Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
August-2018 Volume 53 Issue 2

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2018 Volume 53 Issue 2

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Blocking the Nav1.5 channel using eicosapentaenoic acid reduces migration and proliferation of ovarian cancer cells

Corrigendum in: /10.3892/ijo.2020.5129
  • Authors:
    • Junxiu Liu
    • Dawei Liu
    • Jasmine J. Liu
    • Chang Zhao
    • Shuzhong Yao
    • Liang Hong
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510080, P.R. China, Department of Pathology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510080, P.R. China, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA, Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA
  • Pages: 855-865
    |
    Published online on: June 12, 2018
       https://doi.org/10.3892/ijo.2018.4437
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Activity of the voltage-gated Nav1.5 sodium channel has been reported to be involved in cell proliferation, cancer invasion and gene expression. In addition, eicosapentaenoic acid (EPA) has recently been suggested to inhibit ovarian cancer cell growth and suppress tumor metastasis. The present study aimed to explore the association between EPA, the Nav1.5 sodium channel and ovarian cancer cells. Using patch-clamp technique and RNA interference approaches, sodium currents were recorded in epithelial ovarian cancer cells, and it was confirmed that the Nav1.5 channel carried the sodium currents. Furthermore, EPA effectively inhibited sodium currents in a dose-dependent manner, shifted the steady-state inactivation curve of sodium currents to the hyperpolarizing direction and reduced sodium window currents. In addition, EPA induced a shift in the inactivation curve in a dose-dependent manner. Inhibition of the sodium channel, either by EPA or by Nav1.5 knockdown, attenuated ovarian cancer cell migration and proliferation. To the best of our knowledge, the present study is the first to conduct sodium current recording in ovarian cancer cells, and revealed that EPA may inhibit Nav1.5-mediated ovarian cancer cell migration and growth. These findings not only present a potential prognostic biomarker for ovarian cancer, but also provide a strategy towards the development of novel pharmacological treatments for patients with ovarian cancer.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

View References

1 

Smith RA, Andrews KS, Brooks D, Fedewa SA, Manassaram-Baptiste D, Saslow D, Brawley OW and Wender RC: Cancer screening in the United States, 2017: A review of current American Cancer Society guidelines and current issues in cancer screening. CA Cancer J Clin. 67:100–121. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Jelovac D and Armstrong DK: Recent progress in the diagnosis and treatment of ovarian cancer. CA Cancer J Clin. 61:183–203. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Chen M, Yao S, Cao Q, Xia M, Liu J and He M: The prognostic value of Ki67 in ovarian high-grade serous carcinoma: An 11-year cohort study of Chinese patients. Oncotarget. 8:107877–107885. 2016.

4 

Asher V, Khan R, Warren A, Shaw R, Schalkwyk GV, Bali A and Sowter HM: The Eag potassium channel as a new prognostic marker in ovarian cancer. Diagn Pathol. 5:782010. View Article : Google Scholar : PubMed/NCBI

5 

Yu FH and Catterall WA: Overview of the voltage-gated sodium channel family. Genome Biol. 4:2072003. View Article : Google Scholar : PubMed/NCBI

6 

Liu M, Yang KC and Dudley SC Jr: Cardiac sodium channel mutations: Why so many phenotypes? Nat Rev Cardiol. 11:607–615. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Fraser SP, Diss JK, Lloyd LJ, Pani F, Chioni AM, George AJ and Djamgoz MB: T-lymphocyte invasiveness: Control by voltage-gated Na+ channel activity. FEBS Lett. 569:191–194. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Shan B, Dong M, Tang H, Wang N, Zhang J, Yan C, Jiao X, Zhang H and Wang C: Voltage-gated sodium channels were differentially expressed in human normal prostate, benign prostatic hyperplasia and prostate cancer cells. Oncol Lett. 8:345–350. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Fraser SP, Diss JK, Chioni AM, Mycielska ME, Pan H, Yamaci RF, Pani F, Siwy Z, Krasowska M, Grzywna Z, et al: Voltage-gated sodium channel expression and potentiation of human breast cancer metastasis. Clin Cancer Res. 11:5381–5389. 2005. View Article : Google Scholar : PubMed/NCBI

