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Article

Proteomic identification of potential cancer markers in human urine using subtractive analysis

  • Authors:
    • Holger Husi
    • Richard J.E. Skipworth
    • Andrew Cronshaw
    • Kenneth C.H. Fearon
    • James A. Ross
  • View Affiliations / Copyright

    Affiliations: Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, G12 8QQ, UK, School of Clinical Sciences, University of Edinburgh, Edinburgh, EH16 4SB, UK, School of Biological Sciences, University of Edinburgh, Edinburgh, EH16 4SB, UK
  • Pages: 1921-1932
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    Published online on: March 7, 2016
       https://doi.org/10.3892/ijo.2016.3424
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Abstract

Urine is an ideal medium in which to focus diagnostic cancer research due to the non-invasive nature and ease of sampling. Many large-scale proteomic studies have shown that urine is unexpectedly complex. We hypothesised that novel diagnostic cancer biomarkers could be discovered using a comparative proteomic analysis of pre-existing data. We assembled a database of 100 published datasets of 5,620 urinary proteins, as well as 46 datasets of 8,620 non-redundant proteins derived from kidney and blood proteome analyses. The data were then used to either subtract or compare molecules from a novel urinary proteome profiling dataset that we generated. We identified 1,161 unique proteins in samples from either cancer-bearing or healthy subjects. Subtractive analysis yielded a subset of 44 proteins that were found uniquely in urine from cancer patients, 30 of which were linked previously to cancer. In conclusion, this approach is useful in discovering novel biomarkers in tissues where unrelated profiling data is available. Only a limited disease-specific novel dataset is required to define new targets or substantiate previous findings. We have shared this discovery platform in the form of our Large Scale Screening Resource database, accessible through the Proteomic Analysis DataBase portal (www.PADB.org).
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1 

Good DM, Thongboonkerd V, Novak J, Bascands JL, Schanstra JP, Coon JJ, Dominiczak A and Mischak H: Body fluid proteomics for biomarker discovery: Lessons from the past hold the key to success in the future. J Proteome Res. 6:4549–4555. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Marshall T and Williams K: Two-dimensional electrophoresis of human urinary proteins following concentration by dye precipitation. Electrophoresis. 17:1265–1272. 1996. View Article : Google Scholar : PubMed/NCBI

3 

Pieper R, Gatlin CL, McGrath AM, Makusky AJ, Mondal M, Seonarain M, Field E, Schatz CR, Estock MA, Ahmed N, et al: Characterization of the human urinary proteome: A method for high-resolution display of urinary proteins on two-dimensional electrophoresis gels with a yield of nearly 1400 distinct protein spots. Proteomics. 4:1159–1174. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Büeler MR, Wiederkehr F and Vonderschmitt DJ: Electrophoretic, chromatographic and immunological studies of human urinary proteins. Electrophoresis. 16:124–134. 1995. View Article : Google Scholar : PubMed/NCBI

5 

Spahr CS, Davis MT, McGinley MD, Robinson JH, Bures EJ, Beierle J, Mort J, Courchesne PL, Chen K, Wahl RC, et al: Towards defining the urinary proteome using liquid chromatography-tandem mass spectrometry. I Profiling an unfractionated tryptic digest. Proteomics. 1:93–107. 2001. View Article : Google Scholar : PubMed/NCBI

6 

Cadieux PA, Beiko DT, Watterson JD, Burton JP, Howard JC, Knudsen BE, Gan BS, McCormick JK, Chambers AF, Denstedt JD, et al: Surface-enhanced laser desorption/ionization-time of flight-mass spectrometry (SELDI-TOF-MS): A new proteomic urinary test for patients with urolithiasis. J Clin Lab Anal. 18:170–175. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Roelofsen H, Alvarez-Llamas G, Schepers M, Landman K and Vonk RJ: Proteomics profiling of urine with surface enhanced laser desorption/ionization time of flight mass spectrometry. Proteome Sci. 5:22007. View Article : Google Scholar : PubMed/NCBI

8 

Vanhoutte KJ, Laarakkers C, Marchiori E, Pickkers P, Wetzels JF, Willems JL, van den Heuvel LP, Russel FG and Masereeuw R: Biomarker discovery with SELDI-TOF MS in human urine associated with early renal injury: Evaluation with computational analytical tools. Nephrol Dial Transplant. 22:2932–2943. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Husi H, Stephens N, Cronshaw A, MacDonald A, Gallagher I, Greig C, Fearon KC and Ross JA: Proteomic analysis of urinary upper gastrointestinal cancer markers. Proteomics Clin Appl. 5:289–299. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Petri AL, Simonsen AH, Yip TT, Hogdall E, Fung ET, Lundvall L and Hogdall C: Three new potential ovarian cancer biomarkers detected in human urine with equalizer bead technology. Acta Obstet Gynecol Scand. 88:18–26. 2009. View Article : Google Scholar

