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Article

Inhibitory role of TRIP-Br1 oncoprotein in hypoxia-induced apoptosis in breast cancer cell lines

  • Authors:
    • Chengping Li
    • Samil Jung
    • Young Yang
    • Keun-Il Kim
    • Jong-Seok Lim
    • Chung-Il Cheon
    • Myeong-Sok Lee
  • View Affiliations / Copyright

    Affiliations: Department of Biological Science, Sookmyung Women's University, Seoul 140-742, Republic of Korea
  • Pages: 2639-2646
    |
    Published online on: March 24, 2016
       https://doi.org/10.3892/ijo.2016.3454
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Abstract

TRIP-Br1 oncoprotein is known to be involved in many vital cellular functions. In this study, we examined the role of TRIP-Br1 in hypoxia-induced cell death. Exposure to the overcrowded and CoCl2-induced hypoxic conditions increased TRIP-Br1 expression at the protein level in six breast cancer cell lines (MCF7, MDA-MB-231, T47D, Hs578D, BT549, and MDA-MB-435) but resulted in no significant change in three normal cell lines (MCF10A, MEF and NIH3T3). Our result revealed that CoCl2-induced hypoxia stimulated apoptosis and autophagy, in which TRIP-Br1 expression was found to be upregulated. Interestingly, TRIP-Br1 silencing in the MCF7 and MDA-MB-231 cancer cells accelerated apoptosis and destabilization of XIAP under the CoCl2-induced hypoxic condition, implying that TRIP-Br1 may render cancer cells resistant to apoptosis through the stabilization of XIAP. We also propose that TRIP-Br1 seems to be upregulated at least partly as a result of the inhibition of PI3K/AKT signaling pathway and the overexpression of HIF-1α. In conclusion, our findings suggest that TRIP-Br1 functions as an oncogenic protein by providing cancer cells resistance to the hypoxia-induced cell death.
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1 

Leontieva OV and Blagosklonny MV: Yeast-like chronological senescence in mammalian cells: Phenomenon, mechanism and pharmacological suppression. Aging (Albany, NY). 3:1078–1091. 2011. View Article : Google Scholar

2 

Rubin H: Multistage carcinogenesis in cell culture. Dev Biol (Basel). 106:61–66; discussion 67, 143–160. 2001.

3 

Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Piret JP, Mottet D, Raes M and Michiels C: CoCl2, a chemical inducer of hypoxia-inducible factor-1, and hypoxia reduce apoptotic cell death in hepatoma cell line HepG2. Ann NY Acad Sci. 973:443–447. 2002. View Article : Google Scholar

5 

Semenza GL: HIF-1: mediator of physiological and patho-physiological responses to hypoxia. J Appl Physiol (1985). 88:1474–1480. 2000.

6 

Lee KA, Roth RA and LaPres JJ: Hypoxia, drug therapy and toxicity. Pharmacol Ther. 113:229–246. 2007. View Article : Google Scholar

7 

Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M, Neeman M, Bono F, Abramovitch R, Maxwell P, et al: Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature. 394:485–490. 1998. View Article : Google Scholar : PubMed/NCBI

8 

Rankin EB and Giaccia AJ: The role of hypoxia-inducible factors in tumorigenesis. Cell Death Differ. 15:678–685. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Rofstad EK and Danielsen T: Hypoxia-induced metastasis of human melanoma cells: Involvement of vascular endothelial growth factor-mediated angiogenesis. Br J Cancer. 80:1697–1707. 1999. View Article : Google Scholar : PubMed/NCBI

10 

Kothari S, Cizeau J, McMillan-Ward E, Israels SJ, Bailes M, Ens K, Kirshenbaum LA and Gibson SB: BNIP3 plays a role in hypoxic cell death in human epithelial cells that is inhibited by growth factors EGF and IGF. Oncogene. 22:4734–4744. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Suzuki H, Tomida A and Tsuruo T: Dephosphorylated hypoxia-inducible factor 1alpha as a mediator of p53-dependent apoptosis during hypoxia. Oncogene. 20:5779–5788. 2001. View Article : Google Scholar : PubMed/NCBI