10 

House CD, Vaske CJ, Schwartz AM, Obias V, Frank B, Luu T, Sarvazyan N, Irby R, Strausberg RL, Hales TG, et al: Voltage-gated Na+ channel SCN5A is a key regulator of a gene transcriptional network that controls colon cancer invasion. Cancer Res. 70:6957–6967. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Frede J, Fraser SP, Oskay-Özcelik G, Hong Y, Ioana Braicu E, Sehouli J, Gabra H and Djamgoz MB: Ovarian cancer: Ion channel and aquaporin expression as novel targets of clinical potential. Eur J Cancer. 49:2331–2344. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Gao R, Shen Y, Cai J, Lei M and Wang Z: Expression of voltage-gated sodium channel alpha subunit in human ovarian cancer. Oncol Rep. 23:1293–1299. 2010.PubMed/NCBI

13 

Brinton EA and Mason RP: Prescription omega-3 fatty acid products containing highly purified eicosapentaenoic acid (EPA). Lipids Health Dis. 16:232017. View Article : Google Scholar : PubMed/NCBI

14 

Li GR, Sun HY, Zhang XH, Cheng LC, Chiu SW, Tse HF and Lau CP: Omega-3 polyunsaturated fatty acids inhibit transient outward and ultra-rapid delayed rectifier K+ currents and Na+ current in human atrial myocytes. Cardiovasc Res. 81:286–293. 2009. View Article : Google Scholar

15 

Wan XH, Fu X and Ababaikeli G: Docosahexaenoic acid induces growth suppression on epithelial ovarian cancer cells more effectively than eicosapentaenoic acid. Nutr Cancer. 68:320–327. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Pathak MM, Tran T, Hong L, Joós B, Morris CE and Tombola F: The Hv1 proton channel responds to mechanical stimuli. J Gen Physiol. 148:405–418. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Hong L and Tombola F: Allostery: A lipid two-step. Nat Chem Biol. 12:202–203. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Leifert WR, McMurchie EJ and Saint DA: Inhibition of cardiac sodium currents in adult rat myocytes by n-3 polyunsaturated fatty acids. J Physiol. 520:671–679. 1999. View Article : Google Scholar : PubMed/NCBI

19 

Alkhalil A, Hong L, Nguitragool W and Desai SA: Voltage-dependent inactivation of the plasmodial surface anion channel via a cleavable cytoplasmic component. Biochim Biophys Acta. 1818:367–374. 2012. View Article : Google Scholar :

20 

Hong L, Wang G and Guan Y: Involvement of volume-regulated Cl- current in myocardial hypertrophy. Chinese Pharmacological Bulletin. 23:990–993. 2007.

21 

Hong L, Singh V, Wulff H and Tombola F: Interrogation of the intersubunit interface of the open Hv1 proton channel with a probe of allosteric coupling. Sci Rep. 5:140772015. View Article : Google Scholar : PubMed/NCBI

22 

Kim IH, Hevezi P, Varga C, Pathak MM, Hong L, Ta D, Tran CT, Zlotnik A, Soltesz I and Tombola F: Evidence for functional diversity between the voltage-gated proton channel Hv1 and its closest related protein HVRP1. PLoS One. 9:e1059262014. View Article : Google Scholar : PubMed/NCBI

23 

Zimmer T, Haufe V and Blechschmidt S: Voltage-gated sodium channels in the mammalian heart. Glob Cardiol Sci Pract. 2014:449–463. 2014.PubMed/NCBI

24 

Xiao YF, Ke Q, Wang SY, Auktor K, Yang Y, Wang GK, Morgan JP and Leaf A: Single point mutations affect fatty acid block of human myocardial sodium channel alpha subunit Na+ channels. Proc Natl Acad Sci USA. 98:3606–3611. 2001. View Article : Google Scholar

25 

Xiao YF, Ma L, Wang SY, Josephson ME, Wang GK, Morgan JP and Leaf A: Potent block of inactivation-deficient Na+ channels by n-3 polyunsaturated fatty acids. Am J Physiol Cell Physiol. 290:C362–C370. 2006. View Article : Google Scholar