11 

Tsui KH, Tang P, Lin CY, Chang PL, Chang CH and Yung BY: Bikunin loss in urine as useful marker for bladder carcinoma. J Urol. 183:339–344. 2010. View Article : Google Scholar

12 

Chen YT, Chen CL, Chen HW, Chung T, Wu CC, Chen CD, Hsu CW, Chen MC, Tsui KH, Chang PL, et al: Discovery of novel bladder cancer biomarkers by comparative urine proteomics using iTRAQ technology. J Proteome Res. 9:5803–5815. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Tan LB, Chen KT, Yuan YC, Liao PC and Guo HR: Identification of urine PLK2 as a marker of bladder tumors by proteomic analysis. World J Urol. 28:117–122. 2010. View Article : Google Scholar

14 

Xue A, Scarlett CJ, Chung L, Butturini G, Scarpa A, Gandy R, Wilson SR, Baxter RC and Smith RC: Discovery of serum biomarkers for pancreatic adenocarcinoma using proteomic analysis. Br J Cancer. 103:391–400. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Schröder C, Jacob A, Tonack S, Radon TP, Sill M, Zucknick M, Rüffer S, Costello E, Neoptolemos JP, Crnogorac-Jurcevic T, et al: Dual-color proteomic profiling of complex samples with a microarray of 810 cancer-related antibodies. Mol Cell Proteomics. 9:1271–1280. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Good DM, Zürbig P, Argilés A, Bauer HW, Behrens G, Coon JJ, Dakna M, Decramer S, Delles C, Dominiczak AF, et al: Naturally occurring human urinary peptides for use in diagnosis of chronic kidney disease. Mol Cell Proteomics. 9:2424–2437. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Zhang Y, Zhang Y, Adachi J, Olsen JV, Shi R, de Souza G, Pasini E, Foster LJ, Macek B, Zougman A, et al: MAPU: Max-Planck Unified database of organellar, cellular, tissue and body fluid proteomes. Nucleic Acids Res. 35:D771–D779. 2007. View Article : Google Scholar :

18 

Li SJ, Peng M, Li H, Liu BS, Wang C, Wu JR, Li YX and Zeng R: Sys-BodyFluid: A systematical database for human body fluid proteome research. Nucleic Acids Res. 37:D907–D912. 2009. View Article : Google Scholar :

19 

Agron IA, Avtonomov DM, Kononikhin AS, Popov IA, Moshkovskii SA and Nikolaev EN: Accurate mass tag retention time database for urine proteome analysis by chromatography-mass spectrometry. Biochemistry (Mosc). 75:636–641. 2010. View Article : Google Scholar

20 

Carson JM, Okamura K, Wakashin H, McFann K, Dobrinskikh E, Kopp JB and Blaine J: Podocytes degrade endocytosed albumin primarily in lysosomes. PLoS One. 9:e997712014. View Article : Google Scholar : PubMed/NCBI

21 

Collins MO, Yu L and Choudhary JS: Analysis protein complexes by 1D-SDS-PAGE and tandem mass spectrometry. Protocol Exchange. 2008. View Article : Google Scholar

22 

Kentsis A, Monigatti F, Dorff K, Campagne F, Bachur R and Steen H: Urine proteomics for profiling of human disease using high accuracy mass spectrometry. Proteomics Clin Appl. 3:1052–1061. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Adachi J, Kumar C, Zhang Y, Olsen JV and Mann M: The human urinary proteome contains more than 1500 proteins, including a large proportion of membrane proteins. Genome Biol. 7:R802006. View Article : Google Scholar : PubMed/NCBI

24 

Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS and Knepper MA: Large-scale proteomics and phosphoproteomics of urinary exosomes. J Am Soc Nephrol. 20:363–379. 2009. View Article : Google Scholar :

