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Article

Kinesin family members KIF11 and KIF23 as potential therapeutic targets in malignant pleural mesothelioma

  • Authors:
    • Tatsuya Kato
    • Daiyoon Lee
    • Licun Wu
    • Priya Patel
    • Ahn Jin Young
    • Hironobu Wada
    • Hsin-Pei Hu
    • Hideki Ujiie
    • Mitsuhito Kaji
    • Satoshi Kano
    • Shinichi Matsuge
    • Hiromitsu Domen
    • Kichizo Kaga
    • Yoshiro Matsui
    • Hiromi Kanno
    • Yutaka Hatanaka
    • Kanako C. Hatanaka
    • Yoshihiro Matsuno
    • Marc de Perrot
    • Kazuhiro Yasufuku
  • View Affiliations / Copyright

    Affiliations: Division of Thoracic Surgery, Toronto General Hospital, University Health Network, Toronto, Canada, Department of Thoracic Surgery, Sapporo Minami-sanjo Hospital, Sapporo, Japan, Department of Pathology, Kinikyo-Chuo Hospital, Sapporo, Japan, Department of Surgery, Kinikyo-Chuo Hospital, Sapporo, Japan, Department of Cardiovascular and Thoracic Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan, Department of Surgical Pathology, Hokkaido University Hospital, Sapporo, Japan
  • Pages: 448-456
    |
    Published online on: June 7, 2016
       https://doi.org/10.3892/ijo.2016.3566
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Abstract

Malignant pleural mesothelioma (MPM) is a rare and aggressive form of cancer commonly associated with asbestos exposure that stems from the thoracic mesothelium with high mortality rate. Currently, treatment options for MPM are limited, and new molecular targets for treatments are urgently needed. Using quantitative reverse transcription-polymerase chain reaction (RT-PCR) and an RNA interference-based screening, we screened two kinesin family members as potential therapeutic targets for MPM. Following in vitro investigation of the target silencing effects on MPM cells, a total of 53 MPMs were analyzed immunohistochemically with tissue microarray. KIF11 and KIF23 transcripts were found to be overexpressed in the majority of clinical MPM samples as well as human MPM cell lines as determined by quantitative RT-PCR. Gene knockdown in MPM cell lines identified growth inhibition following knockdown of KIF11 and KIF23. High expression of KIF11 (KIF11-H) and KIF23 (KIF23-H) were found in 43.4 and 50.9% of all the MPM cases, respectively. Patients who received curative resection with tumors displaying KIF23-H showed shorter overall survival (P=0.0194). These results provide that inhibition of KIF11 and KIF23 may hold promise for treatment of MPMs, raising the possibility that kinesin-based drug targets may be developed in the future.
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View References

1 

Yang H, Testa JR and Carbone M: Mesothelioma epidemiology, carcinogenesis, and pathogenesis. Curr Treat Options Oncol. 9:147–157. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Carbone M, Kratzke RA and Testa JR: The pathogenesis of mesothelioma. Semin Oncol. 29:2–17. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Travis WD, Brambilla E, Burke AP, Marx A and Nicholson AG: WHO Classification of Tumours of the Lung, Pleura, Thymus and Heart. WHO Classification of Tumours. 7. 4th edition. IARC Press; Lyon: 2015

4 

Robinson BW and Lake RA: Advances in malignant mesothelioma. N Engl J Med. 353:1591–1603. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Robinson BW, Musk AW and Lake RA: Malignant mesothelioma. Lancet. 366:397–408. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Becklake MR, Bagatin E and Neder JA: Asbestos-related diseases of the lungs and pleura: Uses, trends and management over the last century. Int J Tuberc Lung Dis. 11:356–369. 2007.PubMed/NCBI

7 

Vogelzang NJ, Rusthoven JJ, Symanowski J, Denham C, Kaukel E, Ruffie P, Gatzemeier U, Boyer M, Emri S, Manegold C, et al: Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. J Clin Oncol. 21:2636–2644. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Zucali PA, De Vincenzo F, Simonelli M and Santoro A: Future developments in the management of malignant pleural mesothelioma. Expert Rev Anticancer Ther. 9:453–467. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Kato T, Wada H, Patel P, Hu S, Lee D, Hirohashi K, Nakajima T, Kaji M, Kaga K, Matsui Y, et al: Overexpression of KIF23 predicts clinical outcome in primary lung cancer patients. Lung Cancer. 92:53–61. 2016. View Article : Google Scholar

10 

NCBI. Gene. http://www.ncbi.nlm.nih.gov/gene.

11 

Science WIo. GeneCards. v4.0 Build 17http://www.genecards.org/.