12 

Tafani M, Schito L, Anwar T, Indelicato M, Sale P, Di Vito M, Morgante E, Beraldi R, Makovec F, Letari O, et al: Induction of autophagic cell death by a novel molecule is increased by hypoxia. Autophagy. 4:1042–1053. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Scarlatti F, Granata R, Meijer AJ and Codogno P: Does autophagy have a license to kill mammalian cells? Cell Death Differ. 16:12–20. 2009. View Article : Google Scholar

14 

Bursch W, Karwan A, Mayer M, Dornetshuber J, Fröhwein U, Schulte-Hermann R, Fazi B, Di Sano F, Piredda L, Piacentini M, et al: Cell death and autophagy: Cytokines, drugs, and nutritional factors. Toxicology. 254:147–157. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Zhang H, Bosch-Marce M, Shimoda LA, Tan YS, Baek JH, Wesley JB, Gonzalez FJ and Semenza GL: Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J Biol Chem. 283:10892–10903. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Ou XM, Chen K and Shih JC: Monoamine oxidase A and repressor R1 are involved in apoptotic signaling pathway. Proc Natl Acad Sci USA. 103:10923–10928. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Izuishi K, Kato K, Ogura T, Kinoshita T and Esumi H: Remarkable tolerance of tumor cells to nutrient deprivation: Possible new biochemical target for cancer therapy. Cancer Res. 60:6201–6207. 2000.PubMed/NCBI

18 

Piret JP, Lecocq C, Toffoli S, Ninane N, Raes M and Michiels C: Hypoxia and CoCl2 protect HepG2 cells against serum deprivation- and t-BHP-induced apoptosis: A possible anti-apoptotic role for HIF-1. Exp Cell Res. 295:340–349. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Heyman SN, Leibowitz D, Mor-Yosef Levi I, Liberman A, Eisenkraft A, Elcalai R, Khamaisi M and Rosenberger C: Adaptive response to hypoxia and remote ischemia preconditioning: A new HIF era in clinical medicine. Acta Physiol (Oxf). Oct 9–2015.(Epub ahead of print).

20 

Hirst DG and Wood PJ: The adaptive response of mouse tumours to anaemia and retransfusion. Int J Radiat Biol Relat Stud Phys Chem Med. 51:597–609. 1987. View Article : Google Scholar : PubMed/NCBI

21 

Acker T and Plate KH: A role for hypoxia and hypoxia-inducible transcription factors in tumor physiology. J Mol Med Berl. 80:562–575. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Hsu SI, Yang CM, Sim KG, Hentschel DM, O'Leary E and Bonventre JV: TRIP-Br: A novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1. EMBO J. 20:2273–2285. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Sim KG, Zang Z, Yang CM, Bonventre JV and Hsu SI: TRIP-Br links E2F to novel functions in the regulation of cyclin E expression during cell cycle progression and in the maintenance of genomic stability. Cell Cycle. 3:1296–1304. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Sim KG, Cheong JK and Hsu SI: The TRIP-Br family of transcriptional regulators is essential for the execution of cyclin E-mediated cell cycle progression. Cell Cycle. 5:1111–1115. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Hong SW, Kim CJ, Park WS, Shin JS, Lee SD, Ko SG, Jung SI, Park IC, An SK, Lee WK, et al: p34SEI-1 inhibits apoptosis through the stabilization of the X-linked inhibitor of apoptosis protein: p34SEI-1 as a novel target for anti-breast cancer strategies. Cancer Res. 69:741–746. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Li J, Muscarella P, Joo SH, Knobloch TJ, Melvin WS, Weghorst CM and Tsai MD: Dissection of CDK4-binding and transactivation activities of p34(SEI-1) and comparison between functions of p34(SEI-1) and p16(INK4A). Biochemistry. 44:13246–13256. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Sugimoto M, Nakamura T, Ohtani N, Hampson L, Hampson IN, Shimamoto A, Furuichi Y, Okumura K, Niwa S, Taya Y, et al: Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1). Genes Dev. 13:3027–3033. 1999. View Article : Google Scholar : PubMed/NCBI