25 

Chang KW, Yang PY, Lai HY, Yeh TS, Chen TC and Yeh CT: Identification of a novel actin isoform in hepatocellular carcinoma. Hepatol Res. 36:33–39. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Hunecke D, Spanel R, Länger F, Nam SW and Borlak J: MYC-regulated genes involved in liver cell dysplasia identified in a transgenic model of liver cancer. J Pathol. 228:520–533. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Liu Y, Zhu X, Zhu J, Liao S, Tang Q, Liu K, Guan X, Zhang J and Feng Z: Identification of differential expression of genes in hepatocellular carcinoma by suppression subtractive hybridization combined cDNA microarray. Oncol Rep. 18:943–951. 2007.PubMed/NCBI

28 

Park JH, Nishidate T, Kijima K, Ohashi T, Takegawa K, Fujikane T, Hirata K, Nakamura Y and Katagiri T: Critical roles of mucin 1 glycosylation by transactivated polypeptide N-acetylgalactosaminyltransferase 6 in mammary carcinogenesis. Cancer Res. 70:2759–2769. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Long J, Zhang B, Signorello LB, Cai Q, Deming-Halverson S, Shrubsole MJ, Sanderson M, Dennis J, Michailidou K, Easton DF, et al: Evaluating genome-wide association study-identified breast cancer risk variants in African-American women. PLoS One. 8:e583502013. View Article : Google Scholar : PubMed/NCBI

30 

Fukukawa C, Ueda K, Nishidate T, Katagiri T and Nakamura Y: Critical roles of LGN/GPSM2 phosphorylation by PBK/TOPK in cell division of breast cancer cells. Genes Chromosomes Cancer. 49:861–872. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Yang ZQ, Liu G, Bollig-Fischer A, Giroux CN and Ethier SP: Transforming properties of 8p11–12 amplified genes in human breast cancer. Cancer Res. 70:8487–8497. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Heyn H, Carmona FJ, Gomez A, Ferreira HJ, Bell JT, Sayols S, Ward K, Stefansson OA, Moran S, Sandoval J, et al: DNA methylation profiling in breast cancer discordant identical twins identifies DOK7 as novel epigenetic biomarker. Carcinogenesis. 34:102–108. 2013. View Article : Google Scholar :

33 

Kauppinen JM, Kosma VM, Soini Y, Sironen R, Nissinen M, Nykopp TK, Kärjä V, Eskelinen M, Kataja V and Mannermaa A: ST14 gene variant and decreased matriptase protein expression predict poor breast cancer survival. Cancer Epidemiol Biomarkers Prev. 19:2133–2142. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Hattori N, Okochi-Takada E, Kikuyama M, Wakabayashi M, Yamashita S and Ushijima T: Methylation silencing of angio-poietin-like 4 in rat and human mammary carcinomas. Cancer Sci. 102:1337–1343. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Ni S, Xu L, Huang J, Feng J, Zhu H, Wang G and Wang X: Increased ZO-1 expression predicts valuable prognosis in non-small cell lung cancer. Int J Clin Exp Pathol. 6:2887–2895. 2013.PubMed/NCBI

36 

Paulo P, Ribeiro FR, Santos J, Mesquita D, Almeida M, Barros-Silva JD, Itkonen H, Henrique R, Jerónimo C, Sveen A, et al: Molecular subtyping of primary prostate cancer reveals specific and shared target genes of different ETS rearrangements. Neoplasia. 14:600–611. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Blum R, Gupta R, Burger PE, Ontiveros CS, Salm SN, Xiong X, Kamb A, Wesche H, Marshall L, Cutler G, et al: Molecular signatures of prostate stem cells reveal novel signaling pathways and provide insights into prostate cancer. PLoS One. 4:e57222009. View Article : Google Scholar : PubMed/NCBI

38 

Battaglia S, Maguire O, Thorne JL, Hornung LB, Doig CL, Liu S, Sucheston LE, Bianchi A, Khanim FL, Gommersall LM, et al: Elevated NCOR1 disrupts PPARalpha/gamma signaling in prostate cancer and forms a targetable epigenetic lesion. Carcinogenesis. 31:1650–1660. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Quinn MC, Filali-Mouhim A, Provencher DM, Mes-Masson AM and Tonin PN: Reprogramming of the transcriptome in a novel chromosome 3 transfer tumor suppressor ovarian cancer cell line model affected molecular networks that are characteristic of ovarian cancer. Mol Carcinog. 48:648–661. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Quyun C, Ye Z, Lin SC and Lin B: Recent patents and advances in genomic biomarker discovery for colorectal cancers. Recent Pat DNA Gene Seq. 4:86–93. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature. 487:330–337. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Watanabe Y, Castoro RJ, Kim HS, North B, Oikawa R, Hiraishi T, Ahmed SS, Chung W, Cho MY, Toyota M, et al: Frequent alteration of MLL3 frameshift mutations in microsatellite deficient colorectal cancer. PLoS One. 6:e233202011. View Article : Google Scholar : PubMed/NCBI

