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Article

LncRNA BLACAT1 is involved in chemoresistance of non‑small cell lung cancer cells by regulating autophagy

  • Authors:
    • Feng‑Xiang Huang
    • Hong‑Jie Chen
    • Fu‑Xia Zheng
    • Zeng‑Yan Gao
    • Pan‑Feng Sun
    • Qiang Peng
    • Ying Liu
    • Xiang Deng
    • Ya‑Hui Huang
    • Chang Zhao
    • Li‑Jun Miao
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China, Department of Lung Disease Medicine, Traditional Chinese Medicine Hospital of Henan Province, Zhengzhou, Henan 450052, P.R. China, Department of Respiratory Medicine, The Affiliated Hospital of Weifang Medical University, Weifang, Shandong 261031, P.R. China, Department of Respiratory Medicine, The Affiliated Huaihe Hospital of Henan University, Kaifeng, Henan 475000, P.R. China
  • Pages: 339-347
    |
    Published online on: October 31, 2018
       https://doi.org/10.3892/ijo.2018.4614
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Abstract

The aim of the present study was to determine the effect of the long non‑coding RNA (lncRNA) bladder cancer‑associated transcript 1 (BLACAT1) in chemoresistance of non‑small cell lung cancer (NSCLC) cells. Expression of lncRNA BLACAT1, microRNA (miR)‑17, autophagy‑related protein 7 (ATG7), multidrug‑resistance protein 1 (MRP1), and the autophagy‑associated proteins light chain 3 (LC3)‑II/LC3‑I and Beclin 1 were detected using the reverse transcription‑quantitative polymerase chain reaction and western blot analysis. Cell viability was determined using an MTT assay. The interaction between BLACAT1 and miR‑17 was determined using RNA immunoprecipitation and RNA pull‑down assays. A cisplatin (DDP)‑resistant NSCLC cell A549/DDP xenograft model in nude mice was established to investigate the effect of BLACAT1 on the chemoresistance of NSCLC cells. Compared with in DDP‑sensitive NSCLC cells, expression of BLACAT1, ATG7, MRP1, LC3‑II/LC3‑I and Beclin 1 was significantly upregulated in DDP‑resistant NSCLC cells, whereas miR‑17 was downregulated in DDP‑resistant NSCLC cells. Short interfering RNA against BLACAT1 decreased the viability of DDP‑resistant NSCLC cells. In addition, BLACAT1 interacted with miR‑17, and negatively regulated miR‑17. BLACAT1 promoted ATG7 expression through miR‑17, and facilitated autophagy and promoted chemoresistance of NSCLC cells through miR‑17/ATG7. Finally, in vivo experiments indicated that inhibition of BLACAT1 ameliorated the chemoresistance of NSCLC. BLACAT1 was upregulated in DDP‑resistant NSCLC cells, and promoted autophagy and chemoresistance of NSCLC cells through the miR‑17/ATG7 signaling pathway.
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1 

Sapalidis K, Zarogoulidis P, Pavlidis E, Laskou S, Katsaounis A, Koulouris C, Giannakidis D, Mantalovas S, Huang H, Bai C, et al: Aerosol Immunotherapy with or without Cisplatin for metastatic lung cancer non-small cell lung cancer disease: In vivo Study. A more efficient combination J Cancer. 9:1973–1977. 2018.

2 

Bach DH, Kim D, Bae SY, Kim WK, Hong JY, Lee HJ, Rajasekaran N, Kwon S, Fan Y, Luu TT, et al: Targeting Nicotinamide N-Methyltransferase and miR-449a in EGFR-TKI-Resistant Non-Small-Cell Lung Cancer Cells. Mol Ther Nucleic Acids. 11:455–467. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Boya P, Reggiori F and Codogno P: Emerging regulation and functions of autophagy. Nat Cell Biol. 15:713–720. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Kim M, Jung JY, Choi S, Lee H, Morales LD, Koh JT, Kim SH, Choi YD, Choi C, Slaga TJ, et al: GFRA1 promotes cisplatin-induced chemoresistance in osteosarcoma by inducing autophagy. Autophagy. 13:149–168. 2017. View Article : Google Scholar :

