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International Journal of Oncology
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Article

Long non-coding RNA CASC2 inhibits breast cancer cell growth and metastasis through the regulation of the miR-96-5p/SYVN1 pathway

  • Authors:
    • Zejun Gao
    • Hai Wang
    • Hangyu Li
    • Min Li
    • Jia Wang
    • Wenwen Zhang
    • Xiubin Liang
    • Dongming Su
    • Jinhai Tang
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Department of Pathology, Nanjing Medical University, Nanjing, Jiangsu 211166, P.R. China, Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning 110032, P.R. China, Department of General Surgery, The Second Affiliated Hospital with Dalian Medical University, Dalian, Liaoning 116027, P.R. China, Department of Clinical Laboratory, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210008, P.R. China
  • Pages: 2081-2090
    |
    Published online on: August 13, 2018
       https://doi.org/10.3892/ijo.2018.4522
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Abstract

Cancer susceptibility candidate 2 (CASC2), a long non-coding RNA (lncRNA), has been demonstrated to be a tumor suppressor in several types of cancer. However, the role and mechanism of CASC2 in breast cancer (BC) have not been investigated. In the present study, the expression and functions of CASC2 in BC were investigated. The expression of CASC2 was significantly decreased in BC tissues and cells compared with adjacent normal tissues and mammary epithelial cells, respectively. CASC2 overexpression inhibited the viability, migration and invasion, and elevated apoptosis of BC cells. In addition, CASC2 acted as a competing endogenous RNA for hsa-microRNA (miR)-96-5p and regulated the expression of its target gene, synoviolin (SYVN1). In miR-96-5p-overexpressed MDA-MB-231 cells, cell viability, migration and invasion was increased, and cell apoptosis was decreased, which was reversed by the upregulation of SYVN1. Taken together, the present study data indicated that decreased SYVN1 expression was a tumor suppressor, which inhibited the growth and metastasis of BC through the miR-96-5p/SYVN1 axis.
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Copy and paste a formatted citation
Spandidos Publications style
Gao Z, Wang H, Li H, Li M, Wang J, Zhang W, Liang X, Su D and Tang J: Long non-coding RNA CASC2 inhibits breast cancer cell growth and metastasis through the regulation of the miR-96-5p/SYVN1 pathway. Int J Oncol 53: 2081-2090, 2018.
APA
Gao, Z., Wang, H., Li, H., Li, M., Wang, J., Zhang, W. ... Tang, J. (2018). Long non-coding RNA CASC2 inhibits breast cancer cell growth and metastasis through the regulation of the miR-96-5p/SYVN1 pathway. International Journal of Oncology, 53, 2081-2090. https://doi.org/10.3892/ijo.2018.4522
MLA
Gao, Z., Wang, H., Li, H., Li, M., Wang, J., Zhang, W., Liang, X., Su, D., Tang, J."Long non-coding RNA CASC2 inhibits breast cancer cell growth and metastasis through the regulation of the miR-96-5p/SYVN1 pathway". International Journal of Oncology 53.5 (2018): 2081-2090.
Chicago
Gao, Z., Wang, H., Li, H., Li, M., Wang, J., Zhang, W., Liang, X., Su, D., Tang, J."Long non-coding RNA CASC2 inhibits breast cancer cell growth and metastasis through the regulation of the miR-96-5p/SYVN1 pathway". International Journal of Oncology 53, no. 5 (2018): 2081-2090. https://doi.org/10.3892/ijo.2018.4522
Copy and paste a formatted citation
x
Spandidos Publications style
Gao Z, Wang H, Li H, Li M, Wang J, Zhang W, Liang X, Su D and Tang J: Long non-coding RNA CASC2 inhibits breast cancer cell growth and metastasis through the regulation of the miR-96-5p/SYVN1 pathway. Int J Oncol 53: 2081-2090, 2018.
APA
Gao, Z., Wang, H., Li, H., Li, M., Wang, J., Zhang, W. ... Tang, J. (2018). Long non-coding RNA CASC2 inhibits breast cancer cell growth and metastasis through the regulation of the miR-96-5p/SYVN1 pathway. International Journal of Oncology, 53, 2081-2090. https://doi.org/10.3892/ijo.2018.4522
MLA
Gao, Z., Wang, H., Li, H., Li, M., Wang, J., Zhang, W., Liang, X., Su, D., Tang, J."Long non-coding RNA CASC2 inhibits breast cancer cell growth and metastasis through the regulation of the miR-96-5p/SYVN1 pathway". International Journal of Oncology 53.5 (2018): 2081-2090.
Chicago
Gao, Z., Wang, H., Li, H., Li, M., Wang, J., Zhang, W., Liang, X., Su, D., Tang, J."Long non-coding RNA CASC2 inhibits breast cancer cell growth and metastasis through the regulation of the miR-96-5p/SYVN1 pathway". International Journal of Oncology 53, no. 5 (2018): 2081-2090. https://doi.org/10.3892/ijo.2018.4522
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