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Article

A novel curcuminoid exhibits enhanced antitumor activity in nasopharyngeal carcinoma

  • Authors:
    • Yunbao Pan
    • Guohong Liu
    • Jian Xiao
    • Bojin Su
    • Fuling Zhou
    • Yongchang Wei
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Affiliated Hospital, Jiangnan University, Wuxi, Jiangsu 214062, P.R. China, School of Materials Science and Engineering, Sun Yat-Sen University, Guangzhou 510275, P.R. China, Department of Pathophysiology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, P.R. China, Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China, Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China
  • Pages: 2175-2183
    |
    Published online on: March 7, 2016
       https://doi.org/10.3892/ijo.2016.3425
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Abstract

Curcumin shows growth-inhibition against tumor cells through multi-target mechanisms. Nevertheless, the poor stability and pharmacokinetics considerably limit its clinical functions. Increased effort has been put into the chemical alteration of curcumin to find potential analogues with improved bioavailability and antitumor activities. In this study, the antitumor activity of a novel curcuminoid (B63) in nasopharyngeal carcinoma (NPC) was examined. The MTT and colony formation assays were used to detect NPC cell viability and proliferation. Flow cytometry was used to detect cell cycle distribution. The Annexin V/PI staining assay and cleavage PARP and cleavage caspase-3 expression were used to examine apoptosis. Western blotting was used to examine the protein expression of endoplasmic reticulum (ER) stress pathway markers, XBP-1, ATF-4 and CHOP. The suppressive effect of B63 on tumor growth was examined in vivo by subcutaneously inoculated NPC in a tumor model using nude mice. Treatment with B63 potentially caused growth inhibition and apoptosis in NPC cells in a dose- and time-responsive manner. Its antitumor effect was associated with the ER stress activation. Nevertheless, the same dose of curcumin did not activate ER stress. In addition, knockdown of Chop attenuated B63-induced cell viability inhibition, suggesting that the apoptotic pathway is ER stress-dependent. The tumor volume and weight were significantly reduced by pretreating the NPC cells with B63 before implantation in the in vivo mouse model. B63 exhibited a more potent antitumor action than curcumin in NPC. These observations on the novel compound B63 indicate a novel candidate for NPC therapy.
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View References

1 

Lo KW, Chung GT and To KF: Deciphering the molecular genetic basis of NPC through molecular, cytogenetic, and epigenetic approaches. Semin Cancer Biol. 22:79–86. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Hui EP, Ma BB, Leung SF, King AD, Mo F, Kam MK, Yu BK, Chiu SK, Kwan WH, Ho R, et al: Randomized phase II trial of concurrent cisplatin-radiotherapy with or without neoadjuvant docetaxel and cisplatin in advanced nasopharyngeal carcinoma. J Clin Oncol. 27:242–249. 2009. View Article : Google Scholar

3 

Chan AT: Nasopharyngeal carcinoma. Ann Oncol. 21(Suppl 7): vii308–vii312. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Yip KW, Mocanu JD, Au PY, Sleep GT, Huang D, Busson P, Yeh W-C, Gilbert R, O'Sullivan B, Gullane P, et al: Combination bcl-2 antisense and radiation therapy for nasopharyngeal cancer. Clin Cancer Res. 11:8131–8144. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Lev-Ari S, Lichtenberg D and Arber N: Compositions for treatment of cancer and inflammation. Recent Patents Anticancer Drug Discov. 3:55–62. 2008. View Article : Google Scholar

6 

Gandhy SU, Kim K, Larsen L, Rosengren RJ and Safe S: Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein (Sp) transcription factors by targeting microRNAs. BMC Cancer. 12:5642012. View Article : Google Scholar : PubMed/NCBI

7 

Pan Y, Xiao J, Liang G, Wang M, Wang D, Wang S and Yang H: A new curcumin analogue exhibits enhanced antitumor activity in nasopharyngeal carcinoma. Oncol Rep. 30:239–245. 2013.PubMed/NCBI

