Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
May-2018 Volume 52 Issue 5

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2018 Volume 52 Issue 5

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Ubiquitin-specific peptidase 5 and ovarian tumor deubiquitinase 6A are differentially expressed in p53+/+ and p53-/- HCT116 cells

  • Authors:
    • Soo-Yeon Kim
    • Seul-Ki Kwon
    • So-Young Lee
    • Kwang-Hyun Baek
  • View Affiliations / Copyright

    Affiliations: Department of Biomedical Science, CHA University, Seongnam, Gyeonggi 13488, Republic of Korea, Department of Internal Medicine, Bundang CHA Medical Center, CHA University, Seongnam, Gyeonggi 13496, Republic of Korea
  • Pages: 1705-1714
    |
    Published online on: March 5, 2018
       https://doi.org/10.3892/ijo.2018.4302
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Most proteins undergo ubiquitination, a process by which ubiquitin proteins bind to their substrate proteins; by contrast, deubiquitination is a process that reverses ubiquitination. Deubiquitinating enzymes (DUBs) function to remove ubiquitin proteins from the protein targets and serve an essential role in regulating DNA repair, protein degradation, apoptosis and immune responses. Abnormal regulation of DUBs may affect a number of cellular processes and may lead to a variety of human diseases, including cancer. Therefore, it is important to identify abnormally expressed DUBs to identify DUB-related diseases and biological mechanisms. The present study aimed to develop a multiplex polymerase chain reaction screening platform comprising primers for various DUB genes. This assay was used to identify p53-related DUBs in HCT116 p53+/+ and p53-/- cells. The results demonstrated that ubiquitin-specific peptidase 5 (USP5) and ovarian tumor deubiquitinase 6A (OTUD6A) were differentially expressed in p53+/+ and p53-/- HCT116 cells. Based on the data obtained through DUB screening, the protein expression levels of USP5 and OTUD6A were examined by western blotting, which confirmed that both of these DUBs were also expressed differentially in p53+/+ and p53-/- HCT116 cells. In conclusion, results from the DUB screening performed by the present study revealed that the expression of USP5 and OTUD6A may be affected by p53, and this method may be useful for the rapid and cost-effective identification of possible biomarkers.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Wang J and Maldonado MA: The ubiquitin-proteasome system and its role in inflammatory and autoimmune diseases. Cell Mol Immunol. 3:255–261. 2006.PubMed/NCBI

2 

Zhang X, Berger FG, Yang J and Lu X: USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1. EMBO J. 30:2177–2189. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Callis J: The ubiquitination machinery of the ubiquitin system. Arabidopsis Book. 12:e01742014. View Article : Google Scholar : PubMed/NCBI

4 

Kulathu Y and Komander D: Atypical ubiquitylation - the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages. Nat Rev Mol Cell Biol. 13:508–523. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Husnjak K and Dikic I: Ubiquitin-binding proteins: Decoders of ubiquitin-mediated cellular functions. Annu Rev Biochem. 81:291–322. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Woelk T, Sigismund S, Penengo L and Polo S: The ubiquitination code: A signalling problem. Cell Div. 2:112007. View Article : Google Scholar : PubMed/NCBI

7 

Tan JM, Wong ES, Kirkpatrick DS, Pletnikova O, Ko HS, Tay SP, Ho MW, Troncoso J, Gygi SP, Lee MK, et al: Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases. Hum Mol Genet. 17:431–439. 2008. View Article : Google Scholar

8 

Nathan JA, Kim HT, Ting L, Gygi SP and Goldberg AL: Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? EMBO J. 32:552–565. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Ikeda F and Dikic I: Atypical ubiquitin chains: new molecular signals. 'Protein Modifications: Beyond the Usual Suspects' review series. EMBO Rep. 9:536–542. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Iyer LM, Koonin EV and Aravind L: Novel predicted peptidases with a potential role in the ubiquitin signaling pathway. Cell Cycle. 3:1440–1450. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Park JJ, Lim KH and Baek KH: Annexin-1 regulated by HAUSP is essential for UV-induced damage response. Cell Death Dis. 6:e16542015. View Article : Google Scholar : PubMed/NCBI

