Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
January-2015 Volume 46 Issue 1

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2015 Volume 46 Issue 1

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Feasibility study of personalized peptide vaccination for advanced non-small cell lung cancer patients who failed two or more treatment regimens

  • Authors:
    • Teppei Yamada
    • Yasuhiro Terazaki
    • Shinjiro Sakamoto
    • Koichi Yoshiyama
    • Satoko Matsueda
    • Nobukazu Komatsu
    • Kayoko Waki
    • Akira Yamada
    • Akihiko Kawahara
    • Masayoshi Kage
    • Shunichi Sugawara
    • Yuichi Yamashita
    • Tetsuro Sasada
    • Shinzo Takamori
    • Kyogo Itoh
  • View Affiliations / Copyright

    Affiliations: Department of Immunology and Immunotherapy, Kurume University School of Medicine, Kurume, Fukuoka, Japan, Department of Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan, Research Center for Innovative Cancer Therapy, Kurume University, Kurume, Fukuoka, Japan, Department of Diagnostic Pathology, Kurume University Hospital, Kurume, Fukuoka, Japan, Department of Pulmonary Medicine, Sendai Kousei Hospital, Sendai, Miyagi, Japan, Department of Gastroenterological Surgery, Fukuoka University School of Medicine, Fukuoka, Japan
  • Pages: 55-62
    |
    Published online on: October 7, 2014
       https://doi.org/10.3892/ijo.2014.2699
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The prognosis of non-small cell lung cancer (NSCLC) patients who failed two or more treatment regimens remains very poor. We conducted a phase II study to explore the feasibility of personalized peptide vaccination (PPV), in which peptides are selected and administered based on the pre-existing host immunity before vaccination, as a third or more line treatment in advanced NSCLC patients who failed two or more regimens. Among 57 patients enrolled, 23 or 16 patients received PPV with chemotherapy or targeted therapy, respectively, whereas 18 patients received PPV alone. A maximum of four HLA-matched peptides showing higher peptide-specific IgG responses in pre-vaccination plasma were selected from 31 pooled peptide candidates applicable for patients with HLA-A2, -A24, -A3 supertypes, and/or -A26, followed by subcutaneous administration. No severe adverse events related to PPV were observed. Median survival time was 692, 468, or 226 days in the group of PPV/chemotherapy, PPV/targeted therapy, or PPV alone, respectively. CTL responses to the vaccinated peptides became detectable after vaccination in 58, 50, or 42% of patients in each of these three groups, respectively. In contrast, peptide-specific IgG responses after vaccination augmented in 55, 75, or 62% of patients in each of these groups, respectively. These results suggest the feasibility of PPV for heavily treated advanced NSCLC patients from the view of both immunological responses and safety. Therefore, further evaluation of PPV by prospective randomized trial is warranted for a third or fourth line treatment of advanced NSCLC.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Dela Cruz CS, Tanoue LT and Matthay RA: Lung cancer: epidemiology, etiology, and prevention. Clin Chest Med. 32:605–644. 2011.PubMed/NCBI

2 

Lu F and Zhang HT: DNA methylation and nonsmall cell lung cancer. Anat Rec. 294:1787–1795. 2011. View Article : Google Scholar : PubMed/NCBI

3 

de Marinis F and Grossi F: Clinical evidence for second- and third-line treatment options in advanced non-small cell lung cancer. Oncologist. 13(Suppl 1): 14–20. 2008.PubMed/NCBI

4 

Janku F, Stewart DJ and Kurzrock R: Targeted therapy in non-small-cell lung cancer - is it becoming a reality? Nat Rev Clin Oncol. 7:401–414. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Adjei AA, Mandrekar SJ, Dy GK, et al: Phase II trial of peme-trexed plus bevacizumab for second-line therapy of patients with advanced non-small-cell lung cancer: NCCTG and SWOG study N0426. J Clin Oncol. 28:614–619. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Krzakowski M, Ramlau R, Jassem J, et al: Phase III trial comparing vinflunine with docetaxel in second-line advanced non-small-cell lung cancer previously treated with platinum-containing chemotherapy. J Clin Oncol. 28:2167–2173. 2010. View Article : Google Scholar