28 

Liew CW, Boucher J, Cheong JK, Vernochet C, Koh HJ, Mallol C, Townsend K, Langin D, Kawamori D, Hu J, et al: Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance. Nat Med. 19:217–226. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Fernandez-Marcos PJ, Pantoja C, Gonzalez-Rodriguez A, Martin N, Flores JM, Valverde AM, Hara E and Serrano M: Normal proliferation and tumorigenesis but impaired pancreatic function in mice lacking the cell cycle regulator sei1. PLoS One. 5:e87442010. View Article : Google Scholar : PubMed/NCBI

30 

Jung S, Ohk J, Jeong D, Li C, Lee S, Duan J, Kim C, Lim JS, Yang Y, Kim KI, et al: Distinct regulatory effect of the p34SEI-1 oncoprotein on cancer metastasis in HER2/neu-positive and -negative cells. Int J Oncol. 45:189–196. 2014.PubMed/NCBI

31 

Hong SW, Shin JS, Lee YM, Kim DG, Lee SY, Yoon DH, Jung SY, Hwang JJ, Lee SJ, Cho DH, et al: p34 (SEI-1) inhibits ROS-induced cell death through suppression of ASK1. Cancer Biol Ther. 12:421–426. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Gozuacik D and Kimchi A: Autophagy as a cell death and tumor suppressor mechanism. Oncogene. 23:2891–2906. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Chen S, Rehman SK, Zhang W, Wen A, Yao L and Zhang J: Autophagy is a therapeutic target in anticancer drug resistance. Biochim Biophys Acta. 1806:220–229. 2010.PubMed/NCBI

34 

Jung S, Li C, Duan J, Lee S, Kim K, Park Y, Yang Y, Kim KI, Lim JS, Cheon CI, et al: TRIP-Br1 oncoprotein inhibits autophagy, apoptosis, and necroptosis under nutrient/serum-deprived condition. Oncotarget. 6:29060–29075. 2015.PubMed/NCBI

35 

Jung S, Li C, Jeong D, Lee S, Ohk J, Park M, Han S, Duan J, Kim C, Yang Y, et al: Oncogenic function of p34SEI-1 via NEDD4-1-mediated PTEN ubiquitination/degradation and activation of the PI3K/AKT pathway. Int J Oncol. 43:1587–1595. 2013.PubMed/NCBI

36 

Choi EJ, Kim T and Lee MS: Pro-apoptotic effect and cytotoxicity of genistein and genistin in human ovarian cancer SK-OV-3 cells. Life Sci. 80:1403–1408. 2007. View Article : Google Scholar : PubMed/NCBI

37 

Li C, Jung S, Lee S, Jeong D, Yang Y, Kim KI, Lim JS, Cheon CI, Kim C, Kang YS, et al: Nutrient/serum starvation derived TRIP-Br3 down-regulation accelerates apoptosis by destabilizing XIAP. Oncotarget. 6:7522–7535. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Hayashi R, Goto Y, Ikeda R, Yokoyama KK and Yoshida K: CDCA4 is an E2F transcription factor family-induced nuclear factor that regulates E2F-dependent transcriptional activation and cell proliferation. J Biol Chem. 281:35633–35648. 2006. View Article : Google Scholar : PubMed/NCBI