12 

Lim KH, Park JJ, Gu BH, Kim JO, Park SG and Baek KH: HAUSP-nucleolin interaction is regulated by p53-Mdm2 complex in response to DNA damage response. Sci Rep. 5:127932015. View Article : Google Scholar : PubMed/NCBI

13 

Nijman SM, Luna-Vargas MP, Velds A, Brummelkamp TR, Dirac AM, Sixma TK and Bernards R: A genomic and functional inventory of deubiquitinating enzymes. Cell. 123:773–786. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Mevissen TE, Hospenthal MK, Geurink PP, Elliott PR, Akutsu M, Arnaudo N, Ekkebus R, Kulathu Y, Wauer T, El Oualid F, et al: OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. Cell. 154:169–184. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Sun XX and Dai MS: Deubiquitinating enzyme regulation of the p53 pathway: A lesson from Otub1. World J Biol Chem. 5:75–84. 2014.PubMed/NCBI

16 

Zhong X and Pittman RN: Ataxin-3 binds VCP/p97 and regulates retrotranslocation of ERAD substrates. Hum Mol Genet. 15:2409–2420. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Guterman A and Glickman MH: Deubiquitinating enzymes are IN/(trinsic to proteasome function). Curr Protein Pept Sci. 5:201–211. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Cope GA, Suh GS, Aravind L, Schwarz SE, Zipursky SL, Koonin EV and Deshaies RJ: Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1. Science. 298:608–611. 2002. View Article : Google Scholar : PubMed/NCBI

19 

Hu HY: Editorial: Protein ubiquitination and deubiquitination. Curr Protein Pept Sci. 13:4132012. View Article : Google Scholar : PubMed/NCBI

20 

Lim KH, Song MH and Baek KH: Decision for cell fate: Deubiquitinating enzymes in cell cycle checkpoint. Cell Mol Life Sci. 73:1439–1455. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Kwon SK, Saindane M and Baek KH: p53 stability is regulated by diverse deubiquitinating enzymes. Biochim Biophys Acta. 1868:404–411. 2017.PubMed/NCBI

22 

Park CW and Ryu KY: Cellular ubiquitin pool dynamics and homeostasis. BMB Rep. 47:475–482. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Henry NL and Hayes DF: Cancer biomarkers. Mol Oncol. 6:140–146. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Edwards MC and Gibbs RA: Multiplex PCR: Advantages, development, and applications. PCR Methods Appl. 3:S65–S75. 1994. View Article : Google Scholar : PubMed/NCBI

25 

Wang Z and Sun Y: Targeting p53 for novel anticancer therapy. Transl Oncol. 3:1–12. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Fridman JS and Lowe SW: Control of apoptosis by p53. Oncogene. 22:9030–9040. 2003. View Article : Google Scholar

27 

Dayal S, Sparks A, Jacob J, Allende-Vega N, Lane DP and Saville MK: Suppression of the deubiquitinating enzyme USP5 causes the accumulation of unanchored polyubiquitin and the activation of p53. J Biol Chem. 284:5030–5041. 2009. View Article : Google Scholar :

28 

Potu H, Peterson LF, Pal A, Verhaegen M, Cao J, Talpaz M and Donato NJ: Usp5 links suppression of p53 and FAS levels in melanoma to the BRAF pathway. Oncotarget. 5:5559–5569. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

30 

Marchese FP, Grossi E, Marín-Béjar O, Bharti SK, Raimondi I, González J, Martínez-Herrera DJ, Athie A, Amadoz A, Brosh RM Jr, et al: A long noncoding RNA regulates sister chromatid cohesion. Mol Cell. 63:397–407. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Kessler BM and Edelmann MJ: PTMs in conversation: Activity and function of deubiquitinating enzymes regulated via post-translational modifications. Cell Biochem Biophys. 60:21–38. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Guo Y, Xiao P, Lei S, Deng F, Xiao GG, Liu Y, Chen X, Li L, Wu S, Chen Y, et al: How is mRNA expression predictive for protein expression? A correlation study on human circulating monocytes. Acta Biochim Biophys Sin (Shanghai). 40:426–436. 2008. View Article : Google Scholar

33 

Lakin ND and Jackson SP: Regulation of p53 in response to DNA damage. Oncogene. 18:7644–7655. 1999. View Article : Google Scholar

