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Article

IκBζ, an atypical member of the inhibitor of nuclear factor kappa B family, is induced by γ-irradiation in glioma cells, regulating cytokine secretion and associated with poor prognosis

  • Authors:
    • Heiko Brennenstuhl
    • Angela Armento
    • Anne Kristin Braczysnki
    • Michel Mittelbronn
    • Ulrike Naumann
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    Affiliations: Hertie Institute for Clinical Brain Research and Center Neurology, Molecular Neurology, Karl Eberhards University of Tübingen, Tübingen, Germany, Edinger Institute (Neurological Institute), Goethe University, Frankfurt am Main, Germany
  • Pages: 1971-1980
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    Published online on: September 14, 2015
       https://doi.org/10.3892/ijo.2015.3159
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Abstract

The inhibitor of nuclear factor kappa B zeta (IκBζ) is an atypical member of the IκB protein family. Its function in regulating the activity of the transcription factor nuclear factor kappa B (NFκB) as well as its involvement in cancer-associated processes is poorly understood. In glioma patients, enhanced expression of IκBζ in tumor specimen is associated with poor prognosis. Here we report that IκBζ is upregulated in a glioma cell line resistant towards NFκB-dependent non-apoptotic cell death. Upon γ-irradiation of glioma cells, IκBζ expression is enhanced, and subsequently serves as a transcriptional activator of the tumor promoting cytokines interleukin (IL-6), IL-8 and chemokine (C-X-C motif) ligand 1 (CXCL1) that are known to be involved in glioma associated inflammatory processes. In contrast, shRNA-mediated knockdown of IκBζ reduces the expression of the aforementioned cytokines. We propose a previously unappreciated role of IκBζ in the inflammatory micromilieu as well as progression in glioma.
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Copy and paste a formatted citation
Spandidos Publications style
Brennenstuhl H, Armento A, Braczysnki AK, Mittelbronn M and Naumann U: IκBζ, an atypical member of the inhibitor of nuclear factor kappa B family, is induced by γ-irradiation in glioma cells, regulating cytokine secretion and associated with poor prognosis. Int J Oncol 47: 1971-1980, 2015.
APA
Brennenstuhl, H., Armento, A., Braczysnki, A.K., Mittelbronn, M., & Naumann, U. (2015). IκBζ, an atypical member of the inhibitor of nuclear factor kappa B family, is induced by γ-irradiation in glioma cells, regulating cytokine secretion and associated with poor prognosis. International Journal of Oncology, 47, 1971-1980. https://doi.org/10.3892/ijo.2015.3159
MLA
Brennenstuhl, H., Armento, A., Braczysnki, A. K., Mittelbronn, M., Naumann, U."IκBζ, an atypical member of the inhibitor of nuclear factor kappa B family, is induced by γ-irradiation in glioma cells, regulating cytokine secretion and associated with poor prognosis". International Journal of Oncology 47.5 (2015): 1971-1980.
Chicago
Brennenstuhl, H., Armento, A., Braczysnki, A. K., Mittelbronn, M., Naumann, U."IκBζ, an atypical member of the inhibitor of nuclear factor kappa B family, is induced by γ-irradiation in glioma cells, regulating cytokine secretion and associated with poor prognosis". International Journal of Oncology 47, no. 5 (2015): 1971-1980. https://doi.org/10.3892/ijo.2015.3159
Copy and paste a formatted citation
x
Spandidos Publications style
Brennenstuhl H, Armento A, Braczysnki AK, Mittelbronn M and Naumann U: IκBζ, an atypical member of the inhibitor of nuclear factor kappa B family, is induced by γ-irradiation in glioma cells, regulating cytokine secretion and associated with poor prognosis. Int J Oncol 47: 1971-1980, 2015.
APA
Brennenstuhl, H., Armento, A., Braczysnki, A.K., Mittelbronn, M., & Naumann, U. (2015). IκBζ, an atypical member of the inhibitor of nuclear factor kappa B family, is induced by γ-irradiation in glioma cells, regulating cytokine secretion and associated with poor prognosis. International Journal of Oncology, 47, 1971-1980. https://doi.org/10.3892/ijo.2015.3159
MLA
Brennenstuhl, H., Armento, A., Braczysnki, A. K., Mittelbronn, M., Naumann, U."IκBζ, an atypical member of the inhibitor of nuclear factor kappa B family, is induced by γ-irradiation in glioma cells, regulating cytokine secretion and associated with poor prognosis". International Journal of Oncology 47.5 (2015): 1971-1980.
Chicago
Brennenstuhl, H., Armento, A., Braczysnki, A. K., Mittelbronn, M., Naumann, U."IκBζ, an atypical member of the inhibitor of nuclear factor kappa B family, is induced by γ-irradiation in glioma cells, regulating cytokine secretion and associated with poor prognosis". International Journal of Oncology 47, no. 5 (2015): 1971-1980. https://doi.org/10.3892/ijo.2015.3159
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