39 

Tategu M, Nakagawa H, Hayashi R and Yoshida K: Transcriptional co-factor CDCA4 participates in the regulation of JUN oncogene expression. Biochimie. 90:1515–1522. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Bennetts JS, Fowles LF, Berkman JL, van Bueren KL, Richman JM, Simpson F and Wicking C: Evolutionary conservation and murine embryonic expression of the gene encoding the SERTA domain-containing protein CDCA4 (HEPP). Gene. 374:153–165. 2006. View Article : Google Scholar : PubMed/NCBI

41 

Bohensky J, Shapiro IM, Leshinsky S, Terkhorn SP, Adams CS and Srinivas V: HIF-1 regulation of chondrocyte apoptosis: Induction of the autophagic pathway. Autophagy. 3:207–214. 2007. View Article : Google Scholar : PubMed/NCBI

42 

Pursiheimo JP, Rantanen K, Heikkinen PT, Johansen T and Jaakkola PM: Hypoxia-activated autophagy accelerates degradation of SQSTM1/p62. Oncogene. 28:334–344. 2009. View Article : Google Scholar

43 

Weidemann A and Johnson RS: Biology of HIF-1alpha. Cell Death Differ. 15:621–627. 2008. View Article : Google Scholar : PubMed/NCBI

44 

Greijer AE and van der Wall E: The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis. J Clin Pathol. 57:1009–1014. 2004. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li C, Jung S, Yang Y, Kim K, Lim J, Cheon C and Lee M: Inhibitory role of TRIP-Br1 oncoprotein in hypoxia-induced apoptosis in breast cancer cell lines. Int J Oncol 48: 2639-2646, 2016.
APA
Li, C., Jung, S., Yang, Y., Kim, K., Lim, J., Cheon, C., & Lee, M. (2016). Inhibitory role of TRIP-Br1 oncoprotein in hypoxia-induced apoptosis in breast cancer cell lines. International Journal of Oncology, 48, 2639-2646. https://doi.org/10.3892/ijo.2016.3454
MLA
Li, C., Jung, S., Yang, Y., Kim, K., Lim, J., Cheon, C., Lee, M."Inhibitory role of TRIP-Br1 oncoprotein in hypoxia-induced apoptosis in breast cancer cell lines". International Journal of Oncology 48.6 (2016): 2639-2646.
Chicago
Li, C., Jung, S., Yang, Y., Kim, K., Lim, J., Cheon, C., Lee, M."Inhibitory role of TRIP-Br1 oncoprotein in hypoxia-induced apoptosis in breast cancer cell lines". International Journal of Oncology 48, no. 6 (2016): 2639-2646. https://doi.org/10.3892/ijo.2016.3454
Copy and paste a formatted citation
x
Spandidos Publications style
Li C, Jung S, Yang Y, Kim K, Lim J, Cheon C and Lee M: Inhibitory role of TRIP-Br1 oncoprotein in hypoxia-induced apoptosis in breast cancer cell lines. Int J Oncol 48: 2639-2646, 2016.
APA
Li, C., Jung, S., Yang, Y., Kim, K., Lim, J., Cheon, C., & Lee, M. (2016). Inhibitory role of TRIP-Br1 oncoprotein in hypoxia-induced apoptosis in breast cancer cell lines. International Journal of Oncology, 48, 2639-2646. https://doi.org/10.3892/ijo.2016.3454
MLA
Li, C., Jung, S., Yang, Y., Kim, K., Lim, J., Cheon, C., Lee, M."Inhibitory role of TRIP-Br1 oncoprotein in hypoxia-induced apoptosis in breast cancer cell lines". International Journal of Oncology 48.6 (2016): 2639-2646.
Chicago
Li, C., Jung, S., Yang, Y., Kim, K., Lim, J., Cheon, C., Lee, M."Inhibitory role of TRIP-Br1 oncoprotein in hypoxia-induced apoptosis in breast cancer cell lines". International Journal of Oncology 48, no. 6 (2016): 2639-2646. https://doi.org/10.3892/ijo.2016.3454
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