|
1
|
Siegel RL, Miller KD and Jemal A: Cancer
statistics, 2015. CA Cancer J Clin. 65:5–29. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Neesse A, Michl P, Frese KK, Feig C, Cook
N, Jacobetz MA, Lolkema MP, Buchholz M, Olive KP, Gress TM, et al:
Stromal biology and therapy in pancreatic cancer. Gut. 60:861–868.
2011. View Article : Google Scholar
|
|
3
|
Olive KP, Jacobetz MA, Davidson CJ,
Gopinathan A, McIntyre D, Honess D, Madhu B, Goldgraben MA,
Caldwell ME, Allard D, et al: Inhibition of Hedgehog signaling
enhances delivery of chemotherapy in a mouse model of pancreatic
cancer. Science. 324:1457–1461. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Provenzano PP, Cuevas C, Chang AE, Goel
VK, Von Hoff DD and Hingorani SR: Enzymatic targeting of the stroma
ablates physical barriers to treatment of pancreatic ductal
adenocar-cinoma. Cancer Cell. 21:418–429. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Moss RA, Moore D, Mulcahy MF, Nahum K,
Saraiya B, Eddy S, Kleber M and Poplin EA: A Multi-institutional
phase 2 study of imatinib mesylate and gemcitabine for first-line
treatment of advanced pancreatic cancer. Gastrointest Cancer Res.
5:77–83. 2012.PubMed/NCBI
|
|
6
|
Apte MV, Haber PS, Applegate TL, Norton
ID, McCaughan GW, Korsten MA, Pirola RC and Wilson JS: Periacinar
stellate shaped cells in rat pancreas: Identification, isolation,
and culture. Gut. 43:128–133. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Bachem MG, Schneider E, Gross H,
Weidenbach H, Schmid RM, Menke A, Siech M, Beger H, Grünert A and
Adler G: Identification, culture, and characterization of
pancreatic stellate cells in rats and humans. Gastroenterology.
115:421–432. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Bachem MG, Zhou S, Buck K, Schneiderhan W
and Siech M: Pancreatic stellate cells - role in pancreas cancer.
Langenbecks Arch Surg. 393:891–900. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Hwang RF, Moore T, Arumugam T,
Ramachandran V, Amos KD, Rivera A, Ji B, Evans DB and Logsdon CD:
Cancer-associated stromal fibroblasts promote pancreatic tumor
progression. Cancer Res. 68:918–926. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Vonlaufen A, Joshi S, Qu C, Phillips PA,
Xu Z, Parker NR, Toi CS, Pirola RC, Wilson JS, Goldstein D, et al:
Pancreatic stellate cells: Partners in crime with pancreatic cancer
cells. Cancer Res. 68:2085–2093. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Desgrosellier JS and Cheresh DA: Integrins
in cancer: Biological implications and therapeutic opportunities.
Nat Rev Cancer. 10:9–22. 2010. View
Article : Google Scholar
|
|
12
|
Friedrichs K, Ruiz P, Franke F, Gille I,
Terpe HJ and Imhof BA: High expression level of alpha 6 integrin in
human breast carcinoma is correlated with reduced survival. Cancer
Res. 55:901–906. 1995.PubMed/NCBI
|
|
13
|
Bates RC, Bellovin DI, Brown C, Maynard E,
Wu B, Kawakatsu H, Sheppard D, Oettgen P and Mercurio AM:
Transcriptional activation of integrin beta6 during the
epithelial-mesenchymal transition defines a novel prognostic
indicator of aggressive colon carcinoma. J Clin Invest.
115:339–347. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Landen CN, Kim TJ, Lin YG, Merritt WM,
Kamat AA, Han LY, Spannuth WA, Nick AM, Jennnings NB, Kinch MS, et
al: Tumor-selective response to antibody-mediated targeting of
alphavbeta3 integrin in ovarian cancer. Neoplasia. 10:1259–1267.