34 

Amerik AY and Hochstrasser M: Mechanism and function of deubiquitinating enzymes. Biochim Biophys Acta. 1695:189–207. 2004. View Article : Google Scholar : PubMed/NCBI

35 

Reyes-Turcu FE, Ventii KH and Wilkinson KD: Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes. Annu Rev Biochem. 78:363–397. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Song L and Rape M: Reverse the curse - the role of deubiquitination in cell cycle control. Curr Opin Cell Biol. 20:156–163. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Kennedy RD and D'Andrea AD: The Fanconi Anemia/BRCA pathway: New faces in the crowd. Genes Dev. 19:2925–2940. 2005. View Article : Google Scholar : PubMed/NCBI

38 

Yang JM: Emerging roles of deubiquitinating enzymes in human cancer. Acta Pharmacol Sin. 28:1325–1330. 2007. View Article : Google Scholar : PubMed/NCBI

39 

Han ES, Muller FL, Pérez VI, Qi W, Liang H, Xi L, Fu C, Doyle E, Hickey M, Cornell J, et al: The in vivo gene expression signature of oxidative stress. Physiol Genomics. 34:112–126. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Kishi H, Nakagawa K, Matsumoto M, Suga M, Ando M, Taya Y and Yamaizumi M: Osmotic shock induces G1 arrest through p53 phosphorylation at Ser33 by activated p38MAPK without phosphorylation at Ser15 and Ser20. J Biol Chem. 276:39115–39122. 2001. View Article : Google Scholar : PubMed/NCBI

41 

Bieging KT, Mello SS and Attardi LD: Unravelling mechanisms of p53-mediated tumour suppression. Nat Rev Cancer. 14:359–370. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Pillet S, Lardeux M, Dina J, Grattard F, Verhoeven P, Le Goff J, Vabret A and Pozzetto B: Comparative evaluation of six commercialized multiplex PCR kits for the diagnosis of respiratory infections. PLoS One. 8:e721742013. View Article : Google Scholar : PubMed/NCBI

43 

Kaplun A, Krull M, Lakshman K, Matys V, Lewicki B and Hogan JD: Establishing and validating regulatory regions for variant annotation and expression analysis. BMC Genomics. 17(Suppl 2): 3932016. View Article : Google Scholar : PubMed/NCBI

44 

Luo J, Lu Z, Lu X, Chen L, Cao J, Zhang S, Ling Y and Zhou X: OTUD5 regulates p53 stability by deubiquitinating p53. PLoS One. 8:e776822013. View Article : Google Scholar : PubMed/NCBI

45 

Li Z, Hao Q, Luo J, Xiong J, Zhang S, Wang T, Bai L, Wang W, Chen M, Wang W, et al: USP4 inhibits p53 and NF-κB through deubiquitinating and stabilizing HDAC2. Oncogene. 35:2902–2912. 2016. View Article : Google Scholar

46 

Sheng Y, Saridakis V, Sarkari F, Duan S, Wu T, Arrowsmith CH and Frappier L: Molecular recognition of p53 and MDM2 by USP7/HAUSP. Nat Struct Mol Biol. 13:285–291. 2006. View Article : Google Scholar : PubMed/NCBI

47 

Liu X, Yang X, Li Y, Zhao S, Li C, Ma P and Mao B: Trip12 is an E3 ubiquitin ligase for USP7/HAUSP involved in the DNA damage response. FEBS Lett. 590:4213–4222. 2016. View Article : Google Scholar : PubMed/NCBI

48 

Yuan J, Luo K, Zhang L, Cheville JC and Lou Z: USP10 regulates p53 localization and stability by deubiquitinating p53. Cell. 140:384–396. 2010. View Article : Google Scholar : PubMed/NCBI

49 

Zhang L, Nemzow L, Chen H, Lubin A, Rong X, Sun Z, Harris TK and Gong F: The deubiquitinating enzyme USP24 is a regulator of the UV damage response. Cell Reports. 10:140–147. 2015. View Article : Google Scholar : PubMed/NCBI

50 

Liu YL, Zheng J, Tang LJ, Han W, Wang JM, Liu DW and Tian QB: The deubiquitinating enzyme activity of USP22 is necessary for regulating HeLa cell growth. Gene. 572:49–56. 2015. View Article : Google Scholar : PubMed/NCBI