12 

Schmidt E: GenomeRNAi. 2013, http://genomernai.dkfz.de/GenomeRNAi//.

13 

Research LIfC. CTDatabase. http://www.cta.lncc.br/.

14 

Sobin LH, Gospodarowicz MK and Wittekind C: Union for International Cancer Control (UICC), TNM Classification of Malignant Tumours. 7th edition. Wiley-Blackwell; New York: 2009

15 

Nakajima T, Anayama T, Koike T, Waddell T, Keshavjee S, Kimura H, Yoshino I and Yasufuku K: Simultaneous isolation of total RNA, DNA, and protein using samples obtained by EBUS-TBNA. J Bronchology Interv Pulmonol. 18:301–305. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Nakajima T, Zamel R, Anayama T, Kimura H, Yoshino I, Keshavjee S and Yasufuku K: Ribonucleic acid microarray analysis from lymph node samples obtained by endobronchial ultrasonography-guided transbronchial needle aspiration. Ann Thorac Surg. 94:2097–2101. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Rizzardi AE, Johnson AT, Vogel RI, Pambuccian SE, Henriksen J, Skubitz AP, Metzger GJ and Schmechel SC: Quantitative comparison of immunohistochemical staining measured by digital image analysis versus pathologist visual scoring. Diagn Pathol. 7:422012. View Article : Google Scholar : PubMed/NCBI

18 

Nagashio R, Sato Y, Jiang SX, Ryuge S, Kodera Y, Maeda T and Nakajima T: Detection of tumor-specific autoantibodies in sera of patients with lung cancer. Lung Cancer. 62:364–373. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Nagashio R, Sato Y, Matsumoto T, Kageyama T, Satoh Y, Shinichiro R, Masuda N, Goshima N, Jiang SX and Okayasu I: Expression of RACK1 is a novel biomarker in pulmonary adenocarcinomas. Lung Cancer. 69:54–59. 2010. View Article : Google Scholar

20 

Mayer TU, Kapoor TM, Haggarty SJ, King RW, Schreiber SL and Mitchison TJ: Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science. 286:971–974. 1999. View Article : Google Scholar : PubMed/NCBI

21 

Kapoor TM, Mayer TU, Coughlin ML and Mitchison TJ: Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5. J Cell Biol. 150:975–988. 2000. View Article : Google Scholar : PubMed/NCBI

22 

Takahashi S, Fusaki N, Ohta S, Iwahori Y, Iizuka Y, Inagawa K, Kawakami Y, Yoshida K and Toda M: Downregulation of KIF23 suppresses glioma proliferation. J Neurooncol. 106:519–529. 2012. View Article : Google Scholar

23 

Zhu C, Bossy-Wetzel E and Jiang W: Recruitment of MKLP1 to the spindle midzone/midbody by INCENP is essential for midbody formation and completion of cytokinesis in human cells. Biochem J. 389:373–381. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Liu X, Zhou T, Kuriyama R and Erikson RL: Molecular interactions of Polo-like-kinase 1 with the mitotic kinesin-like protein CHO1/MKLP-1. J Cell Sci. 117:3233–3246. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Kawata E, Ashihara E, Nakagawa Y, Kiuchi T, Ogura M, Yao H, Sakai K, Tanaka R, Nagao R, Yokota A, et al: A combination of a DNA-chimera siRNA against PLK-1 and zoledronic acid suppresses the growth of malignant mesothelioma cells in vitro. Cancer Lett. 294:245–253. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Linton A, Cheng YY, Griggs K, Kirschner MB, Gattani S, Srikaran S, Chuan-Hao Kao S, McCaughan BC, Klebe S, van Zandwijk N, et al: An RNAi-based screen reveals PLK1, CDK1 and NDC80 as potential therapeutic targets in malignant pleural mesothelioma. Br J Cancer. 110:510–519. 2014. View Article : Google Scholar

27 

Le Guellec R, Paris J, Couturier A, Roghi C and Philippe M: Cloning by differential screening of a Xenopus cDNA that encodes a kinesin-related protein. Mol Cell Biol. 11:3395–3398. 1991. View Article : Google Scholar : PubMed/NCBI

28 

Sawin KE, LeGuellec K, Philippe M and Mitchison TJ: Mitotic spindle organization by a plus-end-directed microtubule motor. Nature. 359:540–543. 1992. View Article : Google Scholar : PubMed/NCBI

29 

Sawin KE and Mitchison TJ: Mutations in the kinesin-like protein Eg5 disrupting localization to the mitotic spindle. Proc Natl Acad Sci USA. 92:4289–4293. 1995. View Article : Google Scholar : PubMed/NCBI

