Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
March-2015 Volume 46 Issue 3

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2015 Volume 46 Issue 3

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Genistein exerts growth inhibition on human osteosarcoma MG-63 cells via PPARγ pathway

Corrigendum in: /10.3892/ijo.2024.5635
  • Authors:
    • Mingzhi Song
    • Xiliang Tian
    • Ming Lu
    • Xianbin Zhang
    • Kai Ma
    • Zhichao Lv
    • Zhenxing Wang
    • Yang Hu
    • Chong Xun
    • Zhen Zhang
    • Shouyu Wang
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedics, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China
  • Pages: 1131-1140
    |
    Published online on: January 9, 2015
       https://doi.org/10.3892/ijo.2015.2829
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The peroxisome proliferator-activated receptor γ (PPARγ) is emerging as an important regulator in various metabolic processes of cancer. Genistein, as a major isoflavonoid isolated from dietary soybean, possesses a wide variety of biological activities, particularly, in cancer prevention. However, the mechanisms by which genistein elicits its growth inhibiting effects in osteosarcoma (OS) MG-63 cells have not been extensively elucidated. MG-63 cells were treated for 2 days with various concentrations of genistein and/or GW9662 (a selective antagonist of PPARγ). The effect of different drugs on cell viability was determined by Cell Counting Kit-8 (CCK-8). The assay of cell proliferation was performed using 5-ethynyl-2'-deoxyuridine (EdU). The changes of apoptosis and cell cycle progression were detected by flow cytometry experiments. The protein expression of PPARγ pathway (PPARγ, PTEN, BCL-2, Survivin, P21WAF1/CIP1 and Cyclin B1) was determined by western blot analysis. The expression of PPARγ and PTEN mRNA was detected by real-time quantitative RT-PCR analysis. We report that genistein caused OS cell growth inhibition. We found that the PPARγ expression in OS cells increased after genistein treatment. Further studies on the mechanisms of genistein revealed a series of cell growth changes related to the PPARγ pathway; while cell cycle changes can be reversed by GW9662. Genistein plays an important role in preventing OS cell growth, which can impede the OS cell cycle as a non-toxic activator of PPARγ, providing novel insights into the mechanisms of the therapeutic activities of genistein.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Yang Z, Kulkarni K, Zhu W, et al: Bioavailability and pharmacokinetics of genistein: mechanistic studies on its ADME. Anticancer Agents Med Chem. 10:1264–1280. 2012. View Article : Google Scholar

2 

Banerjee S, Li Y, Wang Z, et al: Multi-targeted therapy of cancer by genistein. Cancer Lett. 2:226–242. 2008. View Article : Google Scholar

3 

Zhang Z, Wang CZ, Du GJ, et al: Genistein induces G2/M cell cycle arrest and apoptosis via atm/p53-dependent pathway in human colon cancer cell. Int J Oncol. 1:289–296. 2013.

4 

Ullah MF, Ahmad A, Zubair H, et al: Soy isoflavone genistein induces cell death in breast cancer cells through mobilization of endogenous copper ions and generation of reactive oxygen species. Mol Nutr Food Res. 4:553–559. 2011. View Article : Google Scholar

5 

Mizushina Y, Shiomi K, Kuriyama I, et al: Inhibitory effects of a major soy isoflavone, genistein, on human DNA topoisomerase II activity and cancer cell proliferation. Int J Oncol. 4:1117–1124. 2013.

6 

Hwang KA, Kang NH, Yi BR, et al: Genistein, a soy phytoestrogen, prevents the growth of BG-1 ovarian cancer cells induced by 17beta-estradiol or bisphenol A via the inhibition of cell cycle progression. Int J Oncol. 2:733–740. 2013.

7 

Xia J, Cheng L, Mei C, et al: Genistein inhibits cell growth and invasion through regulation of mir-27a in pancreatic cancer cells. Curr Pharm Des. 33:5348–5353. 2014. View Article : Google Scholar

8 

Hilakivi-Clarke L, Onojafe I, Raygada M, et al: Prepubertal exposure to zearalenone or genistein reduces mammary tumorigenesis. Br J Cancer. 11:16821999. View Article : Google Scholar

9 

Zhou JR, Mukherjee P, Gugger ET, et al: Inhibition of murine bladder tumorigenesis by soy isoflavones via alterations in the cell cycle, apoptosis, and angiogenesis. Cancer Res. 22:5231–5238. 1998.