5 

Mani J, Vallo S, Rakel S, Antonietti P, Gessler F, Blaheta R, Bartsch G, Michaelis M, Cinatl J, Haferkamp A, et al: Chemoresistance is associated with increased cytoprotective autophagy and diminished apoptosis in bladder cancer cells treated with the BH3 mimetic (-)-Gossypol (AT-101). BMC Cancer. 15:2242015. View Article : Google Scholar : PubMed/NCBI

6 

Kim TW, Lee SY, Kim M, Cheon C, Jang BH, Shin YC and Ko SG: DSGOST regulates resistance via activation of autophagy in gastric cancer. Cell Death Dis. 9:6492018. View Article : Google Scholar : PubMed/NCBI

7 

Hong SB, Kim BW, Lee KE, Kim SW, Jeon H, Kim J and Song HK: Insights into noncanonical E1 enzyme activation from the structure of autophagic E1 Atg7 with Atg8. Nat Struct Mol Biol. 18:1323–1330. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Noda NN, Satoo K, Fujioka Y, Kumeta H, Ogura K, Nakatogawa H, Ohsumi Y and Inagaki F: Structural basis of Atg8 activation by a homodimeric E1, Atg7. Mol Cell. 44:462–475. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Yamaguchi M, Satoo K, Suzuki H, Fujioka Y, Ohsumi Y, Inagaki F and Noda NN: Atg7 Activates an Autophagy-Essential Ubiquitin-like Protein Atg8 through Multi-Step Recognition. J Mol Biol. 430:249–257. 2018. View Article : Google Scholar

10 

Wang G, Chen EN, Liang C, Liang J, Gao LR, Chuai M, Münsterberg A, Bao Y, Cao L and Yang X: Atg7-Mediated Autophagy Is Involved in the Neural Crest Cell Generation in Chick Embryo. Mol Neurobiol. 55:3523–3536. 2018. View Article : Google Scholar

11 

Gonzalez Y, Aryal B, Chehab L and Rao VA: Atg7- and Keap1-dependent autophagy protects breast cancer cell lines against mitoquinone-induced oxidative stress. Oncotarget. 5:1526–1537. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Zhang Hu J, Mei L, Jiang Z, Yi Y, Liu Y, Meng L, Zhou Y, Zeng L, Wu JH, et al: Interaction of E3 ubiquitin ligase MARCH7 with long noncoding RNA MALAT1 and autophagy-related protein ATG7 promotes autophagy and invasion in ovarian cancer. Cell Physiol Biochem. 47:654–666. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Mandelbaum J, Rollins N, Shah P, Bowman D, Lee JY, Tayber O, Bernard H, LeRoy P, Li P, Koenig E, et al: Identification of a lung cancer cell line deficient in atg7-dependent autophagy. Autophagy. Jun 19–2015.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI

14 

Desai S, Liu Z, Yao J, Patel N, Chen J, Wu Y, Ahn EE, Fodstad O and Tan M: Heat shock factor 1 (HSF1) controls chemoresistance and autophagy through transcriptional regulation of autophagy-related protein 7 (ATG7). J Biol Chem. 288:9165–9176. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Xu N, Zhang J, Shen C, Luo Y, Xia L, Xue F and Xia Q: Cisplatin-induced downregulation of miR-199a-5p increases drug resistance by activating autophagy in HCC cell. Biochem Biophys Res Commun. 423:826–831. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Sun W, Zu Y, Fu X and Deng Y: Knockdown of lncRNA-XIST enhances the chemosensitivity of NSCLC cells via suppression of autophagy. Oncol Rep. 38:3347–3354. 2017.PubMed/NCBI