30 

Blangy A, Lane HA, d'Hérin P, Harper M, Kress M and Nigg EA: Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo. Cell. 83:1159–1169. 1995. View Article : Google Scholar : PubMed/NCBI

31 

Martens-de Kemp SR, Nagel R, Stigter-van Walsum M, van der Meulen IH, van Beusechem VW, Braakhuis BJ and Brakenhoff RH: Functional genetic screens identify genes essential for tumor cell survival in head and neck and lung cancer. Clin Cancer Res. 19:1994–2003. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Ding S, Xing N, Lu J, Zhang H, Nishizawa K, Liu S, Yuan X, Qin Y, Liu Y, Ogawa O, et al: Overexpression of Eg5 predicts unfavorable prognosis in non-muscle invasive bladder urothelial carcinoma. Int J Urol. 18:432–438. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Sun D, Lu J, Ding K, Bi D, Niu Z, Cao Q, Zhang J and Ding S: The expression of Eg5 predicts a poor outcome for patients with renal cell carcinoma. Med Oncol. 30:4762013. View Article : Google Scholar : PubMed/NCBI

34 

Vijapurkar U, Wang W and Herbst R: Potentiation of kinesin spindle protein inhibitor-induced cell death by modulation of mitochondrial and death receptor apoptotic pathways. Cancer Res. 67:237–245. 2007. View Article : Google Scholar : PubMed/NCBI

35 

Garcia-Saez I, DeBonis S, Lopez R, Trucco F, Rousseau B, Thuéry P and Kozielski F: Structure of human Eg5 in complex with a new monastrol-based inhibitor bound in the R configuration. J Biol Chem. 282:9740–9747. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Luo L, Parrish CA, Nevins N, McNulty DE, Chaudhari AM, Carson JD, Sudakin V, Shaw AN, Lehr R, Zhao H, et al: ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism. Nat Chem Biol. 3:722–726. 2007. View Article : Google Scholar : PubMed/NCBI

37 

Brier S, Lemaire D, Debonis S, Forest E and Kozielski F: Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of the mitotic kinesin Eg5. Biochemistry. 43:13072–13082. 2004. View Article : Google Scholar : PubMed/NCBI

38 

Sakowicz R, Finer JT, Beraud C, Crompton A, Lewis E, Fritsch A, Lee Y, Mak J, Moody R, Turincio R, et al: Antitumor activity of a kinesin inhibitor. Cancer Res. 64:3276–3280. 2004. View Article : Google Scholar

39 

Lad L, Luo L, Carson JD, Wood KW, Hartman JJ, Copeland RA and Sakowicz R: Mechanism of inhibition of human KSP by ispinesib. Biochemistry. 47:3576–3585. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Cox CD, Coleman PJ, Breslin MJ, Whitman DB, Garbaccio RM, Fraley ME, Buser CA, Walsh ES, Hamilton K, Schaber MD, et al: Kinesin spindle protein (KSP) inhibitors. 9 Discovery of (2S)-4-(2,5-difluorophenyl)-N-[(3R,4S)-3-fluoro-1-methyl-piperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the treatment of taxane-refractory cancer. J Med Chem. 51:4239–4252. 2008. View Article : Google Scholar : PubMed/NCBI

41 

Theoclitou ME, Aquila B, Block MH, Brassil PJ, Castriotta L, Code E, Collins MP, Davies AM, Deegan T, Ezhuthachan J, et al: Discovery of (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2] thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methyl-benzamide (AZD4877), a kinesin spindle protein inhibitor and potential anticancer agent. J Med Chem. 54:6734–6750. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Souid AK, Dubowy RL, Ingle AM, Conlan MG, Sun J, Blaney SM and Adamson PC: A pediatric phase I trial and pharmacokinetic study of ispinesib: A Children's Oncology Group phase I consortium study. Pediatr Blood Cancer. 55:1323–1328. 2010. View Article : Google Scholar : PubMed/NCBI

43 

Infante JR, Kurzrock R, Spratlin J, Burris HA, Eckhardt SG, Li J, Wu K, Skolnik JM, Hylander-Gans L, Osmukhina A, et al: A Phase I study to assess the safety, tolerability, and pharmacokinetics of AZD4877, an intravenous Eg5 inhibitor in patients with advanced solid tumors. Cancer Chemother Pharmacol. 69:165–172. 2012. View Article : Google Scholar

44 

Glotzer M: The molecular requirements for cytokinesis. Science. 307:1735–1739. 2005. View Article : Google Scholar : PubMed/NCBI