10 

Li C, Teng RH, Tsai YC, et al: H-Ras oncogene counteracts the growth-inhibitory effect of genistein in T24 bladder carcinoma cells. Br J Cancer. 1:80–88. 2004.

11 

Yang CH, Murti A, Pfeffer SR, et al: Interferon α/β promotes cell survival by activating nuclear factor κB through phosphatidylinositol 3-kinase and Akt. J Biol Chem. 17:13756–13761. 2001.

12 

Yamashita K, Suzuki M, Iwata H, et al: Tyrosine phosphorylation is crucial for growth signaling by tissue inhibitors of metalloproteinases. FEBS Lett. 1:103–107. 1996. View Article : Google Scholar

13 

Nikitovic D, Tsatsakis AM, Karamanos NK, et al: The effects of genistein on the synthesis and distribution of glycosaminoglycans/proteoglycans by two osteosarcoma cell lines depends on tyrosine kinase and the estrogen receptor density. Anticancer Res. 23(1A): 459–464. 2003.PubMed/NCBI

14 

Morris C, Thorpe J, Ambrosio L, et al: The soybean isoflavone genistein induces differentiation of MG63 human osteosarcoma osteoblasts. J Nutr. 5:1166–1170. 2006.

15 

Zhang B, Shi ZL, Liu B, et al: Enhanced anticancer effect of gemcitabine by genistein in osteosarcoma: the role of Akt and nuclear factor-κB. Anticancer Drugs. 3:288–296. 2010. View Article : Google Scholar

16 

Liang C, Li H, Shen C, et al: Genistein potentiates the anti-cancer effects of gemcitabine in human osteosarcoma via the downregulation of Akt and nuclear factor-kappaB pathway. Anticancer Agents Med Chem. 5:554–563. 2012. View Article : Google Scholar

17 

Nakamura A, Aizawa J, Sakayama K, et al: Genistein inhibits cell invasion and motility by inducing cell differentiation in murine osteosarcoma cell line LM8. BMC Cell Biol. 1:242012. View Article : Google Scholar

18 

Rickard DJ, Monroe DG, Ruesink TJ, et al: Phytoestrogen genistein acts as an estrogen agonist on human osteoblastic cells through estrogen receptors alpha and beta. J Cell Biochem. 3:633–646. 2003. View Article : Google Scholar

19 

Salvatori L, Caporuscio F, Coroniti G, et al: Down-regulation of epidermal growth factor receptor induced by estrogens and phytoestrogens promotes the differentiation of U2OS human osteosarcoma cells. J Cell Physiol. 1:35–44. 2009. View Article : Google Scholar

20 

Djiogue S, Njamen D, Halabalaki M, et al: Estrogenic properties of naturally occurring prenylated isoflavones in U2OS human osteosarcoma cells: Structure-activity relationships. J Steroid Biochem Mol Biol. 4–5:184–191. 2010. View Article : Google Scholar

21 

Nakamura H, Wang Y, Kurita T, et al: Genistein increases epidermal growth factor receptor signaling and promotes tumor progression in advanced human prostate cancer. PLoS One. 5:e200342011. View Article : Google Scholar

22 

Dang ZC, Audinot V, Papapoulos SE, et al: Peroxisome proliferator-activated receptor gamma as a molecular target for the soy phytoestrogen genistein. J Biol Chem. 2:962–967. 2003. View Article : Google Scholar

23 

Mezei O, Banz WJ, Steger RW, et al: Soy isoflavones exert anti-diabetic and hypolipidemic effects through the PPAR pathways in obese Zucker rats and murine RAW 264.7 cells. J Nutr. 5:1238–1243. 2003.