17 

Fabian MR, Sonenberg N and Filipowicz W: Regulation of mRNA translation and stability by microRNAs. Annu Rev Biochem. 79:351–379. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Filipska M, Skrzypski M, Czetyrbok K, Stokowy T, Stasiłojć G, Supernat A, Jassem J, Żaczek AJ and Bigda J: MiR-192 and miR-662 enhance chemoresistance and invasiveness of squamous cell lung carcinoma. Lung Cancer. 118:111–118. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Wei X, Shen X, Ren Y and Hu W: The roles of micrornas in regulating chemotherapy resistance of non-small cell lung cancer. Curr Pharm Des. 23:5983–5988. 2018. View Article : Google Scholar

20 

Zhao J, Fu W, Liao H, Dai L, Jiang Z, Pan Y, Huang H, Mo Y, Li S, Yang G, et al: The regulatory and predictive functions of miR-17 and miR-92 families on cisplatin resistance of non-small cell lung cancer. BMC Cancer. 15:7312015. View Article : Google Scholar : PubMed/NCBI

21 

Comincini S, Allavena G, Palumbo S, Morini M, Durando F, Angeletti F, Pirtoli L and Miracco C: microRNA-17 regulates the expression of ATG7 and modulates the autophagy process, improving the sensitivity to temozolomide and low-dose ionizing radiation treatments in human glioblastoma cells. Cancer Biol Ther. 14:574–586. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Hu B, Zhang H, Wang Z, Zhang F, Wei H and Li L: LncRNA CCAT1/miR-130a-3p axis increases cisplatin resistance in non-small-cell lung cancer cell line by targeting SOX4. Cancer Biol Ther. 18:974–983. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Wang P, Chen D, Ma H and Li Y: LncRNA SNHG12 contributes to multidrug resistance through activating the MAPK/Slug pathway by sponging miR-181a in non-small cell lung cancer. Oncotarget. 8:84086–84101. 2017.PubMed/NCBI

24 

Ye JR, Liu L and Zheng F: Long noncoding RNA bladder cancer associated transcript 1 promotes the proliferation, migration, and invasion of nonsmall cell lung cancer through sponging miR-144. DNA Cell Biol. 36:845–852. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Wu X, Zheng Y, Han B and Dong X: Long noncoding RNA BLACAT1 modulates ABCB1 to promote oxaliplatin resistance of gastric cancer via sponging miR-361. Biomed Pharmacother. 99:832–838. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar

27 

Zhang W, Cai X, Yu J, Lu X, Qian Q and Qian W: Exosome-mediated transfer of lncRNA RP11 838N2.4 promotes erlotinib resistance in non-small cell lung cancer. Int J Oncol. 53:527–538. 2018.PubMed/NCBI

28 

He W, Cai Q, Sun F, Zhong G, Wang P, Liu H, Luo J, Yu H, Huang J and Lin T: linc-UBC1 physically associates with polycomb repressive complex 2 (PRC2) and acts as a negative prognostic factor for lymph node metastasis and survival in bladder cancer. Biochim Biophys Acta. 1832.1528–1537. 2013.

29 

Zhang Su J, Han E, Yin L, Liu D, He Z, Zhang X, Lin Y, Lin F, Mao QP, et al: Long noncoding RNA BLACAT1 indicates a poor prognosis of colorectal cancer and affects cell proliferation by epigenetically silencing of p15. Cell Death Dis. 8:e26652017. View Article : Google Scholar : PubMed/NCBI

30 

Wang Gu J, Zhang D, Zhu J, Li Y, Chen Y, Shi H, Wang M, Shen X, Deng BX, et al: GFRα2 prompts cell growth and chemoresistance through down-regulating tumor suppressor gene PTEN via Mir-17-5p in pancreatic cancer. Cancer Lett. 380:434–441. 2016. View Article : Google Scholar

31 

Ao X, Nie P, Wu B, Xu W, Zhang T, Wang S, Chang H and Zou Z: Decreased expression of microRNA-17 and microRNA-20b promotes breast cancer resistance to taxol therapy by upregu-lation of NCOA3. Cell Death Dis. 7:e24632016. View Article : Google Scholar

