|
1
|
Molina JR1, Yang P, Cassivi SD, Schild SE
and Adjei AA: Non-small cell lung cancer: Epidemiology, risk
factors, treatment, and survivorship. Mayo Clin Proc. 83:584–594.
2008. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Ferlay J, Steliarova-Foucher E,
Lortet-Tieulent J, Rosso S, Coebergh JW, Comber H, Forman D and
Bray F: Cancer incidence and mortality patterns in Europe:
Estimates for 40 countries in 2012. Eur J Cancer. 49:1374–1403.
2013. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Bareschino MA, Schettino C, Rossi A,
Maione P, Sacco PC, Zeppa R and Gridelli C: Treatment of advanced
non small cell lung cancer. J Thorac Dis. 3:122–133. 2011.
|
|
4
|
Hensley K and Floyd RA: Reactive oxygen
species and protein oxidation in aging: A look back, a look ahead.
Arch Biochem Biophys. 397:377–383. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Nadkar A, Pungaliya C, Drake K, Zajac E,
Singhal SS and Awasthi S: Therapeutic resistance in lung cancer.
Expert Opin Drug Metab Toxicol. 2:753–777. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Kensler TW and Wakabayashi N: Nrf2: Friend
or foe for chemo-prevention? Carcinogenesis. 31:90–99. 2010.
View Article : Google Scholar :
|
|
7
|
Kovac S, Angelova PR, Holmström KM, Zhang
Y, Dinkova-Kostova AT and Abramov AY: Nrf2 regulates ROS production
by mitochondria and NADPH oxidase. Biochim Biophys Acta.
1850:794–801. 2015. View Article : Google Scholar :
|
|
8
|
Zhou R, Lin J and Wu D: Sulforaphane
induces Nrf2 and protects against CYP2E1-dependent binge
alcohol-induced liver steatosis. Biochim Biophys Acta.
1840:209–218. 2014. View Article : Google Scholar
|
|
9
|
Huber S, Valente S, Chaimbault P and
Schohn H: Evaluation of Δ2-pioglitazone, an analogue of
pioglitazone, on colon cancer cell survival: Evidence of drug
treatment association with autophagy and activation of the
Nrf2/Keap1 pathway. Int J Oncol. 45:426–438. 2014.PubMed/NCBI
|
|
10
|
Shibata T, Ohta T, Tong KI, Kokubu A,
Odogawa R, Tsuta K, Asamura H, Yamamoto M and Hirohashi S: Cancer
related mutations in NRF2 impair its recognition by Keap1-Cul3 E3
ligase and promote malignancy. Proc Natl Acad Sci USA.
105:13568–13573. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Wang P, Peng X, Wei ZF, Wei FY, Wang W, Ma
WD, Yao LP, Fu YJ and Zu YG: Geraniin exerts cytoprotective effect
against cellular oxidative stress by upregulation of Nrf2-mediated
anti-oxidant enzyme expression via PI3K/AKT and ERK1/2 pathway.
Biochim Biophys Acta. 1850:1751–1761. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Ding M, Zhao J, Bowman L, Lu Y and Shi X:
Inhibition of AP-1 and MAPK signaling and activation of Nrf2/ARE
pathway by quercitrin. Int J Oncol. 36:59–67. 2010.
|
|
13
|
Alam J, Stewart D, Touchard C, Boinapally
S, Choi AM and Cook JL: Nrf2, a Cap'n'Collar transcription factor,
regulates induction of the heme oxygenase-1 gene. J Biol Chem.
274:26071–26078. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Kansanen E, Kuosmanen SM, Leinonen H and
Levonen A-L: The Keap1-Nrf2 pathway: Mechanisms of activation and
dysregulation in cancer. Redox Biol. 1:45–49. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Rana T, Schultz MA, Freeman ML and Biswas
S: Loss of Nrf2 accelerates ionizing radiation-induced bone loss by
upregulating RANKL. Free Radic Biol Med. 53:2298–2307. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Singh A, Boldin-Adamsky S, Thimmulappa RK,
Rath SK, Ashush H, Coulter J, Blackford A, Goodman SN, Bunz F,
Watson WH, et al: RNAi-mediated silencing of nuclear factor
erythroid-2-related factor 2 gene expression in non-small cell lung
cancer inhibits tumor growth and increases efficacy of
chemotherapy. Cancer Res. 68:7975–7984. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Greenwald I: LIN-12/Notch signaling:
Lessons from worms and flies. Genes Dev. 12:1751–1762. 1998.