24 

Xiang Q, Lin G, Fu X, et al: The role of peroxisome proliferator-activated receptor-γ and estrogen receptors in genistein-induced regulation of vascular tone in female rat aortas. Pharmacology. 2:117–124. 2010. View Article : Google Scholar

25 

Youssef J and Badr M: Peroxisome proliferator-activated receptors and cancer: challenges and opportunities. Br J Pharmacol. 1:68–82. 2011. View Article : Google Scholar

26 

Willson TM, Lambert MH and Kliewer SA: Peroxisome proliferator-activated receptor gamma and metabolic disease. Annu Rev Biochem. 70:341–367. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Berger J and Moller DE: The mechanisms of action of PPARs. Annu Rev Med. 53:409–435. 2002. View Article : Google Scholar : PubMed/NCBI

28 

Bundscherer A, Reichle A, Hafner C, et al: Targeting the tumor stroma with peroxisome proliferator activated receptor agonists. Anticancer Agents Med Chem. 7:816–821. 2009. View Article : Google Scholar

29 

Rumi MA, Ishihara S, Kazumori H, et al: Can PPAR gamma ligands be used in cancer therapy? Curr Med Chem Anticancer Agents. 6:465–477. 2004. View Article : Google Scholar

30 

Tontonoz P, Singer S, Forman BM, et al: Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor. Proc Natl Acad Sci USA. 1:237–241. 1997. View Article : Google Scholar

31 

Kubota T, Koshizuka K, Williamson EA, et al: Ligand for peroxisome proliferator-activated receptor gamma has potent antitumor effect against human prostate cancer both in vitro and in vivo. Cancer Res. 15:3344–3352. 1998.

32 

Asou H, Verbeek W, Williamson E, et al: Growth inhibition of myeloid leukemia cells by troglitazone, a ligand for peroxisome proliferator activated receptor gamma, and retinoids. Int J Oncol. 5:1027–1031. 1999.

33 

Kitamura S, Miyazaki Y, Shinomura Y, et al: Peroxisome proliferator-activated receptor gamma induces growth arrest and differentiation markers of human colon cancer cells. Jpn J Cancer Res. 1:75–80. 1999. View Article : Google Scholar

34 

Elstner E, Muller C, Koshizuka K, et al: Ligands for peroxisome proliferator-activated receptorgamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice. Proc Natl Acad Sci USA. 15:8806–8811. 1998. View Article : Google Scholar

35 

Mueller E, Sarraf P, Tontonoz P, et al: Terminal differentiation of human breast cancer through PPAR gamma. Mol Cell. 3:465–470. 1998. View Article : Google Scholar

36 

Chang TH and Szabo E: Induction of differentiation and apoptosis by ligands of peroxisome proliferator-activated receptor gamma in non-small cell lung cancer. Cancer Res. 4:1129–1138. 2000.

37 

Ali AA, Weinstein RS, Stewart SA, et al: Rosiglitazone causes bone loss in mice by suppressing osteoblast differentiation and bone formation. Endocrinology. 3:1226–1235. 2005. View Article : Google Scholar

38 

Rzonca SO, Suva LJ, Gaddy D, et al: Bone is a target for the antidiabetic compound rosiglitazone. Endocrinology. 1:401–406. 2004. View Article : Google Scholar

39 

Rajkumar T and Yamuna M: Multiple pathways are involved in drug resistance to doxorubicin in an osteosarcoma cell line. Anticancer Drugs. 3:257–265. 2008. View Article : Google Scholar

40 

Yamaguchi K, Whitlock NC, Liggett JL, et al: Molecular characterisation of canine nonsteroidal anti-inflammatory drug-activated gene. Vet J. 1:89–95. 2008. View Article : Google Scholar

41 

He BC, Chen L, Zuo GW, et al: Synergistic antitumor effect of the activated PPARgamma and retinoid receptors on human osteosarcoma. Clin Cancer Res. 8:2235–2245. 2010. View Article : Google Scholar

42 

Haydon RC, Luu HH and He TC: Osteosarcoma and osteoblastic differentiation: a new perspective on oncogenesis. Clin Orthop Relat Res. 454:237–246. 2007. View Article : Google Scholar

43 

Haydon RC, Zhou L, Feng T, et al: Nuclear receptor agonists as potential differentiation therapy agents for human osteosarcoma. Clin Cancer Res. 5:1288–1294. 2002.