43 

Shain AH, Salari K, Giacomini CP and Pollack JR: Integrative genomic and functional profiling of the pancreatic cancer genome. BMC Genomics. 14:6242013. View Article : Google Scholar : PubMed/NCBI

44 

Liu H, Ma Q and Li J: High glucose promotes cell proliferation and enhances GDNF and RET expression in pancreatic cancer cells. Mol Cell Biochem. 347:95–101. 2011. View Article : Google Scholar

45 

Fernstad R, Pousette A, Carlström K and Sköldefors H: A novel assay for pancreatic cellular damage: IV. Serum concentrations of pancreas-specific protein (PASP) in acute pancreatitis and other abdominal diseases. Pancreas. 5:42–49. 1990. View Article : Google Scholar : PubMed/NCBI

46 

Hansel DE, Rahman A, House M, Ashfaq R, Berg K, Yeo CJ and Maitra A: Met proto-oncogene and insulin-like growth factor binding protein 3 overexpression correlates with metastatic ability in well-differentiated pancreatic endocrine neoplasms. Clin Cancer Res. 10:6152–6158. 2004. View Article : Google Scholar : PubMed/NCBI

47 

Iio A, Takagi T, Miki K, Naoe T, Nakayama A and Akao Y: DDX6 post-transcriptionally down-regulates miR-143/145 expression through host gene NCR143/145 in cancer cells. Biochim Biophys Acta. 1829:1102–1110. 2013. View Article : Google Scholar : PubMed/NCBI

48 

Bai RY, Koester C, Ouyang T, Hahn SA, Hammerschmidt M, Peschel C and Duyster J: SMIF, a Smad4-interacting protein that functions as a co-activator in TGFbeta signaling. Nat Cell Biol. 4:181–190. 2002. View Article : Google Scholar : PubMed/NCBI

49 

Lu YC, Yao X, Crystal JS, Li YF, El-Gamil M, Gross C, Davis L, Dudley ME, Yang JC, Samuels Y, et al: Efficient identification of mutated cancer antigens recognized by T cells associated with durable tumor regressions. Clin Cancer Res. 20:3401–3410. 2014. View Article : Google Scholar : PubMed/NCBI

50 

Fernández-Sáiz V, Targosz BS, Lemeer S, Eichner R, Langer C, Bullinger L, Reiter C, Slotta-Huspenina J, Schroeder S, Knorn AM, et al: SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma. Nat Cell Biol. 15:72–81. 2013. View Article : Google Scholar

51 

Lee LR, Teng PN, Nguyen H, Hood BL, Kavandi L, Wang G, Turbov JM, Thaete LG, Hamilton CA, Maxwell GL, et al: Progesterone enhances calcitriol antitumor activity by upregulating vitamin D receptor expression and promoting apoptosis in endometrial cancer cells. Cancer Prev Res (Phila). 6:731–743. 2013. View Article : Google Scholar

52 

Giefing M, Zemke N, Brauze D, Kostrzewska-Poczekaj M, Luczak M, Szaumkessel M, Pelinska K, Kiwerska K, Tönnies H, Grenman R, et al: High resolution ArrayCGH and expression profiling identifies PTPRD and PCDH17/PCH68 as tumor suppressor gene candidates in laryngeal squamous cell carcinoma. Genes Chromosomes Cancer. 50:154–166. 2011. View Article : Google Scholar : PubMed/NCBI

53 

Al-Shali K, Wang J, Rosen F and Hegele RA: Ileal adenocarcinoma in a mild phenotype of abetalipoproteinemia. Clin Genet. 63:135–138. 2003. View Article : Google Scholar : PubMed/NCBI

54 

Silvério R, Laviano A, Rossi Fanelli F and Seelaender M: L-Carnitine induces recovery of liver lipid metabolism in cancer cachexia. Amino Acids. 42:1783–1792. 2012. View Article : Google Scholar

55 

Hjortland GO, Meza-Zepeda LA, Beiske K, Ree AH, Tveito S, Hoifodt H, Bohler PJ, Hole KH, Myklebost O, Fodstad O, et al: Genome wide single cell analysis of chemotherapy resistant metastatic cells in a case of gastroesophageal adenocarcinoma. BMC Cancer. 11:4552011. View Article : Google Scholar : PubMed/NCBI