45 

Neef R, Klein UR, Kopajtich R and Barr FA: Cooperation between mitotic kinesins controls the late stages of cytokinesis. Curr Biol. 16:301–307. 2006. View Article : Google Scholar : PubMed/NCBI

46 

Zou JX, Duan Z, Wang J, Sokolov A, Xu J, Chen CZ, Li JJ and Chen HW: Kinesin family deregulation coordinated by bromo-domain protein ANCCA and histone methyltransferase MLL for breast cancer cell growth, survival, and tamoxifen resistance. Mol Cancer Res. 12:539–549. 2014. View Article : Google Scholar : PubMed/NCBI

47 

Murakami H, Ito S, Tanaka H, Kondo E, Kodera Y and Nakanishi H: Establishment of new intraperitoneal paclitaxel-resistant gastric cancer cell lines and comprehensive gene expression analysis. Anticancer Res. 33:4299–4307. 2013.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kato T, Lee D, Wu L, Patel P, Young AJ, Wada H, Hu H, Ujiie H, Kaji M, Kano S, Kano S, et al: Kinesin family members KIF11 and KIF23 as potential therapeutic targets in malignant pleural mesothelioma. Int J Oncol 49: 448-456, 2016.
APA
Kato, T., Lee, D., Wu, L., Patel, P., Young, A.J., Wada, H. ... Yasufuku, K. (2016). Kinesin family members KIF11 and KIF23 as potential therapeutic targets in malignant pleural mesothelioma. International Journal of Oncology, 49, 448-456. https://doi.org/10.3892/ijo.2016.3566
MLA
Kato, T., Lee, D., Wu, L., Patel, P., Young, A. J., Wada, H., Hu, H., Ujiie, H., Kaji, M., Kano, S., Matsuge, S., Domen, H., Kaga, K., Matsui, Y., Kanno, H., Hatanaka, Y., Hatanaka, K. C., Matsuno, Y., de Perrot, M., Yasufuku, K."Kinesin family members KIF11 and KIF23 as potential therapeutic targets in malignant pleural mesothelioma". International Journal of Oncology 49.2 (2016): 448-456.
Chicago
Kato, T., Lee, D., Wu, L., Patel, P., Young, A. J., Wada, H., Hu, H., Ujiie, H., Kaji, M., Kano, S., Matsuge, S., Domen, H., Kaga, K., Matsui, Y., Kanno, H., Hatanaka, Y., Hatanaka, K. C., Matsuno, Y., de Perrot, M., Yasufuku, K."Kinesin family members KIF11 and KIF23 as potential therapeutic targets in malignant pleural mesothelioma". International Journal of Oncology 49, no. 2 (2016): 448-456. https://doi.org/10.3892/ijo.2016.3566
Copy and paste a formatted citation
x
Spandidos Publications style
Kato T, Lee D, Wu L, Patel P, Young AJ, Wada H, Hu H, Ujiie H, Kaji M, Kano S, Kano S, et al: Kinesin family members KIF11 and KIF23 as potential therapeutic targets in malignant pleural mesothelioma. Int J Oncol 49: 448-456, 2016.
APA
Kato, T., Lee, D., Wu, L., Patel, P., Young, A.J., Wada, H. ... Yasufuku, K. (2016). Kinesin family members KIF11 and KIF23 as potential therapeutic targets in malignant pleural mesothelioma. International Journal of Oncology, 49, 448-456. https://doi.org/10.3892/ijo.2016.3566
MLA
Kato, T., Lee, D., Wu, L., Patel, P., Young, A. J., Wada, H., Hu, H., Ujiie, H., Kaji, M., Kano, S., Matsuge, S., Domen, H., Kaga, K., Matsui, Y., Kanno, H., Hatanaka, Y., Hatanaka, K. C., Matsuno, Y., de Perrot, M., Yasufuku, K."Kinesin family members KIF11 and KIF23 as potential therapeutic targets in malignant pleural mesothelioma". International Journal of Oncology 49.2 (2016): 448-456.
Chicago
Kato, T., Lee, D., Wu, L., Patel, P., Young, A. J., Wada, H., Hu, H., Ujiie, H., Kaji, M., Kano, S., Matsuge, S., Domen, H., Kaga, K., Matsui, Y., Kanno, H., Hatanaka, Y., Hatanaka, K. C., Matsuno, Y., de Perrot, M., Yasufuku, K."Kinesin family members KIF11 and KIF23 as potential therapeutic targets in malignant pleural mesothelioma". International Journal of Oncology 49, no. 2 (2016): 448-456. https://doi.org/10.3892/ijo.2016.3566
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