32 

Notte A, Leclere L and Michiels C: Autophagy as a mediator of chemotherapy-induced cell death in cancer. Biochem Pharmacol. 82:427–434. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Wu WK, Coffelt SB, Cho CH, Wang XJ, Lee CW, Chan FK, Yu J and Sung JJ: The autophagic paradox in cancer therapy. Oncogene. 31:939–953. 2012. View Article : Google Scholar

34 

Piya S, Kornblau SM, Ruvolo VR, Mu H, Ruvolo PP, McQueen T, Davis RE, Hail N Jr, Kantarjian H, Andreeff M, et al: Atg7 suppression enhances chemotherapeutic agent sensitivity and overcomes stroma-mediated chemoresistance in acute myeloid leukemia. Blood. 128:1260–1269. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Huang FX, Chen HJ, Zheng FX, Gao ZY, Sun PF, Peng Q, Liu Y, Deng X, Huang YH, Zhao C, Zhao C, et al: LncRNA BLACAT1 is involved in chemoresistance of non‑small cell lung cancer cells by regulating autophagy. Int J Oncol 54: 339-347, 2019.
APA
Huang, F., Chen, H., Zheng, F., Gao, Z., Sun, P., Peng, Q. ... Miao, L. (2019). LncRNA BLACAT1 is involved in chemoresistance of non‑small cell lung cancer cells by regulating autophagy. International Journal of Oncology, 54, 339-347. https://doi.org/10.3892/ijo.2018.4614
MLA
Huang, F., Chen, H., Zheng, F., Gao, Z., Sun, P., Peng, Q., Liu, Y., Deng, X., Huang, Y., Zhao, C., Miao, L."LncRNA BLACAT1 is involved in chemoresistance of non‑small cell lung cancer cells by regulating autophagy". International Journal of Oncology 54.1 (2019): 339-347.
Chicago
Huang, F., Chen, H., Zheng, F., Gao, Z., Sun, P., Peng, Q., Liu, Y., Deng, X., Huang, Y., Zhao, C., Miao, L."LncRNA BLACAT1 is involved in chemoresistance of non‑small cell lung cancer cells by regulating autophagy". International Journal of Oncology 54, no. 1 (2019): 339-347. https://doi.org/10.3892/ijo.2018.4614
Copy and paste a formatted citation
x
Spandidos Publications style
Huang FX, Chen HJ, Zheng FX, Gao ZY, Sun PF, Peng Q, Liu Y, Deng X, Huang YH, Zhao C, Zhao C, et al: LncRNA BLACAT1 is involved in chemoresistance of non‑small cell lung cancer cells by regulating autophagy. Int J Oncol 54: 339-347, 2019.
APA
Huang, F., Chen, H., Zheng, F., Gao, Z., Sun, P., Peng, Q. ... Miao, L. (2019). LncRNA BLACAT1 is involved in chemoresistance of non‑small cell lung cancer cells by regulating autophagy. International Journal of Oncology, 54, 339-347. https://doi.org/10.3892/ijo.2018.4614
MLA
Huang, F., Chen, H., Zheng, F., Gao, Z., Sun, P., Peng, Q., Liu, Y., Deng, X., Huang, Y., Zhao, C., Miao, L."LncRNA BLACAT1 is involved in chemoresistance of non‑small cell lung cancer cells by regulating autophagy". International Journal of Oncology 54.1 (2019): 339-347.
Chicago
Huang, F., Chen, H., Zheng, F., Gao, Z., Sun, P., Peng, Q., Liu, Y., Deng, X., Huang, Y., Zhao, C., Miao, L."LncRNA BLACAT1 is involved in chemoresistance of non‑small cell lung cancer cells by regulating autophagy". International Journal of Oncology 54, no. 1 (2019): 339-347. https://doi.org/10.3892/ijo.2018.4614
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