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Article

Identification of WISP1 as a novel oncogene in glioblastoma

  • Authors:
    • Di Jing
    • Qian Zhang
    • Haiming Yu
    • Yajie Zhao
    • Liangfang Shen
  • View Affiliations / Copyright

    Affiliations: Department of Oncology Radiotherapy, Xiangya Hospital of Central South University, Changsha, Hunan 410008, P.R. China, Teaching and Research Section of Surgery, Xiangnan University Affiliated Hospital, Chenzhou, Hunan 423000, P.R. China, Department of Critical Care Medicine, Hunan Provincial Peopel's Hospital, Changsha, Hunan 410005, P.R. China, Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China
  • Pages: 1261-1270
    |
    Published online on: September 5, 2017
       https://doi.org/10.3892/ijo.2017.4119
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Abstract

Glioblastoma is the most common and aggressive primary brain tumor and has a high mortality in humans. However, mechanisms and factors involved in the progression of glioblastoma remain elusive. WISP1 (WNT1 inducible signaling pathway protein 1), has been suggested to be a critical regulator of cancer development. The aim of this study was to investigate the role of WISP1 in regulating the progression of glioblastoma. Clinicopathological characteristics of glioblastoma were assessed, and higher levels of WISP1 were positively associated with advanced clinical stage and a poor prognosis. Consistently, WISP1 expression was significantly upregulated in glioblastoma tissue and cell lines compared with normal tissue and cells. Additionally, inhibition of WISP1 greatly suppressed cell proliferation, migration, and invasion and promoted apoptosis and cell cycle arrest of glioblastoma cells. Further study indicated that downregulation of WISP1 suppressed cell proliferation associated with the gene expression of c‑myc and cyclin D1 and cellular signaling such as through the ERK pathway, while inhibiting epithelial-mesenchymal transition and MMP9. Finally, knockdown of WISP1 markedly suppressed in vivo tumor growth and sensitized glioblastoma cells to temozolomide. This study identified WISP1 as an oncogene in glioblastoma and suggests that WISP1 may serve as a potential molecular marker and treatment target for glioblastoma.
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Copy and paste a formatted citation
Spandidos Publications style
Jing D, Zhang Q, Yu H, Zhao Y and Shen L: Identification of WISP1 as a novel oncogene in glioblastoma. Int J Oncol 51: 1261-1270, 2017.
APA
Jing, D., Zhang, Q., Yu, H., Zhao, Y., & Shen, L. (2017). Identification of WISP1 as a novel oncogene in glioblastoma. International Journal of Oncology, 51, 1261-1270. https://doi.org/10.3892/ijo.2017.4119
MLA
Jing, D., Zhang, Q., Yu, H., Zhao, Y., Shen, L."Identification of WISP1 as a novel oncogene in glioblastoma". International Journal of Oncology 51.4 (2017): 1261-1270.
Chicago
Jing, D., Zhang, Q., Yu, H., Zhao, Y., Shen, L."Identification of WISP1 as a novel oncogene in glioblastoma". International Journal of Oncology 51, no. 4 (2017): 1261-1270. https://doi.org/10.3892/ijo.2017.4119
Copy and paste a formatted citation
x
Spandidos Publications style
Jing D, Zhang Q, Yu H, Zhao Y and Shen L: Identification of WISP1 as a novel oncogene in glioblastoma. Int J Oncol 51: 1261-1270, 2017.
APA
Jing, D., Zhang, Q., Yu, H., Zhao, Y., & Shen, L. (2017). Identification of WISP1 as a novel oncogene in glioblastoma. International Journal of Oncology, 51, 1261-1270. https://doi.org/10.3892/ijo.2017.4119
MLA
Jing, D., Zhang, Q., Yu, H., Zhao, Y., Shen, L."Identification of WISP1 as a novel oncogene in glioblastoma". International Journal of Oncology 51.4 (2017): 1261-1270.
Chicago
Jing, D., Zhang, Q., Yu, H., Zhao, Y., Shen, L."Identification of WISP1 as a novel oncogene in glioblastoma". International Journal of Oncology 51, no. 4 (2017): 1261-1270. https://doi.org/10.3892/ijo.2017.4119
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