56 

Adachi R, Horiuchi S, Sakurazawa Y, Hasegawa T, Sato K and Sakamaki T: ErbB2 down-regulates microRNA-205 in breast cancer. Biochem Biophys Res Commun. 411:804–808. 2011. View Article : Google Scholar : PubMed/NCBI

57 

Janku F, Garrido-Laguna I, Petruzelka LB, Stewart DJ and Kurzrock R: Novel therapeutic targets in non-small cell lung cancer. J Thorac Oncol. 6:1601–1612. 2011. View Article : Google Scholar : PubMed/NCBI

58 

Goldin RD and Roa JC: Gallbladder cancer: A morphological and molecular update. Histopathology. 55:218–229. 2009. View Article : Google Scholar : PubMed/NCBI

59 

Komoto M, Nakata B, Amano R, Yamada N, Yashiro M, Ohira M, Wakasa K and Hirakawa K: HER2 overexpression correlates with survival after curative resection of pancreatic cancer. Cancer Sci. 100:1243–1247. 2009. View Article : Google Scholar : PubMed/NCBI

60 

Elsahwi KS and Santin AD: erbB2 overexpression in uterine serous cancer: A molecular target for trastuzumab therapy. Obstet Gynecol Int. 2011:1282952011. View Article : Google Scholar : PubMed/NCBI

61 

Mazzio EA, Boukli N, Rivera N and Soliman KF: Pericellular pH homeostasis is a primary function of the Warburg effect: Inversion of metabolic systems to control lactate steady state in tumor cells. Cancer Sci. 103:422–432. 2012. View Article : Google Scholar : PubMed/NCBI

62 

Hu Y, Wang J, Yang B, Zheng N, Qin M, Ji Y, Lin G, Tian L, Wu X, Wu L, et al: Guanylate binding protein 4 negatively regulates virus-induced type I IFN and antiviral response by targeting IFN regulatory factor 7. J Immunol. 187:6456–6462. 2011. View Article : Google Scholar : PubMed/NCBI

63 

Maes T, Barceló A and Buesa C: Neuron navigator: A human gene family with homology to unc-53, a cell guidance gene from Caenorhabditis elegans. Genomics. 80:21–30. 2002. View Article : Google Scholar : PubMed/NCBI

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Husi H, Skipworth RJ, Cronshaw A, Fearon KC and Ross JA: Proteomic identification of potential cancer markers in human urine using subtractive analysis. Int J Oncol 48: 1921-1932, 2016.
APA
Husi, H., Skipworth, R.J., Cronshaw, A., Fearon, K.C., & Ross, J.A. (2016). Proteomic identification of potential cancer markers in human urine using subtractive analysis. International Journal of Oncology, 48, 1921-1932. https://doi.org/10.3892/ijo.2016.3424
MLA
Husi, H., Skipworth, R. J., Cronshaw, A., Fearon, K. C., Ross, J. A."Proteomic identification of potential cancer markers in human urine using subtractive analysis". International Journal of Oncology 48.5 (2016): 1921-1932.
Chicago
Husi, H., Skipworth, R. J., Cronshaw, A., Fearon, K. C., Ross, J. A."Proteomic identification of potential cancer markers in human urine using subtractive analysis". International Journal of Oncology 48, no. 5 (2016): 1921-1932. https://doi.org/10.3892/ijo.2016.3424
Copy and paste a formatted citation
x
Spandidos Publications style
Husi H, Skipworth RJ, Cronshaw A, Fearon KC and Ross JA: Proteomic identification of potential cancer markers in human urine using subtractive analysis. Int J Oncol 48: 1921-1932, 2016.
APA
Husi, H., Skipworth, R.J., Cronshaw, A., Fearon, K.C., & Ross, J.A. (2016). Proteomic identification of potential cancer markers in human urine using subtractive analysis. International Journal of Oncology, 48, 1921-1932. https://doi.org/10.3892/ijo.2016.3424
MLA
Husi, H., Skipworth, R. J., Cronshaw, A., Fearon, K. C., Ross, J. A."Proteomic identification of potential cancer markers in human urine using subtractive analysis". International Journal of Oncology 48.5 (2016): 1921-1932.
Chicago
Husi, H., Skipworth, R. J., Cronshaw, A., Fearon, K. C., Ross, J. A."Proteomic identification of potential cancer markers in human urine using subtractive analysis". International Journal of Oncology 48, no. 5 (2016): 1921-1932. https://doi.org/10.3892/ijo.2016.3424
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