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Article

Pro-metastatic intracellular signaling of the elaidic trans fatty acid

  • Authors:
    • Kiyomu Fujii
    • Yi Luo
    • Rina Fujiwara-Tani
    • Shingo Kishi
    • Song He
    • Shuyun Yang
    • Takamitsu Sasaki
    • Hitoshi Ohmori
    • Hiroki Kuniyasu
  • View Affiliations / Copyright

    Affiliations: Department of Molecular Pathology, Nara Medical University, Kashihara 634-8521, Japan, Department of Pathology, Nantong University Cancer Hospital, Nantong, Jiangsu 226361, P.R. China, Department of Gastroenterological Surgery, Fukuoka University School of Medicine, Jonan-ku, Fukuoka 814-0180, Japan
  • Pages: 85-92
    |
    Published online on: December 8, 2016
       https://doi.org/10.3892/ijo.2016.3797
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Abstract

Trans fatty acids (TFAs) are risk factors of cardiovascular disorders, and a few studies have reported the cancer-promoting effects of TFAs. In the present study, we examined the effects and signaling of elaidic acid (EA), a TFA, in colorectal cancer (CRC) cells. Oral intake of EA increased the metastasis of CT26 mouse CRC cells by inducing the expression of stemness markers nucleostemin (NS) and CD133. Mechanisms underlying EA-induced signaling were confirmed by determining the binding of EA to G-protein coupled receptor 40 (GPR40) and GPR120 by performing surface protein internalization assay. We found that c-SRC mediated EGFR transactivation was induced by the binding of EA to GPR40 and GPR120. Moreover, EGFR signaling upregulated NS and Snail expression and downregulated E-cadherin expression in wild-type APC-containing CT26 cells, and upregulated NS, Wnt5a and CD44 expression in APC-null HT29 cells. These results indicate that EA enhances the stemness and epithelial-mesenchymal transition of CRC cells. These results also indicate the prominent metastatic potential of EA-treated cancer cells and highlight the important implications of EA on public health.
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Copy and paste a formatted citation
Spandidos Publications style
Fujii K, Luo Y, Fujiwara-Tani R, Kishi S, He S, Yang S, Sasaki T, Ohmori H and Kuniyasu H: Pro-metastatic intracellular signaling of the elaidic trans fatty acid. Int J Oncol 50: 85-92, 2017.
APA
Fujii, K., Luo, Y., Fujiwara-Tani, R., Kishi, S., He, S., Yang, S. ... Kuniyasu, H. (2017). Pro-metastatic intracellular signaling of the elaidic trans fatty acid. International Journal of Oncology, 50, 85-92. https://doi.org/10.3892/ijo.2016.3797
MLA
Fujii, K., Luo, Y., Fujiwara-Tani, R., Kishi, S., He, S., Yang, S., Sasaki, T., Ohmori, H., Kuniyasu, H."Pro-metastatic intracellular signaling of the elaidic trans fatty acid". International Journal of Oncology 50.1 (2017): 85-92.
Chicago
Fujii, K., Luo, Y., Fujiwara-Tani, R., Kishi, S., He, S., Yang, S., Sasaki, T., Ohmori, H., Kuniyasu, H."Pro-metastatic intracellular signaling of the elaidic trans fatty acid". International Journal of Oncology 50, no. 1 (2017): 85-92. https://doi.org/10.3892/ijo.2016.3797
Copy and paste a formatted citation
x
Spandidos Publications style
Fujii K, Luo Y, Fujiwara-Tani R, Kishi S, He S, Yang S, Sasaki T, Ohmori H and Kuniyasu H: Pro-metastatic intracellular signaling of the elaidic trans fatty acid. Int J Oncol 50: 85-92, 2017.
APA
Fujii, K., Luo, Y., Fujiwara-Tani, R., Kishi, S., He, S., Yang, S. ... Kuniyasu, H. (2017). Pro-metastatic intracellular signaling of the elaidic trans fatty acid. International Journal of Oncology, 50, 85-92. https://doi.org/10.3892/ijo.2016.3797
MLA
Fujii, K., Luo, Y., Fujiwara-Tani, R., Kishi, S., He, S., Yang, S., Sasaki, T., Ohmori, H., Kuniyasu, H."Pro-metastatic intracellular signaling of the elaidic trans fatty acid". International Journal of Oncology 50.1 (2017): 85-92.
Chicago
Fujii, K., Luo, Y., Fujiwara-Tani, R., Kishi, S., He, S., Yang, S., Sasaki, T., Ohmori, H., Kuniyasu, H."Pro-metastatic intracellular signaling of the elaidic trans fatty acid". International Journal of Oncology 50, no. 1 (2017): 85-92. https://doi.org/10.3892/ijo.2016.3797
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