51 

Hock AK, Vigneron AM, Carter S, Ludwig RL and Vousden KH: Regulation of p53 stability and function by the deubiquitinating enzyme USP42. EMBO J. 30:4921–4930. 2011. View Article : Google Scholar : PubMed/NCBI

52 

Pirrone V, Mell J, Janto B and Wigdahl B: Biomarkers of HIV Susceptibility and Disease Progression. EBioMedicine. 1:99–100. 2014. View Article : Google Scholar

53 

Kim K and Lee JH: Risk factors and biomarkers of ischemic stroke in cancer patients. J Stroke. 16:91–96. 2014. View Article : Google Scholar : PubMed/NCBI

54 

Al-Qazzaz NK, Ali SH, Ahmad SA, Chellappan K, Islam MS and Escudero J: Role of EEG as biomarker in the early detection and classification of dementia. Sci World J. 2014:9060382014. View Article : Google Scholar

55 

Goossens N, Nakagawa S, Sun X and Hoshida Y: Cancer biomarker discovery and validation. Transl Cancer Res. 4:256–269. 2015.PubMed/NCBI

56 

Haynes HR, Camelo-Piragua S and Kurian KM: Prognostic and predictive biomarkers in adult and pediatric gliomas: Toward personalized treatment. Front Oncol. 4:472014. View Article : Google Scholar : PubMed/NCBI

57 

Nalejska E, Mączyńska E and Lewandowska MA: Prognostic and predictive biomarkers: Tools in personalized oncology. Mol Diagn Ther. 18:273–284. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kim S, Kwon S, Lee S and Baek K: Ubiquitin-specific peptidase 5 and ovarian tumor deubiquitinase 6A are differentially expressed in p53+/+ and p53-/- HCT116 cells. Int J Oncol 52: 1705-1714, 2018.
APA
Kim, S., Kwon, S., Lee, S., & Baek, K. (2018). Ubiquitin-specific peptidase 5 and ovarian tumor deubiquitinase 6A are differentially expressed in p53+/+ and p53-/- HCT116 cells. International Journal of Oncology, 52, 1705-1714. https://doi.org/10.3892/ijo.2018.4302
MLA
Kim, S., Kwon, S., Lee, S., Baek, K."Ubiquitin-specific peptidase 5 and ovarian tumor deubiquitinase 6A are differentially expressed in p53+/+ and p53-/- HCT116 cells". International Journal of Oncology 52.5 (2018): 1705-1714.
Chicago
Kim, S., Kwon, S., Lee, S., Baek, K."Ubiquitin-specific peptidase 5 and ovarian tumor deubiquitinase 6A are differentially expressed in p53+/+ and p53-/- HCT116 cells". International Journal of Oncology 52, no. 5 (2018): 1705-1714. https://doi.org/10.3892/ijo.2018.4302
Copy and paste a formatted citation
x
Spandidos Publications style
Kim S, Kwon S, Lee S and Baek K: Ubiquitin-specific peptidase 5 and ovarian tumor deubiquitinase 6A are differentially expressed in p53+/+ and p53-/- HCT116 cells. Int J Oncol 52: 1705-1714, 2018.
APA
Kim, S., Kwon, S., Lee, S., & Baek, K. (2018). Ubiquitin-specific peptidase 5 and ovarian tumor deubiquitinase 6A are differentially expressed in p53+/+ and p53-/- HCT116 cells. International Journal of Oncology, 52, 1705-1714. https://doi.org/10.3892/ijo.2018.4302
MLA
Kim, S., Kwon, S., Lee, S., Baek, K."Ubiquitin-specific peptidase 5 and ovarian tumor deubiquitinase 6A are differentially expressed in p53+/+ and p53-/- HCT116 cells". International Journal of Oncology 52.5 (2018): 1705-1714.
Chicago
Kim, S., Kwon, S., Lee, S., Baek, K."Ubiquitin-specific peptidase 5 and ovarian tumor deubiquitinase 6A are differentially expressed in p53+/+ and p53-/- HCT116 cells". International Journal of Oncology 52, no. 5 (2018): 1705-1714. https://doi.org/10.3892/ijo.2018.4302
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team