7 

Okamoto I, Yoshioka H, Morita S, et al: Phase III trial comparing oral S-1 plus carboplatin with paclitaxel plus carboplatin in chemotherapy-naïve patients with advanced non-small-cell lung cancer: results of a west Japan oncology group study. J Clin Oncol. 28:5240–5246. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Brahmer JR, Tykodi SS, Chow LQ, et al: Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med. 366:2455–2465. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Lynch TJ, Bondarenko I, Luft A, et al: Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: results from a randomized, double-blind, multicenter phase II study. J Clin Oncol. 30:2046–2054. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Reck M, Bondarenko I, Luft A, et al: Ipilimumab in combination with paclitaxel and carboplatin as first-line therapy in extensive-disease-small-cell lung cancer: results from a randomized, double-blind, multicenter phase 2 trial. Ann Oncol. 24:75–83. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Topalian SL, Hodi FS, Brahmer JR, et al: Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 366:2443–2454. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Terasaki M, Shibui S, Narita Y, et al: Phase I trial of a personalized peptide vaccine for patients positive for human leukocyte antigen - A24 with recurrent or progressive glioblastoma multiforme. J Clin Oncol. 29:337–344. 2011. View Article : Google Scholar

13 

Takahashi R, Ishibashi Y, Hiraoka K, et al: Phase II study of personalized peptide vaccination for refractory bone and soft tissue sarcoma patients. Cancer Sci. 104:1285–1294. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Noguchi M, Kakuma T, Uemura H, et al: A randomized phase II trial of personalized peptide vaccine plus low dose estramustine phosphate (EMP) versus standard dose EMP in patients with castration resistant prostate cancer. Cancer Immunol Immunother. 59:1001–1009. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Terazaki Y, Yoshiyama K, Matsueda S, et al: Immunological evaluation of personalized peptide vaccination in refractory small cell lung cancer. Cancer Sci. 103:638–644. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Noguchi M, Sasada T and Itoh K: Personalized peptide vaccination: a new approach for advanced cancer as therapeutic cancer vaccine. Cancer Immunol Immunother. 62:919–929. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Yoshiyama K, Terazaki Y, Matsueda S, et al: Personalized peptide vaccination in patients with refractory non-small cell lung cancer. Int J Oncol. 40:1492–1500. 2012.PubMed/NCBI

18 

Noguchi M, Mine T, Komatsu N, et al: Assessment of immunological biomarkers in patients with advanced cancer treated by personalized peptide vaccination. Cancer Biol Ther. 10:1266–1279. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Komatsu N, Shichijo S, Nakagawa M and Itoh K: New multiplexed flow cytometric assay to measure anti-peptide antibody: a novel tool for monitoring immune responses to peptides used for immunization. Scan J Clin Lab Invest. 64:535–545. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Yoshida K, Noguchi M, Mine T, et al: Characteristics of severe adverse events after peptide vaccination for advanced cancer patients: analysis of 500 cases. Oncol Rep. 25:57–62. 2011.PubMed/NCBI

21 

Harashima N, Tanaka K, Sasatomi T, et al: Recognition of the Lck tyrosine kinase as a tumor antigen by cytotoxic T lymphocytes of cancer patients with distant metastases. Eur J Immunol. 31:323–332. 2001. View Article : Google Scholar : PubMed/NCBI

22 

McCracken S, Kim CS, Xu Y, Minden M and Miyamoto NG: An alternative pathway for expression of p56lck from type I promoter transcripts in colon carcinoma. Oncogene. 15:2929–2937. 1997. View Article : Google Scholar : PubMed/NCBI

23 

Chen YM, Shih JF, Fan WC, et al: Third-line or fourth-line chemotherapy in non-small-cell lung cancer patients with relatively good performance status. J Chin Med Assoc. 74:209–214. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Asahina H, Sekine I, Horinouchi H, et al: Retrospective analysis of third-line and fourth-line chemotherapy for advanced non-small-cell lung cancer. Clin Lung Cancer. 13:39–43. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Carnio S, Novello S, Mele T, Levra MG and Scagliotti GV: Extending survival of stage IV non-small cell lung cancer. Semin Oncol. 41:69–92. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Mok TS, Lee K and Leung L: Targeting epidermal growth factor receptor in the management of lung cancer. Semin Oncol. 41:101–109. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Langer CJ, Mok T and Postmus PE: Targeted agents in the third-/fourth-line treatment of patients with advanced (stage III/IV) non-small cell lung cancer (NSCLC). Cancer Treat Rev. 39:252–260. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Cromwell I, van der Hoek K, Malfair Taylor SC, Melosky B and Peacock S: Erlotinib or best supportive care for third-line treatment of advanced non-small-cell lung cancer: a real-world cost-effectiveness analysis. Lung Cancer. 76:472–477. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Corbière V, Chapiro J, Stroobant V, et al: Antigen spreading contributes to MAGE vaccination-induced regression of melanoma metastases. Cancer Res. 71:1253–1262. 2011.PubMed/NCBI