2008. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Avraamides CJ, Garmy-Susini B and Varner
JA: Integrins in angiogenesis and lymphangiogenesis. Nat Rev
Cancer. 8:604–617. 2008. View
Article : Google Scholar : PubMed/NCBI
|
|
16
|
Zhu CQ, Popova SN, Brown ER,
Barsyte-Lovejoy D, Navab R, Shih W, Li M, Lu M, Jurisica I, Penn
LZ, et al: Integrin alpha 11 regulates IGF2 expression in
fibroblasts to enhance tumorigenicity of human non-small-cell lung
cancer cells. Proc Natl Acad Sci USA. 104:11754–11759. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Taverna D, Moher H, Crowley D, Borsig L,
Varki A and Hynes RO: Increased primary tumor growth in mice null
for beta3- or beta3/beta5-integrins or selectins. Proc Natl Acad
Sci USA. 101:763–768. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Jin H, Su J, Garmy-Susini B, Kleeman J and
Varner J: Integrin alpha4beta1 promotes monocyte trafficking and
angiogenesis in tumors. Cancer Res. 66:2146–2152. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Hynes RO: Integrins: Bidirectional,
allosteric signaling machines. Cell. 110:673–687. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Ludbrook SB, Barry ST, Delves CJ and
Horgan CM: The integrin alphavbeta3 is a receptor for the
latency-associated peptides of transforming growth factors beta1
and beta3. Biochem J. 369:311–318. 2003. View Article : Google Scholar
|
|
21
|
Hinz B: It has to be the αv: Myofibroblast
integrins activate latent TGF-β1. Nat Med. 19:1567–1568. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Saalbach A, Wetzel A, Haustein UF,
Sticherling M, Simon JC and Anderegg U: Interaction of human Thy-1
(CD 90) with the integrin alphavbeta3 (CD51/CD61): An important
mechanism mediating melanoma cell adhesion to activated
endothelium. Oncogene. 24:4710–4720. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Wang JT, Liu Y, Kan X, Liu M and Lu JG:
Cilengitide, a small molecule antagonist, targeted to integrin
alphanu inhibits proliferation and induces apoptosis of laryngeal
cancer cells in vitro. Eur Arch Otorhinolaryngol. 271:2233–2240.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Ohuchida K, Mizumoto K, Murakami M, Qian
LW, Sato N, Nagai E, Matsumoto K, Nakamura T and Tanaka M:
Radiation to stromal fibroblasts increases invasiveness of
pancreatic cancer cells through tumor-stromal interactions. Cancer
Res. 64:3215–3222. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Hosotani R, Kawaguchi M, Masui T, Koshiba
T, Ida J, Fujimoto K, Wada M, Doi R and Imamura M: Expression of
integrin alphaVbeta3 in pancreatic carcinoma: Relation to MMP-2
activation and lymph node metastasis. Pancreas. 25:e30–e35. 2002.
View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Eguchi D, Ikenaga N, Ohuchida K, Kozono S,
Cui L, Fujiwara K, Fujino M, Ohtsuka T, Mizumoto K and Tanaka M:
Hypoxia enhances the interaction between pancreatic stellate cells
and cancer cells via increased secretion of connective tissue
growth factor. J Surg Res. 181:225–233. 2013. View Article : Google Scholar
|
|
27
|
Gao Z, Wang X, Wu K, Zhao Y and Hu G:
Pancreatic stellate cells increase the invasion of human pancreatic
cancer cells through the stromal cell-derived factor-1/CXCR4 axis.
Pancreatology. 10:186–193. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Yang C, Zeisberg M, Mosterman B, Sudhakar
A, Yerramalla U, Holthaus K, Xu L, Eng F, Afdhal N and Kalluri R:
Liver fibrosis: Insights into migration of hepatic stellate cells
in response to extracellular matrix and growth factors.
Gastroenterology. 124:147–159. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Nabors LB, Mikkelsen T, Rosenfeld SS,
Hochberg F, Akella NS, Fisher JD, Cloud GA, Zhang Y, Carson K,
Wittemer SM, et al: Phase I and correlative biology study of
cilengitide in patients with recurrent malignant glioma. J Clin
Oncol. 25:1651–1657. 2007. View Article : Google Scholar : PubMed/NCBI
|