View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Artavanis-Tsakonas S, Rand MD and Lake RJ:
Notch signaling: Cell fate control and signal integration in
development. Science. 284:770–776. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Wang X, Zhang J, Zhou L, Sun W, Zheng ZG,
Lu P, Gao Y, Yang XS, Zhang ZC, Tao KS, et al: Fbxw7 regulates
hepatocellular carcinoma migration and invasion via Notch1
signaling pathway. Int J Oncol. 47:231–243. 2015.PubMed/NCBI
|
|
20
|
Xue TC, Zou JH, Chen RX, Cui JF, Tang ZY
and Ye SL: Spatial localization of the JAG1/Notch1/osteopontin
cascade modulates extrahepatic metastasis in hepatocellular
carcinoma. Int J Oncol. 45:1883–1890. 2014.PubMed/NCBI
|
|
21
|
Ayaz F and Osborne BA: Non-canonical notch
signaling in cancer and immunity. Front Oncol. 4:3452014.
View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Swiatek PJ, Lindsell CE, del Amo FF,
Weinmaster G and Gridley T: Notch1 is essential for
postimplantation development in mice. Genes Dev. 8:707–719. 1994.
View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Fre S, Huyghe M, Mourikis P, Robine S,
Louvard D and Artavanis-Tsakonas S: Notch signals control the fate
of immature progenitor cells in the intestine. Nature. 435:964–968.
2005. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Ersvaer E, Hatfield KJ, Reikvam H and
Bruserud O: Future perspectives: Therapeutic targeting of notch
signalling may become a strategy in patients receiving stem cell
transplantation for hematologic malignancies. Bone Marrow Res.
2011:5707962011. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Wang J, Wakeman TP, Lathia JD, Hjelmeland
AB, Wang XF, White RR, Rich JN and Sullenger BA: Notch promotes
radioresistance of glioma stem cells. Stem Cells. 28:17–28.
2010.
|
|
26
|
Bataller R, Schwabe RF, Choi YH, Yang L,
Paik YH, Lindquist J, Qian T, Schoonhoven R, Hagedorn CH, Lemasters
JJ, et al: NADPH oxidase signal transduces angiotensin II in
hepatic stellate cells and is critical in hepatic fibrosis. J Clin
Invest. 112:1383–1394. 2003. View
Article : Google Scholar : PubMed/NCBI
|
|
27
|
Wakabayashi N, Skoko JJ, Chartoumpekis DV,
Kimura S, Slocum SL, Noda K, Palliyaguru DL, Fujimuro M, Boley PA,
Tanaka Y, et al: Notch-Nrf2 axis: Regulation of Nrf2 gene
expression and cytoprotection by notch signaling. Mol Cell Biol.
34:653–663. 2014. View Article : Google Scholar :
|
|
28
|
Wakabayashi N, Shin S, Slocum SL, Agoston
ES, Wakabayashi J, Kwak MK, Misra V, Biswal S, Yamamoto M and
Kensler TW: Regulation of notch1 signaling by Nrf2: Implications
for tissue regeneration. Sci Signal. 3:ra522010.PubMed/NCBI
|
|
29
|
Paul MK, Bisht B, Darmawan DO, Chiou R, Ha
VL, Wallace WD, Chon AT, Hegab AE, Grogan T, Elashoff DA, et al:
Dynamic changes in intracellular ROS levels regulate airway basal
stem cell homeostasis through Nrf2-dependent Notch signaling. Cell
Stem Cell. 15:199–214. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Kim JH, Thimmulappa RK, Kumar V, Cui W,
Kumar S, Kombairaju P, Zhang H, Margolick J, Matsui W, Macvittie T,
et al: NRF2-mediated Notch pathway activation enhances
hematopoietic reconstitution following myelosuppressive radiation.