30 

Pohla H, Buchner A, Stadlbauer B, et al: High immune response rates and decreased frequencies of regulatory T cells in meta-static renal cell carcinoma patients after tumor cell vaccination. Mol Med. 18:1499–1508. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Wang Y, Harada M, Yano H, et al: Prostatic acid phosphatase as a target molecule in specific immunotherapy for patients with nonprostate adenocarcinoma. J Immunother. 28:535–541. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Kinoshita Y, Kuratsukuri K, Landas S, et al: Expression of prostate-specific membrane antigen in normal and malignant human tissues. World J Surg. 30:628–636. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Chang SS, Reuter VE, Heston WD, Bander NH, Grauer LS and Gaudin PB: Five different anti-prostate-specific membrane antigen (PSMA) antibodies confirm PSMA expression in tumor-associated neovasculature. Cancer Res. 59:3192–3198. 1999.PubMed/NCBI

34 

Wang Y, Harada M, Yano H, et al: Prostate-specific antigen-reactive cytotoxic T lymphocyte precursors in colon cancer patients. Oncol Rep. 15:317–321. 2006.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yamada T, Terazaki Y, Sakamoto S, Yoshiyama K, Matsueda S, Komatsu N, Waki K, Yamada A, Kawahara A, Kage M, Kage M, et al: Feasibility study of personalized peptide vaccination for advanced non-small cell lung cancer patients who failed two or more treatment regimens. Int J Oncol 46: 55-62, 2015.
APA
Yamada, T., Terazaki, Y., Sakamoto, S., Yoshiyama, K., Matsueda, S., Komatsu, N. ... Itoh, K. (2015). Feasibility study of personalized peptide vaccination for advanced non-small cell lung cancer patients who failed two or more treatment regimens. International Journal of Oncology, 46, 55-62. https://doi.org/10.3892/ijo.2014.2699
MLA
Yamada, T., Terazaki, Y., Sakamoto, S., Yoshiyama, K., Matsueda, S., Komatsu, N., Waki, K., Yamada, A., Kawahara, A., Kage, M., Sugawara, S., Yamashita, Y., Sasada, T., Takamori, S., Itoh, K."Feasibility study of personalized peptide vaccination for advanced non-small cell lung cancer patients who failed two or more treatment regimens". International Journal of Oncology 46.1 (2015): 55-62.
Chicago
Yamada, T., Terazaki, Y., Sakamoto, S., Yoshiyama, K., Matsueda, S., Komatsu, N., Waki, K., Yamada, A., Kawahara, A., Kage, M., Sugawara, S., Yamashita, Y., Sasada, T., Takamori, S., Itoh, K."Feasibility study of personalized peptide vaccination for advanced non-small cell lung cancer patients who failed two or more treatment regimens". International Journal of Oncology 46, no. 1 (2015): 55-62. https://doi.org/10.3892/ijo.2014.2699
Copy and paste a formatted citation
x
Spandidos Publications style
Yamada T, Terazaki Y, Sakamoto S, Yoshiyama K, Matsueda S, Komatsu N, Waki K, Yamada A, Kawahara A, Kage M, Kage M, et al: Feasibility study of personalized peptide vaccination for advanced non-small cell lung cancer patients who failed two or more treatment regimens. Int J Oncol 46: 55-62, 2015.
APA
Yamada, T., Terazaki, Y., Sakamoto, S., Yoshiyama, K., Matsueda, S., Komatsu, N. ... Itoh, K. (2015). Feasibility study of personalized peptide vaccination for advanced non-small cell lung cancer patients who failed two or more treatment regimens. International Journal of Oncology, 46, 55-62. https://doi.org/10.3892/ijo.2014.2699
MLA
Yamada, T., Terazaki, Y., Sakamoto, S., Yoshiyama, K., Matsueda, S., Komatsu, N., Waki, K., Yamada, A., Kawahara, A., Kage, M., Sugawara, S., Yamashita, Y., Sasada, T., Takamori, S., Itoh, K."Feasibility study of personalized peptide vaccination for advanced non-small cell lung cancer patients who failed two or more treatment regimens". International Journal of Oncology 46.1 (2015): 55-62.
Chicago
Yamada, T., Terazaki, Y., Sakamoto, S., Yoshiyama, K., Matsueda, S., Komatsu, N., Waki, K., Yamada, A., Kawahara, A., Kage, M., Sugawara, S., Yamashita, Y., Sasada, T., Takamori, S., Itoh, K."Feasibility study of personalized peptide vaccination for advanced non-small cell lung cancer patients who failed two or more treatment regimens". International Journal of Oncology 46, no. 1 (2015): 55-62. https://doi.org/10.3892/ijo.2014.2699
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team