8 

Lin SS, Huang HP, Yang JS, Wu JY, Hsia TC, Lin CC, Lin CW, Kuo CL, Gibson Wood W and Chung JG: DNA damage and endoplasmic reticulum stress mediated curcumin-induced cell cycle arrest and apoptosis in human lung carcinoma A-549 cells through the activation caspases cascade- and mitochondrial-dependent pathway. Cancer Lett. 272:77–90. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Bakhshi J, Weinstein L, Poksay KS, Nishinaga B, Bredesen DE and Rao RV: Coupling endoplasmic reticulum stress to the cell death program in mouse melanoma cells: effect of curcumin. Apoptosis. 13:904–914. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Anand P, Kunnumakkara AB, Newman RA and Aggarwal BB: Bioavailability of curcumin: Problems and promises. Mol Pharm. 4:807–818. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Yogosawa S, Yamada Y, Yasuda S, Sun Q, Takizawa K and Sakai T: Dehydrozingerone, a structural analogue of curcumin, induces cell-cycle arrest at the G2/M phase and accumulates intracellular ROS in HT-29 human colon cancer cells. J Nat Prod. 75:2088–2093. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Subramaniam D, May R, Sureban SM, Lee KB, George R, Kuppusamy P, Ramanujam RP, Hideg K, Dieckgraefe BK, Houchen CW, et al: Diphenyl difluoroketone: A curcumin derivative with potent in vivo anticancer activity. Cancer Res. 68:1962–1969. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Liang G, Yang S, Zhou H, Shao L, Huang K, Xiao J, Huang Z and Li X: Synthesis, crystal structure and anti-inflammatory properties of curcumin analogues. Eur J Med Chem. 44:915–919. 2009. View Article : Google Scholar

14 

Liang G, Shao L, Wang Y, Zhao C, Chu Y, Xiao J, Zhao Y, Li X and Yang S: Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents. Bioorg Med Chem. 17:2623–2631. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Xiao J, Wang Y, Peng J, Guo L, Hu J, Cao M, Zhang X, Zhang H, Wang Z, Li X, et al: A synthetic compound, 1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one (B63), induces apoptosis and activates endoplasmic reticulum stress in non-small cell lung cancer cells. Int J Cancer. 131:1455–1465. 2012. View Article : Google Scholar

16 

Pan Y, Zhang Q, Tian L, Wang X, Fan X, Zhang H, Claret FX and Yang H: Jab1/CSN5 negatively regulates p27 and plays a role in the pathogenesis of nasopharyngeal carcinoma. Cancer Res. 72:1890–1900. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Pan Y, Wang M, Bu X, Zuo Y, Wang S, Wang D, Liu Q, Su B, Xu T, Wang C, et al: Curcumin analogue T83 exhibits potent antitumor activity and induces radiosensitivity through inactivation of Jab1 in nasopharyngeal carcinoma. BMC Cancer. 13:3232013. View Article : Google Scholar : PubMed/NCBI

18 

Pan Y, Zhang Q, Atsaves V, Yang H and Claret FX: Suppression of Jab1/CSN5 induces radio- and chemo-sensitivity in nasopharyngeal carcinoma through changes to the DNA damage and repair pathways. Oncogene. 32:2756–2766. 2013. View Article : Google Scholar :

19 

Lazebnik YA, Kaufmann SH, Desnoyers S, Poirier GG and Earnshaw WC: Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature. 371:346–347. 1994. View Article : Google Scholar : PubMed/NCBI

20 

Nicholson DW, Ali A, Thornberry NA, Vaillancourt JP, Ding CK, Gallant M, Gareau Y, Griffin PR, Labelle M, Lazebnik YA, et al: Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature. 376:37–43. 1995. View Article : Google Scholar : PubMed/NCBI

21 

Tabas I and Ron D: Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat Cell Biol. 13:184–190. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Szegezdi E, Logue SE, Gorman AM and Samali A: Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep. 7:880–885. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Hatcher H, Planalp R, Cho J, Torti FM and Torti SV: Curcumin: From ancient medicine to current clinical trials. Cell Mol Life Sci. 65:1631–1652. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Strimpakos AS and Sharma RA: Curcumin: preventive and therapeutic properties in laboratory studies and clinical trials. Antioxid Redox Signal. 10:511–545. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Sharma RA, Euden SA, Platton SL, Cooke DN, Shafayat A, Hewitt HR, Marczylo TH, Morgan B, Hemingway D, Plummer SM, et al: Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance. Clin Cancer Res. 10:6847–6854. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Dhillon N, Aggarwal BB, Newman RA, Wolff RA, Kunnumakkara AB, Abbruzzese JL, Ng CS, Badmaev V and Kurzrock R: Phase II trial of curcumin in patients with advanced pancreatic cancer. Clin Cancer Res. 14:4491–4499. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Padhye S, Chavan D, Pandey S, Deshpande J, Swamy KV and Sarkar FH: Perspectives on chemopreventive and therapeutic potential of curcumin analogs in medicinal chemistry. Mini Rev Med Chem. 10:372–387. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Tomren MA, Másson M, Loftsson T and Tønnesen HH: Studies on curcumin and curcuminoids XXXI. Symmetric and asymmetric curcuminoids: Stability, activity and complexation with cyclodextrin. Int J Pharm. 338:27–34. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Moragoda L, Jaszewski R and Majumdar AP: Curcumin induced modulation of cell cycle and apoptosis in gastric and colon cancer cells. Anticancer Res. 21A:873–878. 2001.

