Chronic exposure to asbestos enhances TGF-β1 production in the human adult T cell leukemia virus-immortalized T cell line MT-2". International Journal of Oncology 45.6 (2014): 2522-2532.
Chicago
Maeda, M., Chen, Y., Hayashi, H., Kumagai-Takei, N., Matsuzaki, H., Lee, S., Nishimura, Y., Otsuki, T."Chronic exposure to asbestos enhances TGF-β1 production in the human adult T cell leukemia virus-immortalized T cell line MT-2". International Journal of Oncology 45, no. 6 (2014): 2522-2532. https://doi.org/10.3892/ijo.2014.2682
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