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MicroRNA-98-5p inhibits proliferation and metastasis in non-small cell lung cancer by targeting TGFBR1

  • Authors:
    • Feng Jiang
    • Qiuhua Yu
    • Ying Chu
    • Xiaobo Zhu
    • Wenbin Lu
    • Qian Liu
    • Qiang Wang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiothoracic Surgery, Wujin People's Hospital of Changzhou, Changzhou, Jiangsu 213017, P.R. China, Central Laboratory, Wujin People's Hospital of Changzhou, Changzhou, Jiangsu 213017, P.R. China, Department of Oncology, Wujin People's Hospital of Changzhou, Changzhou, Jiangsu 213017, P.R. China
    Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 128-138
    |
    Published online on: October 29, 2018
       https://doi.org/10.3892/ijo.2018.4610
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Abstract

MicroRNAs (miRNAs or miRs) have recently emerged as key regulators of various types of cancer, including non‑small cell lung cancer (NSCLC). The disrupted expression of miRNAs is associated with tumorigenesis and metastasis; however, the underlying mechanisms remain unclear. In this study, we demonstrate that miR‑98‑5p is downregulated in NSCLC and that miR‑98‑5p deficiency is associated with an advanced clinical stage and metastasis. A dual‑luciferase reporter assay was performed to confirm that transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR‑98‑5p. miR‑98‑5p overexpression resulted in the downregulation of TGFBR1 and the suppression of the viability, proliferation, migration and invasion of A549 and H1299 cells. Furthermore, miR‑98‑5p was demonstrated to be an efficient suppressor of tumor growth in an A549 subcutaneous xenograft tumor mouse model. Finally, miR‑98‑5p overexpression exerted a significant anti‑metastatic effect in a mouse model of pulmonary metastasis. On the whole, the results of the present study suggest that miR‑98‑5p/TGFBR1 may serve as promising targets for NSCLC therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Jiang F, Yu Q, Chu Y, Zhu X, Lu W, Liu Q and Wang Q: MicroRNA-98-5p inhibits proliferation and metastasis in non-small cell lung cancer by targeting TGFBR1. Int J Oncol 54: 128-138, 2019.
APA
Jiang, F., Yu, Q., Chu, Y., Zhu, X., Lu, W., Liu, Q., & Wang, Q. (2019). MicroRNA-98-5p inhibits proliferation and metastasis in non-small cell lung cancer by targeting TGFBR1. International Journal of Oncology, 54, 128-138. https://doi.org/10.3892/ijo.2018.4610
MLA
Jiang, F., Yu, Q., Chu, Y., Zhu, X., Lu, W., Liu, Q., Wang, Q."MicroRNA-98-5p inhibits proliferation and metastasis in non-small cell lung cancer by targeting TGFBR1". International Journal of Oncology 54.1 (2019): 128-138.
Chicago
Jiang, F., Yu, Q., Chu, Y., Zhu, X., Lu, W., Liu, Q., Wang, Q."MicroRNA-98-5p inhibits proliferation and metastasis in non-small cell lung cancer by targeting TGFBR1". International Journal of Oncology 54, no. 1 (2019): 128-138. https://doi.org/10.3892/ijo.2018.4610
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang F, Yu Q, Chu Y, Zhu X, Lu W, Liu Q and Wang Q: MicroRNA-98-5p inhibits proliferation and metastasis in non-small cell lung cancer by targeting TGFBR1. Int J Oncol 54: 128-138, 2019.
APA
Jiang, F., Yu, Q., Chu, Y., Zhu, X., Lu, W., Liu, Q., & Wang, Q. (2019). MicroRNA-98-5p inhibits proliferation and metastasis in non-small cell lung cancer by targeting TGFBR1. International Journal of Oncology, 54, 128-138. https://doi.org/10.3892/ijo.2018.4610
MLA
Jiang, F., Yu, Q., Chu, Y., Zhu, X., Lu, W., Liu, Q., Wang, Q."MicroRNA-98-5p inhibits proliferation and metastasis in non-small cell lung cancer by targeting TGFBR1". International Journal of Oncology 54.1 (2019): 128-138.
Chicago
Jiang, F., Yu, Q., Chu, Y., Zhu, X., Lu, W., Liu, Q., Wang, Q."MicroRNA-98-5p inhibits proliferation and metastasis in non-small cell lung cancer by targeting TGFBR1". International Journal of Oncology 54, no. 1 (2019): 128-138. https://doi.org/10.3892/ijo.2018.4610
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