26 

Besson P, Driffort V, Bon É, Gradek F, Chevalier S and Roger S: How do voltage-gated sodium channels enhance migration and invasiveness in cancer cells? Biochim Biophys Acta. 1848:2493–2501. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Pappalardo G, Almeida A and Ravasco P: Eicosapentaenoic acid in cancer improves body composition and modulates metabolism. Nutrition. 31:549–555. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Sharma A, Belna J, Espat J, Rodriguez G, Cannon VT and Hurteau JA: Effects of omega-3 fatty acids on components of the transforming growth factor beta-1 pathway: implication for dietary modification and prevention in ovarian cancer. Am J Obstet Gynecol. 200:516.e1–6. 2009. View Article : Google Scholar

29 

Sharma A, Belna J, Logan J, Espat J and Hurteau JA: The effects of Omega-3 fatty acids on growth regulation of epithelial ovarian cancer cell lines. Gynecol Oncol. 99:58–64. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Attwell D, Cohen I, Eisner D, Ohba M and Ojeda C: The steady state TTX-sensitive ('window') sodium current in cardiac Purkinje fibres. Pflugers Arch. 379:137–142. 1979. View Article : Google Scholar : PubMed/NCBI

31 

Frenz CT, Hansen A, Dupuis ND, Shultz N, Levinson SR, Finger TE and Dionne VE: NaV1.5 sodium channel window currents contribute to spontaneous firing in olfactory sensory neurons. J Neurophysiol. 112:1091–1104. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Moreau A, Krahn AD, Gosselin-Badaroudine P, Klein GJ, Christé G, Vincent Y, Boutjdir M and Chahine M: Sodium overload due to a persistent current that attenuates the arrhythmogenic potential of a novel LQT3 mutation. Front Pharmacol. 4:1262013. View Article : Google Scholar : PubMed/NCBI

33 

Janssen LJ: T-type and L-type Ca2+ currents in canine bronchial smooth muscle: Characterization and physiological roles. Am J Physiol. 272:C1757–C1765. 1997. View Article : Google Scholar : PubMed/NCBI

34 

Brackenbury WJ, Chioni AM, Diss JK and Djamgoz MB: The neonatal splice variant of Nav1.5 potentiates in vitro invasive behaviour of MDA-MB-231 human breast cancer cells. Breast Cancer Res Treat. 101:149–160. 2007. View Article : Google Scholar

35 

Baptista-Hon DT, Robertson FM, Robertson GB, Owen SJ, Rogers GW, Lydon EL, Lee NH and Hales TG: Potent inhibition by ropivacaine of metastatic colon cancer SW620 cell invasion and NaV1.5 channel function. Br J Anaesth. 113(Suppl 1): i39–i48. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Gillet L, Roger S, Besson P, Lecaille F, Gore J, Bougnoux P, Lalmanach G and Le Guennec JY: Voltage-gated sodium channel activity promotes cysteine cathepsin-dependent invasiveness and colony growth of human cancer cells. J Biol Chem. 284:8680–8691. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Xing D, Wang J, Ou S, Wang Y, Qiu B, Ding D, Guo F and Gao Q: Expression of neonatal Nav1.5 in human brain astrocytoma and its effect on proliferation, invasion and apoptosis of astrocytoma cells. Oncol Rep. 31:2692–2700. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Nelson M, Yang M, Millican-Slater R and Brackenbury WJ: Nav1.5 regulates breast tumor growth and metastatic dissemi-nation in vivo. Oncotarget. 6:32914–32929. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Ozkucur N, Monsees TK, Perike S, Do HQ and Funk RH: Local calcium elevation and cell elongation initiate guided motility in electrically stimulated osteoblast-like cells. PLoS One. 4:e61312009. View Article : Google Scholar : PubMed/NCBI

40 

Perike S, Özkucur N, Sharma P, Staroske W, Bläsche R, Barth K and Funk RH: Phospho-NHE3 forms membrane patches and interacts with beta-actin to sense and maintain constant direction during cell migration. Exp Cell Res. 324:13–29. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Ozkucur N, Perike S, Sharma P and Funk RH: Persistent directional cell migration requires ion transport proteins as direction sensors and membrane potential differences in order to maintain directedness. BMC Cell Biol. 12:42011. View Article : Google Scholar : PubMed/NCBI