44 

Yu LX, Yan HX, Liu Q, et al: Endotoxin accumulation prevents carcinogen-induced apoptosis and promotes liver tumorigenesis in rodents. Hepatology. 4:1322–1333. 2010. View Article : Google Scholar

45 

Lv L, Xiao XY, Gu ZH, et al: Silencing USP22 by asymmetric structure of interfering RNA inhibits proliferation and induces cell cycle arrest in bladder cancer cells. Mol Cell Biochem. 1–2:11–21. 2011. View Article : Google Scholar

46 

Lu Q, Lu S, Gao X, et al: Norisoboldine, an alkaloid compound isolated from Radix Linderae, inhibits synovial angiogenesis in adjuvant-induced arthritis rats by moderating Notch1 pathway-related endothelial tip cell phenotype. Exp Biol Med. 8:919–932. 2012. View Article : Google Scholar

47 

Seargent JM, Yates EA and Gill JH: GW9662, a potent antagonist of PPARgamma, inhibits growth of breast tumour cells and promotes the anticancer effects of the PPARgamma agonist rosiglitazone, independently of PPARgamma activation. Br J Pharmacol. 8:933–937. 2004. View Article : Google Scholar

48 

Patel L, Pass I, Coxon P, et al: Tumor suppressor and anti-inflammatory actions of PPARgamma agonists are mediated via upregulation of PTEN. Curr Biol. 10:764–768. 2001. View Article : Google Scholar

49 

Wu ZX, Song TB, Li DM, et al: Overexpression of PTEN suppresses growth and induces apoptosis by inhibiting the expression of survivin in bladder cancer cells. Tumour Biol. 1:9–15. 2007. View Article : Google Scholar

50 

Mikhail M, Velazquez E, Shapiro R, et al: PTEN expression in melanoma: relationship with patient survival, Bcl-2 expression, and proliferation. Clin Cancer Res. 14:5153–5157. 2005. View Article : Google Scholar

51 

Raffoul JJ, Wang Y, Kucuk O, et al: Genistein inhibits radiation-induced activation of NF-kappaB in prostate cancer cells promoting apoptosis and G2/M cell cycle arrest. BMC Cancer. 6:1072006. View Article : Google Scholar : PubMed/NCBI

52 

Ouyang G, Yao L, Ruan K, et al: Genistein induces G2/M cell cycle arrest and apoptosis of human ovarian cancer cells via activation of DNA damage checkpoint pathways. Cell Biol Int. 12:1237–1244. 2009. View Article : Google Scholar

53 

Wagner ER, He BC, Chen L, et al: Therapeutic implications of PPARgamma in human osteosarcoma. PPAR Res. 9564272010.PubMed/NCBI

54 

Miao J, Wu S, Peng Z, et al: MicroRNAs in osteosarcoma: diagnostic and therapeutic aspects. Tumour Biol. 4:2093–2098. 2013. View Article : Google Scholar

55 

Weng L, Brown J and Eng C: PTEN induces apoptosis and cell cycle arrest through phosphoinositol-3-kinase/Akt-dependent and -independent pathways. Hum Mol Genet. 3:237–242. 2001. View Article : Google Scholar

56 

Waite KA, Sinden MR and Eng C: Phytoestrogen exposure elevates PTEN levels. Hum Mol Genet. 11:1457–1463. 2005. View Article : Google Scholar

57 

Choi YH, Lee WH, Park KY, et al: p53-independent induction of p21, reduction of Cyclin B1 and G2/M arrest by the isoflavone genistein in human prostate carcinoma cells. Jpn J Cancer Res. 2:164–173. 2000. View Article : Google Scholar

58 

Mayo LD and Donner DB: The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network. Trends Biochem Sci. 9:462–467. 2002. View Article : Google Scholar

59 

Zhang T, Wang F, Xu H-X, et al: Activation of nuclear factor erythroid 2-related factor 2 and PPARγ plays a role in the genis-tein-mediated attenuation of oxidative stress-induced endothelial cell injury. Br J Nutr. 2:223–235. 2013. View Article : Google Scholar

60 

Halasova E, Adamkov M, Matakova T, et al: Expression of Ki-67, Bcl-2, survivin and p53 proteins in patients with pulmonary carcinoma. Adv Exp Med Biol. 756:15–21. 2013. View Article : Google Scholar

61 

Gao Q, Yang S and Kang MQ: Influence of survivin and Bcl-2 expression on the biological behavior of non-small cell lung cancer. Mol Med Rep. 6:1409–1414. 2012.