J Clin Invest. 124:730–741. 2014. View
Article : Google Scholar : PubMed/NCBI
|
|
31
|
Wakabayashi N, Chartoumpekis DV and
Kensler TW: Crosstalk between Nrf2 and Notch signaling. Free Radic
Biol Med. 88B:158–167. 2015. View Article : Google Scholar
|
|
32
|
Iso T, Kedes L and Hamamori Y: HES and
HERP families: Multiple effectors of the Notch signaling pathway. J
Cell Physiol. 194:237–255. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Yang H, Ramani K, Xia M, Ko KS, Li TW, Oh
P, Li J and Lu SC: Dysregulation of glutathione synthesis during
cholestasis in mice: Molecular mechanisms and therapeutic
implications. Hepatology. 49:1982–1991. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Tan Y, Ichikawa T, Li J, Si Q, Yang H,
Chen X, Goldblatt CS, Meyer CJ, Li X, Cai L, et al: Diabetic
downregulation of Nrf2 activity via ERK contributes to oxidative
stress-induced insulin resistance in cardiac cells in vitro and in
vivo. Diabetes. 60:625–633. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Goldring CE, Kitteringham NR, Elsby R,
Randle LE, Clement YN, Williams DP, McMahon M, Hayes JD, Itoh K,
Yamamoto M, et al: Activation of hepatic Nrf2 in vivo by
acetaminophen in CD-1 mice. Hepatology. 39:1267–1276. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Rizvi F, Mathur A and Kakkar P: Morin
mitigates acetaminophen-induced liver injury by potentiating Nrf2
regulated survival mechanism through molecular intervention in
PHLPP2-Akt-Gsk3beta axis. Apoptosis. 20:12962015. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Lee S, Lim MJ, Kim MH, Yu CH, Yun YS, Ahn
J and Song JY: An effective strategy for increasing the
radiosensitivity of Human lung Cancer cells by blocking
Nrf2-dependent antioxidant responses. Free Radic Biol Med.
53:807–816. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Singh A, Bodas M, Wakabayashi N, Bunz F
and Biswal S: Gain of Nrf2 function in non-small-cell lung cancer
cells confers radioresistance. Antioxid Redox Signal. 13:1627–1637.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Singh A, Misra V, Thimmulappa RK, Lee H,
Ames S, Hoque MO, Herman JG, Baylin SB, Sidransky D, Gabrielson E,
et al: Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung
cancer. PLoS Med. 3:e4202006. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
McDonald JT, Kim K, Norris AJ, Vlashi E,
Phillips TM, Lagadec C, Della Donna L, Ratikan J, Szelag H, Hlatky
L, et al: Ionizing radiation activates the Nrf2 antioxidant
response. Cancer Res. 70:8886–8895. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Licciulli S, Avila JL, Hanlon L, Troutman
S, Cesaroni M, Kota S, Keith B, Simon MC, Puré E, Radtke F, et al:
Notch1 is required for Kras-induced lung adenocarcinoma and
controls tumor cell survival via p53. Cancer Res. 73:5974–5984.
2013. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Donnem T, Andersen S, Al-Shibli K, Al-Saad
S, Busund LT and Bremnes RM: Prognostic impact of Notch ligands and
receptors in nonsmall cell lung cancer: Coexpression of Notch-1 and
vascular endothelial growth factor-A predicts poor survival.
Cancer. 116:5676–5685. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Tsukimoto M, Tamaishi N, Homma T and
Kojima S: Low-dose gamma-ray irradiation induces translocation of
Nrf2 into nuclear in mouse macrophage RAW264.7 cells. J Radiat Res
(Tokyo). 51:349–353. 2010. View Article : Google Scholar
|
|
44
|
Ettinger DS, Wood DE, Akerley W, Bazhenova
LA, Borghaei H, Camidge DR, Cheney RT, Chirieac LR, D'Amico TA,
Demmy TL, et al: Non-small cell lung cancer, version 6.2015. J Natl
Compr Cancer Netw. 13:515–524. 2015.