42 

Roger S, Gillet L, Le Guennec JY and Besson P: Voltage-gated sodium channels and cancer: Is excitability their primary role? Front Pharmacol. 6:1522015. View Article : Google Scholar : PubMed/NCBI

43 

Yang M and Brackenbury WJ: Membrane potential and cancer progression. Front Physiol. 4:1852013. View Article : Google Scholar : PubMed/NCBI

44 

Redmann K, Müller V, Tanneberger S and Kalkoff W: The membrane potential of primary ovarian tumor cells in vitro and its dependence on the cell cycle. Acta Biol Med Ger. 28:853–856. 1972.PubMed/NCBI

45 

Brisson L, Driffort V, Benoist L, Poet M, Counillon L, Antelmi E, Rubino R, Besson P, Labbal F, Chevalier S, et al: NaV1.5 Na+ channels allosterically regulate the NHE-1 exchanger and promote the activity of breast cancer cell invadopodia. J Cell Sci. 126:4835–4842. 2013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu J, Liu D, Liu JJ, Zhao C, Yao S and Hong L: Blocking the Nav1.5 channel using eicosapentaenoic acid reduces migration and proliferation of ovarian cancer cells Corrigendum in /10.3892/ijo.2020.5129. Int J Oncol 53: 855-865, 2018.
APA
Liu, J., Liu, D., Liu, J.J., Zhao, C., Yao, S., & Hong, L. (2018). Blocking the Nav1.5 channel using eicosapentaenoic acid reduces migration and proliferation of ovarian cancer cells Corrigendum in /10.3892/ijo.2020.5129. International Journal of Oncology, 53, 855-865. https://doi.org/10.3892/ijo.2018.4437
MLA
Liu, J., Liu, D., Liu, J. J., Zhao, C., Yao, S., Hong, L."Blocking the Nav1.5 channel using eicosapentaenoic acid reduces migration and proliferation of ovarian cancer cells Corrigendum in /10.3892/ijo.2020.5129". International Journal of Oncology 53.2 (2018): 855-865.
Chicago
Liu, J., Liu, D., Liu, J. J., Zhao, C., Yao, S., Hong, L."Blocking the Nav1.5 channel using eicosapentaenoic acid reduces migration and proliferation of ovarian cancer cells Corrigendum in /10.3892/ijo.2020.5129". International Journal of Oncology 53, no. 2 (2018): 855-865. https://doi.org/10.3892/ijo.2018.4437
Copy and paste a formatted citation
x
Spandidos Publications style
Liu J, Liu D, Liu JJ, Zhao C, Yao S and Hong L: Blocking the Nav1.5 channel using eicosapentaenoic acid reduces migration and proliferation of ovarian cancer cells Corrigendum in /10.3892/ijo.2020.5129. Int J Oncol 53: 855-865, 2018.
APA
Liu, J., Liu, D., Liu, J.J., Zhao, C., Yao, S., & Hong, L. (2018). Blocking the Nav1.5 channel using eicosapentaenoic acid reduces migration and proliferation of ovarian cancer cells Corrigendum in /10.3892/ijo.2020.5129. International Journal of Oncology, 53, 855-865. https://doi.org/10.3892/ijo.2018.4437
MLA
Liu, J., Liu, D., Liu, J. J., Zhao, C., Yao, S., Hong, L."Blocking the Nav1.5 channel using eicosapentaenoic acid reduces migration and proliferation of ovarian cancer cells Corrigendum in /10.3892/ijo.2020.5129". International Journal of Oncology 53.2 (2018): 855-865.
Chicago
Liu, J., Liu, D., Liu, J. J., Zhao, C., Yao, S., Hong, L."Blocking the Nav1.5 channel using eicosapentaenoic acid reduces migration and proliferation of ovarian cancer cells Corrigendum in /10.3892/ijo.2020.5129". International Journal of Oncology 53, no. 2 (2018): 855-865. https://doi.org/10.3892/ijo.2018.4437
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team