62 

Ma Y and Wang HS: Correlations of Bcl-2 and survivin gene protein expressions in colorectal cancer. Applied Mech Mater. 423–426:362–365. 2013. View Article : Google Scholar

63 

Kumar P, Miller AI and Polverini PJ: p38 MAPK mediates gamma-irradiation-induced endothelial cell apoptosis, and vascular endothelial growth factor protects endothelial cells through the phosphoinositide 3-kinase-Akt-Bcl-2 pathway. J Biol Chem. 41:43352–43360. 2004. View Article : Google Scholar

64 

Fong WH, Tsai HD, Chen YC, et al: Anti-apoptotic actions of PPAR-gamma against ischemic stroke. Mol Neurobiol. 2–3:180–186. 2010. View Article : Google Scholar

65 

Ren Y, Sun C, Sun Y, et al: PPAR gamma protects cardiomyocytes against oxidative stress and apoptosis via Bcl-2 upregulation. Vascul Pharmacol. 2–3:169–174. 2009. View Article : Google Scholar

66 

Kim YJ, Park KJ, Song JK, et al: The PPARgamma agonist protects cardiomyocytes from oxidative stress and apoptosis via thioredoxin overexpression. Biosci Biotechnol Biochem. 12:2181–2187. 2012. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Song M, Tian X, Lu M, Zhang X, Ma K, Lv Z, Wang Z, Hu Y, Xun C, Zhang Z, Zhang Z, et al: Genistein exerts growth inhibition on human osteosarcoma MG-63 cells via PPARγ pathway Corrigendum in /10.3892/ijo.2024.5635. Int J Oncol 46: 1131-1140, 2015.
APA
Song, M., Tian, X., Lu, M., Zhang, X., Ma, K., Lv, Z. ... Wang, S. (2015). Genistein exerts growth inhibition on human osteosarcoma MG-63 cells via PPARγ pathway Corrigendum in /10.3892/ijo.2024.5635. International Journal of Oncology, 46, 1131-1140. https://doi.org/10.3892/ijo.2015.2829
MLA
Song, M., Tian, X., Lu, M., Zhang, X., Ma, K., Lv, Z., Wang, Z., Hu, Y., Xun, C., Zhang, Z., Wang, S."Genistein exerts growth inhibition on human osteosarcoma MG-63 cells via PPARγ pathway Corrigendum in /10.3892/ijo.2024.5635". International Journal of Oncology 46.3 (2015): 1131-1140.
Chicago
Song, M., Tian, X., Lu, M., Zhang, X., Ma, K., Lv, Z., Wang, Z., Hu, Y., Xun, C., Zhang, Z., Wang, S."Genistein exerts growth inhibition on human osteosarcoma MG-63 cells via PPARγ pathway Corrigendum in /10.3892/ijo.2024.5635". International Journal of Oncology 46, no. 3 (2015): 1131-1140. https://doi.org/10.3892/ijo.2015.2829
Copy and paste a formatted citation
x
Spandidos Publications style
Song M, Tian X, Lu M, Zhang X, Ma K, Lv Z, Wang Z, Hu Y, Xun C, Zhang Z, Zhang Z, et al: Genistein exerts growth inhibition on human osteosarcoma MG-63 cells via PPARγ pathway Corrigendum in /10.3892/ijo.2024.5635. Int J Oncol 46: 1131-1140, 2015.
APA
Song, M., Tian, X., Lu, M., Zhang, X., Ma, K., Lv, Z. ... Wang, S. (2015). Genistein exerts growth inhibition on human osteosarcoma MG-63 cells via PPARγ pathway Corrigendum in /10.3892/ijo.2024.5635. International Journal of Oncology, 46, 1131-1140. https://doi.org/10.3892/ijo.2015.2829
MLA
Song, M., Tian, X., Lu, M., Zhang, X., Ma, K., Lv, Z., Wang, Z., Hu, Y., Xun, C., Zhang, Z., Wang, S."Genistein exerts growth inhibition on human osteosarcoma MG-63 cells via PPARγ pathway Corrigendum in /10.3892/ijo.2024.5635". International Journal of Oncology 46.3 (2015): 1131-1140.
Chicago
Song, M., Tian, X., Lu, M., Zhang, X., Ma, K., Lv, Z., Wang, Z., Hu, Y., Xun, C., Zhang, Z., Wang, S."Genistein exerts growth inhibition on human osteosarcoma MG-63 cells via PPARγ pathway Corrigendum in /10.3892/ijo.2024.5635". International Journal of Oncology 46, no. 3 (2015): 1131-1140. https://doi.org/10.3892/ijo.2015.2829
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team