|
|
45
|
Diehn M, Cho RW, Lobo NA, Kalisky T, Dorie
MJ, Kulp AN, Qian D, Lam JS, Ailles LE, Wong M, et al: Association
of reactive oxygen species levels and radioresistance in cancer
stem cells. Nature. 458:780–783. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Caro AA, Commissariat A, Dunn C, Kim H,
García SL, Smith A, Strang H, Stuppy J, Desrochers LP and Goodwin
TE: Prooxidant and antioxidant properties of salicylaldehyde
isonicotinoyl hydrazone iron chelators in HepG2 cells. Biochim
Biophys Acta. 1850:2256–2264. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Hwang GH, Ryu JM, Jeon YJ, Choi J, Han HJ,
Lee YM, Lee S, Bae JS, Jung JW, Chang W, et al: The role of
thioredoxin reductase and glutathione reductase in
plumbagin-induced, reactive oxygen species-mediated apoptosis in
cancer cell lines. Eur J Pharmacol. 765:384–393. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Ernst IM, Schuemann C, Wagner AE and
Rimbach G: 3,3′-Diindolylmethane but not indole-3-carbinol
activates Nrf2 and induces Nrf2 target gene expression in cultured
murine fibroblasts. Free Radic Res. 45:941–949. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Zhang Y, Guan L, Wang X, Wen T, Xing J and
Zhao J: Protection of chlorophyllin against oxidative damage by
inducing HO-1 and NQO1 expression mediated by PI3K/Akt and Nrf2.
Free Radic Res. 42:362–371. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Schmidt EE: Interplay between cytosolic
disulfide reductase systems and the Nrf2/Keap1 pathway. Biochem Soc
Trans. 43:632–638. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Bi P and Kuang S: Notch signaling as a
novel regulator of metabolism. Trends Endocrinol Metab. 26:248–255.
2015. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Phillips TM, McBride WH and Pajonk F: The
response of CD24(−/low)/CD44+ breast cancer-initiating
cells to radiation. J Natl Cancer Inst. 98:1777–1785. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Purow BW, Haque RM, Noel MW, Su Q, Burdick
MJ, Lee J, Sundaresan T, Pastorino S, Park JK, Mikolaenko I, et al:
Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1,
is critical for glioma cell survival and proliferation. Cancer Res.
65:2353–2363. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Farnie G, Clarke RB, Spence K, Pinnock N,
Brennan K, Anderson NG and Bundred NJ: Novel cell culture technique
for primary ductal carcinoma in situ: Role of Notch and epidermal
growth factor receptor signaling pathways. J Natl Cancer Inst.
99:616–627. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Kim JH, Thimmulappa RK, Kumar V, Cui W,
Kumar S, Kombairaju P, Zhang H, Margolick J, Matsui W, Macvittie T,
et al: NRF2-mediated Notch pathway activation enhances
hematopoietic reconstitution following myelosuppressive radiation.
J Clin Invest. 124:730–741. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Kim W, Youn H, Kang C and Youn B:
Inflammation-induced radioresistance is mediated by ROS-dependent
inactivation of protein phosphatase 1 in non-small cell lung cancer
cells. Apoptosis. 20:1242–1252. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Servettaz A, Goulvestre C, Kavian N, Nicco
C, Guilpain P, Chéreau C, Vuiblet V, Guillevin L, Mouthon L, Weill
B, et al: Selective oxidation of DNA topoisomerase 1 induces
systemic sclerosis in the mouse. J Immunol. 182:5855–5864. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Kavian N, Servettaz A, Mongaret C, Wang A,
Nicco C, Chéreau C, Grange P, Vuiblet V, Birembaut P, Diebold MD,
et al: Targeting ADAM-17/notch signaling abrogates the development
of systemic sclerosis in a murine model. Arthritis Rheum.
62:3477–3487. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Kavian N, Servettaz A, Weill B and Batteux
F: New insights into the mechanism of notch signalling in fibrosis.
Open Rheumatol J. 6:96–102. 2012. View Article : Google Scholar : PubMed/NCBI
|