30 

Dolai S, Pal S, Yadav RK and Adak S: Endoplasmic reticulum stress-induced apoptosis in Leishmania through Ca2+-dependent and caspase-independent mechanism. J Biol Chem. 286:13638–13646. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Rasheva VI and Domingos PM: Cellular responses to endoplasmic reticulum stress and apoptosis. Apoptosis. 14:996–1007. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Schleicher SM, Moretti L, Varki V and Lu B: Progress in the unraveling of the endoplasmic reticulum stress/autophagy pathway and cancer: Implications for future therapeutic approaches. Drug Resist Updat. 13:79–86. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Oyadomari S and Mori M: Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ. 11:381–389. 2004. View Article : Google Scholar

34 

Huang SM, Cheung CW, Chang CS, Tang CH, Liu JF, Lin YH, Chen JH, Ko SH, Wong KL and Lu DY: Phloroglucinol derivative MCPP induces cell apoptosis in human colon cancer. J Cell Biochem. 112:643–652. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Ma J, Qiu Y, Yang L, Peng L, Xia Z, Hou LN, Fang C, Qi H and Chen HZ: Desipramine induces apoptosis in rat glioma cells via endoplasmic reticulum stress-dependent CHOP pathway. J Neurooncol. 101:41–48. 2011. View Article : Google Scholar

36 

Wali VB, Bachawal SV and Sylvester PW: Endoplasmic reticulum stress mediates gamma-tocotrienol-induced apoptosis in mammary tumor cells. Apoptosis. 14:1366–1377. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Shelton SN, Dillard CD and Robertson JD: Activation of caspase-9, but not caspase-2 or caspase-8, is essential for heat-induced apoptosis in Jurkat cells. J Biol Chem. 285:40525–40533. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Freudlsperger C, Greten J and Schumacher U: Curcumin induces apoptosis in human neuroblastoma cells via inhibition of NFkappaB. Anticancer Res. 28A:209–214. 2008.

39 

Krueger SA, Wilson GD, Piasentin E, Joiner MC and Marples B: The effects of G2-phase enrichment and checkpoint abrogation on low-dose hyper-radiosensitivity. Int J Radiat Oncol Biol Phys. 77:1509–1517. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Fernet M, Mégnin-Chanet F, Hall J and Favaudon V: Control of the G2/M checkpoints after exposure to low doses of ionising radiation: Implications for hyper-radiosensitivity. DNA Repair (Amst). 9:48–57. 2010. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Pan Y, Liu G, Xiao J, Su B, Zhou F and Wei Y: A novel curcuminoid exhibits enhanced antitumor activity in nasopharyngeal carcinoma. Int J Oncol 48: 2175-2183, 2016.
APA
Pan, Y., Liu, G., Xiao, J., Su, B., Zhou, F., & Wei, Y. (2016). A novel curcuminoid exhibits enhanced antitumor activity in nasopharyngeal carcinoma. International Journal of Oncology, 48, 2175-2183. https://doi.org/10.3892/ijo.2016.3425
MLA
Pan, Y., Liu, G., Xiao, J., Su, B., Zhou, F., Wei, Y."A novel curcuminoid exhibits enhanced antitumor activity in nasopharyngeal carcinoma". International Journal of Oncology 48.5 (2016): 2175-2183.
Chicago
Pan, Y., Liu, G., Xiao, J., Su, B., Zhou, F., Wei, Y."A novel curcuminoid exhibits enhanced antitumor activity in nasopharyngeal carcinoma". International Journal of Oncology 48, no. 5 (2016): 2175-2183. https://doi.org/10.3892/ijo.2016.3425
Copy and paste a formatted citation
x
Spandidos Publications style
Pan Y, Liu G, Xiao J, Su B, Zhou F and Wei Y: A novel curcuminoid exhibits enhanced antitumor activity in nasopharyngeal carcinoma. Int J Oncol 48: 2175-2183, 2016.
APA
Pan, Y., Liu, G., Xiao, J., Su, B., Zhou, F., & Wei, Y. (2016). A novel curcuminoid exhibits enhanced antitumor activity in nasopharyngeal carcinoma. International Journal of Oncology, 48, 2175-2183. https://doi.org/10.3892/ijo.2016.3425
MLA
Pan, Y., Liu, G., Xiao, J., Su, B., Zhou, F., Wei, Y."A novel curcuminoid exhibits enhanced antitumor activity in nasopharyngeal carcinoma". International Journal of Oncology 48.5 (2016): 2175-2183.
Chicago
Pan, Y., Liu, G., Xiao, J., Su, B., Zhou, F., Wei, Y."A novel curcuminoid exhibits enhanced antitumor activity in nasopharyngeal carcinoma". International Journal of Oncology 48, no. 5 (2016): 2175-2183. https://doi.org/10.3892/ijo.2016.3425
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